Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society最新文献

{"title":"Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy.","authors":"Yingna Shi, Peipei Xu","doi":"10.1111/psyg.13233","DOIUrl":"10.1111/psyg.13233","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium (POD) poses significant clinical challenges regarding its diagnosis and treatment. Identifying biomarkers that can predict and diagnose POD is crucial for improving patient outcomes.</p><p><strong>Methods: </strong>To explore potential biomarkers for POD, we conducted bulk RNA sequencing (bulk-seq) on peripheral blood samples from POD patients and healthy controls. The expression levels of genes downstream of the phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt) signalling pathway were analysed. We then validated the expression of these genes using quantitative real-time polymerase chain reaction (RT-qPCR) in an independent cohort of 30 healthy controls and 30 POD patients. Receiver operating characteristic (ROC) analysis and six machine learning models were used to evaluate the predictive and diagnostic value of these genes. Additionally, single-cell RNA sequencing (scRNA-seq) was performed to validate gene expression in specific subsets of peripheral blood mononuclear cells (PBMCs), including T-cells, B-cells, natural killer (NK) cells, dendritic cells (DCs), and monocytes.</p><p><strong>Results: </strong>Bulk-seq revealed increased expression of genes downstream of the PI3K-Akt signalling pathway, specifically CHRM2, IL6, NOS3, NGF, and IL6R, in the peripheral blood of POD patients compared to healthy controls. Conversely, the expression of IGF1 was significantly decreased. RT-qPCR validation confirmed these findings. ROC analysis and machine learning models indicated that these genes are useful for predicting and diagnosing POD. scRNA-seq further validated the expression of these genes in specific PBMC subsets, including T-cells, B-cells, NK cells, DCs, and monocytes, with results consistent with the bulk-seq and RT-qPCR data.</p><p><strong>Conclusions: </strong>The abnormal activation of the PI3K-Akt signalling pathway in T-cells, B-cells, NK cells, DCs, and monocytes may serve as potential biomarkers for predicting and diagnosing POD. These findings could inform the development of novel therapeutic strategies for managing POD.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":"25 1","pages":"e13233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death anxiety among the oldest old in Germany. Evidence from the nationally representative 'Old Age in Germany (D80+)'.","authors":"André Hajek, Louis Jacob, Supa Pengpid, Karl Peltzer, Razak M Gyasi, Pinar Soysal, Nicola Veronese, Karel Kostev, Ghazal Aarabi, Hans-Helmut König","doi":"10.1111/psyg.13200","DOIUrl":"10.1111/psyg.13200","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of studies investigating death anxiety among the oldest old based on a large, nationally representative sample during the pandemic. Thus, our aim was to investigate the prevalence and determinants of death anxiety among the oldest old in Germany during the Covid-19 pandemic.</p><p><strong>Methods: </strong>Cross-sectional data were taken from the 'Old Age in Germany' (D80+) study. This is a large, nationwide representative study including individuals 80 years and over living at home and individuals in institutionalised settings (N = 9542 individuals in the analytic sample).</p><p><strong>Results: </strong>Overall, 30% of the respondents reported the absence of death anxiety, 45.5% reported a rather not strong death anxiety, 20.2% reported a rather strong death anxiety, and 4.3% reported a very strong death anxiety. Linear regressions revealed that higher death anxiety was significantly associated with being female (β = 0.21, P < 0.01), younger age (β = -0.02, P < 0.001), being married (β = 0.09, P < 0.001), high education (compared to low education, β = 0.07, P < 0.05), the presence of meaning in life (β = 0.13, P < 0.001), higher loneliness levels (β = 0.18, P < 0.001), the presence of multimorbidity (β = 0.07, P < 0.05), and poorer self-rated health (β = -0.07, P < 0.001). A further analysis showed that probable depression (β = 0.31, P < 0.001) is also associated with higher death anxiety.</p><p><strong>Conclusion: </strong>About one in four individuals had a strong or very strong fear of death during the pandemic. Several sociodemographic, psychosocial, and health-related factors are associated with higher death anxiety. This better understanding of the determinants of death anxiety can be relevant for, among others, the affected individuals, informal and professional carers, as well as friends and relatives.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1347-1355"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study.","authors":"Guanghao Zheng, Shuaiyun Xiao, Yu Cheng, Jianbiao Huang, Chengwei Luo, Lifen Peng, Tao Zeng","doi":"10.1111/psyg.13180","DOIUrl":"10.1111/psyg.13180","url":null,"abstract":"<p><strong>Background: </strong>Evidence from various cohort studies indicate a potential association between depressive disorder and benign prostatic hyperplasia (BPH), yet findings are inconsistent. This study employs bidirectional two-sample Mendelian randomisation (MR) analysis to explore the causal relationship between BPH and major depressive disorder (MDD).