Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society最新文献

{"title":"A Case of Late-Onset Semantic Dementia With Right-Predominant Temporal Lobe Atrophy due to Primary Tauopathy.","authors":"Yuta Sudo, Masashi Tamura, Kenjiro Nakayama, Kiyotaka Nemoto, Osamu Yokota, Kenji Tagai, Hironobu Endo, Takahiko Tokuda, Makoto Higuchi, Kentaro Hatano, Tetsuaki Arai","doi":"10.1111/psyg.70094","DOIUrl":"10.1111/psyg.70094","url":null,"abstract":"<p><p>Semantic dementia (SD) is a type of dementia characterized by a loss of semantic memory, typically presenting with left-predominant temporal lobe atrophy and a frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) type C pathology. However, atypical variants, such as those with a late-onset or right-predominant atrophy, exhibit considerable pathological diversity. We report an 81-year-old woman with atypical SD who presented with impaired naming, mild word comprehension deficits, and prosopagnosia. Brain MRI revealed right-predominant atrophy in the amygdala, hippocampus, and anterior temporal lobes. Cerebrospinal fluid analysis showed a normal Aβ level, suggesting a non-Alzheimer's disease pathology. Tau PET imaging demonstrated a high signal in the right anterior temporal lobe, consistent with primary tauopathy. The patient's clinical presentation and imaging findings, particularly the atrophy in the amygdala and hippocampus, as well as the preserved communication ability, raised the possibility of argyrophilic grain disease (AGD) as the underlying pathology. This case highlights the importance of molecular imaging in diagnosing atypical SD. It suggests that AGD should be considered a possible underlying pathology for atypical SD cases, particularly those with late onset and right-sided predominance. A longer follow-up and eventual autopsy would be necessary to confirm the pathological diagnosis.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 5","pages":"e70094"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Hearing Impairment Associated With Specific Behavioural and Psychological Symptoms of Dementia in Japanese Older Adults Attending a Memory Clinic?","authors":"Saki Tanaka, Ryo Katayose, Teruaki Kawasaki, Ichiro Akiguchi, Mihoko Ogita","doi":"10.1111/psyg.70090","DOIUrl":"10.1111/psyg.70090","url":null,"abstract":"<p><strong>Background: </strong>Behavioural and psychological symptoms of dementia (BPSD), encompassing disturbances in perception, thought, mood and behaviour, are prevalent among individuals with dementia and can substantially affect their quality of life. Although prior research has suggested that hearing impairment (HI) may exacerbate BPSD due to communication difficulties and diminished social engagement, the relationship between HI and specific BPSD manifestations remains insufficiently explored. This study aims to examine the association between HI and distinct BPSD in individuals with cognitive decline attending a memory clinic.</p><p><strong>Methods: </strong>This study included 179 individuals with cognitive decline and their accompanying persons who visited a memory clinic between July 2023 and March 2024. Pure-tone audiometry and a questionnaire survey were conducted. HI was defined as an average hearing level of 40 dB or higher. BPSD was assessed using a questionnaire derived from the BPSD25Q, a 25-item questionnaire designed to evaluate BPSD. The association between HI and BPSD was analyzed using modified Poisson regression, with adjusted risk ratios (aRR) and 95% confidence intervals (CI) calculated.</p><p><strong>Results: </strong>A total of 144 individuals were included in the analysis, with a mean age of 82.7 years, approximately 70% of whom were female. The aRR (95% CI) for the presence of specific BPSD among individuals with HI were as follows: anxiety, 2.08 (1.09-3.99); irritability, 1.73 (1.05-2.86); verbally aggressive behaviour, 3.41 (1.24-9.40); physically aggressive behaviour, 5.54 (1.31-23.40); leaving home unannounced, 4.22 (1.25-14.16); hoarding behaviour, 1.83 (1.06-3.16); resistance to care, 2.12 (1.02-4.40); and carelessness with fire, 4.46 (1.12-17.83). No significant association was observed between HI and other BPSD.</p><p><strong>Conclusions: </strong>These findings suggest that HI may contribute to the presence of specific BPSD. Tailored interventions incorporating communication strategies and environmental modifications may help mitigate BPSD in individuals with cognitive decline and HI.