Revista de gastroenterologia de Mexico (English)最新文献

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A comparison of endoscopic procedures performed at a tertiary care hospital before and during the SARS-CoV-2 pandemic 一家三级医院在 SARS-CoV-2 大流行之前和期间进行的内窥镜手术对比。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2023.10.003
{"title":"A comparison of endoscopic procedures performed at a tertiary care hospital before and during the SARS-CoV-2 pandemic","authors":"","doi":"10.1016/j.rgmxen.2023.10.003","DOIUrl":"10.1016/j.rgmxen.2023.10.003","url":null,"abstract":"<div><h3>Introduction and aim</h3><p>SARS-CoV-2 emerged in 2019 and had a huge impact on the world. The area of endoscopy suffered great changes, causing a reduction in the number of procedures and its indications. The aim of our study was to compare the quantity, indication, and type of procedures in 2019 with those in 2020.</p></div><div><h3>Method</h3><p>A retrospective, observational, analytic, and cross-sectional study was conducted, obtaining information from the endoscopy registry. The STROBE checklist was employed.</p></div><div><h3>Statistical analysis</h3><p>The quantitative variables were analyzed with descriptive statistics (measures of central tendency and dispersion) and the categorical variables with frequencies and percentages. The quantitative variables were compared, using the Student’s t test/Mann–Whitney U test, and the categorical variables with contingency tables, using the Fisher’s exact test.</p></div><div><h3>Results</h3><p>In 2019, a total of 277 procedures were performed, compared with 139 in 2020. Mean patient age was 98.53 months (61.46 SD) in 2019 and 77.02 months (59.81 SD) in 2020; 352 diagnostic procedures and 136 therapeutic procedures were carried out in 2019, compared with 51 diagnostic procedures and 88 therapeutic procedures in 2020. The number of diagnostic and therapeutic procedures were inverted (72.1%–36.7% and 27.9%–63.3%, respectively) (p<!--> <!-->&lt;<!--> <!-->0.0001). Esophageal varices, upper gastrointestinal bleeding (UGIB), and foreign body extraction were the indications, in order of predominance in 2019, compared with foreign body extraction (p<!--> <!-->&lt;<!--> <!-->0.05), UGIB, and esophageal varices in 2020. There were no differences regarding colonoscopy.</p></div><div><h3>Conclusion</h3><p>There was a clear difference in indication and type of procedure, with an increase in foreign body extraction in preschoolers.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 362-368"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000495/pdfft?md5=2cd0609ca8ccd693fa5a853a7e5ade9d&pid=1-s2.0-S2255534X24000495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new formula proposal for placing pH-impedance catheters in pediatric patients 为儿科患者放置 pH 值阻抗导管的新公式建议。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2023.08.009
{"title":"A new formula proposal for placing pH-impedance catheters in pediatric patients","authors":"","doi":"10.1016/j.rgmxen.2023.08.009","DOIUrl":"10.1016/j.rgmxen.2023.08.009","url":null,"abstract":"<div><h3>Introduction</h3><p>Esophageal pH-impedance monitoring is a tool for diagnosing gastroesophageal reflux in children. The position of the pH catheter is essential for a reliable reading and the current formulas for calculating catheter insertion length are not completely accurate. The aim of the present study was to develop a new formula for adequate insertion of the pH catheter.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study was conducted on children that underwent pH-impedance monitoring and later radiographic control, to calculate the correct catheter insertion length. The documented variables were age, sex, weight, height, naris to tragus distance, tragus to sternal notch distance, sternal notch to xiphoid process distance, and initial insertion length determined by the Strobel and height interval formulas. A multivariate regression analysis was carried out to predict the final insertion length. Regression ANOVA and Pearson’s adjusted R-squared tests were performed.</p></div><div><h3>Results</h3><p>Forty-five pH-impedance studies were carried out, 53% of which were in males. The age and weight variables were not normally distributed. In the initial regression model, the variables that did not significantly correlate with the final insertion length were: sex (<em>P</em> 0.124), length determined by the Strobel or height interval formulas (<em>P</em> 0.078), naris to tragus distance (<em>P</em> 0.905), and tragus to sternal notch distance (<em>P</em> 0.404). The final equation: 5.6 + (height in cm * 0.12) + (sternal notch to xiphoid process distance * 0.57) produced an R<sup>2</sup> of 0.93 (<em>P</em> 0.000).