</p><p><strong>Methods: </strong>Genetic variants strongly associated with MDD were extracted as instrumental variables conducted by the Psychiatric Genomics Consortium (PGC). Two sets of genetic variants associated with BPH were extracted from the recent FinnGen and Medical Research Council-Integrative Epidemiology Unit Consortium of BPH as the discovery and replication stages, respectively. Bidirectional MR analysis employed methods such as inverse variance weighted, MR-Egger, weighted median, maximum likelihood, and weighted mode. The inverse variance weighted method was primarily used to evaluate the causal relationship.</p><p><strong>Results: </strong>MR analysis in both the discovery and replication stages showed a significant causal relationship between MDD and the risk of BPH (discovery stages, odds ratio (OR) = 1.1146, 95% CI 1.0058-1.2353, P = 0.03852; replication stage, OR: 1.0042, 95% CI 1.0019-1.0065, P = 0.0004). No causal relationship was found between BPH and MDD risk in the reverse MR analysis.</p><p><strong>Conclusions: </strong>Our findings highlight a significant association between MDD and an increased risk of BPH development. Further investigation is needed to elucidate the underlying mechanisms linking depression and BPH.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1217-1226"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal nerve fibre loss as a marker to identify the impact of diabetes on Parkinson's disease.","authors":"Xuebin Niu, Peixiao Yin, Qiuyue Shao, Lu Chen, Guiyun Cui, Chuanying Xu, Kun Zan","doi":"10.1111/psyg.13187","DOIUrl":"10.1111/psyg.13187","url":null,"abstract":"<p><strong>Background: </strong>Patients with Parkinson's disease (PD) suffer from serious quality of life problems. Diabetes has been demonstrated as an independent risk element for PD, aggravating its severity and accelerating its progression. There are currently no suitable biomarkers to reveal the impact of diabetes on PD. The purpose of our research was to study the impact of diabetes on PD using corneal confocal microscopy (CCM), a non-invasive and objective test.</p><p><strong>Methods: </strong>Fourteen PD patients with diabetes (PD-DM), 60 PD patients without diabetes (PD-NDM), and 30 healthy controls (HC) were included in the study. The clinical symptoms of patients with PD were assessed using the Unified Parkinson's Disease Rating Scale-3 (UPDRS-3) and the Parkinson's Disease Autonomic Symptom Prognosis Scale (SCOPA-AUT). Participants underwent CCM to quantify the corneal nerve fibres.</p><p><strong>Results: </strong>Corneal nerve fibre density (CNFD) and corneal nerve fibre length (CNFL) in patients with PD were lower than HC. Furthermore, CNFD in PD-DM was lower than in PD-NDM (P < 0.01). We also assessed the relationship between CCM parameters and clinical scores. CNFL and Hamilton anxiety (HAMA) have a negative correlation (r = -0.261, P = 0.032), but this study did not observe a significant correlation between CCM parameters and SCOPA-AUT. Additionally, CNFD could distinguish PD-DM from PD-NDM, achieving an area under the curve of 75.06% (95% CI, 61.76%-88.36%).</p><p><strong>Conclusions: </strong>The CCM could be served as an objective and sensitive biomarker to investigate the impact of diabetes in PD.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1267-1274"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring expressed emotion and its influencing factors among family caregivers of dementia people: a 3-month study in Japan.","authors":"Xiaoji Liu, Reiko Kanaya, Kazue Shigenobu, Keigo Takiue, Wenping Mo, Eriko Koujiya, Yasushi Takeya, Miyae Yamakawa","doi":"10.1111/psyg.13183","DOIUrl":"10.1111/psyg.13183","url":null,"abstract":"<p><strong>Background: </strong>Family caregivers of dementia patients face significant challenges, including managing their own emotional responses. Understanding factors influencing expressed emotion (EE) is crucial for effective support interventions. The aim of this study was to explore and describe changes in EE among family caregivers of dementia and its associated factors at different time points over 3 months.</p><p><strong>Methods: </strong>A 3-month observational study was conducted in Japan. We collected demographically detailed data on family caregivers currently providing care, including care burden, relationship closeness, and depression. We assessed EE using the validated Family Attitude Scale (FAS). After adjustment for multiple confounding factors, multivariate linear regression analysis was performed to assess factors affecting EE at various time points. Linear regression analysis with generalised estimating equations was used to assess associations between 3-month time-varying EE and burden, intimacy, and depression.</p><p><strong>Results: </strong>Fifty-six family caregivers completed the study. Changes in FAS scores did not show statistical differences over 3 months. It is worth noting that the degree of relationship closeness and care burden are important influencing factors of EE in both cross-sectional analysis and longitudinal analysis.</p><p><strong>Conclusions: </strong>Early identification of risk factors can aid in developing interventions aimed at preventing high levels of EE in the dementia family, thereby mitigating their detrimental effects. Tailored interventions are essential to enhance caregiver well-being and cultivate positive caregiver-patient relationships.