Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia最新文献

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Mayer-Rokitansky-Kuster-Hauser syndrome. Mayer-Rokitansky-Kuster-Hauser综合症。
Claudia Cristina Takano Novoa, Mila Torii Correa Leite, Marair Gracio Ferreira Sartori
{"title":"Mayer-Rokitansky-Kuster-Hauser syndrome.","authors":"Claudia Cristina Takano Novoa, Mila Torii Correa Leite, Marair Gracio Ferreira Sartori","doi":"10.61622/rbgo/2025FPS4","DOIUrl":"10.61622/rbgo/2025FPS4","url":null,"abstract":"<p><p>•Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is the leading cause of vaginal agenesis. •It is characterized by primary amenorrhea with typical adrenarche and telarche and may be associated with congenital urological and skeletal conditions that should be investigated. •Differential diagnoses include: vaginal obstructions (imperforate hymen, distal vaginal atresia, transverse vaginal septum), uterine obstructions (cervical atresia), and differences in sexual development (gonadal dysgenesis, complete androgen insensitivity and congenital adrenal hyperplasia due to CYP17 deficiency). •Laboratory tests (testosterone, follicle-stimulating hormone [FSH] and karyotype) and radiological tests (pelvic ultrasound and MRI) are necessary. •Vaginal dilation is the first line of treatment with high success rates.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials. 氨甲环酸在妇产科应用的疗效:随机试验的系统评价综述。
Nicole Cristina Lottermann, Nathalia Luiza Andreazza, Matheus de Araújo Moura Cavalcante, Laura Andrade Fernandez, Carla Vitola Gonçalvez, Linjie Zhang
{"title":"Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials.","authors":"Nicole Cristina Lottermann, Nathalia Luiza Andreazza, Matheus de Araújo Moura Cavalcante, Laura Andrade Fernandez, Carla Vitola Gonçalvez, Linjie Zhang","doi":"10.61622/rbgo/2025rbgo18","DOIUrl":"10.61622/rbgo/2025rbgo18","url":null,"abstract":"<p><strong>Objective: </strong>This umbrella review aimed to synthesize evidence from systematic reviews of clinical trials on the efficacy of tranexamic acid in gynecology and obstetrics procedures.</p><p><strong>Methods: </strong>We searched Medline, Embase, SciELO and Cochrane Database of Systematic Reviews on March 11, 2024, using the term \"tranexamic acid\". Four reviewers independently select studies and extract data. We assessed the quality of systematic review and the quality of evidence, using AMSTAR 2 and GRADE tools, respectively.</p><p><strong>Results: </strong>Of 651 systematic reviews identified, 16 reviews with 96663 patients were included. The surgical procedures were cesarean section, myomectomy, hysterectomy, and cervical intraepithelial neoplasia surgery. All reviews showed a statistically significant and clinically relevant reduction in intraoperative and post-procedure blood loss, associated with intravenous or topical use of tranexamic acid. Tranexamic acid resulted in a significant reduction in the need for blood transfusions and a less pronounced drop in postoperative hematocrit and hemoglobin levels in cesarean section. Several reviews addressed the same question, but the number of included trials varied substantially, which might indicate flaws in search and selection of studies of these reviews. The quality of systematic reviews was low or critically low, and the quality of evidence was moderate.</p><p><strong>Conclusions: </strong>This umbrella review shows that tranexamic acid can reduce blood loss and hemorrhage in gynecology and obstetrics procedures. High quality systematic reviews are still needed.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of total antioxidant and oxidant parameters and their correlation with embryo quality in in-vitro fertilization patients. 体外受精患者总抗氧化剂和氧化剂参数及其与胚胎质量的相关性评估。
Utkucan Okuducu, Gökhan Bayhan, Dilek Ulusoy Karatopuk