</p></div><div><h3>Conclusions</h3><p>This formula can be considered a valid option for placement of the pH-impedance monitoring catheter in pediatrics.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 347-353"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000471/pdfft?md5=38299e837174239f94ece846b65afa9c&pid=1-s2.0-S2255534X24000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blundering in high-resolution esophageal manometry in patients with achalasia 贲门失弛缓症患者高分辨率食管测压的误区。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.04.003
{"title":"Blundering in high-resolution esophageal manometry in patients with achalasia","authors":"","doi":"10.1016/j.rgmxen.2024.04.003","DOIUrl":"10.1016/j.rgmxen.2024.04.003","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 444-446"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000550/pdfft?md5=6a8dcec625f5b12d3000e5a4075205c7&pid=1-s2.0-S2255534X24000550-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Position paper on perioperative management and surgical risk in the patient with cirrhosis 关于肝硬化患者围手术期管理和手术风险的立场文件。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.05.001
J.A. Velarde-Ruiz Velasco , J. Crespo , A. Montaño-Loza , J.M. Aldana-Ledesma , A.D. Cano-Contreras , E. Cerda-Reyes , N.J. Fernández Pérez , G.E. Castro-Narro , E.S. García-Jiménez , J.E. Lira-Vera , Y.I. López-Méndez , J. Meza-Cardona , R. Moreno-Alcántar , J. Pérez-Escobar , J.L. Pérez-Hernández , D.K. Tapia-Calderón , F. Higuera-de-la-Tijera
{"title":"Position paper on perioperative management and surgical risk in the patient with cirrhosis","authors":"J.A. Velarde-Ruiz Velasco ,&nbsp;J. Crespo ,&nbsp;A. Montaño-Loza ,&nbsp;J.M. Aldana-Ledesma ,&nbsp;A.D. Cano-Contreras ,&nbsp;E. Cerda-Reyes ,&nbsp;N.J. Fernández Pérez ,&nbsp;G.E. Castro-Narro ,&nbsp;E.S. García-Jiménez ,&nbsp;J.E. Lira-Vera ,&nbsp;Y.I. López-Méndez ,&nbsp;J. Meza-Cardona ,&nbsp;R. Moreno-Alcántar ,&nbsp;J. Pérez-Escobar ,&nbsp;J.L. Pérez-Hernández ,&nbsp;D.K. Tapia-Calderón ,&nbsp;F. Higuera-de-la-Tijera","doi":"10.1016/j.rgmxen.2024.05.001","DOIUrl":"10.1016/j.rgmxen.2024.05.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Management of the patient with cirrhosis of the liver that requires surgical treatment has been relatively unexplored. In Mexico, there is currently no formal stance or expert recommendations to guide clinical decision-making in this context.</p></div><div><h3>Aims</h3><p>The present position paper reviews the existing evidence on risks, prognoses, precautions, special care, and specific management or procedures for patients with cirrhosis that require surgical interventions or invasive procedures. Our aim is to provide recommendations by an expert panel, based on the best published evidence, and consequently ensure timely, quality, efficient, and low-risk care for this specific group of patients.</p></div><div><h3>Results</h3><p>Twenty-seven recommendations were developed that address preoperative considerations, intraoperative settings, and postoperative follow-up and care.</p></div><div><h3>Conclusions</h3><p>The assessment and care of patients with cirrhosis that require major surgical or invasive procedures should be overseen by a multidisciplinary team that includes the anesthesiologist, hepatologist, gastroenterologist, and clinical nutritionist. With respect to decompensated patients, a nephrology specialist may be required, given that kidney function is also a parameter involved in the prognosis of these patients.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 418-441"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000574/pdfft?md5=5cee550d2160a3852de6a2d958dc232b&pid=1-s2.0-S2255534X24000574-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center 一家三级医疗中心肝细胞癌手术治疗的存活率分析。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2022.12.001
