Progress in biomedical engineering (Bristol, England)最新文献

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Translational prospects of untethered medical microrobots 无约束医疗微型机器人的转化前景

Progress in biomedical engineering (Bristol, England) Pub Date : 2019-07-16 DOI: 10.1088/2516-1091/ab22d5

H. Ceylan, I. Yasa, Ugur Kilic, Wenqi Hu, M. Sitti

{"title":"Translational prospects of untethered medical microrobots","authors":"H. Ceylan, I. Yasa, Ugur Kilic, Wenqi Hu, M. Sitti","doi":"10.1088/2516-1091/ab22d5","DOIUrl":"https://doi.org/10.1088/2516-1091/ab22d5","url":null,"abstract":"Untethered mobile microrobots have the potential to transform medicine radically. Their small size and wireless mobility can enable access to and navigation in confined, small, hard-to-reach, and sensitive inner body sites, where they can provide new ways of minimally invasive interventions and targeted diagnosis and therapy down to the cellular length scales with high precision and repeatability. The exponential recent progress of the field at the preclinical level raises anticipations for their near-future clinical prospects. To pave the way for this transformation to happen, however, the formerly proposed microrobotic system designs need a comprehensive review by including essential aspects that a microrobot needs to function properly and safely in given in vivo conditions of a targeted medical problem. The present review provides a translational perspective on medical microrobotics research with an application-oriented, integrative design approach. The blueprint of a medical microrobot needs to take account of microrobot shape, material composition, manufacturing technique, permeation of biological barriers, deployment strategy, actuation and control methods, medical imaging modality, and the execution of the prescribed medical tasks altogether at the same time. The incorporation of functional information pertaining each such element to the physical design of the microrobot is highly dependent on the specific clinical application scenario. We discuss the complexity of the challenges ahead and the potential directions to overcome them. We also throw light on the potential regulatory aspects of medical microrobots toward their bench-to-bedside translation. Such a multifaceted undertaking entails multidisciplinary involvement of engineers, materials scientists, biologists and medical doctors, and bringing their focus on specific medical problems where microrobots could make a disruptive or radical impact.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab22d5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44515409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 104

The emergence of 3D bioprinting in organ-on-chip systems 器官芯片系统中3D生物打印的出现

Progress in biomedical engineering (Bristol, England) Pub Date : 2019-07-16 DOI: 10.1088/2516-1091/ab23df

Kirsten Fetah, Peyton J. Tebon, M. Goudie, J. Eichenbaum, Li Ren, N. Barros, Rohollah Nasiri, S. Ahadian, N. Ashammakhi, M. Dokmeci, A. Khademhosseini

{"title":"The emergence of 3D bioprinting in organ-on-chip systems","authors":"Kirsten Fetah, Peyton J. Tebon, M. Goudie, J. Eichenbaum, Li Ren, N. Barros, Rohollah Nasiri, S. Ahadian, N. Ashammakhi, M. Dokmeci, A. Khademhosseini","doi":"10.1088/2516-1091/ab23df","DOIUrl":"https://doi.org/10.1088/2516-1091/ab23df","url":null,"abstract":"Understanding complex cell–cell interactions and physiological microenvironments is critical for the development of new therapies for treating human diseases. Current animal models fail to accurately predict success of therapeutic compounds and clinical treatments. Advances in biomaterials, engineering, and additive manufacturing have led to the development of printed tissues, lab-on-chip devices, and, more recently, organ-on-chip systems. These technologies have promising applications for the fabrication of more physiologically representative human tissues and can be used for high-throughput testing of human cells and organoids. These organ-on-chip systems can be fabricated with integrated fluidics to allow for the precise control and manipulation of cellular microenvironments with multiple cell types. Further control over these cellular environments can be achieved with bioprinting, allowing for three-dimensional (3D) printing of multiple materials and cell types to provide precisely controlled structures manufactured in a one-step process. As cell behavior is highly dependent on the physical and chemical properties of the environment, the behavior of cells in two-dimensional and 3D culture systems varies drastically. Providing devices that can support long-term cell culture and controlled stimulation of 3D culture systems will have a profound impact on the study of physiological processes and disease, as well as the development of new therapies. This review highlights recent advances in organ-on-chip systems and 3D bioprinting techniques for the development of in vitro physiological models.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab23df","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41283312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57

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