{"title":"An assessment of total antioxidant and oxidant parameters and their correlation with embryo quality in in-vitro fertilization patients.","authors":"Utkucan Okuducu, Gökhan Bayhan, Dilek Ulusoy Karatopuk","doi":"10.61622/rbgo/2025rbgo22","DOIUrl":"10.61622/rbgo/2025rbgo22","url":null,"abstract":"<p><strong>Objective: </strong>In vitro, fertilization is the primary treatment method for infertility. Follicular fluid analysis is an approach used to optimize the results of assisted reproductive techniques. Oxidative stress represents the imbalance between the production of reactive oxygen species and their detoxification. Total Antioxidant and Oxidant Status, and Oxidative Stress Index levels are the main oxidative stress markers. This study investigated the effects of oxidative stress markers on infertility etiology, embryo quality, and success of In vitro fertilization.</p><p><strong>Methods: </strong>Before enrolling in the ICSI-ET cycle, participants had their FSH and LH levels assessed on the second day of the cycle. The ovarian degrees of the participants were evaluated by transvaginal ultrasonography. Participants underwent controlled ovarian stimulation using the GnRH antagonist protocol. TV-USG and serial E2 measurements were performed at appropriate intervals to follow follicular development. Follicle sizes, quantity, and endometrial thickness were recorded. Total Antioxidant and Oxidant Status, and Oxidative analyses were conducted using Rel Assay Diagnostics Assay Kits.</p><p><strong>Results: </strong>The average number of total oocytes in the participants was 10.25±6.66, and the average of mature M2 stage oocytes was 6.71±3.72. The average number of fertilized oocytes was 4.65±2.81. Fertilization rates were calculated as approximately 54.75±25.58%. A statistically significant positive correlation was found between embryo quality and serum Total Antioxidant Status levels (p=0.004). Similarly, a significant positive correlation was observed between embryo quality and follicular Total Antioxidant Status values (r = 0.42, p = 0.01).</p><p><strong>Conclusion: </strong>This study concluded that oxidative stress markers affect certain stages of the IVF treatment process.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support. 受COVID-19影响、需要呼吸支持的孕妇和产后妇女的临床和流行病学概况
Carolina Maria Pires Cunha, Melania Maria Ramos Amorim, Julianna de Azevedo Guendler, Alex Sandro Rolland Souza, Leila Katz
{"title":"Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support.","authors":"Carolina Maria Pires Cunha, Melania Maria Ramos Amorim, Julianna de Azevedo Guendler, Alex Sandro Rolland Souza, Leila Katz","doi":"10.61622/rbgo/2025rbgo14","DOIUrl":"10.61622/rbgo/2025rbgo14","url":null,"abstract":"<p><strong>Objective: </strong>This study described the clinical and epidemiological profile and the management provided to pregnant and postpartum women with COVID-19 who required respiratory support.</p><p><strong>Methods: </strong>A descriptive study was conducted with pregnant and postpartum women with confirmed COVID-19 who received care between April 2020 and December 2021 in eight referral centers in northeastern Brazil. Statistical analysis was conducted using Epi-Info 7.2.5 and Medcalc, version 20.112.</p><p><strong>Results: </strong>Of the 720 patients admitted, 208 (32.7%) required respiratory support. Mean age of the participants was 28.9±7.1 years. Most (52.8%) were brown-skinned; 31.3% had little formal schooling; 41.1% had a personal income and 23.1% were married. Around half were referred from another hospital. Overall, 36.8% were obese and 36.9% were hypertensive. Criteria for severe acute respiratory syndrome (SARS) were present in 80.7% of cases. Overall, 151 patients (74.7%) required corticoids, and 150 (76.1%) were admitted to an intensive care unit. Non-invasive ventilation was needed in 89.4% of cases, with nasal catheters being the most common type (55.3% of cases). Invasive mechanical ventilation was necessary in 35.5% of cases and 91.6% had a cesarean section. Maternal near miss and death occurred in 24% and 12.9% of cases, respectively.</p><p><strong>Conclusion: </strong>Pregnant and postpartum women with COVID-19 who required respiratory support were predominantly brown-skinned, in the third trimester of pregnancy and had been referred from another hospital. The cesarean section rate was high; the presence of criteria for SARS was common and the rates of COVID-19-related maternal near miss and death were high.</p><p><strong>Clinical trials registry: </strong>NCT04462367.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of antiphospholipid syndrome among women with recurrent pregnancy loss: a cohort study. 复发性流产妇女中抗磷脂综合征的患病率:一项队列研究