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 5","pages":"e70090"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.","authors":"Kazuhiro Yoshiura, Miki Murata, Miyuki Hamasuna, Yusuke Miyagawa, Keiichiro Kaneda, Ryuji Fukuhara, Mamoru Hashimoto, Minoru Takebayashi","doi":"10.1111/psyg.70085","DOIUrl":"10.1111/psyg.70085","url":null,"abstract":"<p><strong>Background: </strong>The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD plays a critical role in dementia care. This study examined whether the addition of short-term exercise therapy to group occupational therapy (OT) was effective in reducing BPSD.</p><p><strong>Methods: </strong>This single-blind randomised controlled trial included inpatients aged 60 years or older in a dementia-specialised psychiatric ward. Participants were randomly assigned to either an intervention group (OT plus exercise therapy) or a control group (OT only), with both groups receiving interventions five times per week over a two-week period. The primary outcome was the change in BPSD after 2 weeks.</p><p><strong>Results: </strong>Seventeen of 18 participants completed the trial. In the full analysis set, there was no significant difference in BPSD between the intervention and control groups. However, in a supplementary per-protocol analysis including 14 participants who completed all interventions, there was a significant improvement in Neuropsychiatric Inventory-Nursing Home version scores for patients in the intervention group.</p><p><strong>Conclusions: </strong>The addition of short-term exercise therapy to group OT did not result in a significant reduction in BPSD. However, supplementary analysis suggested a potential benefit among participants with high adherence. While these findings suggest that short-term exercise may not immediately enhance the effects of OT, the limited sample size prevents definitive conclusions. This study provides hypothesis-generating insights for future research.</p><p><strong>Trail registration: </strong>Information Network Clinical Trials Registry (UMIN-CTR): UMIN000038201.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 5","pages":"e70085"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzodiazepine-Resistant Catatonia Treated With Amantadine in Dementia With Lewy Bodies: A Case Report.","authors":"Yuske Saito, Ryota Kobayashi, Keisuke Noto, Akihito Suzuki","doi":"10.1111/psyg.70095","DOIUrl":"https://doi.org/10.1111/psyg.70095","url":null,"abstract":"","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 5","pages":"e70095"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Paradox of Care: Family Support and Its Complex Role in the Depression and Anxiety Comorbidity Among Older Adults With Chronic Kidney Disease.","authors":"Shujian Wang, Meiling Gu, Xinyuan Zou, Xiangping Liu, Yanqiang Tao","doi":"10.1111/psyg.70083","DOIUrl":"10.1111/psyg.70083","url":null,"abstract":"<p><strong>Background: </strong>With global ageing trends, the well-being of older adults is a growing concern. Chronic kidney disease (CKD) is a common ailment among older adults, often accompanied by mental distress such as depression and anxiety. This study investigates how family support impacts the comorbidity of depression and anxiety in older adults, comparing healthy individuals with those afflicted by CKD.</p><p><strong>Methods: </strong>We recruited 228 healthy older adults and 89 with CKD. Using the Multidimensional Scale of Perceived Social Support (MSPSS), the Centre for Epidemiologic Studies Depression (CES-D) scale and the Self-Rating Anxiety Scale (SAS), we measured family support levels and the severity of depression and anxiety. The Bayesian Information Criterion (BIC) based hierarchical Least Absolute Shrinkage and Selection Operator (LASSO) regression method was used to estimate the moderated network models. Two separate moderated network models for the CKD and healthy groups were constructed to assess the differential effects of family support.</p><p><strong>Results: </strong>Older adults with CKD experience significantly more severe depression (t = 6.39, p < 0.001), anxiety (t = 7.23, p < 0.001) and perceive less family support than their healthy counterparts (t = 5.03, p < 0.001). For healthy older adults, family support alleviates comorbidity by reducing the impact of peer rejection on mental disintegration symptoms (β = -0.02, p < 0.01). In CKD-affected older adults, family support mitigates comorbidity by lessening the effect of unfounded fear on guilt (β = -0.07, p < 0.01). However, among older individuals with CKD, family support may exacerbate comorbidity by intensifying the impact of frequent urination on feelings of life despair (β = 0.09, p < 0.05).