Psychedelic medicine (New Rochelle, N.Y.)最新文献

{"title":"Efficacy and Safety of Psychoactive Tryptamines in Addiction: A Systematic Review.","authors":"Pim B van der Meer, Nout Schukking, Maarten Dik, Aumer van Reemst, Juan J Fuentes, Ad A Kaptein, Jan W Schoones, Sebastiaan Verboeket, Marleen M de Waal, Anneke E Goudriaan, Cornelis Kramers, Arnt Schellekens, Matthijs G Bossong, Metten Somers, Albert Batalla","doi":"10.1177/28314425251364182","DOIUrl":"10.1177/28314425251364182","url":null,"abstract":"<p><strong>Background: </strong>Psychedelics such as lysergic acid diethylamide (LSD) and psilocybin have shown a beneficial effect on substance use disorder (SUD) symptoms. In this systematic review, we aimed to assess the efficacy and safety of psychoactive tryptamines in patients with an SUD or non-substance-related disorder (i.e., gambling disorder) in order to provide a comprehensive overview of the available evidence and identify potential research gaps.</p><p><strong>Methods: </strong>A systematic literature search was performed in eight different databases up to February 2024. Clinical trials were included that assessed the efficacy and safety of psychoactive tryptamines other than psilocybin and ibogaine. A quality assessment of the included trials was done based on the revised Cochrane risk-of-bias tools.</p><p><strong>Results: </strong>A total of four clinical trials (three randomized controlled trials and one single-arm clinical trial; <i>n</i> = 176 patients) were included, all in patients with alcohol use disorder. Dipropyltryptamine and diethyltryptamine were the two investigated psychoactive tryptamines. Abstinence ranged from 10% (duration of follow-up unknown) to 38% at 26 weeks of follow-up, and severity of alcohol use did not differ between the psychoactive tryptamine group and the control groups. Adverse effects were not well reported in the trials.</p><p><strong>Conclusion: </strong>Studies assessing the efficacy of psychoactive tryptamines other than psilocybin and ibogaine in addiction are scarce and show limited evidence for effectiveness in the treatment of addictive disorders.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"4 1","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelics, Eleusis, and the Invention of Religious Experience.","authors":"Sharday Mosurinjohn, Richard Ascough","doi":"10.1177/28314425251361835","DOIUrl":"10.1177/28314425251361835","url":null,"abstract":"<p><strong>Introduction: </strong>This article corrects an idea in psychedelic science and culture that the ancient Eleusynian Mysteries used psychedelics, as claimed by Carl Ruck and co-authors in <i>The Road to Eleusis: Unveiling the Secret of the Mysteries</i> (1978), revitalized by Brian Muraresku's <i>The Immortality Key: The Secret History of the Religion with No Name</i> (2020), and popularized by social media heavyweights such as Joe Rogan.</p><p><strong>Methods: </strong>It begins by exposing critical methodological flaws in the arguments, namely, a pattern of presenting claims, followed by mild circumstantial evidence, rhetorically solidifying the interpretation of this evidence into a \"fact,\" on which is built each subsequent round of conjecture.</p><p><strong>Analysis: </strong>We then explore how the dogged pursuit of evidentiary mirages contributes to the project of establishing a western civilizational pedigree to dignify the use of stigmatized drugs and revitalize experiential religion.</p><p><strong>Discussion: </strong>Although the desire for legitimacy and meaning is understandable, the strategies used by the writers of this pseudo-history constitute a kind of religious fundamentalism. Their writing attempts to show that a relatively new practice is the old, true religion, in this case, the \"religion with no name\" that underlies every religious tradition. In doing so, they miss seriously relating to the many well-documented historical and living Indigenous histories of psychedelics, or seeing contemporary psychedelic practice in continuity with other, and maybe even older, nonpharmacological methods of changing consciousness. Overall, the \"psychedelic Eleusis\" discourse focuses on the purported Eleusynian drug and its phenomenology rather than focusing on practices for taking up the spiritual injunctions of those psychedelic experiences.</p><p><strong>Conclusions: </strong>We conclude that, given how the psychedelic hypothesis is fundamentally flawed in its study of antiquity, it is a shaky foundation on which to build an argument for modern psychedelic use for therapeutic and spiritual practice. Since scholarly research is key to moving forward decriminalization, legalization, medical regulation, and other roles for psychedelics in society, it is crucial that scholars and popular audiences communicate effectively around psychedelic history and culture. Instead of committing to a specific (and erroneous) view of history, psychedelic scholarship must commit to academic discussion and debate.