Elaine Cristina Fontes de Oliveira, Daniel Dias Ribeiro, Janaína Campos Senra, Fernando Marcos Dos Reis
{"title":"Prevalence of antiphospholipid syndrome among women with recurrent pregnancy loss: a cohort study.","authors":"Elaine Cristina Fontes de Oliveira, Daniel Dias Ribeiro, Janaína Campos Senra, Fernando Marcos Dos Reis","doi":"10.61622/rbgo/2025rbgo23","DOIUrl":"10.61622/rbgo/2025rbgo23","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the prevalence of antiphospholipid syndrome (APS) among women experiencing recurrent pregnancy loss (RPL).</p><p><strong>Methods: </strong>A cross-sectional was conducted, reviewing the medical records of 134 women with a history of two or more miscarriages, treated between January 2014 and May 2024 at a tertiary university center in Belo Horizonte, Brazil. APS screening was performed by assessing anticardiolipin (IgG and IgM), lupus anticoagulant, and anti-β2-glycoprotein-1 (IgG and IgM) antibodies, based on Sapporo criteria. All tests were performed during non-pregnant periods and at least 12 weeks after the last miscarriage.</p><p><strong>Results: </strong>The study included 134 women with a mean age of 33.8 ± 5.7 years. The number of prior miscarriages ranged from 2 to 11 per couple. Among the patients who presented the lupus anticoagulant, only two (1.49%) tested positive in two samples, as per revised Sapporo criteria. Considering IgG and IgM anticardiolipin antibodies, four patients (2.98%) tested positive in two samples according to old Sapporo criteria, with one patient having a positive IgG test in two samples, two having positive IgM in two samples and a single patient having both positive tests. None of the 56 patients tested positive for anti-β2-glycoprotein-1 antibodies in two samples.</p><p><strong>Conclusion: </strong>The prevalence of antiphospholipid antibodies, in line with revised Sapporo criteria, is low among Brazilian women with recurrent pregnancy loss, consistent with recent studies in literature. Ensuring the appropriateness of diagnostic criteria is crucial to avoid unnecessary treatment with platelet anticoagulants and heparin in this population.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hysterectomy rates per resident in final year of training in teaching hospitals: an ecologic study. 在教学医院接受最后一年培训的每位住院医师子宫切除术率:一项生态学研究。
Luiza Nestori Chiozzotto, Nino José Wilson Moterani, Laura Bresciani Bento Gonçalves Moterani, Vinicius César Moterani, Francisco José Candido Dos Reis
{"title":"Hysterectomy rates per resident in final year of training in teaching hospitals: an ecologic study.","authors":"Luiza Nestori Chiozzotto, Nino José Wilson Moterani, Laura Bresciani Bento Gonçalves Moterani, Vinicius César Moterani, Francisco José Candido Dos Reis","doi":"10.61622/rbgo/2025rbgo24","DOIUrl":"10.61622/rbgo/2025rbgo24","url":null,"abstract":"<p><strong>Objective: </strong>Analyze the hysterectomy rates per resident in graduation year in teaching hospitals in the state of São Paulo (Brazil).</p><p><strong>Methods: </strong>We selected teaching hospitals in the state of São Paulo and gathered information from two public databases to estimate the hysterectomy rates per resident in their final year of training between 2009 and 2019.