Progress in biomedical engineering (Bristol, England)最新文献

{"title":"Closing the loop between wearable technology and human biology: a new paradigm for steering neuromuscular form and function","authors":"Massimo Sartori, G. Sawicki","doi":"10.1088/2516-1091/abe3e0","DOIUrl":"https://doi.org/10.1088/2516-1091/abe3e0","url":null,"abstract":"Wearable technologies such as bionic limbs, robotic exoskeletons and neuromodulation devices have long been designed with the goal of enhancing human movement. However, current technologies have shown only modest results in healthy individuals and limited clinical impact. A central element hampering progress is that wearable technologies do not interact directly with tissues in the composite neuromuscular system. That is, current wearable systems do not take into account how biological targets (e.g. joints, tendons, muscles, nerves) react to mechanical or electrical stimuli, especially at extreme ends of the spatiotemporal scale (e.g. cell growth over months or years). Here, we outline a framework for ‘closing-the-loop’ between wearable technology and human biology. We envision a new class of wearable systems that will be classified as ‘steering devices’ rather than ‘assistive devices’ and outline the suggested research roadmap for the next 10–15 years. Wearable systems that steer, rather than assist, should be capable of delivering coordinated electro-mechanical stimuli to alter, in a controlled way, neuromuscular tissue form and function over time scales ranging from seconds (e.g. a movement cycle) to months (e.g. recovery stage following neuromuscular injuries) and beyond (e.g. across ageing stages). With an emphasis on spinal cord electrical stimulation and exosuits for the lower extremity, we explore developments in three key directions: (a) recording neuromuscular cellular activity from the intact moving human in vivo, (b) predicting tissue function and adaptation in response to electro-mechanical stimuli over time and (c) controlling tissue form and function with enough certainty to induce targeted, positive changes in the future. We discuss how this framework could restore, maintain or augment human movement and set the course for a new era in the development of bioprotective wearable devices. That is, devices designed to directly respond to biological cues to maintain integrity of underlying physiological systems over the lifespan.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42500324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering bone from fat: a review of the in vivo mechanisms of adipose derived stem cell-mediated bone regeneration","authors":"Allison L Horenberg, Alexandra N. Rindone, W. Grayson","doi":"10.1088/2516-1091/ac1522","DOIUrl":"https://doi.org/10.1088/2516-1091/ac1522","url":null,"abstract":"Adipose-derived stromal/stem cells (ASCs) have considerable potential to promote bone regeneration due to their ease of isolation, abundance, and osteogenic capacity. However, despite two decades of research, studies of the precise mechanisms underlying their in vivo osteo-regenerative capacity remain contradictory. Specifically, there are multiple reports that suggest either a direct mechanism (i.e. ASCs directly differentiate into osteoblasts and lay done new bone matrix) or an indirect mechanism (i.e. ASCs stimulate endogenous cells via their secretory profiles) of bone regeneration. To address this discrepancy we critically reviewed studies utilizing ASCs for in vivo bone regeneration and employed methods to track cell fate. We evaluated the rigor of individual studies by examining the specific defect and animal models employed, cell sorting or pretreatment methods, and quantitative assessments of cell dosing and cell survival/distribution data to determine the strength of their claims. There is robust evidence to support both a direct differentiation of ASCs and indirect signaling based on secreted factors: osteogenic/angiogenic, immunomodulatory, or extracellular matrix factors, suggesting that a combination of factors underlie the pro-regenerative capacity of ASCs. However, there remains significant knowledge gaps regarding the precise efficiency of ASC engraftment following transplantation, the types of spatiotemporal interactions that occur between ASCs and host cells during the different stages of healing, and the contributions of osteoclasts, nerves, and immune cells to ASC-mediated regeneration. Emerging technologies will enable further elucidation of the specific mechanisms of action of ASCs in bone regeneration.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61183255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unifying system identification and biomechanical formulations for the estimation of muscle, tendon and joint stiffness during human movement","authors":"Christopher P. Cop, G. Cavallo, R. C. van 't Veld, Bart FJM Koopman, J. Lataire, A. Schouten, Massimo Sartori","doi":"10.1088/2516-1091/ac12c4","DOIUrl":"https://doi.org/10.1088/2516-1091/ac12c4","url":null,"abstract":"In vivo joint stiffness estimation during time-varying conditions remains an open challenge. Multiple communities, e.g. system identification and biomechanics, have tackled the problem from different perspectives and using different methods, each of which entailing advantages and limitations, often complementary. System identification formulations provide data-driven estimates of stiffness at the joint level, while biomechanics often relies on musculoskeletal models to estimate stiffness at multiple levels, i.e. joint, muscle, and tendon. Collaboration across these two scientific communities seems to be a logical step toward a reliable multi-level understanding of joint stiffness. However, differences at the theoretical, computational, and experimental levels have limited inter-community interaction. In this article we present a roadmap to achieve a unified framework for the estimation of time-varying stiffness in the composite human neuromusculoskeletal system during movement. We present our perspective on future developments to obtain data-driven system identification and musculoskeletal models that are compatible at the theoretical, computational, and experimental levels. Moreover, we propose a novel combined closed-loop paradigm, in which reference estimates of joint stiffness via system identification