{"title":"Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center","authors":"","doi":"10.1016/j.rgmxen.2022.12.001","DOIUrl":"10.1016/j.rgmxen.2022.12.001","url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making.</p></div><div><h3>Materials and methods</h3><p>Patients with HCC that underwent surgery with curative intent at the <em>Hospital Universitario Marqués de Valdecilla</em>, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed.</p></div><div><h3>Results</h3><p>Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality.</p></div><div><h3>Conclusions</h3><p>There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 323-331"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000392/pdfft?md5=ccfbfbb8ad720031933157b65cff1b4c&pid=1-s2.0-S2255534X24000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jejunal perforation associated with immune reconstitution inflammatory syndrome due to cytomegalovirus: A case report 巨细胞病毒引起的免疫重建炎症综合征伴有空肠穿孔:病例报告。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.04.007
{"title":"Jejunal perforation associated with immune reconstitution inflammatory syndrome due to cytomegalovirus: A case report","authors":"","doi":"10.1016/j.rgmxen.2024.04.007","DOIUrl":"10.1016/j.rgmxen.2024.04.007","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 457-459"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000604/pdfft?md5=7a32bb3d97b32c55c71bc01b2d2aa1b8&pid=1-s2.0-S2255534X24000604-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The string sign in Crohn’s disease 克罗恩病的弦征。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.04.004
{"title":"The string sign in Crohn’s disease","authors":"","doi":"10.1016/j.rgmxen.2024.04.004","DOIUrl":"10.1016/j.rgmxen.2024.04.004","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 447-448"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000562/pdfft?md5=86eeea4ff29179f2db577bf018e01cbc&pid=1-s2.0-S2255534X24000562-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute liver failure: Management update and prognosis 急性肝衰竭:管理更新和预后。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.05.002
L.M. Martínez-Martínez , G. Rosales-Sotomayor , E.A. Jasso-Baltazar , J.A. Torres-Díaz , D. Aguirre-Villarreal , I. Hurtado-Díaz de León , V.M. Páez-Zayas , A. Sánchez-Cedillo , S.E. Martínez-Vázquez , H.N. Tadeo-Espinoza , J.P. Guerrero-Cabrera , M. García-Alanis , I. García-Juárez
{"title":"Acute liver failure: Management update and prognosis","authors":"L.M. Martínez-Martínez ,&nbsp;G. Rosales-Sotomayor ,&nbsp;E.A. Jasso-Baltazar ,&nbsp;J.A. Torres-Díaz ,&nbsp;D. Aguirre-Villarreal ,&nbsp;I. Hurtado-Díaz de León ,&nbsp;V.M. Páez-Zayas ,&nbsp;A. Sánchez-Cedillo ,&nbsp;S.E. Martínez-Vázquez ,&nbsp;H.N. Tadeo-Espinoza ,&nbsp;J.P. Guerrero-Cabrera ,&nbsp;M. García-Alanis ,&nbsp;I. García-Juárez","doi":"10.1016/j.rgmxen.2024.05.002","DOIUrl":"10.1016/j.rgmxen.2024.05.002","url":null,"abstract":"<div><p>Acute liver failure is a rare but serious syndrome, with an incidence of approximately 2,000 to 3,000 cases per year in North America. Its pathophysiology and clinical course vary, depending on the cause of the primary liver injury, and can lead to high morbidity and mortality or the need for liver transplantation, despite available therapies. This syndrome involves excessive activation of the immune system, with damage in other organs, contributing to its high mortality rate. The most accepted definition includes liver injury with hepatic encephalopathy and coagulopathy within the past 26 weeks in a patient with no previous liver disease. The main causes are paracetamol poisoning, viral hepatitis, and drug-induced liver injury, among others. Identifying the cause is crucial, given that it influences prognosis and treatment. Survival has improved with supportive measures, intensive therapy, complication prevention, and the use of medications, such as N-acetylcysteine. Liver transplantation is a curative option for nonresponders to medical treatment, but adequate evaluation of transplantation timing is vital for improving results. Factors such as patient age, underlying cause, and severity of organ failure influence the post-transplant outcomes and survival.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 404-417"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000628/pdfft?md5=c8db886ea379421ed12b38f3a466c347&pid=1-s2.0-S2255534X24000628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclic vomiting syndrome: From pathophysiology to treatment 周期性呕吐综合征:从病理生理学到治疗。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.06.001
R.A. Jiménez-Castillo , R. Frazier , T. Venkatesan , J.M. Remes-Troche
