Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo最新文献

{"title":"Effects of balance, coordination, and strength training in children with low vision: a randomized controlled study.","authors":"Server Erdoğmuş Gülcan, Erdoğan Kavlak","doi":"10.1590/1984-0462/2026/44/2025242","DOIUrl":"10.1590/1984-0462/2026/44/2025242","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of an eight-week physiotherapy program focusing on balance, coordination, and muscle strengthening on gait, mobility, posture, and motor proficiency in children with low vision.</p><p><strong>Methods: </strong>Twenty-two children aged 7-14 years with ophthalmologist-diagnosed low vision, based on World Health Organization criteria, were randomly assigned to treatment (n=10) or control (n=12) groups. The treatment group completed three 75-minute sessions per week for eight weeks, including balance, coordination, and muscle-strengthening exercises. Outcomes were assessed using the BOT-2 Short Form, New York Posture Assessment Test, Lovett muscle grading, and BTS G-Walk. Statistical analyses were performed using Statistical Package for the Social Sciences, version 25.0.</p><p><strong>Results: </strong>The treatment group showed significant pre- to post-intervention gains in total BOT-2 SF scores and in subscales related to fine motor integration, bilateral coordination, running speed, agility, and strength (p<0.05), with small to moderate effect sizes (Cohen's d ≈ 0.30-0.90). The control group demonstrated smaller improvements, significant only in some subscales. Postural alignment increased significantly in both groups, with greater effect observed in the treatment group (Cohen's d=0.74) (p<0.05). Gait analysis revealed increases in left step length and right pelvic propulsion only in the treatment group (p<0.05), whereas no significant changes were observed in the remaining spatiotemporal gait parameters. Manual muscle testing showed strength gains in both groups, with no statistically significant differences between them.</p><p><strong>Conclusions: </strong>An eight-week, thrice-weekly physiotherapy-based balance, coordination, and strengthening program improves motor proficiency, posture, gait, and muscle strength in children with low vision, supporting its use in pediatric rehabilitation.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025242"},"PeriodicalIF":2.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of artificial intelligence on scientific production: reflections in times of intense technological and social transformation.","authors":"Tulio Konstantyner, Marina Carvalho de Moraes Barros, Fabio Carmona","doi":"10.1590/1984-0462/2026/44/Editorial","DOIUrl":"10.1590/1984-0462/2026/44/Editorial","url":null,"abstract":"","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"eEditorial"},"PeriodicalIF":2.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Full Outline of Unresponsiveness (FOUR) Score and Glasgow Coma Scale (GCS) in critically ill children to predict outcome: A prospective observational study.","authors":"Bageshree Saha, Sanjay Halder, Moumita Samanta, Saikat Mahato, Sandipan Sen, Tapan Kumar Sinhamahapatra","doi":"10.1590/1984-0462/2026/44/2025181","DOIUrl":"10.1590/1984-0462/2026/44/2025181","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic value of the Outline of Unresponsiveness (FOUR) Score and Glasgow Coma Scale (GCS) to predict mortality in critically ill children with non-traumatic impaired consciousness.</p><p><strong>Methods: </strong>In this single-center prospective observational study, children aged one month to 12 years admitted to the pediatric Intensive Care Unit (PICU) were included, and serial FOUR score and GCS at admission, 12th, and 24th hour were recorded. Children with PICU stay of <24 hours, with convulsion within the last hour, visual or motor impairment, or use of sedatives/ neuromuscular relaxants were excluded. Primary outcome: in-hospital mortality. Secondary outcome: requirement of intubation, and comparison of two scores for mortality.</p><p><strong>Results: </strong>One hundred critically ill children were enrolled with a median (interquartile - IQR) age of 46.0 (10.0-84.0) months, and 53 children died during the hospital course. The GCS and FOUR scores were significantly higher among survivors (p<0.001). Both scores were independent predictors of mortality at admission and the 12th hour, but only the FOUR score was a statistically significant predictor of mortality at the 24th hour. The adjusted odds ratio (AOR) for mortality for FOUR24 was 0.505 (95% confidence interval - 95%CI 0.399-0.863) and for GCS24 score was 2.728 (95%CI 0.932-2.273). Sixty-three children needed intubation, with a median duration of 4.0 (1.0-7.0) days, and of these, 69.8% died.</p><p><strong>Conclusions: </strong>GCS and FOUR scores have comparable efficacy in predicting mortality during initial assessment. However, the FOUR score is better than GCS at the 24th hour and can hence be considered a prognostic tool.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025181"},"PeriodicalIF":2.