are decomposed into underlying muscle and tendon contribution via high-density-electromyography-driven musculoskeletal modeling. We highlight the need for aligning experimental requirements to be able to compare both joint stiffness formulations. Unifying both biomechanics’ and system identification’s formulations is a necessary step for truly generalizing stiffness estimation across individuals, movement conditions, training and impairment levels. From an application point of view, this is central for enabling patient-specific neurorehabilitation therapies, as well as biomimetic control of assistive robotic technologies. The roadmap we propose could serve as an inspiration for future collaborations across broadly different scientific communities to truly understand joint stiffness bio- and neuromechanics. Video Abstract: Unifying system identification and biomechanical formulations for the estimation of muscle, tendon and joint stiffness during human movement","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61182816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current and emerging techniques for oral cancer screening and diagnosis: a review","authors":"S. Bisht, P. Mishra, D. Yadav, R. Rawal, Karla P. Mercado-Shekhar","doi":"10.1088/2516-1091/ac1f6c","DOIUrl":"https://doi.org/10.1088/2516-1091/ac1f6c","url":null,"abstract":"Oral cancer causes over 350 000 deaths annually worldwide. Although most cases are in Asia, the incidence of oral cancer is rising across the world. Despite recent advances in screening methods, oral cancer remains a significant cause of mortality and morbidity. The 5-year survival rate (50%–60%) has not improved over the past several decades. Early detection and accurate diagnosis of the disease can improve the survival rate and patients’ quality of life. This article provides a topical review of current and emerging techniques for screening and diagnosing oral cancer. Currently available technologies have only been moderately useful towards identifying oral cancer early, motivating the development of novel approaches to address this goal. In this article, we provide an overview of adjunctive screening aids, including biofluid (saliva and serum) diagnostics, vital staining, brush biopsy, chemiluminescence, and tissue autofluorescence. Furthermore, we discuss diagnostic imaging modalities, such as computed tomography, magnetic resonance imaging, positron emission tomography, ultrasound (including traditional B-mode imaging, color Doppler, and elastography), photoacoustics imaging, and optical coherence tomography, and artificial intelligence-based methods, which are either being used clinically or are under development for oral cancer staging. The physical and biological basis underpinning each technique are discussed, along with their advantages and limitations in the technological and clinical context. The review concludes with a discussion of the future perspectives in this rapidly evolving field.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61183410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and challenges in biomarker enrichment for cancer early detection","authors":"P. D. Sinawang, Fernando Soto, M. Ozen, D. Akin, U. Demirci","doi":"10.1088/2516-1091/ac1ea3","DOIUrl":"https://doi.org/10.1088/2516-1091/ac1ea3","url":null,"abstract":"Cancer cells generate and secrete diverse molecules into circulation that could be used as signatures for health and disease. A significant obstacle in detecting such molecules derives from their low signal-to-noise ratio in subsequent downstream analyses. Developing reliable tools and methods for cancer early detection is crucial for advancing global strategies to decrease mortality, monitor disease progression and therapy, and improve the quality of life of patients. This perspective critically addresses recent developments in cancer early detection, highlighting current trends in the enrichment of cancer-related biomarkers, dividing them into biochemical and biophysical methods. Finally, we provide insights into the challenges and opportunities in biomarker isolation and enrichment protocols. Integrating these methods into clinical decision-making pipelines could lead to a better understanding of cancer progression, treatment efficacy, and hence improving the medical outcomes for cancer patients.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61183210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-ray to MR: the progress of flexible instruments for endovascular navigation","authors":"Mohamed E. M. K. Abdelaziz, Libaihe Tian, M. Hamady, Guang-Zhong Yang, B. Temelkuran","doi":"10.1088/2516-1091/ac12d6","DOIUrl":"https://doi.org/10.1088/2516-1091/ac12d6","url":null,"abstract":"Interventional radiology and cardiology are rapidly growing areas of minimally invasive surgery, covering multiple diagnostic and interventional procedures. Treatment via endovascular techniques has become the go-to approach, thanks to its minimally invasive nature and its effectiveness in reducing hospitalisation and total time to recovery when compared to open surgery. Although x-ray fluoroscopy is currently the gold standard imaging technique for endovascular interventions, it presents occupational safety hazards to medical personnel and potential risks to patients, especially paediatric patients, because of its inherent ionising radiation. Magnetic resonance imaging (MRI), with its unique ability to provide radiation-free imaging, and acquiring morphologic and functional information, holds great promise in the advancement of image-guided navigation through the vasculature. Moreover, MRI has the potential to combine diagnosis, therapy and early evaluation of therapy in the same intervention. However, MR-guided interventions face a major challenge due to the presence of a large magnetic field (1.5/3 Tesla), which limits the set of materials suitable for the construction of key instrumentation (sheaths, catheters and guidewires). Despite these challenges, in recent years, significant progress has been made in the development of interventional devices, which comprise biocompatible, MR safe and MR visible materials. In an attempt to encourage and accelerate the development of MR-guided endovascular instrumentation, we present a systematic and illustrated overview of the plethora of work targeting