The role of innate lymphoid cells in chronic rhinosinusitis severity in children: a cross-sectional study

IF 0.2 Q4 ALLERGY

Alergologia Polska - Polish Journal of Allergology Pub Date : 2023-01-01 DOI:10.5114/pja.2023.129090

Marta Latek, P. Lacwik, K. Molińska, A. Błauż, B. Rychlik, Dominik Strapagiel, J. Majak, Dorota Czech, P. Kuna, P. Majak

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引用次数: 1

Abstract

Introduction: The microbiome has been identified as a significant factor in the pathogenesis of various inflammatory and autoimmune diseases, including chronic rhinosinusitis (CRS), a condition that affects up to 12% of the global population. Aim: To evaluate the role of innate lymphoid cells (ILC1, ILC2, and ILC3) and their relationship with nasal microbiota in CRS in children. Material and methods: We assessed the clinical, microbiological, and immunological characteristics of 63 children with CRS. We evaluated disease severity using the Sinus and Nasal Quality of Life Survey (SN-5) and measured ILC1, ILC2, and ILC3 levels in nasal scrapings; microbial diversity was expressed as OTU richness. Results: We found a statistically significant relationship between ILC1 levels and CRS severity, suggesting a potential role of ILC1 in the development of the disease. ILC3 levels were significantly associated with lower microbial richness. While atopy was more common in children with high levels of ILC2, the relationship was not significant. Conclusions: Our results indicate that innate lymphoid cells may play a significant role in the inflammatory processes underlying the development and severity of chronic rhinosinusitis, with ILC1 activation being particularly strongly associated with CRS severity in young children. Additionally, ILC3 may play a role in modulating the nasal microbiome in CRS patients, but the relationship is not strong enough to significantly impact the clinical characteristics.

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先天性淋巴样细胞在儿童慢性鼻窦炎严重程度中的作用:横断面研究

微生物组已被确定为各种炎症和自身免疫性疾病发病机制的重要因素，包括影响全球12%人口的慢性鼻窦炎(CRS)。目的:探讨先天性淋巴样细胞(ILC1、ILC2和ILC3)在儿童CRS中的作用及其与鼻腔微生物群的关系。材料和方法:我们评估63例CRS患儿的临床、微生物学和免疫学特征。我们使用鼻窦和鼻腔生活质量调查(SN-5)评估疾病严重程度，并测量鼻刮伤中ILC1、ILC2和ILC3的水平;微生物多样性以OTU丰富度表示。结果:我们发现ILC1水平与CRS严重程度之间存在统计学意义上的关系，提示ILC1在疾病发展中的潜在作用。ILC3水平与较低的微生物丰富度显著相关。虽然特异反应在ILC2水平高的儿童中更为常见，但两者之间的关系并不显著。结论:我们的研究结果表明，先天淋巴样细胞可能在慢性鼻窦炎的发展和严重程度的炎症过程中发挥重要作用，ILC1激活与幼儿CRS严重程度特别密切相关。此外，ILC3可能在CRS患者的鼻腔微生物组中发挥调节作用，但其相关性不足以显著影响临床特征。

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来源期刊

Alergologia Polska - Polish Journal of Allergology ALLERGY-

自引率

50.00%

发文量

期刊介绍： Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.