Advances in Virology最新文献

{"title":"Knowledge and Attitude towards Human Papilloma Virus Infection, Vaccines, and Cervical Cancer Prevention among School Students in Kano, Nigeria.","authors":"Ismail Rabiu,&nbsp;Zainab Yahuza","doi":"10.1155/2023/2803420","DOIUrl":"https://doi.org/10.1155/2023/2803420","url":null,"abstract":"<p><p>The rising cases of human papillomavirus (HPV) infection and cervical cancer cases in Nigeria are alarming. Only a few studies have looked at secondary school students in Nigeria's understanding of HPV infection and vaccine acceptance, whereas earlier studies have mostly focused on screening. In this study, 400 students from two secondary schools in Kano State, Nigeria, were engaged with the aim of assessing their level of knowledge and attitudes regarding HPV infection. The study further seeks to understand the respondent's opinion on HPV vaccination and sensitize them to the health effects of HPV infection, thereby communicating the findings to the authorities concerned with policy making. The study revealed that only 128 (32%) and 142 (35.5%) respondents have knowledge about HPV and cervical cancer, respectively. Furthermore, none of the respondents were administered the HPV vaccine, with 81% of them not ready to take the vaccine. It was observed that the majority of the respondents (91%) believed that early hospital visits could help in mitigating HPV or cervical cancer cases. Following their sensitization, the respondents were observed to have different levels of satisfaction, ranging from very satisfied and satisfied to not satisfied. Effective awareness creation amongst students as well as parents is therefore essential in HPV vaccination projects, as well as in reducing the burden of cervical cancer in Nigeria.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":"2023 ","pages":"2803420"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10527343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rab7 Investigation Insights into the Existence of White Spot Syndrome Virus in Crustaceans: An <i>In Silico</i> Approach.","authors":"Mehedi Mahmudul Hasan,&nbsp;M Nazmul Hoque,&nbsp;Md Robiul Hasan,&nbsp;Mohammad Asaduzzaman,&nbsp;Farha Matin Juliana","doi":"10.1155/2022/3887441","DOIUrl":"https://doi.org/10.1155/2022/3887441","url":null,"abstract":"<p><p>In this study, previously published Rab7 sequences from National Center for Biotechnology Information (NCBI) have been investigated from chordates, mollusks, annelids, cnidarians, amphibians, priapulids, brachiopods, and arthropods including decapods and other groups. Among decapod crustacean isolates, amino acid variations were found in 13 locations. Penaeid shrimps had variations in positions 13 (I ⟶ J), 22 (T ⟶ A), 124 (G ⟶ X), and 149 (V ⟶ X) while interestingly the freshwater prawn and mitten crab both had amino acid substitutions in positions 87 (V ⟶ C) and 95 (T ⟶ S) along with the other disagreements in amino acid positions 178 (S ⟶ N), 201 (D ⟶ E), 181 (E ⟶ D), 182 (L ⟶ I), 183 (Y ⟶ G), 184 (N ⟶ H), and 198 (A ⟶ T). Among 100 isolates of Rab7 from organisms of various phyla, mutations were observed in several positions. These mutations caused variations in hydrophobicity and isoelectric point which impact the ligand-protein binding affinity. Some common mutations were found in the organisms of the same phylum and among different phyla. Homology modeling of Rab7 proteins from different organisms was done using SWISS-MODEL and validated further by developing Ramachandran plots. Protein-protein docking showed that active residues were there in the binding interfaces of Rab7 from organisms of seven different phyla and VP28 of WSSV. Similarities were observed in the Rab7-VP28 complexes in those selected organisms which differed from the Rab7-VP28 complex in the case of Penaeid shrimp. The findings of this study suggest that WSSV may exist in different marine organisms that have Rab7 protein and transmit to crustaceans like shrimps and crabs which are of commercial importance.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"3887441"},"PeriodicalIF":2.2,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Silico Exploration of Plant Metabolites as Potential Remedies of Norovirus.","authors":"Zenifer Alam,&nbsp;Md Nazmul Islam Bappy,&nbsp;Abida Sultana,&nbsp;Fayeza Sadia Laskar,&nbsp;Kawsar Miah,&nbsp;Kazi Md Ali Zinnah,&nbsp;Sudeb Saha","doi":"10.1155/2022/8905962","DOIUrl":"https://doi.org/10.1155/2022/8905962","url":null,"abstract":"<p><p>Research is still being carried out to develop specific medications or vaccinations to fight norovirus, a key contributor to foodborne illness. This study evaluated certain plant-based active chemicals as prospective candidates for such treatments using virtual screening techniques and other computer assessments. Twenty (20) plant metabolites were tested against the norovirus VP1, VP2, P48, and P22 protein domains using the molecular docking method. In terms of the lowest global binding energy, Asiatic