Schizophrenia (Heidelberg, Germany)最新文献_第2页

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-07-09 DOI: 10.1038/s41537-026-00784-5

Fei Jiang, Qing Tian, Lulu Xu, Qun Yang, Peijuan Wang, Lei Ji, Jing Cao, Xiaoying Zhang, Yong Yang, Xiaobin Zhang

{"title":"Glutathione-related redox imbalance and cognitive impairment in drug-naïve, first-episode schizophrenia: a focus on GSSG.","authors":"Fei Jiang, Qing Tian, Lulu Xu, Qun Yang, Peijuan Wang, Lei Ji, Jing Cao, Xiaoying Zhang, Yong Yang, Xiaobin Zhang","doi":"10.1038/s41537-026-00784-5","DOIUrl":"https://doi.org/10.1038/s41537-026-00784-5","url":null,"abstract":"Cognitive impairment is a core feature of schizophrenia, yet the biological basis has not been established. Redox dysregulation has been implicated in cognitive impairment of patients with schizophrenia but evidence in early-stage, drug-naïve patients is limited and inconsistent. Herein we examined glutathione-related redox markers and the associations with cognition in 96 drug-naïve, first-episode schizophrenia patients and 94 matched controls. Patients with schizophrenia exhibited a systemic redox imbalance that was characterized by increased glutathione (GSH) and glutathione disulfide (GSSG) levels with a reduced GSH-to-GSSG ratio, while glutathione reductase activity remained unchanged. Marked cognitive deficits were observed across all domains. Among redox markers, GSSG showed robust and consistent negative associations with global cognition and multiple domains, and emerged as an independent predictor after covariate adjustment. In contrast, GSH and the GSH-to-GSSG ratio had weaker and less stable associations. No reliable relationships were demonstrated between redox markers and clinical symptoms after correction for multiple comparisons. These findings are the basis for a functionally asymmetric redox dysregulation model, in which increased oxidative load, indexed by GSSG, has a central role in early cognitive impairment, relatively independent of antioxidant capacity. These findings highlight GSSG as a candidate biomarker for early cognitive impairment and suggest redox-targeted interventions as a potential therapeutic strategy in schizophrenia.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared genetic architecture between schizophrenia and subcortical brain susceptibility phenotypes. 精神分裂症与皮层下脑易感性表型之间的共享遗传结构。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-07-07 DOI: 10.1038/s41537-026-00782-7

Yingying Xie, Jiaojiao Du, Yao Zhao, Jie Sun, Shiqi Lin, Ningnannan Zhang, Zhang Zhang, Feng Liu, Dairong Cao

{"title":"Shared genetic architecture between schizophrenia and subcortical brain susceptibility phenotypes.","authors":"Yingying Xie, Jiaojiao Du, Yao Zhao, Jie Sun, Shiqi Lin, Ningnannan Zhang, Zhang Zhang, Feng Liu, Dairong Cao","doi":"10.1038/s41537-026-00782-7","DOIUrl":"https://doi.org/10.1038/s41537-026-00782-7","url":null,"abstract":"Schizophrenia (SCZ) is a highly heritable and complex neuropsychiatric disorder. Emerging evidence implicates dysregulated brain iron, particularly in subcortical regions, in SCZ pathophysiology. Here, we systematically dissected the shared genetic architecture between SCZ and subcortical brain susceptibility phenotypes by integrating large-scale genome-wide association study (GWAS) data with quantitative susceptibility mapping (QSM) phenotypes across 16 subcortical regions. Using the MiXeR framework, we quantified the extent and pattern of shared genetic overlap between SCZ and each QSM phenotype, revealing the strongest overlap in the left and right nucleus accumbens. Conditional and conjunction false discovery rate analyses identified 666 unique shared SNPs. Functional annotation highlighted enrichment in pathways related to synaptic function and neuronal development, with pronounced expression in neurons. Additionally, we characterized their spatio-temporal expression patterns of shared genes and identified 89 significant expression-trait associations linked to SCZ-related phenotypes. Furthermore, the virtual drug screen identified 691 potential protein-drug pairs that may contribute to both iron regulation and SCZ. Our findings provide new insights into the complex interaction between subcortical brain susceptibility phenotypes and SCZ, highlighting pathways that may offer novel therapeutic strategies for SCZ and related brain susceptibility-associated conditions.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reading body and face language in male schizophrenia. 男性精神分裂症的肢体和面部语言解读。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-07-07 DOI: 10.1038/s41537-026-00775-6