</p><p><strong>Results: </strong>Between 2009 and 2019, there was a 37.5% increase in the number of residents in their final year of training, a 4.31% increase in the number of hysterectomies, and a drop in the hysterectomy rates per resident of 24.1%. The reduction of the rate of hysterectomy per resident was more pronounced for vaginal route (46.4%) followed by abdominal route (23.3%). The ratio of laparoscopic hysterectomy per resident increased 264% during the period, however, this route was used in only 7% of the surgeries in 2019.</p><p><strong>Conclusions: </strong>The hysterectomy rates per resident in their final year of training showed a notable reduction. This trend, particularly pronounced in vaginal and abdominal routes, signals a shift towards minimally invasive techniques.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy. 接受新辅助治疗的乳腺癌患者病理完全缓解率的评价。
Gabriella Ferezini Oliveira de Sá, Pedro Vilar de Oliveira Villarim, Pedro Hortêncio Saboia da Escossia Melo, Ayane Cristine Alves Sarmento, Ana Katherine Gonçalves, Kleyton Santos de Medeiros, Cristina Rocha de Medeiros Miranda
{"title":"Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy.","authors":"Gabriella Ferezini Oliveira de Sá, Pedro Vilar de Oliveira Villarim, Pedro Hortêncio Saboia da Escossia Melo, Ayane Cristine Alves Sarmento, Ana Katherine Gonçalves, Kleyton Santos de Medeiros, Cristina Rocha de Medeiros Miranda","doi":"10.61622/rbgo/2025rbgo13","DOIUrl":"10.61622/rbgo/2025rbgo13","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the rate of pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant therapy and to explore its correlation with clinical, molecular, and prognostic factors.</p><p><strong>Methods: </strong>We conducted this retrospective observational study at Liga Contra o Câncer, a major public oncology reference center in Northeast Brazil. We included patients diagnosed with breast cancer who initiated neoadjuvant therapy between June 2018 and June 2019. Patients with a history of recurrent breast cancer or those who did not undergo surgery were excluded. The primary outcome was the pCR rate, with secondary outcomes including Overall Survival (OS), Disease-Free Survival (DFS), mortality, and disease recurrence. Follow-up extended until August 2022. We performed multivariate Cox regression analysis to correlate outcomes with predetermined variables.</p><p><strong>Results: </strong>Of the 292 included patients, 63 (21.6%) achieved pCR. The mean follow-up duration was 42.8 months. Multivariate logistic regression analysis revealed an association between pCR and the AC-TH regimen [OR = 2.4; 95%CI = 1.13 - 5.24; p=0.023], as well as between pCR and HER2-positive tumors [OR 2.49; 95% CI = 1.14 - 5.86; p=0.028]. Complete pathological response was associated with higher DFS [HR 0.33; 95%CI 0.13-0.86; p=0.024].</p><p><strong>Conclusion: </strong>Neoadjuvant therapy demonstrated significant efficacy in achieving pathological response in breast cancer patients. We observed a strong association between the AC-TH regimen, HER2-positive status, and pCR.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of small-for-gestational-age newborns in pregnant women with COVID-19. COVID-19孕妇中小于胎龄新生儿的发病率。
Gustavo Dos Santos Raupp, Renato Teixeira Souza, Maria Laura Costa, Jose Guilherme Cecatti, Annerose Barros, Ellen Machado Arlindo, Edson Vieira Cunha, Janete Vettorazzi
{"title":"Incidence of small-for-gestational-age newborns in pregnant women with COVID-19.","authors":"Gustavo Dos Santos Raupp, Renato Teixeira Souza, Maria Laura Costa, Jose Guilherme Cecatti, Annerose Barros, Ellen Machado Arlindo, Edson Vieira Cunha, Janete Vettorazzi","doi":"10.61622/rbgo/2025rbgo20","DOIUrl":"10.61622/rbgo/2025rbgo20","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the incidence of small for gestational age (SGA) newborns in pregnant women infected with COVID-19 and examine the associated neonatal outcomes.</p><p><strong>Methods: </strong>This study involved a secondary analysis of the REBRACO Network, a prospective cohort study conducted in 15 maternity hospitals in Brazil before the introduction of COVID-19 vaccination (February 2020 to February 2021). Demographic data of pregnant women tested for COVID-19 were analyzed, and fetal outcomes were compared between women with positive and negative COVID-19 results who had SGA fetuses.