The Role of Vitamins in Neurodegeneration: A Brief Review of Mechanisms, Clinical Evidence, and Therapeutic Perspectives.

This review evaluates the role of vitamins in neurodegeneration. Low levels of B vitamins have been associated with cognitive decline. B vitamins may help inhibit amyloid plaque aggregation. Vitamin D deficiency has been linked to an increased risk of cognitive impairment, correlating with Alzheimer's pathology. Vitamin E may help delay Alzheimer's disease progression and support functional abilities. In Parkinson's disease, vitamin D shows promise in reducing dopaminergic neuron loss and improving motor and cognitive outcomes. Vitamin C reduces oxidative stress and preserves neuronal integrity. Vitamin K has gained attention for its role in cognitive health, with studies suggesting that higher levels may be linked to improved cognitive performance. In conclusion, a better understanding of the translational potential of these vitamins may inform preventive and therapeutic strategies for neurodegenerative diseases. Clinicians should consider vitamin supplementation for aging-related conditions. Further studies are needed to confirm its therapeutic potential and clarify underlying mechanisms in neurodegeneration.