Annika Resch, Alexander N Sokolov, Patrick Steinwand, Andreas J Fallgatter, Marina A Pavlova

{"title":"Reading body and face language in male schizophrenia.","authors":"Annika Resch, Alexander N Sokolov, Patrick Steinwand, Andreas J Fallgatter, Marina A Pavlova","doi":"10.1038/s41537-026-00775-6","DOIUrl":"10.1038/s41537-026-00775-6","url":null,"abstract":"Neurotypical people are generally quite adept at interpreting social signals from dynamic bodies and faces. This ability prevents one from incurring high costs associated with ineffective and maladaptive social interactions. Individuals with mental disorders, such as schizophrenia (SZ), often exhibit deficits in nonverbal social cognition. It remains unclear whether reading the language of bodies and faces is affected by SZ, and if this is indeed the case, how these potential deficits are related to one another. In the present study, participants (28 males with SZ and 28 typically developing, TD, matched controls) were administered face-to-face computer tasks on inferring emotions from dynamic point-light body motion and faces. The outcome indicates that SZ patients exhibit global impairments in both body and face reading, albeit patients demonstrate a similar emotion recognition profile as TD controls. In SZ patients only, a positive link was found between accuracy of recognizing emotions expressed through faces and bodies, whereas processing speed of emotions conveyed through bodies and faces was tied to each other in both SZ and TD individuals. For SZ patients, inferring social signals from dynamic faces and bodies may be rather challenging in terms of neurocognitive mechanisms, which is reflected in the tight link in recognition accuracy. Along with previous data on inferring emotions in the eyes collected in the same cohort, this work provides novel insights into the specific global aberrations in social cognition in SZ and offers a blueprint for the development of strategies for the targeted treatment of gender-specific mental disorders.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the molecular mechanisms of clozapine-induced seizures: a network pharmacology and molecular docking-based investigation. 揭示氯氮平诱发癫痫发作的分子机制：基于网络药理学和分子对接的研究。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-29 DOI: 10.1038/s41537-026-00773-8

Daxiang Lian, Jian Li, Bo Han, Xia Liu, Ranli Li, Xiaoyan Ma, Fuqiang Mao, Chuanjun Zhuo

{"title":"Unveiling the molecular mechanisms of clozapine-induced seizures: a network pharmacology and molecular docking-based investigation.","authors":"Daxiang Lian, Jian Li, Bo Han, Xia Liu, Ranli Li, Xiaoyan Ma, Fuqiang Mao, Chuanjun Zhuo","doi":"10.1038/s41537-026-00773-8","DOIUrl":"10.1038/s41537-026-00773-8","url":null,"abstract":"Clozapine is the preferred treatment for refractory schizophrenia. However, clozapine use is constrained by the risk of clozapine‑induced seizures (CISs). The molecular mechanisms behind CISs are complex and poorly understood. The objective of this study was to identify the core targets and signaling pathways contributing to CISs using network pharmacology and molecular docking. Potential targets for clozapine and seizures were screened using multiple databases, and overlapping targets were identified. Protein-protein interaction (PPI) networks were constructed using the STRING database and visualized in Cytoscape to identify core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of the core targets were performed, and a disease-target-pathway-drug network was constructed. The docking of clozapine with the core targets was evaluated to determine the stability of their interactions. Of the 656 potential targets for clozapine and 1260 targets for seizure, 104 targets overlapped. PPI analysis of the overlapping targets yielded 12 core targets. KEGG pathway enrichment analysis demonstrated that glutamatergic, dopaminergic, and GABAergic synapses may be key pathways mediating CIS. The molecular docking results showed that clozapine had strong binding affinities for the core targets, BDNF, GRIN2B, GRIN2A, and GAD1. Thus, clozapine may interfere with the glutamatergic, dopaminergic, and GABAergic synaptic pathways by modulating BDNF, GRIN2B, GRIN2A, and GAD1. Modulation of these core targets may contribute to excitatory-inhibitory imbalance in the central nervous system, thereby potentially increasing seizure susceptibility. This study provides an integrative perspective on the potential pathophysiology of CIS and suggests directions for future experimental validation and risk intervention strategies.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stressful life events and their association with symptom severity and functioning in first-episode psychosis. 应激性生活事件及其与首发精神病症状严重程度和功能的关系