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1238-1244"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multimodal non-pharmacological intervention for persons with dementia in nursing homes: a multicentre randomised controlled trial.","authors":"Kyosuke Yorozuya, Yuta Kubo, Yoshihiro Asaoka, Hiroyuki Hayashi, Takashi Fujita, Hideaki Hanaoka","doi":"10.1111/psyg.13186","DOIUrl":"10.1111/psyg.13186","url":null,"abstract":"<p><strong>Background: </strong>Persons with dementia in nursing homes often experience cognitive decline (e.g., memory and visuospatial/construction problems), behavioural and psychological symptoms of dementia (BPSD), and impaired activities of daily living. Therefore, comprehensive interventions for this population are needed. We assessed whether a multimodal non-pharmacological intervention improved cognitive functions, BPSD, and activities of daily living in persons with dementia in nursing homes.</p><p><strong>Methods: </strong>This was a multicentre randomised controlled trial. Participants were 40 persons with dementia (38 women) living in four nursing homes (intervention group = 21; control group = 19). The intervention was conducted for 8 weeks, followed by an 8-week follow-up. Outcome measures were scores on the Japanese version of the Neurobehavioral Cognitive Status Examination Five and the ABC Dementia Scale. In the analysis, parameters were estimated using Bayesian statistics and a mixed-effects linear regression model for the change in each outcome measure.</p><p><strong>Results: </strong>There were significant between-group differences in changes in ABC Dementia Scale BPSD scores (8-week: posteriori median = 1.66, 95% Bayesian confidence interval 0.36-3.01; 16-week: median = 2.37, 95% Bayesian confidence interval 0.05-4.65). There was also a significant between-group difference in changes in Neurobehavioral Cognitive Status Examination Five constructional ability scores (16-week: median = 0.93, 95% Bayesian confidence interval 0.35-1.50).</p><p><strong>Conclusion: </strong>This intervention may have a maintenance and improvement effect on BPSD in persons with dementia in nursing homes, and a sustained effect on constructional ability post-intervention. The intervention may be useful and easy to apply in practice.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1255-1266"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and associated characteristics in caregivers of Parkinson's disease patients.","authors":"Ali Inaltekin, Idris Kocatürk","doi":"10.1111/psyg.13191","DOIUrl":"10.1111/psyg.13191","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) increases patient load and requirements of care. Determining the burden on PD patients' caregivers and associated factors may help to identify methods to reduce caregiver burden. This study investigated the factors associated with caregiver burden among PD patients caregivers.</p><p><strong>Methods: </strong>Eighty-five PD patients and 85 caregivers were included in the study. Zarit Burden Interview (ZBI) was used to measure caregiver burden; the Ways of Coping Scale (WCS) was used for coping; Modified Hoehn-Yahr Staging (MHYS) was used for staging patients. The International Parkinson and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts 1 and 3 were used to evaluate non-motor and motor problems. Caregivers' depression and anxiety levels were evaluated with the Beck Depression Inventory and Beck Anxiety Inventory (BAI). Spearmen correlation coefficient was used to evaluate the relationship of variables with the ZBI score, and multiple linear regression analysis was used to determine the predictors of the ZBI score.</p><p><strong>Results: </strong>A positive significant relationship was found between the ZBI score and BAI score, MHYS score, WCS total score, and subscales: keeping to self, seeking refuge in fate, and seeking refuge in supernatural forces. MHYS score, WCS total score, BAI score, and MDS-UPDRS-1 were predictors of the ZBI score.</p><p><strong>Conclusions: </strong>The anxiety levels of caregivers, their ways of coping, and the patient's stage of the disease are important in caregiver burden. Coping ways can be changed to reduce the care burden. Developing psychological interventions for caregivers to change their coping styles can be important.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1297-1304"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing patterns for older-age bipolar disorder patients discharged from two public mental hospitals in Taiwan, 2006-2019.","authors":"Ching-Hua Lin, Ching-Chi Hsu, Hung-Yu Chan, Jiahn-Jyh Chen","doi":"10.1111/psyg.13197","DOIUrl":"10.1111/psyg.13197","url":null,"abstract":"<p><strong>Background: </strong>Older-age bipolar disorder (OABD) is commonly defined as bipolar disorder in individuals aged 60 or more. There have been no studies to examine temporal trends in the pharmacological treatment of OABD. We aimed to investigate prescription changes among OABD patients discharged from two public mental hospitals in Taiwan from 2006 to 2019.</p><p><strong>Methods: </strong>OABD patients discharged from the two study hospitals, from 1 January 2006 to 31 December 2019 (n = 1072), entered the analysis. Prescribed drugs at discharge, including mood stabilisers (i.e., lithium, valproate, carbamazepine, and lamotrigine), antipsychotics (i.e., second- and first-generation antipsychotics (SGAs and FGAs)), and antidepressants, were investigated. Complex polypharmacy was defined as the use of three or more agents among the prescribed drugs. Temporal trends of each prescribing pattern were analyzed using the Cochran-Armitage Trend test.