</p><p><strong>Results: </strong>A total of 729 symptomatic pregnant women with COVID-19 were included in the study. However, there were 248 participants with missing information regarding childbirth or loss of follow-up, and 107 participants without confirmatory tests for COVID-19. Among the remaining participants, 198 had confirmed COVID-19 and 176 tested negative. The incidence of SGA among women with COVID-19 was 22.4%, whereas the incidence among women who tested negative for COVID-19 was 14.8%. SGA newborns born to COVID-19 positive pregnant women were 1.6 times more likely to experience adverse outcomes (such as prematurity, stillbirth, neonatal death, and admission to a neonatal ICU) compared to non-SGA newborns [OR = 1.655 (1.145 - 2.394); P=0.017]. In SGA newborns of pregnant women with confirmed COVID-19 infection, mechanical ventilation use was found to be associated with the infection [OR = 0.692 (0.562 - 0.853); P=0.002].</p><p><strong>Conclusion: </strong>The higher incidence of SGA newborns and its stronger association with prematurity in pregnant women with confirmed COVID-19 infection suggest that COVID-19 infection is a significant factor contributing to neonatal morbidity and mortality.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis. 来曲唑联合克罗米芬与来曲唑单独用于PCOS女性促排卵:一项系统综述和荟萃分析。
Karine Eskandar, Juliana Almeida Oliveira, Sandro Augusto Ribeiro, Matheus Pedrotti Chavez, Ana Isabela de Araujo Zotti, Yasmin Jardim Meirelles Dias, Andrea Mora de Marco Novellino
{"title":"Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis.","authors":"Karine Eskandar, Juliana Almeida Oliveira, Sandro Augusto Ribeiro, Matheus Pedrotti Chavez, Ana Isabela de Araujo Zotti, Yasmin Jardim Meirelles Dias, Andrea Mora de Marco Novellino","doi":"10.61622/rbgo/2025rbgo21","DOIUrl":"10.61622/rbgo/2025rbgo21","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to compare the efficacy and safety of letrozole and clomiphene versus letrozole alone for ovulation induction in patients with Polycystic Ovary Syndrome (PCOS).</p><p><strong>Data sources: </strong>We systematically searched EMBASE, PubMed, and Cochrane databases on October 31, 2024.</p><p><strong>Study selection: </strong>We included studies of women with PCOS treated with a combination of clomiphene and letrozole or letrozole alone to induce ovulation that reported any of the outcomes of interest, namely rate of mature follicles and ovulation, ovulation, pregnancy, miscarriages, endometrial thickness, and number of mature follicles.</p><p><strong>Data collection: </strong>We pooled odds ratios (OR) and mean difference (MD) with 95% confidence intervals (CI) using a random effects model using R statistical software, version 4.2.1. Heterogeneity was assessed with I<sup>2</sup> statistics, and a random effects model was used.</p><p><strong>Data synthesis: </strong>Four RCTs and two observational studies comprising 592 patients were included. Combined therapy was associated with a higher rate of a mature follicle (OR 2.74; 95% CI 1.72-4.37; p< 0.001; I<sup>2</sup>=0%) and ovulation (OR 2.55; 95% CI 1.57-4.12; p< 0.001; I<sup>2</sup>=35.9%). The number of mature follicles, number of pregnancies, thickness of endometrial lining, and the incidence of adverse events, including headache, abdominal bloating, fatigue, back pain, breast discomfort, and night sweats, were similar between groups.</p><p><strong>Conclusion: </strong>In women with anovulatory infertility secondary to PCOS, letrozole and clomiphene citrate combined therapy was associated with improved mature follicle and ovulation rates, with a similar safety profile compared to letrozole alone. However, no significant impact was observed on pregnancy rates.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes. 人口统计学和产科因素对创伤性分娩和母乳喂养态度的影响ımpact。
Ayşe Çuvadar, Elnaz Karamelikli, Yeter Çuvadar Baş
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