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-26 DOI: 10.1038/s41537-026-00778-3

Stefania Tognin, Mariia Moroz, Aljawharah Almuqrin, Maria Chiara Del Piccolo, Ryan Hammoud, Anna Georgiades, Andrea Mechelli

{"title":"Stressful life events and their association with symptom severity and functioning in first-episode psychosis.","authors":"Stefania Tognin, Mariia Moroz, Aljawharah Almuqrin, Maria Chiara Del Piccolo, Ryan Hammoud, Anna Georgiades, Andrea Mechelli","doi":"10.1038/s41537-026-00778-3","DOIUrl":"10.1038/s41537-026-00778-3","url":null,"abstract":"Stressful life events (SLEs) are a risk factor for psychosis; however, evidence on the impact of SLEs in individuals with first-episode psychosis (FEP) is limited. The current study draws on longitudinal data from the social mind study (ISRCTN85485447) and examines whether SLEs predict subsequent symptom severity, functioning, and relapse among individuals with first-episode psychosis (FEP). We hypothesised that greater exposure to SLEs at baseline would be associated with poorer clinical outcomes at follow-up. Data from 265 FEP participants across 10 sites in the United Kingdom were examined to investigate the associations between baseline SLEs and changes in symptom severity, functioning, and relapse over a 1-year follow-up. Statistical models were adjusted for age, sex, ethnicity, and site. Greater baseline SLE exposure predicted more severe general psychopathology both across assessment timepoints (p < 0.05) and at 12 months (p < 0.05). Baseline SLEs predicted poorer functioning (measured using GAF symptoms and disability) across assessment timepoints (p < 0.05). Baseline SLE exposure was not associated with increased odds of relapse. In conclusion, this study shows that FEP individuals who were exposed to SLEs prior to baseline exhibited more severe general psychopathology and poorer functioning. SLEs assessment should be integrated into early psychosis care and inform early intervention strategies addressing social stress.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring interaction with environmental affordances in schizophrenia spectrum disorders using virtual reality. 利用虚拟现实技术探索精神分裂症谱系障碍与环境可视性的相互作用。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-25 DOI: 10.1038/s41537-026-00774-7

Marco Kramer, Dustin Hirsch, Alice Sader, Julien Willms, Georg Juckel, Paraskevi Mavrogiorgou

{"title":"Exploring interaction with environmental affordances in schizophrenia spectrum disorders using virtual reality.","authors":"Marco Kramer, Dustin Hirsch, Alice Sader, Julien Willms, Georg Juckel, Paraskevi Mavrogiorgou","doi":"10.1038/s41537-026-00774-7","DOIUrl":"10.1038/s41537-026-00774-7","url":null,"abstract":"Schizophrenia has been associated with disturbances in perceiving affordances, i.e. action possibilities offered by the environment. However, empirical research has largely relied on static laboratory tasks that poorly capture the dynamic perception-action loops of everyday environments. In this exploratory study, we used immersive virtual reality (VR) to examine environmental exploration and interaction in patients with schizophrenia and healthy controls (n = 19 each). Participants completed baseline questionnaires including self-report measures of anomalous world experience and were exposed to natural and urban 360° video environments and an interactive VR game. Their field of view was recorded and manually coded using a predefined coding scheme. Subjective affect, stress, and presence were assessed before and after VR exposure. Patients with schizophrenia showed reduced visual exploration of the environments, reflected by fewer gaze shifts per minute compared with controls, particularly in urban scenes. In the interactive VR game, overall object interaction patterns were comparable, although patients showed a tendency toward longer latencies before initiating social interaction with a virtual non-player character. Reduced fixation of the character's face was strongly associated with domains of anomalous world experience related to other persons, language, and atmosphere. Qualitative observations further suggested that immersive environments could interact with the sense-making of psychotic experiences in a few participants. Although preliminary given the limited sample size, these findings indicate subtle alterations in how patients with schizophrenia explore their surroundings, while basic object interaction remains preserved. Immersive VR paradigms may provide a promising experimental platform to investigate altered subject-world relations in psychosis.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion recognition misclassification patterns in individuals with psychotic spectrum disorders and history of interpersonal aggression. 有人际攻击史的精神病谱系障碍患者的情绪识别错误分类模式。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-24 DOI: 10.1038/s41537-026-00776-5