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn screening versus clinical diagnosis: comparison of nutritional status in children with cystic fibrosis - a longitudinal study.","authors":"Gabriella Santana Fernandes Dos Santos, Carla Hilário da Cunha Daltro, Edna Lúcia D'Souza","doi":"10.1590/1984-0462/2026/44/2025204","DOIUrl":"10.1590/1984-0462/2026/44/2025204","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the nutritional status of individuals with cystic fibrosis (CF) diagnosed either through newborn screening (NBS) or based on clinical findings (early vs. late), at the time of diagnosis and 1 year later.</p><p><strong>Methods: </strong>This was an observational study including CF patients followed at a Referral Center from 2005 to 2023. Participants were classified into three subgroups according to the method and age at diagnosis: 1 (NBS); 2 (early signs and symptoms if the CF diagnosis was before 2 years of age); and 3 (late signs and symptoms if the CF diagnosis was after 2 years of age). Nutritional parameters were compared at diagnosis and 1 year after treatment.</p><p><strong>Results: </strong>A total of 63 individuals were included, 57.1% male, 81.0% non-white, and median (interquartile range) age at diagnosis of 6 (2-42) months. There were 21, 23, and 19 in subgroups 1, 2, and 3, respectively. At diagnosis, 26 (41.3%) individuals had short stature (SST) or very SST, corresponding to 57.1, 43.5, and 21.1% of children in subgroups 1, 2, and 3, respectively. After 1 year, these proportions decreased to 28.5 and 30.4% in subgroups 1 and 2, while remaining unchanged in subgroup 3. Pancreatic insufficiency was present in 85.7, 69.6, and 68.4% of participants in subgroups 1, 2, and 3, respectively.</p><p><strong>Conclusions: </strong>Short stature was frequent at diagnosis, even among children identified by NBS. After 1 year of follow-up, height improved in subgroups 1 and 2 but remained unchanged in subgroup 3. Early diagnosis and timely nutritional interventions are essential to prevent and correct growth deficits in individuals with CF.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025204"},"PeriodicalIF":2.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet screeners and their association with constipation and stool consistency in school-aged children.","authors":"Giovana Canela Spadotto, Maria Antonieta de Barros Leite Carvalhaes, Cristina Maria Garcia de Lima Parada, Michelly da Silva Alves, Maria Isabel Cuaio, Camila Maria de Arruda, Débora Avellaneda Penatti, Caroline de Barros Gomes","doi":"10.1590/1984-0462/2026/44/2025276","DOIUrl":"10.1590/1984-0462/2026/44/2025276","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of constipation and stool consistency with diet quality screeners in school-aged children.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using data from the second phase of the Botucatu Infant Cohort Study. During home visits, stool consistency was assessed using the Bristol Stool Form Scale, and the presence of constipation (yes/no) was defined according to the adapted Rome IV criteria. Dietary intake (yes/no) on weekdays and weekends of the seven foods used as dietary quality screeners by the Food and Nutrition Surveillance System (SISVAN) was assessed through telephone interviews. Two scores were calculated: the Healthy Eating Score (three fresh or minimally processed foods, range: 0-6) and the Unhealthy Eating Score (four ultra-processed foods, range: 0-8). Associations were tested using linear regression (scores vs. stool consistency) and Poisson regression (scores vs. constipation), with the significance level set at p<0.05.</p><p><strong>Results: </strong>Among 394 children (mean age: 7.9 years; SD=0.4), constipation prevalence was 10.2%. Most (68.5%) had daily bowel movements, with type 3 on the Bristol Scale being the most frequent (43.8%). Mean Healthy Eating Score was 3.7; Unhealthy Eating Score was 4.0, with no significant differences by constipation. The Unhealthy Eating Score was negatively associated with stool consistency (β=-0.10; 95%CI -0.18 to -0.02), but not with constipation.</p><p><strong>Conclusions: </strong>In school-aged children, poor dietary quality, indicated by the consumption of ultraprocessed foods and sugar-sweetened beverages, was associated with harder stools, but not with constipation. These findings reinforce the usefulness of SISVAN dietary assessment forms for identifying children at risk of constipation.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025276"},"PeriodicalIF":2.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and morbidity caused by pneumonia in children and adolescents are associated with socioeconomic and urban conditions in São Paulo, Brazil.","authors":"William Cabral-Miranda, Celina de Almeida Lamas, Cauê Beloni, Karen Regina Amato Samos, Fátima Rodrigues Fernandes, Gustavo Falbo Wandalsen","doi":"10.1590/1984-0462/2026/44/2025214","DOIUrl":"10.1590/1984-0462/2026/44/2025214","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the association between pneumoniarelated mortality and morbidity and urban, environmental, and socioeconomic conditions in the administrative districts of São Paulo, Brazil.</p><p><strong>Methods: </strong>We conducted an ecological study using aggregated data from 2010 to 2020 across 96 administrative districts in ã Paulo. Mortality and hospitalization data for individuals up to 19 years old were analyzed in relation to the Geographic Index of the Socioeconomic Context for Health and Social Studies (GeoSES), housing standards, and urban conditions. Spatial analysis involved estimating relative risk using SaTScan, and Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) were applied to assess spatial associations.