Marta Latek, P. Lacwik, K. Molińska, A. Błauż, B. Rychlik, Dominik Strapagiel, J. Majak, Dorota Czech, P. Kuna, P. Majak
{"title":"先天性淋巴样细胞在儿童慢性鼻窦炎严重程度中的作用:横断面研究","authors":"Marta Latek, P. Lacwik, K. Molińska, A. Błauż, B. Rychlik, Dominik Strapagiel, J. Majak, Dorota Czech, P. Kuna, P. Majak","doi":"10.5114/pja.2023.129090","DOIUrl":null,"url":null,"abstract":"Introduction: The microbiome has been identified as a significant factor in the pathogenesis of various inflammatory and autoimmune diseases, including chronic rhinosinusitis (CRS), a condition that affects up to 12% of the global population. Aim: To evaluate the role of innate lymphoid cells (ILC1, ILC2, and ILC3) and their relationship with nasal microbiota in CRS in children. Material and methods: We assessed the clinical, microbiological, and immunological characteristics of 63 children with CRS. We evaluated disease severity using the Sinus and Nasal Quality of Life Survey (SN-5) and measured ILC1, ILC2, and ILC3 levels in nasal scrapings; microbial diversity was expressed as OTU richness. Results: We found a statistically significant relationship between ILC1 levels and CRS severity, suggesting a potential role of ILC1 in the development of the disease. ILC3 levels were significantly associated with lower microbial richness. While atopy was more common in children with high levels of ILC2, the relationship was not significant. Conclusions: Our results indicate that innate lymphoid cells may play a significant role in the inflammatory processes underlying the development and severity of chronic rhinosinusitis, with ILC1 activation being particularly strongly associated with CRS severity in young children. Additionally, ILC3 may play a role in modulating the nasal microbiome in CRS patients, but the relationship is not strong enough to significantly impact the clinical characteristics.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The role of innate lymphoid cells in chronic rhinosinusitis\\nseverity in children: a cross-sectional study\",\"authors\":\"Marta Latek, P. Lacwik, K. Molińska, A. Błauż, B. Rychlik, Dominik Strapagiel, J. Majak, Dorota Czech, P. Kuna, P. Majak\",\"doi\":\"10.5114/pja.2023.129090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: The microbiome has been identified as a significant factor in the pathogenesis of various inflammatory and autoimmune diseases, including chronic rhinosinusitis (CRS), a condition that affects up to 12% of the global population. Aim: To evaluate the role of innate lymphoid cells (ILC1, ILC2, and ILC3) and their relationship with nasal microbiota in CRS in children. Material and methods: We assessed the clinical, microbiological, and immunological characteristics of 63 children with CRS. We evaluated disease severity using the Sinus and Nasal Quality of Life Survey (SN-5) and measured ILC1, ILC2, and ILC3 levels in nasal scrapings; microbial diversity was expressed as OTU richness. Results: We found a statistically significant relationship between ILC1 levels and CRS severity, suggesting a potential role of ILC1 in the development of the disease. ILC3 levels were significantly associated with lower microbial richness. While atopy was more common in children with high levels of ILC2, the relationship was not significant. Conclusions: Our results indicate that innate lymphoid cells may play a significant role in the inflammatory processes underlying the development and severity of chronic rhinosinusitis, with ILC1 activation being particularly strongly associated with CRS severity in young children. Additionally, ILC3 may play a role in modulating the nasal microbiome in CRS patients, but the relationship is not strong enough to significantly impact the clinical characteristics.\",\"PeriodicalId\":7469,\"journal\":{\"name\":\"Alergologia Polska - Polish Journal of Allergology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alergologia Polska - Polish Journal of Allergology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/pja.2023.129090\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alergologia Polska - Polish Journal of Allergology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pja.2023.129090","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
The role of innate lymphoid cells in chronic rhinosinusitis
severity in children: a cross-sectional study
Introduction: The microbiome has been identified as a significant factor in the pathogenesis of various inflammatory and autoimmune diseases, including chronic rhinosinusitis (CRS), a condition that affects up to 12% of the global population. Aim: To evaluate the role of innate lymphoid cells (ILC1, ILC2, and ILC3) and their relationship with nasal microbiota in CRS in children. Material and methods: We assessed the clinical, microbiological, and immunological characteristics of 63 children with CRS. We evaluated disease severity using the Sinus and Nasal Quality of Life Survey (SN-5) and measured ILC1, ILC2, and ILC3 levels in nasal scrapings; microbial diversity was expressed as OTU richness. Results: We found a statistically significant relationship between ILC1 levels and CRS severity, suggesting a potential role of ILC1 in the development of the disease. ILC3 levels were significantly associated with lower microbial richness. While atopy was more common in children with high levels of ILC2, the relationship was not significant. Conclusions: Our results indicate that innate lymphoid cells may play a significant role in the inflammatory processes underlying the development and severity of chronic rhinosinusitis, with ILC1 activation being particularly strongly associated with CRS severity in young children. Additionally, ILC3 may play a role in modulating the nasal microbiome in CRS patients, but the relationship is not strong enough to significantly impact the clinical characteristics.
期刊介绍:
Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.