Gabriela Gavalova, Petri Laukka, Lennart Högman, Malin V Källman, Marianne Kristiansson, Märta Wallinius, Håkan Fischer, Anette G M Johansson

{"title":"Emotion recognition misclassification patterns in individuals with psychotic spectrum disorders and history of interpersonal aggression.","authors":"Gabriela Gavalova, Petri Laukka, Lennart Högman, Malin V Källman, Marianne Kristiansson, Märta Wallinius, Håkan Fischer, Anette G M Johansson","doi":"10.1038/s41537-026-00776-5","DOIUrl":"10.1038/s41537-026-00776-5","url":null,"abstract":"Research suggests a need for more ecologically valid assessments of emotion recognition in aggressive individuals with psychotic spectrum disorder (PSD). We employed a task featuring dynamic, multimodal (visual and auditory) expressions of a broad range of positive and negative emotions. Emotion recognition accuracy and misclassification patterns were compared between individuals with PSD and a history of interpersonal aggression (PSD+AGG; n = 79), individuals with PSD without such a history (PSD-AGG; n = 72), and healthy controls (HC; n = 86). Analyses of variance investigated effects of presentation modality (visual, auditory, multimodal), emotion category (12 emotions), valence (positive, negative), and arousal (high, low). Across analyses, the PSD+AGG group showed significantly lower accuracy than the PSD-AGG group, which in turn showed significantly lower accuracy than the HC group. Misclassification patterns revealed that the PSD+AGG group was more likely to misclassify negative emotions as positive emotions compared to the PSD-AGG group. Multiple regression analyses indicated that accuracy was most strongly predicted by fluid intelligence and semantic understanding of emotion words in individuals with PSD, with significant additional effects of gender, history of substance use disorders in remission, and educational attainment. PSD group remained a significant predictor of accuracy after controlling for these factors. In summary, individuals with PSD and a history of interpersonal aggression exhibit more pronounced deficits in emotion recognition than those with PSD alone. This underscores the potential value of incorporating emotion recognition assessment and training into clinical interventions to reduce aggression risk and improve social functioning in individuals with PSD.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"12 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric properties of Lehman's quality of life interview and its modifications: a systematic review using the COSMIN methodology. 雷曼生活质量访谈的心理测量特性及其修正：使用COSMIN方法的系统回顾。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-23 DOI: 10.1038/s41537-026-00777-4

Max Wiessner, Milena Zúñiga Le-Bert, Sophia Wehr, Lucia Weigel, Stefan Leucht

{"title":"Psychometric properties of Lehman's quality of life interview and its modifications: a systematic review using the COSMIN methodology.","authors":"Max Wiessner, Milena Zúñiga Le-Bert, Sophia Wehr, Lucia Weigel, Stefan Leucht","doi":"10.1038/s41537-026-00777-4","DOIUrl":"10.1038/s41537-026-00777-4","url":null,"abstract":"Background: Schizophrenia is a severe mental disorder with significant impact on quality of life (QoL). Reliable measurement of QoL is essential for evaluating treatment outcomes.Methods: We applied the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) systematic review guideline to evaluate the psychometric properties of Lehman's Quality of Life Interview (QOLI), the Lancashire Quality of Life Profile (LQOLP), and the Manchester Short Assessment of Quality of Life (MANSA) as patient-reported outcome measures (PROMs).Results: The combined search of PubMed and EMBASE yielded 19 included studies: 4 for QOLI, 10 for LQOLP, and 4 for MANSA. The overall results of the measurement properties across all three scales are largely insufficient or indeterminate. Evidence for several measurement properties is missing for the individual scales, with studies on content validity in particular being absent for all three scales.Conclusion: All three scales fall in COSMIN category B, meaning they have potential to be recommended but certain important evidence for recommendation is missing. However, newer scales - such as the Schizophrenia Quality of Life Scale - have been developed using more modern approaches. Consequently, prioritizing the further evaluation of these newer instruments may prove more productive than continued research into older scales.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"12 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13291225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial. 情绪调节是虚拟现实辅助听觉幻觉治疗的一种改变机制吗？CHALLENGE随机临床试验的二次分析。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-21 DOI: 10.1038/s41537-026-00779-2