acid, avicularin, guaijaverin, and curcumin exhibited the highest binding affinity with all selected proteins. Each viral protein's essential binding sites with the potential drugs and drug surface hotspots were uncovered. The ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis was used to further analyze the pharmacological profiles of the top candidates. According to the results, none of the substances showed any adverse consequences that would reduce their drug-like properties. According to the analysis of the toxicity pattern, no detectable tumorigenic, mutagenic, irritating, or reproductive effects of the compounds were discovered. However, among the top four alternatives, curcumin exhibited the highest levels of cytotoxicity and immunotoxicity. These discoveries may open the way for the development of effective norovirus therapies and safety measures. Due to the positive outcomes, we strongly propose more <i>in vivo</i> experiments for the experimental validation of our findings.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"8905962"},"PeriodicalIF":2.2,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9613402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Seroprevalence and Associated Risk Factors of Newcastle Disease in Smallholder Poultry Farms in Sodo Zuria District, Wolaita Zone, Southern Ethiopia.","authors":"Saliman Aliye,&nbsp;Habtamu Endale,&nbsp;Mesfin Mathewos,&nbsp;Haben Fesseha","doi":"10.1155/2022/7478018","DOIUrl":"https://doi.org/10.1155/2022/7478018","url":null,"abstract":"<p><p>Newcastle disease (NCD) is a highly contagious viral disease of poultry and remains a constant threat in poultry farms that causes huge economic losses. The objective of this study was to estimate and assess the seroprevalence and associated risk factors of Newcastle disease in the Sodo Zuria district, southern Ethiopia. A cross-sectional survey followed by a simple random sampling technique was conducted from May to July 2021 on 384 apparently healthy nonvaccinated chickens on 30 smallholder poultry farms using commercial indirect ELISA kits and a questionnaire survey. The data were analyzed by using STATA for windows version 20 and a logistic regression reporting odds ratiowas applied to describe the seroprevalence of Newcastle disease with associated risk factors. The result of the study demonstrates that there was a high seroprevalence 48.7% (<i>n</i>= 187/384) of Newcastle disease in the study district. Information on associated risk factors were assessed using a semistructured questionnaire. The sex of the chicken showed a statistically significant difference (<i>x</i> ² = 4.842; <i>p</i> = 0.028) with the seroprevalence of the disease. The difference in seroprevalence among intensive, semi-intensive, and extensive management system was statistically significant (<i>x</i> ² = 3.84; <i>p</i> = 0.0001). There was also a statistical significant difference (<i>x</i> ² = 2.3854; <i>p</i> = 0.496) in the absence and presence of safe disposal of a dead chicken with the occurence of Newcastle disease. However, no statistically significant difference was observed among age groups (<i>x</i> ² = 4.335; <i>p</i> = 0.114), disinfection of poultry house (<i>x</i> ² = 0.0; <i>p</i> = 0.998), presence and absence of footbath (<i>x</i> ² = 2.969; <i>p</i> = 0.085), the breeds (<i>x</i> ² = 4.490; <i>p</i> = 0.106), type of chicken (<i>x</i> ² = 0.302; <i>p</i> = 0.583), and housing system (<i>x</i> ² = 1.926; <i>p</i> = 0.588). A high seroprevalence without vaccination history showed that the virus was circulating within the poultry. Therefore, further molecular study has to be conducted to identify circulating strains and develop an evidence-based control program.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"7478018"},"PeriodicalIF":2.2,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40393791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The BioFire® RP2.1 Panel Did Not Identify Concurrent Respiratory Virus Infection in Adults with Variable SARS-CoV-2 Disease Severity and Infection Duration.","authors":"Kendra M Quicke,&nbsp;Bridget A Baxter,&nbsp;Sophia Stromberg,&nbsp;Emily N Gallichotte,&nbsp;Emily Fitzmeyer,&nbsp;Michael C Young,&nbsp;Kristy L Pabilonia,&nbsp;Nicole Ehrhart,&nbsp;Julie Dunn,&nbsp;Gregory D Ebel,&nbsp;Elizabeth P Ryan","doi":"10.1155/2022/1378482","DOIUrl":"https://doi.org/10.1155/2022/1378482","url":null,"abstract":"<p><p>SARS-CoV-2 emerged in 2019 and rapidly surged into a global pandemic. The rates of concurrent infection with other respiratory pathogens and the effects of possible coinfections on the severity of COVID-19 cases and the length of viral infection are not well defined. In this retrospective study, nasopharyngeal swab samples collected in Colorado between March 2020 and May 2021 from SARS-CoV-2 PCR-positive individuals were tested for a panel of 21 additional respiratory pathogens, including 17 viral and 4 bacterial pathogens. We detected significant positive correlations