</p><p><strong>Conclusions: </strong>These results contribute to the understanding of mental health in the older population and inform clinical practices and policies to enhance home care measures for older adults, particularly those with CKD. As caregivers help older adults with CKD deal with physical problems that may bring shame (e.g., urinary problems), care should be taken to protect the older adult's privacy and self-esteem and not to show excessive concern for these problems.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 5","pages":"e70083"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Interventions for Managing Acute Geriatric Pain and Delirium: A Systematic Review.","authors":"Chen Zeng, Fengcai Liu","doi":"10.1111/psyg.70066","DOIUrl":"10.1111/psyg.70066","url":null,"abstract":"<p><p>Delirium and acute pain are significant clinical challenges in the care of hospitalised elderly patients, both of which are associated with increased mortality, functional disability and prolonged hospital stays. The aim of this study was to systematically review and perform both qualitative and quantitative analyses of the effectiveness of various pharmacological interventions in preventing delirium and controlling acute pain in hospitalised elderly individuals. A comprehensive search was conducted in PubMed, Scopus, Embase, Cochrane, Google Scholar and Web of Science databases up to February 2025. Randomised controlled trials (RCTs) and controlled trials focusing on medications used to prevent delirium or alleviate pain in hospitalised elderly patients were selected. Data were extracted qualitatively and categorised and analysed considering delirium and pain outcomes. Among the studies screened, 12 studies were included in the final analysis. Interventions such as iliac fascia block, multi-drug anti-inflammatory bundles, gabapentin and butorphanol were effective in reducing pain intensity and some inflammatory markers. However, most medications had no significant effect on reducing delirium incidence or provided conflicting results. Interventions targeting systemic inflammation, such as methylprednisolone, dexamethasone and preoperative saline solution, showed more promising results in preventing delirium. The findings suggest that single pharmacological approaches are often ineffective in preventing delirium and the use of combined strategies, including anti-inflammatory interventions along with effective pain control, may yield better outcomes. Future study designs should focus on larger sample sizes, more diverse populationsand standardisation of measurement tools.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70066"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Individual Cognitive Stimulation Therapy on Cognitive Function and Depressive Mood in Dementia Patients: A Systematic Review and Meta-Analysis.","authors":"Pan Liu, Yue Zhang, Ziying Yu, Xinyu Wang, Qinghui Meng","doi":"10.1111/psyg.70054","DOIUrl":"10.1111/psyg.70054","url":null,"abstract":"<p><p>To assess the effects of individualised cognitive stimulation therapy (ICST) on dementia patients, we searched Chinese and English databases for intervention studies on individual cognitive stimulation therapy in dementia patients and used Review Manager 5.3 software for meta-analysis. The results of the meta-analysis indicated that the Mini-Mental State Examination (MMSE) showed a significant difference in cognitive function (MD: 1.65; 95% CI: 0.06-3.24). However, no significant effect was found in the assessment of the Cognitive Subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog). Overall, ICST demonstrated improved cognitive function in dementia patients and led to a reduction in depression (MD: -1.18; 95% CI: -2.14 to -0.22). Nevertheless, there were no significant effects on quality of life, neuropsychiatric symptoms, or activities of daily living observed. ICST can effectively improve the cognitive ability of dementia patients and reduce depression. There is a need for further studies to confirm these findings and investigate potential mechanisms.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70054"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Older Adults With Late-Onset Suicide Attempts: A Hospital-Based Retrospective Study.","authors":"Daichi Morioka, Ryota Kobayashi, Kazutaka Sakamoto, Toshinori Shirata, Tadahiro Kobayashi, Akihito Suzuki","doi":"10.1111/psyg.70063","DOIUrl":"https://doi.org/10.1111/psyg.70063","url":null,"abstract":"<p><strong>Background: </strong>No previous study has fully described older adults who make a first suicide attempt late in life. We retrospectively reviewed adults ≥ 60 years admitted to a university psychiatric ward after an attempt to (1) detail their demographic and clinical features; (2) compare admission and discharge diagnoses to measure diagnostic shifts-especially from major depressive disorder (MDD) to dementia; and (3) determine whether certain dementia subtypes, notably dementia with Lewy bodies (DLB), are over-represented.