Louise Birkedal Glenthøj, Ditte Lammers Vernal, Lise Sandvig Mariegaard, Lisa Charlotte Smith, Mads Juul Christensen, Sara Breivik Soleim, Tina Dam Kristensen, Neil Thomas, Merete Nordentoft, Carsten Hjorthøj

{"title":"Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial.","authors":"Louise Birkedal Glenthøj, Ditte Lammers Vernal, Lise Sandvig Mariegaard, Lisa Charlotte Smith, Mads Juul Christensen, Sara Breivik Soleim, Tina Dam Kristensen, Neil Thomas, Merete Nordentoft, Carsten Hjorthøj","doi":"10.1038/s41537-026-00779-2","DOIUrl":"10.1038/s41537-026-00779-2","url":null,"abstract":"Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these improvements remain unclear. Emotional processes may play a role during therapeutic encounters with simulated voices, but it is unknown whether treatment effects involve broader changes in emotion regulation. We conducted secondary analyses of the CHALLENGE randomized clinical trial (N = 270), comparing a seven-session immersive VR-based avatar therapy with enhanced treatment as usual (standard care plus additional supportive counseling). Mediation models tested whether changes in cognitive reappraisal or expressive suppression, assessed using the Emotion Regulation Questionnaire (ERQ), mediated treatment effects on AVH severity and frequency at treatment end. Randomization to VR-assisted therapy did not significantly change ERQ reappraisal or suppression. Although higher reappraisal at follow-up was associated with lower AVH severity, no significant indirect effects were observed. These findings suggest that improvements following VR-assisted avatar therapy are unlikely to be explained by changes in self-reported trait emotion regulation strategies and may instead reflect more context-specific processes during voice confrontation.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding neurodevelopmental changes in schizophrenia: a comprehensive systematic review of neurogenic alterations. 解码精神分裂症的神经发育变化：对神经源性改变的全面系统回顾。

IF 4.1

Schizophrenia (Heidelberg, Germany) Pub Date : 2026-06-16 DOI: 10.1038/s41537-026-00769-4

Noemí Rueda, Ana Gómez-Garrido, María Alemany-Navarro, Nathalia Garrido-Torres, Miguel Ruíz-Veguilla, Benedicto Crespo-Facorro, Susana García-Cerro

{"title":"Decoding neurodevelopmental changes in schizophrenia: a comprehensive systematic review of neurogenic alterations.","authors":"Noemí Rueda, Ana Gómez-Garrido, María Alemany-Navarro, Nathalia Garrido-Torres, Miguel Ruíz-Veguilla, Benedicto Crespo-Facorro, Susana García-Cerro","doi":"10.1038/s41537-026-00769-4","DOIUrl":"https://doi.org/10.1038/s41537-026-00769-4","url":null,"abstract":"Schizophrenia (SCZ) is a chronic brain disorder with significant impacts on patients, families, and society, affecting health, social life, and economic well-being. Despite extensive research, the biological basis of SCZ remains unclear. However, evidence suggests that disruptions in brain development, including neurogenesis, neuronal migration, synaptogenesis, and circuit maturation, may contribute to the risk of developing SCZ later in life. This review integrates findings from in vivo and in vitro studies on SCZ tissues, providing a comprehensive overview of neurodevelopmental alterations, with a particular focus on neurogenesis. We examine alterations in brain trophic support, inflammatory states, and alterations in cell markers, molecular pathways, and genetic factors implicated in both neurogenic and broader developmental processes. Additionally, we explore anomalies in miRNAs and genetic variations, such as single nucleotide polymorphisms (SNPs) and chromosome structure alterations, linked to SCZ. This review provides a framework to guide future research on the genetic, cellular, and molecular mechanisms underlying SCZ, with particular emphasis on neurogenesis within a broader neurodevelopmental context.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0