</p><p><strong>Results: </strong>Between 2010 and 2020, 1486 deaths and 1,56,112 hospitalizations due to pneumonia were recorded among individuals up to 19 years old. Mortality was higher among males (54.7%) and displayed spatial clustering. Mortality rates were negatively associated with the proportion of high-standard residences and the GeoSES index and positively associated with the presence of rapid-transit roadways. The GWR model outperformed the OLS model (adjusted R2=0.44 vs. 0.40) for mortality. Hospitalization rates were more uniformly distributed and showed a weaker association with socioeconomic indicators (adjusted R2=0.17 for OLS).</p><p><strong>Conclusions: </strong>Pneumonia mortality among children and adolescents in São Paulo is spatially associated with socioeconomic and urban conditions. These findings underscore the need for geographically targeted public health interventions that address urban planning and social inequalities in disease prevention strategies.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025214"},"PeriodicalIF":2.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of percutaneous musculotendinous lengthening in children with Cerebral Palsy: a systematic review.","authors":"Ana Paula Tedesco, Renata D'Agostini Nicolini-Panisson","doi":"10.1590/1984-0462/2026/44/2025294","DOIUrl":"10.1590/1984-0462/2026/44/2025294","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to analyze the outcomes - joint range of motion, functional aspects, anatomical aspects, and complications - of percutaneous musculotendinous lengthening in children with cerebral palsy.</p><p><strong>Data source: </strong>In total, six databases were searched (Medline/PubMed, Cochrane Library, Physiotherapy Evidence Database/PEDro, LILACS, Biblioteca Virtual em Saúde/BVS, and SciELO) for publications from 2004 to 2024 on percutaneous musculotendinous lengthening in children with cerebral palsy (0-18 years), with ≥1 year of follow-up, in English or Portuguese. The quality of nonrandomized studies was assessed using the Newcastle-Ottawa Scale, and that of randomized trials using the Cochrane risk-of-bias tool.</p><p><strong>Data synthesis: </strong>Of 151 studies identified, 14 met the inclusion criteria, including three randomized trials. Methodological limitations were frequent, including short follow-up periods, demographic heterogeneity, nonuniform evaluation methods, and the lack of confounder control. Only three studies used three-dimensional gait analysis. Notably, seven studies on hamstring percutaneous musculotendinous lengthening showed functional and range-of-motion improvements. Comparisons with open techniques showed no consistent kinematic differences. Evidently, three studies on adductor percutaneous musculotendinous lengthening found increased hip abduction, with no additional benefit from subsequent open procedures. Notably, the literature regarding Achilles issues is limited to three studies; of these, a single long-term clinical trial identified a 43% recurrence rate without calcaneus deformity, whereas the remaining two were restricted to anatomical and compartment pressure-related issues. Significantly, one study confirmed lower costs and blood loss in comparison with open procedures. The use of post-op immobilization and complications - overcorrection, recurrence, nerve and muscle injury, and increased pelvic tilt - were reported.</p><p><strong>Conclusions: </strong>Percutaneous musculotendinous lengthening may offer benefits, but stronger evidence from high-quality, long-term studies is needed to confirm its effectiveness.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025294"},"PeriodicalIF":2.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver burden in children with medical complexity: an approach based on the identification of associated factors.","authors":"Fernando Sarin da Mota E Albuquerque, Danton Matheus de Souza, Lidice Valeriana Oliveira Diop, Ana Paula Scoleze Ferrer","doi":"10.1590/1984-0462/2026/44/2025260","DOIUrl":"10.1590/1984-0462/2026/44/2025260","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to identify factors associated with increased caregiver burden of children with medical complexity and to guide management strategies.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in a specialized service for patients with complex chronic conditions. Caregiver burden was assessed using the Zarit Burden Interview, which measures subjective burden, encompassing emotional, social, and personal impacts associated with caregiving, and is categorized as mild, moderate, or severe according to the total score. Bivariate analyses used chi-square tests, followed by multivariable Poisson regression with robust variance estimation, with results expressed as prevalence ratios (PRs) and 95% confidence intervals; p<0.05 was considered significant.