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"4 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Past-Year Lysergic Acid Diethylamide Use in United States Sexual Minorities from 2015 to 2019.","authors":"Brian S Barnett, Akhil Anand, Tatiana Falcone, Murat Altinay, Elizabeth N Dewey, Jeremy Weleff","doi":"10.1177/28314425251410086","DOIUrl":"https://doi.org/10.1177/28314425251410086","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to characterize changes in estimated past-year lysergic acid diethylamide (LSD) use among sexual minorities in the United States using nationally representative data and to compare correlates of LSD use between lesbian, gay, and bisexual individuals (LGB) and heterosexual individuals.</p><p><strong>Method: </strong>Using National Survey on Drug Use and Health data on adults from 2015 to 2019, we investigated correlates of past-year LSD use among LGB individuals compared with heterosexual individuals and changes in the prevalence of past-year LSD use during that period. Correlates were identified with weighted logistic regression.</p><p><strong>Results: </strong>LGB individuals constituted approximately 5% of the sample. From 2015 to 2019 estimated prevalence of past-year LSD use rose 43% in heterosexual individuals, 58% in bisexual individuals, and 106% in lesbian/gay individuals. The relative risk for LSD use ranged from 3.3 to 4.4 times higher for LGB individuals compared with heterosexual individuals during the study period, depending on the year. Interaction analysis found that living in poverty, being divorced versus married, living in a small metropolitan area versus a non-metropolitan area, and past-year suicide attempt were unique correlates of past-year LSD use for heterosexual individuals compared with LGB individuals.</p><p><strong>Conclusions: </strong>Sexual minorities are at increased risk of past-year LSD use compared with heterosexual individuals. There were notable increases in past-year LSD use from 2015 to 2019 among heterosexual, bisexual, and lesbian/gay individuals, with a marked increase in the latter group. These findings highlight the possible need for targeted LSD harm reduction strategies based on sexual identity and more inclusive research on psychedelic use.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":" ","pages":"28314425251410086"},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Griffiths et al.'s Study of Psilocybin with Religious Professionals: A Theological Response from a Christian Perspective.","authors":"Joseph Lorenz, Scott Hawkins, Bryan McCarthy","doi":"10.1177/28314425251406251","DOIUrl":"https://doi.org/10.1177/28314425251406251","url":null,"abstract":"<p><p>Griffiths et al.'s recent \"Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions\" is an important study in the literature on psychedelic medicine and religious experience. In this commentary on the study, we argue: (1) The study design's implicit presupposition of perennialism in its conception of mysticism burdens it with metaphysical and theological freight it doesn't need to support its hypothesis; and (2) Psychedelic usage in pursuit of mysticism, however construed, risks two pathologies-hyper-individualism and idolatry-that religious traditions and communities are well-positioned to counter.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"202-206"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Science and Religion Are Incompatible-Or Are They?","authors":"Elaine Pagels","doi":"10.1177/28314425251409218","DOIUrl":"https://doi.org/10.1177/28314425251409218","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"213-214"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions, by Griffiths et al.","authors":"Harriet de Wit","doi":"10.1177/28314425251409219","DOIUrl":"https://doi.org/10.1177/28314425251409219","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"211-212"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Publisher's Note re:</i> \"Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions\" (doi: 10.1089/psymed.2023.0044).","authors":"","doi":"10.1089/psymed.2025.68798.pn","DOIUrl":"https://doi.org/10.1089/psymed.2025.68798.pn","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"171"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin, Spirituality, and the Potential for Personal Transformation: Commentary on Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions by Griffiths et al.","authors":"Kenneth I Pargament","doi":"10.1177/28314425251406613","DOIUrl":"https://doi.org/10.1177/28314425251406613","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"207-208"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions: The Great Promise of Psychedelics: Evolving Human Consciousness.","authors":"Tara Brach","doi":"10.1177/28314425251408081","DOIUrl":"https://doi.org/10.1177/28314425251408081","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"209-210"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Insights from a Study of Psilocybin with Clergy to Advance Research on Psychedelics, Spirituality, and the Sacred: Commentary on Griffiths et al. (2025).","authors":"Roman Palitsky, George H Grant","doi":"10.1177/28314425251393983","DOIUrl":"https://doi.org/10.1177/28314425251393983","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"3 4","pages":"192-199"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}