</p><p><strong>Results: </strong>The most commonly prescribed drugs were SGAs (72.0%), followed by valproate (48.4%) and antidepressants (21.7%). The prescription rates of SGAs, antidepressants, antidepressants without mood stabilisers, and complex polypharmacy significantly increased over time, whereas the prescription rates of mood stabilisers, lithium, FGAs, and antidepressants plus mood stabilisers significantly decreased.</p><p><strong>Conclusions: </strong>Prescribing patterns changed remarkably for OABD patients over a 14-year period. The decreased use of lithium and increased use of antidepressants did not reflect bipolar treatment guidelines. Future research should examine whether such prescribing patterns are associated with adverse clinical outcomes.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1324-1334"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of the COVID-19 pandemic on the activities of Initial-phase Intensive Support Team for Dementia in Kobe City.","authors":"Kyoko Ibi, Mami Kubota, Yoko Matsuzaki, Noriko Hasegawa","doi":"10.1111/psyg.13179","DOIUrl":"10.1111/psyg.13179","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to review the activities of the Kobe City Initial-phase Intensive Support Team for Dementia pre- and during the coronavirus disease 2019 (COVID-19) pandemic, to compare the characteristics of the target population and the performance of the team's activities, and determine the impact of the pandemic on the team's project.</p><p><strong>Methods: </strong>The summary data obtained at the time of consultation, team activities, and participants' characteristics were extracted from 662 participants who started to receive support between April 2018 and March 2022. Statistical analysis was performed by dividing the participants into the following two groups: pre- and during COVID-19 pandemic groups.</p><p><strong>Results: </strong>There was no significant difference in the number of new cases or cases that led to a dementia diagnosis between the pre- and during COVID-19 pandemic groups. However, there were significant differences in the number of home visits and rate of introduction of medical care between the two groups. In our study population, the number of participants with financial management difficulties and delusions increased and the number of participants who refused visitations slightly decreased.</p><p><strong>Conclusion: </strong>The Kobe City Initial-phase Intensive Support Team was able to continue its activities during the pandemic partly because the team is an independent, dedicated team. During the pandemic, there was an increase in the number of participants who were isolated because they were deprived of opportunities to interact with others, and who developed delusions and other psychiatric symptoms. Despite this situation, the professional team responded quickly through individual assessment of the individual needs by continuous outreach, taking into account the infection situation, and thus this outreach team functioned well even under the COVID-19 pandemic.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1207-1216"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life review for older adults: an integrative review.","authors":"Vincent Jiang, Alexandra Galin, Xanthe Lea","doi":"10.1111/psyg.13194","DOIUrl":"10.1111/psyg.13194","url":null,"abstract":"<p><p>Life review therapy is a form of psychotherapy framework which involves the guided reflection of life events throughout a patient's life journey. Patients are encouraged to actively recall and analyze important life events, both negative and positive. Through this process, patients may be able to come to terms with, or even resolve negative events such as conflicts and regrets. The aim of this study is to gain an understanding of the current knowledge of the use of life review therapy in older adults, and to identify areas for future research. A systematic literature search was conducted across CINAHL, Medline, PsycInfo, Embase and Scopus. Papers were screened and selected using predetermined inclusion and exclusion criteria using Covidence and exported into Excel. Data analysis was conducted to synthesise thematic analyses. One hundred and thirty-one articles from 1974 to 2023 were included in this study and were used to develop four themes: life satisfaction and self-esteem, depression and depressive symptoms, institutional care and cognitive decline, and post-traumatic stress disorder (PTSD) and trauma. Life review has some benefit in older adults in certain groups and situations, although the extent and duration of effectiveness of this benefit is unclear. Life review unlikely improves self-esteem. However, in the short term, life review appears to improve life satisfaction, depression or depressive symptoms, and PTSD symptoms in the elderly. Life review may be a useful therapeutic tool for older adults with cognitive decline for as long as the intervention continues. Areas for future research are explored.</p>","PeriodicalId":74597,"journal":{"name":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society","volume":" ","pages":"1402-1417"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}