</p><p><strong>Results: </strong>A total of 173 caregivers were interviewed, predominantly mothers (88.4%), with a mean age of 38.8 years, from low-income households. Among the patients, 28.7% had cerebral palsy, 59.4% used assistive devices, and 57.2% required help with daily life activities. A severe burden score was reported by 31.2%. Polypharmacy was associated with a higher prevalence of moderateto-severe caregiver burden (PR=1.48; p=0.015), whereas daily care support (PR=0.79; p=0.039) and adequate sleep (PR=0.78; p=0.027) were associated with a lower prevalence of the outcome.</p><p><strong>Conclusions: </strong>Care-related needs, particularly polypharmacy, daily care support, and sleep quality, were associated with caregiver burden level. These findings highlight potentially modifiable factors and support the integration of a family-centered approach in the clinical follow-up of children and adolescents with medical complexity.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025260"},"PeriodicalIF":2.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between self-reported discrimination and body weight dissatisfaction among adolescents in a city in Santa Catarina, Brazil.","authors":"Melquesedek Ferreira da Silva Almeida, Suellem Zanlorenci, Diego Augusto Santos Silva","doi":"10.1590/1984-0462/2026/44/2025190","DOIUrl":"10.1590/1984-0462/2026/44/2025190","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association between body weight dissatisfaction and self-reported experiences of discrimination among Brazilian adolescents, stratified by sex.</p><p><strong>Methods: </strong>Data were obtained from the \"Brazilian Guide for the Assessment of Physical Fitness and Lifestyle Habits-Stage II\", conducted in 2019 with a city-representative sample of school adolescents aged 14-17 years from São José, Santa Catarina, Brazil. Body weight dissatisfaction and experiences of discrimination were measured using standardized instruments and through self-report. Weighted prevalence estimates and sex-stratified logistic regression models were used to evaluate associations, adjusting for sociodemographic variables.</p><p><strong>Results: </strong>In the adjusted analysis, adolescents of both sexes who reported discrimination had higher odds of wanting to increase their body weight (odds ratio - OR 2.05; 95% confidence interval - 95%CI 1.41-2.98) and to decrease their body weight (OR 1.42; 95%CI 1.09-1.85). Stratified analyses revealed different patterns by sex: among male adolescents, discrimination was associated with higher odds of wanting to decrease body weight (OR 1.66; 95%CI 1.58-1.74), whereas among female adolescents, discrimination was associated with higher odds of wanting to increase body weight (OR 3.02; 95%CI 1.72-5.31).</p><p><strong>Conclusions: </strong>Dissatisfaction with body weight and experiences of discrimination are prevalent among Brazilian adolescents, with distinct patterns between boys and girls. Discrimination was associated with both the desire to gain and to lose weight, but in sex-specific directions, suggesting that social pressures shape body image differently for male and female adolescents.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025190"},"PeriodicalIF":2.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and oxidative stress in the sputum of patients with cystic fibrosis: correlations with lung function, aerobic fitness, and morbidity.","authors":"Denise Lautenschleger Fischer, Fernanda Maria Vendrusculo, Mariana Severo da Costa, Maria Claudia Rosa Garcia, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadio","doi":"10.1590/1984-0462/2026/44/2025147","DOIUrl":"10.1590/1984-0462/2026/44/2025147","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the sputum inflammatory profile of children and adolescents with cystic fibrosis (CF) to that of healthy saliva controls and to assess the association between these markers and key clinical variables.</p><p><strong>Methods: </strong>This is an observational study comparing a group of CF patients with a healthy control group, including sputum samples from patients aged 6-18 years, followed up at a CF referral center. All procedures were performed on the same day, including spirometry, cardiopulmonary exercise testing, and sputum collection and processing. Demographic and clinical data were collected from patient records.</p><p><strong>Results: </strong>A total of 12 CF patients were included with a mean age of 13.0±2.8 years, a mean forced expiratory volume in one second of 86.4±20.8%, and a peak oxygen consumption (VO2peak) of 35.4±4.6 mL kg -1 min-1. A predominance of neutrophils was found in the sputum. The median (interquartile range) of interleukin-8 (IL-8) was 386.8 (310.5) pg/g of protein, and thiobarbituric acid-reactive substances (TBARS) had a median of 2.2 (0.9) μM/g of protein. When comparing CF patients and healthy individuals, the CF group showed higher IL-8 concentrations (p<0.001) and increased TBARS levels (p=0.01). A correlation was found between IL-6 concentration and the number of days on antibiotics (rho=0.71; p=0.009), and an inverse moderate correlation was found between IL-8 and forced expiratory flow between 25 and 75% (FEF25-75%) (rho=-0.62; p=0.033).</p><p><strong>Conclusions: </strong>Individuals with CF exhibited increased sputum inflammation compared with healthy controls, which correlated with lung function and morbidity but not with aerobic fitness.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"44 ","pages":"e2025147"},"PeriodicalIF":2.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}