between levels of SARS-CoV-2 RNA and infectious virus titers for both cohorts, as well as a positive correlation between viral RNA levels and disease severity scores for one cohort. We hypothesized that severe COVID-19 cases and longer SARS-CoV-2 infections may be associated with concurrent respiratory infections. Only one individual exhibited evidence of a concurrent infection- SARS -CoV-2 and human rhinovirus/enterovirus- leading us to conclude that viral respiratory coinfections were uncommon during this time and thus not responsible for the variations in disease severity and infection duration observed in the two cohorts examined. Mask wearing and other public health measures were imposed in Colorado during the time of collection and likely contributed to low rates of coinfection.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"1378482"},"PeriodicalIF":2.2,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40422466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts.","authors":"Mustak Ibn Ayub","doi":"10.1155/2022/5618222","DOIUrl":"https://doi.org/10.1155/2022/5618222","url":null,"abstract":"<p><p>SARS-CoV-2, the novel coronavirus behind the COVID-19 pandemic, is acquiring new mutations in its genome. Although some mutations provide benefits to the virus against human immune response, others may result in their reduced pathogenicity and virulence. By analyzing more than 3000 high-coverage, complete sequences deposited in the GISAID database up to April 2020, here I report the uniqueness of the 28881-28883: GGG > AAC trinucleotide-bloc mutation in the SARS-CoV-2 genome that results in two substrains, described here as SARS-CoV-2g (28881-28883: GGG genotype) and SARS-CoV-2a (28881-28883: AAC genotype). Computational analysis and literature review suggest that this bloc mutation would bring 203-204: RG (arginine-glycine)>KR (lysine-arginine) amino acid changes in the nucleocapsid (N) protein affecting the SR (serine-arginine)-rich motif of the protein, a critical region for the transcription of viral RNA and replication of the virus. Thus, 28881-28883: GGG > AAC bloc mutation is expected to modulate the pathogenicity of SARS-CoV-2. These analyses suggest that SARS-CoV-2 has evolved into SARS-CoV-2a affecting COVID-19 infectivity and severity. To confirm these assumptions, retrospective and prospective epidemiological studies should be conducted in different countries to understand the course of pathogenicity of SARS-CoV-2a and SARS-CoV-2g. Laboratory research should focus on the bloc mutation to understand its true impacts on the course of the pandemic. Potential drug and vaccine development should also keep the 28881-28883 region of the N protein under consideration.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"5618222"},"PeriodicalIF":2.2,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Early Favipiravir Therapy in Hospitalised COVID-19 Patients.","authors":"Abdulrahman Tawfik,&nbsp;Abdulrahman Alzahrani,&nbsp;Sami Alharbi,&nbsp;Jamal Almitairi,&nbsp;Arwa Alzahrani,&nbsp;Mohammed Ali Alshehri,&nbsp;Mohammed S Aldughaim,&nbsp;Hani Alothaid","doi":"10.1155/2022/9240941","DOIUrl":"https://doi.org/10.1155/2022/9240941","url":null,"abstract":"<p><p>COVID-19 is a disease caused by a novel coronavirus with no specific, standard treatment. We investigated the clinical data of COVID-19 patients admitted to King Fahad Specialist Hospital (KFSH) in Buraydah by comparing the patients who were treated early with favipiravir (within 3 days of admission) to patients who were treated after three days of admission or not treated. 165 patients were confirmed with PCR tests and admitted to KFSH for treatment. Comorbidities contributed significantly to increasing the length of stay in hospital at 11.4 ± 0.8 days compared to patients with no comorbidities at 8.6 ± 0.9 days (<i>p</i>=0.041). A total of 103 patients were treated with favipiravir, and we found that early treatment with favipiravir (within 3 days) reduced the length of stay in hospital significantly (8.8 ± 1.4 days) compared to patients who were treated after 3 days (13.3 ± 4.6 days) (<i>p</i>=0.0015). Moreover, patients with comorbidities in both early and late treatment groups had significantly higher average lengths of stay in hospital (11.2 ± 0.9 days) compared to patients with no comorbidities (7.9 ± 0.7 days) (<i>p</i>=0.017). Interestingly, patients treated early with favipiravir (with comorbidities and without) stayed fewer days in hospital compared to those with late treatment (<i>p</i>=0.021; a difference of 4.5 ± 1.9 days; and <i>p</i>=0.018; a difference of 4.2 ± 1.7 days, respectively). In conclusion, our analysis indicates that early treatment with favipiravir can reduce the length of stay in hospital and improve clinical manifestations of COVID-19 patients.