</p><p><strong>Methods: </strong>Medical charts of patients transported to the emergency department and hospitalised between April 2015 and March 2024 were screened. After excluding cases with psychiatric disorders before the age of 60 years, 63 late-onset attempters were analysed. Diagnoses were reassessed with DSM-5-TR and standard neurodegenerative criteria; discrepancies were resolved by two senior psychiatrists. Mini-Mental State Examination scores, suicide methods and demographics were compared across final diagnoses.</p><p><strong>Results: </strong>At discharge, psychiatric disorders predominated (65.1%), but dementia was present in 31.7%; DLB was the leading subtype (19.0%), followed by Alzheimer's disease (9.5%). Diagnostic revision was common: 17 patients (27.0%) changed diagnosis during hospitalisation, including 15 who shifted from MDD to dementia; 10 of these reclassifications were to DLB and six met criteria for psychiatric-onset DLB. Mini-Mental State Examination scores did not differ between MDD and DLB, although scores were lower in Alzheimer's disease. Suicide methods-most often drug overdose-showed no relation to diagnosis.</p><p><strong>Conclusions: </strong>Almost one-third of older first-time attempters harboured unrecognised dementia, most frequently DLB and over one-quarter of initial MDD diagnoses converted to dementia after full assessment. Brief cognitive screens alone missed these cases. Routine post-attempt care for older adults should therefore include informant history, detailed neuropsychological testing and dementia-specific biomarkers to guide targeted prevention and treatment.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70063"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neural Correlates of Delusions in Dementia: A Scoping Review.","authors":"Adèle Gagnon, Bryn H Manns, Karina Atanasiu, Dominique Lumley, Mallar Chakravarty, Serge Gauthier, Ian Gold","doi":"10.1111/psyg.70060","DOIUrl":"10.1111/psyg.70060","url":null,"abstract":"<p><p>Delusions are common symptoms of dementia and are clinically significant. The objective of this scoping review is to identify possible neural correlates. MEDLINE (OVID), EMBASE (OVID) and Web of Science were searched in December 2020 for the keywords 'delusions' and 'dementia'. Two informal searches were carried out subsequently. Results were limited to those in English. Intervention and study characteristics were extracted using standardised tools. Eighteen published studies, using four distinct experimental methods, were included, and 31 brain regions were identified as correlates of delusions. No region was identified consistently within included studies or found in more than four studies. Despite the range of brain regions identified, a number form part of the default mode network, the salience network or the central executive network. We explore the implications of these findings for understanding delusions in dementia.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70060"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Vitamins in Neurodegeneration: A Brief Review of Mechanisms, Clinical Evidence, and Therapeutic Perspectives.","authors":"Alberto Raggi, Raffaele Ferri","doi":"10.1111/psyg.70071","DOIUrl":"https://doi.org/10.1111/psyg.70071","url":null,"abstract":"<p><p>This review evaluates the role of vitamins in neurodegeneration. Low levels of B vitamins have been associated with cognitive decline. B vitamins may help inhibit amyloid plaque aggregation. Vitamin D deficiency has been linked to an increased risk of cognitive impairment, correlating with Alzheimer's pathology. Vitamin E may help delay Alzheimer's disease progression and support functional abilities. In Parkinson's disease, vitamin D shows promise in reducing dopaminergic neuron loss and improving motor and cognitive outcomes. Vitamin C reduces oxidative stress and preserves neuronal integrity. Vitamin K has gained attention for its role in cognitive health, with studies suggesting that higher levels may be linked to improved cognitive performance. In conclusion, a better understanding of the translational potential of these vitamins may inform preventive and therapeutic strategies for neurodegenerative diseases. Clinicians should consider vitamin supplementation for aging-related conditions. Further studies are needed to confirm its therapeutic potential and clarify underlying mechanisms in neurodegeneration.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 4","pages":"e70071"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}