{"title":"Cyclic vomiting syndrome: From pathophysiology to treatment","authors":"R.A. Jiménez-Castillo ,&nbsp;R. Frazier ,&nbsp;T. Venkatesan ,&nbsp;J.M. Remes-Troche","doi":"10.1016/j.rgmxen.2024.06.001","DOIUrl":"10.1016/j.rgmxen.2024.06.001","url":null,"abstract":"<div><p>Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent and unpredictable episodes of intense vomiting, interspersed with periods of apparent wellbeing. This disorder, which primarily affects children and adolescents but can persist into adulthood, has recently been the subject of extensive study and analysis in the medical literature. The aim of the present review is to examine the most important aspects of the epidemiology, pathophysiology, subtypes, diagnostic criteria, and current management of CVS. Even though the exact etiology remains unknown, genetic factors (polymorphisms), nervous system alterations and autonomic dysregulation, and environmental factors (use and abuse of cannabinoids) are postulated as possible triggers. CVS has significant diagnostic challenges, given that there is no specific test for confirming its presence. Thorough evaluation of symptoms and the ruling out of other possible causes of recurrent vomiting are required. Management of CVS typically involves a multidisciplinary approach. Pharmacologic options are explored, such as antiemetics and preventive medications, as well as behavioral and psychologic support therapies. Treatment personalization is essential, adapting it to the individual needs of each patient. Despite advances in the understanding of CVS, it remains a significant clinical challenge. This disorder impacts the quality of life of those affected and their families, underscoring the ongoing need for research and the development of more effective treatment strategies.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 389-403"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000616/pdfft?md5=bbb72d6aa141ff7bff490e20bc845ef7&pid=1-s2.0-S2255534X24000616-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOX9 immunosuppression in primary colorectal cancer tumors with lymph node metastasis 伴有淋巴结转移的原发性结直肠癌肿瘤中的 SOX9 免疫抑制。
Revista de gastroenterologia de Mexico (English) Pub Date : 2024-07-01 DOI: 10.1016/j.rgmxen.2024.01.004
{"title":"SOX9 immunosuppression in primary colorectal cancer tumors with lymph node metastasis","authors":"","doi":"10.1016/j.rgmxen.2024.01.004","DOIUrl":"10.1016/j.rgmxen.2024.01.004","url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Colorectal cancer is the most frequent malignant tumor of the digestive system. Its pathogeny is complex and involves the APC/β-catenin sequence. Lymph node metastases are a significant indicator for determining treatment and are a prognostic factor. SOX9 overexpression is related to oncogenic qualities and the capacity for metastasis. Our aim was to analyze SOX9 immunoexpression in primary colorectal cancer and lymph node metastasis status.</p></div><div><h3>Material and methods</h3><p>Seventy-nine available cases were divided into the group with lymph node metastasis (n<!--> <!-->=<!--> <!-->38) and the group without lymph node metastasis (n<!--> <!-->=<!--> <!-->41), evaluating their SOX9 expression. The IBM SPSS version 27 program in Spanish was utilized to carry out the statistical analysis, obtaining measures of central tendency, the kappa index, standard deviation, Wilcoxon Mann-Whitney nonparametric measurements, Spearman’s correlation coefficient, and chi-square test and Student’s t test values. SOX9 immunoexpression was evaluated through the mean-based H-score, with high immunoexpression as a score ≥145 and low immunoexpression as a score ≤144.</p></div><div><h3>Results</h3><p>A p<!--> <!-->=<!--> <!-->0.73 was obtained that was not statistically significant, regarding the relation of SOX9 expression in primary colorectal cancer to lymph node metastasis.</p></div><div><h3>Conclusions</h3><p>The absence or presence of lymph node metastasis was independent from SOX9 immunoexpression in primary colorectal cancer. However, due to the limited size of the population analyzed, further research is needed.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 3","pages":"Pages 369-378"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000501/pdfft?md5=614f03d8239e6fad3a67e5fc13c01ec0&pid=1-s2.0-S2255534X24000501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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