Alergologia Polska - Polish Journal of Allergology最新文献

{"title":"The harmful effects of plant preparations","authors":"Nicole Stefańska, Joanna Wieczfinska, R. Pawliczak","doi":"10.5114/pja.2023.129091","DOIUrl":"https://doi.org/10.5114/pja.2023.129091","url":null,"abstract":"Natural medicine, although it has been used for centuries, has only recently gained increasing interest and is treated as a remedy for all ailments. It is very often abused due to a lack of sufficient knowledge about potential adverse reactions and possible interactions between plant preparations and particular drugs. Moreover, traditional medicine used for a long period of time without restriction can lead to permanent damage to health and even death. This paper outlines the dangers of harmful effects of plant preparations when used inappropriately and when co-interacting substances are combined.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70482097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cytokines and chemokines in the inflammatory response","authors":"Gabriela Harvanová, Silvia Duranková, Jarmila Bernasovská","doi":"10.5114/pja.2023.131708","DOIUrl":"https://doi.org/10.5114/pja.2023.131708","url":null,"abstract":"AMA Harvanová G, Duranková S, Bernasovská J. The role of cytokines and chemokines in the inflammatory response. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):210-219. doi:10.5114/pja.2023.131708. APA Harvanová, G., Duranková, S., & Bernasovská, J. (2023). The role of cytokines and chemokines in the inflammatory response. Alergologia Polska - Polish Journal of Allergology, 10(3), 210-219. https://doi.org/10.5114/pja.2023.131708 Chicago Harvanová, Gabriela, Silvia Duranková, and Jarmila Bernasovská. 2023. \"The role of cytokines and chemokines in the inflammatory response\". Alergologia Polska - Polish Journal of Allergology 10 (3): 210-219. doi:10.5114/pja.2023.131708. Harvard Harvanová, G., Duranková, S., and Bernasovská, J. (2023). The role of cytokines and chemokines in the inflammatory response. Alergologia Polska - Polish Journal of Allergology, 10(3), pp.210-219. https://doi.org/10.5114/pja.2023.131708 MLA Harvanová, Gabriela et al. \"The role of cytokines and chemokines in the inflammatory response.\" Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 3, 2023, pp. 210-219. doi:10.5114/pja.2023.131708. Vancouver Harvanová G, Duranková S, Bernasovská J. The role of cytokines and chemokines in the inflammatory response. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):210-219. doi:10.5114/pja.2023.131708.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study","authors":"Adam Górka, Paulina Natalia Kopa-Stojak, Rafał Pawliczak","doi":"10.5114/pja.2023.131709","DOIUrl":"https://doi.org/10.5114/pja.2023.131709","url":null,"abstract":"AMA Górka A, Kopa-Stojak P, Pawliczak R. Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):187-198. doi:10.5114/pja.2023.131709. APA Górka, A., Kopa-Stojak, P., & Pawliczak, R. (2023). Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study. Alergologia Polska - Polish Journal of Allergology, 10(3), 187-198. https://doi.org/10.5114/pja.2023.131709 Chicago Górka, Adam, Paulina Natalia Kopa-Stojak, and Rafał Pawliczak. 2023. \"Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study\". Alergologia Polska - Polish Journal of Allergology 10 (3): 187-198. doi:10.5114/pja.2023.131709. Harvard Górka, A., Kopa-Stojak, P., and Pawliczak, R. (2023). Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study. Alergologia Polska - Polish Journal of Allergology, 10(3), pp.187-198. https://doi.org/10.5114/pja.2023.131709 MLA Górka, Adam et al. \"Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study.\" Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 3, 2023, pp. 187-198. doi:10.5114/pja.2023.131709. Vancouver Górka A, Kopa-Stojak P, Pawliczak R. Specific allergen immunotherapy – comparison between allergoids and allergen vaccines. A real-life study. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):187-198. doi:10.5114/pja.2023.131709.