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"9240941"},"PeriodicalIF":2.2,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40578232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirmatory Virucidal Activity of Ionised Active Water S-100® on the SARS-CoV-2 Virus.","authors":"Nathalie Wurtz,&nbsp;Issam Hasni,&nbsp;Audrey Bancod,&nbsp;Bernard La Scola","doi":"10.1155/2022/5995775","DOIUrl":"https://doi.org/10.1155/2022/5995775","url":null,"abstract":"<p><p>Ionised active water S-100® has been proposed as an original solution for use in dermocosmetics and for the treatment of wounds such as burns and atopic dermatitis. Among the mechanisms of action that are not completely understood, an antimicrobial activity would appear to be important. In the context of the COVID-19 pandemic, we assessed the inactivating efficacy of this solution on SARS-CoV-2 based on the recommendations of the NF-EN-14476+A2 standard. The tests carried out demonstrated that ionised active water S-100® 40% has a virucidal activity on SARS-CoV-2 which is at least 3.1 log after a contact time of 30 seconds and 3.5 log after two minutes at 20°C under clean conditions. Assays were also performed at 4°C and 37°C, and the results obtained are identical to those obtained at 20°C. This demonstration of the virucidal effect of ionised water against SARS-CoV-2 paves the way for the development of usage as an alternative disinfectant in SARS-CoV-2 control.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"5995775"},"PeriodicalIF":2.2,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40402094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex.","authors":"Hayder B Sahib,&nbsp;Omer Abid Kathum,&nbsp;Rafal Shakeeb Alanee,&nbsp;Rehab A M Jawad,&nbsp;Ahmed Majeed Al-Shammari","doi":"10.1155/2022/1575605","DOIUrl":"https://doi.org/10.1155/2022/1575605","url":null,"abstract":"<p><p>Cytokine storm is one of the causative deaths in a patient with severe acute respiratory syndrome. This study aimed at evaluating the prophylaxis effect of quercetin complexes with zinc and buffered ascorbic acid upon cytokine storm induction in mice and identifying the complex's acute toxicity. Mice were randomly divided into three groups: group A, control group, received 0.9% normal saline; group B received 100 mg/kg of the complex one hour before lipopolysaccharide (LPS) administration; and group C received the LPS IP 5 mg/kg. Then, levels of interleukin 1 and interleukin 6 were measured in the serum, and lung and kidney tissues were investigated for any changes that may have happened. Thirty mice were used to investigate the acute toxicity; mice were distributed into six groups: one control group and five treated groups; then several serial dilutions from the complex have been prepared for different concentrations from 5 g/kg to 0.312 g/kg. The animals were observed for 14 days. The LD₅₀ was deduced by the straight-line equation calculated from the dose-response curve. The results in this study showed that group A had no significant tissue change. LPS group C showed tissue damage in the lung and kidney, which significantly prevented by the pretreated complex in group B. Moreover, the complex's acute toxicity value (LD₅₀) was 655 mg/kg. In conclusion, the complex has significantly ameliorated LPS-induced acute lung and kidney injury, largely through suppression of inflammation; the large lethal dose value may make the complex have a promising therapeutic effect in the prevention of cytokine storm.</p>","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":"1575605"},"PeriodicalIF":2.2,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40041571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Analysis of the Capsid Protein (VP1) of Human Sapovirus Isolated from Children with Diarrhoea in Rural Communities of South Africa","authors":"Mpho Magwalivha, J. K. Ngandu, A. Traoré, N. Potgieter","doi":"10.1155/2022/9928378","DOIUrl":"https://doi.org/10.1155/2022/9928378","url":null,"abstract":"Background Viral diarrhoea is a concern in acute gastroenteritis cases among children younger than 5 years of age. Sapovirus has been noted as an emerging causative agent of acute gastroenteritis worldwide. Objective/Study Design. The aim of this study was to characterize human sapoviruses targeting the VP1 (NVR and N-terminal) region. Twenty-five samples were randomly selected from 40 sapovirus-positive samples previously detected and analyzed for the VP1 region using the One-Step RT-PCR assay. The PCR products were subjected to Sanger sequencing analysis. Results The polyprotein segment (NVR and N-terminal) was successfully amplified from 10/25 samples. Sapovirus GI.1 was the most predominant strain (6/10; 60%), followed by SV-GII.1 (2/10; 20%) and 10% of each GI.3 and GII.3. Conclusion Through the partial analysis of the VP1 region, this study provides more data to add on the human sapovirus genetic characterization of circulating strains in South Africa, with the proposition of further analysis of sapovirus VP1 fragments for the viral structure and function.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47688527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}