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135909159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of new antibiotics in the treatment of community-acquired pneumonia","authors":"Nikodem Trzcina, Joanna Wieczfinska, R. Pawliczak","doi":"10.5114/pja.2023.129082","DOIUrl":"https://doi.org/10.5114/pja.2023.129082","url":null,"abstract":"Community-acquired pneumonia (CAP), defined as acute pulmonary parenchymal infection acquired outside the hospital, remains one of the most common causes of hospitalization and death, especially among people over 65 and those with impaired immunity. This is a serious problem due to aging societies in many countries and comorbidities. Despite the development of diagnostic methods, in half of the patients with CAP, the etiology cannot be determined, which emphasizes the importance of empirical treatment and the risk of increasing antibiotic resistance to available preparations. In recent years, new antibiotics have been approved for the treatment of CAP, which may significantly improve the possibilities of empirical treatment of CAP","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70481329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?","authors":"Przemysław Seweryn, Andrzej Emeryk, Maciej Kupczyk, Radosław Gawlik, Tomasz Dębowski, Grzegorz Sztaba, Rafał Pawliczak","doi":"10.5114/pja.2023.131710","DOIUrl":"https://doi.org/10.5114/pja.2023.131710","url":null,"abstract":"AMA Seweryn P, Emeryk A, Kupczyk M, et al. Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):189-201. doi:10.5114/pja.2023.131710. APA Seweryn, P., Emeryk, A., Kupczyk, M., Gawlik, R., Dębowski, T., & Sztaba, G. et al. (2023). Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?. Alergologia Polska - Polish Journal of Allergology, 10(3), 189-201. https://doi.org/10.5114/pja.2023.131710 Chicago Seweryn, Przemysław, Andrzej Emeryk, Maciej Kupczyk, Radosław Gawlik, Tomasz Dębowski, Grzegorz Sztaba, and Rafał Pawliczak. 2023. \"Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?\". Alergologia Polska - Polish Journal of Allergology 10 (3): 189-201. doi:10.5114/pja.2023.131710. Harvard Seweryn, P., Emeryk, A., Kupczyk, M., Gawlik, R., Dębowski, T., Sztaba, G., and Pawliczak, R. (2023). Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?. Alergologia Polska - Polish Journal of Allergology, 10(3), pp.189-201. https://doi.org/10.5114/pja.2023.131710 MLA Seweryn, Przemysław et al. \"Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?.\" Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 3, 2023, pp. 189-201. doi:10.5114/pja.2023.131710. Vancouver Seweryn P, Emeryk A, Kupczyk M, Gawlik R, Dębowski T, Sztaba G et al. Formodual – a new therapeutic option in asthma and chronic obturative pulmonary disease treatment with low copayment. Does the therapy cost influence patients’ compliance?. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):189-201. doi:10.5114/pja.2023.131710.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the diagnosis and management of histamine intolerance","authors":"Krzysztof Buczyłko, Anna Bartnicka, Jerzy Kruszewski, Katarzyna Plata-Nazar, Krzysztof Piwowarek, Maciej Kupczyk, Radosław Gawlik, Dariusz Lebensztejn, Zbigniew Bartuzi, Jan Mazela, Agnieszka Szlagatys-Sidorkiewicz","doi":"10.5114/pja.2023.131553","DOIUrl":"https://doi.org/10.5114/pja.2023.131553","url":null,"abstract":"AMA Buczyłko K, Bartnicka A, Kruszewski J, et al. Guidelines for the diagnosis and management of histamine intolerance. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):141-151. doi:10.5114/pja.2023.131553. APA Buczyłko, K., Bartnicka, A., Kruszewski, J., Plata-Nazar, K., Piwowarek, K., & Kupczyk, M. et al. (2023). Guidelines for the diagnosis and management of histamine intolerance. Alergologia Polska - Polish Journal of Allergology, 10(3), 141-151. https://doi.org/10.5114/pja.2023.131553 Chicago Buczyłko, Krzysztof, Anna Bartnicka, Jerzy Kruszewski, Katarzyna Plata-Nazar, Krzysztof Piwowarek, Maciej Kupczyk, and Radosław Gawlik et al. 2023. \"Guidelines for the diagnosis and management of histamine intolerance\". Alergologia Polska - Polish Journal of Allergology 10 (3): 141-151. doi:10.5114/pja.2023.131553. Harvard Buczyłko, K., Bartnicka, A., Kruszewski, J., Plata-Nazar, K., Piwowarek, K., Kupczyk, M., Gawlik, R., Lebensztejn, D., Bartuzi, Z., Mazela, J., and Szlagatys-Sidorkiewicz, A. (2023). Guidelines for the diagnosis and management of histamine intolerance. Alergologia Polska - Polish Journal of Allergology, 10(3), pp.141-151. https://doi.org/10.5114/pja.2023.131553 MLA Buczyłko, Krzysztof et al. \"Guidelines for the diagnosis and management of histamine intolerance.\" Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 3, 2023, pp. 141-151. doi:10.5114/pja.2023.131553. Vancouver Buczyłko K, Bartnicka A, Kruszewski J, Plata-Nazar K, Piwowarek K, Kupczyk M et al. Guidelines for the diagnosis and management of histamine intolerance. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):141-151. doi:10.5114/pja.2023.131553.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of premedication to prevent reactions in cluster immunotherapy","authors":"Müge Olgaç, Semra Demir, Derya Ünal, Raif Coşkun, Bahaauddin Çolakoğlu, Suna Büyüköztürk, Aslı Gelincik","doi":"10.5114/pja.2023.131707","DOIUrl":"https://doi.org/10.5114/pja.2023.131707","url":null,"abstract":"AMA Olgaç M, Demir S, Ünal D, et al. Role of premedication to prevent reactions in cluster immunotherapy. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):180-186. doi:10.5114/pja.2023.131707. APA Olgaç, M., Demir, S., Ünal, D., Coşkun, R., Çolakoğlu, B., & Büyüköztürk, S. et al. (2023). Role of premedication to prevent reactions in cluster immunotherapy. Alergologia Polska - Polish Journal of Allergology, 10(3), 180-186. https://doi.org/10.5114/pja.2023.131707 Chicago Olgaç, Müge, Semra Demir, Derya Ünal, Raif Coşkun, Bahaauddin Çolakoğlu, Suna Büyüköztürk, and Aslı Gelincik. 2023. \"Role of premedication to prevent reactions in cluster immunotherapy\". Alergologia Polska - Polish Journal of Allergology 10 (3): 180-186. doi:10.5114/pja.2023.131707. Harvard Olgaç, M., Demir, S., Ünal, D., Coşkun, R., Çolakoğlu, B., Büyüköztürk, S., and Gelincik, A. (2023). Role of premedication to prevent reactions in cluster immunotherapy. Alergologia Polska - Polish Journal of Allergology, 10(3), pp.180-186. https://doi.org/10.5114/pja.2023.131707 MLA Olgaç, Müge et al. \"Role of premedication to prevent reactions in cluster immunotherapy.\" Alergologia Polska - Polish Journal of Allergology, vol. 10, no. 3, 2023, pp. 180-186. doi:10.5114/pja.2023.131707. Vancouver Olgaç M, Demir S, Ünal D, Coşkun R, Çolakoğlu B, Büyüköztürk S et al. Role of premedication to prevent reactions in cluster immunotherapy. Alergologia Polska - Polish Journal of Allergology. 2023;10(3):180-186. doi:10.5114/pja.2023.131707.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significantly higher death toll along with COVID-19 mortality than influenza have been reduced by vaccination and restrictions","authors":"P. Rieske","doi":"10.5114/pja.2023.125766","DOIUrl":"https://doi.org/10.5114/pja.2023.125766","url":null,"abstract":"The article demonstrates estimated data of influenza and COVID-19 morbidity and infection fatality rate (IFR) mortality in the context of restrictions and vaccination (years 2020-2021 mostly developed countries). A division into two age groups was included: Up to 65 years of age and over 65 years of age. Influenza mortality (IFR) did not change between 2020 and 2021 and was about 0.05% among all, and 0.005 among those under 65 years of age. IFR COVID-19 was on average approx. 0.5% overall, and in groups under 65 years of age a minimum of 0.07%. COVID-19 morbidity varied greatly from about 50/100,000 in Japan to 600/100,000 in Peru during 2020 plus 2021. In the United States and Poland, about 250 per 100 thousand in 2 years. The morbidity rate of COVID-19 in lower risk groups was 70/100 thousand in the United States. The pre-2020 flu morbidity rate in the United States ranged from 1-10 per 100,000 per season. In the 2020/21 season, it decreased to 1/100 thousand. In groups 65 age old and younger, influenza morbidity in the United States was about 0.3 per 100,000 in the 2020/2021 season, and in typical seasons 0.3 to 3/100,000. Examples of absolute numbers. In the United States, in 2021, COVID-19 471,000 victims (a year of available vaccinations). Influenza season 2021 max. 4,500 victims. The average flu season in unrestricted seasons, was about 25,000 victims. Predictions of the consequenc-es of the lack of restrictions and vaccinations are theoretical, because the preliminary ones talk about 2-3 million COVID-19 victims and even more than ten million additional hospitalizations in the United States, which may mean the collapse of the health system, and thus in practice a greater number of victims. The data presented did not result from diagnostic errors. A proper epidemic assessment confirms the effectiveness of vaccination and targeted therapy. COVID-19 vaccination reduced IFR mortality by about 10-fold.Copyright © 2023, Termedia Publishing House Ltd.. All rights reserved.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70481156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of COVID-19 vaccination among patients with history of allergic reactions","authors":"Katarzyna Furman, Ewelina Kasprzyk-Wieczorkowska, J. Glück, R. Gawlik","doi":"10.5114/pja.2023.125767","DOIUrl":"https://doi.org/10.5114/pja.2023.125767","url":null,"abstract":"Introduction: Vaccination is considered the most effective method of preventing diseases and their complications. Unfortunately, many people question their legitimacy and safety. At the beginning of 2021, a few months after the announcement of the SARS-CoV-2 pandemic by the World Health Organization (WHO), the first COVID-19 vaccines were granted a conditional marketing authorization. mRNA vaccines have attracted great interest due to the use of new technology and the content of polyethylene glycol (PEG 2000) in their composition, which may induce anaphylaxis. Due to vaccine tolerance concerns, some vaccination centres have refused to administer the vaccine to patients. Aim(s): Risk assessment of allergic reactions after administration of the COVID-19 vaccine. Material(s) and Method(s): 115 patients were admitted to the Department of Allergology and Clinical Immunology in Katowice, including 107 patients with a high risk of anaphylaxis after vaccination according to the referring physician and 8 patients with a history of hypersensitivity reactions after the first dose of COVID-19 vaccination. Patients were referred for diagnosis of hypersensitivity to components of the Pfizer/BioNTech COVID-19 vaccine and administration of the vaccine in a hospital setting. During hospitalization, all patients underwent skin prick and intradermal tests with the Pfizer/BioNTech COVID-19 vaccine components, with negative results. Patients were administered the Pfizer/BioNTech COVID-19 vaccine intramuscularly, followed by at least 60 minutes of observation in the Department. Result(s): No symptoms of early hypersensitivity were observed. One patient developed urticarial lesions on the skin of the neck approximately 4-5 hours after vaccination. Conclusion(s): The risk of anaphylaxis after COVID-19 vaccine administration is low, and only a small group of patients with an allergic history require a specialised diagnostics. Physicians authorised to administer the vaccine should be acquainted with the latest recommendations, assess the risk of anaphylaxis and avoid unnecessary delays in administering a vaccine that can protect against severe morbidity and death.Copyright © 2023, Termedia Publishing House Ltd.. All rights reserved.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70481312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of innate lymphoid cells in chronic rhinosinusitis\u0000severity in children: a cross-sectional study","authors":"Marta Latek, P. Lacwik, K. Molińska, A. Błauż, B. Rychlik, Dominik Strapagiel, J. Majak, Dorota Czech, P. Kuna, P. Majak","doi":"10.5114/pja.2023.129090","DOIUrl":"https://doi.org/10.5114/pja.2023.129090","url":null,"abstract":"Introduction: The microbiome has been identified as a significant factor in the pathogenesis of various inflammatory and autoimmune diseases, including chronic rhinosinusitis (CRS), a condition that affects up to 12% of the global population. Aim: To evaluate the role of innate lymphoid cells (ILC1, ILC2, and ILC3) and their relationship with nasal microbiota in CRS in children. Material and methods: We assessed the clinical, microbiological, and immunological characteristics of 63 children with CRS. We evaluated disease severity using the Sinus and Nasal Quality of Life Survey (SN-5) and measured ILC1, ILC2, and ILC3 levels in nasal scrapings; microbial diversity was expressed as OTU richness. Results: We found a statistically significant relationship between ILC1 levels and CRS severity, suggesting a potential role of ILC1 in the development of the disease. ILC3 levels were significantly associated with lower microbial richness. While atopy was more common in children with high levels of ILC2, the relationship was not significant. Conclusions: Our results indicate that innate lymphoid cells may play a significant role in the inflammatory processes underlying the development and severity of chronic rhinosinusitis, with ILC1 activation being particularly strongly associated with CRS severity in young children. Additionally, ILC3 may play a role in modulating the nasal microbiome in CRS patients, but the relationship is not strong enough to significantly impact the clinical characteristics.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70482079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}