to overcome the aforementioned limitations which are underpinned by the interdependent advancements in science, technology, engineering, mathematics and medicine (STEMM).","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61182501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestible devices for long-term gastrointestinal residency: a review","authors":"M. M. Mau, Sunandita Sarker, B. Terry","doi":"10.1088/2516-1091/ac1731","DOIUrl":"https://doi.org/10.1088/2516-1091/ac1731","url":null,"abstract":"Ingestible devices have been gaining attention from the medical community due to their noninvasive use in diagnostics and treatment of the gastrointestinal (GI) tract. However, their passive locomotion limits their GI residency period. Ingestible sensors residing in the GI tract are capable of providing continuous data, while long-acting ingestible drug delivery systems can reduce medication nonadherence. This paper presents a comprehensive overview of the state-of-the-art, long-term ingestible devices (LTIDs). Additionally, this review summarizes the current status of ingestible devices that persist in the GI tract for a prolonged period, as well as their inhabitance mechanisms and applications. Also included are relevant information about the GI structure and design considerations for understanding the significance and challenges associated with LTIDs. Finally, we discuss several potential applications of the LTIDs for therapeutic intervention in the GI tract and monitoring the physiology and pathophysiology of the GI tract for an extended period.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61182958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is in vivo sensing in a total hip replacement a possibility? A review on past systems and future challenges","authors":"O. Vickers, P. Culmer, G. Isaac, R. Kay, M. P. Shuttleworth, T. Board, S. Williams","doi":"10.1088/2516-1091/ac1b7f","DOIUrl":"https://doi.org/10.1088/2516-1091/ac1b7f","url":null,"abstract":"Surgery to implant a total hip replacement (THR) is very successful in reducing pain and restoring function. This procedure has become more prevalent, and projections estimate further increases in demand. However, complications can arise, and current diagnostic techniques often fail to expose underlying issues before they result in a catastrophic failure that requires revision surgery. An instrumented implant, with embedded sensors capable of real time condition monitoring, would be an attractive proposition to incorporate within a THR. Continued advances in the performance and miniaturisation of electronic components, embedded systems, sensing and wireless communications have given the tools and resources medical device manufacturers need to innovate in the field of implantable medical devices. Smart implants are already being widely used in healthcare including pacemakers, cochlear implants, glucose monitors and insulin pumps however, a widely used smart THR has not yet been realised. Since the implantation of the first instrumented hip implant in the 1960s there have been several in vitro studies monitoring levels of implant loosening. Additionally, significant research has been conducted using instrumented THRs to perform in vivo measurement of biomechanical metrics, including force and moments. To date less than 100 patients have successfully received an instrumented implant. The results of these studies have aided researchers, designers and surgeons in wider research projects, however, the motivation behind the work was to provide discrete biomechanical data sets and not provide real-time condition monitoring of an implants performance or highlight early indications for revision surgery. If in vivo sensing within a THR is to be achieved and adopted in regular clinical practice then the following challenges need to be addressed: choice of the sensing method, biocompatibility and integration within the implant, power supply, communication, and regulatory considerations.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61183123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning in medical image registration","authors":"Xiang Chen, A. Diaz-Pinto, N. Ravikumar, Alejandro F Frangi","doi":"10.1088/2516-1091/abd37c","DOIUrl":"https://doi.org/10.1088/2516-1091/abd37c","url":null,"abstract":"Image registration is a fundamental task in multiple medical image analysis applications. With the advent of deep learning, there have been significant advances in algorithmic performance for various computer vision tasks in recent years, including medical image registration. The last couple of years have seen a dramatic increase in the development of deep learning-based medical image registration algorithms. Consequently, a comprehensive review of the current state-of-the-art algorithms in the field is timely, and necessary. This review is aimed at understanding the clinical applications and challenges that drove this innovation, analysing the functionality and limitations of existing approaches, and at providing insights to open challenges and as yet unmet clinical needs that could shape future research directions. To this end, the main contributions of this paper are: (a) discussion of all deep learning-based medical image registration papers published since 2013 with significant methodological and/or functional contributions to the field; (b) analysis of the development and evolution of deep learning-based image registration methods, summarising the current trends and challenges in the domain; and (c) overview of unmet clinical needs and potential directions for future research in deep learning-based medical image registration.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46426844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel biomaterials to support and guide vascularization","authors":"R. Chapla, J. West","doi":"10.1088/2516-1091/abc947","DOIUrl":"https://doi.org/10.1088/2516-1091/abc947","url":null,"abstract":"Biomaterials can be intentionally designed to support and even guide vascularization for applications ranging from engineered organs to treatment of ischemic diseases like myocardial infarction and stroke. In order to appropriately design bioactive biomaterials for vascularization, it is important to understand the cellular and molecular events involved in angiogenesis and vasculogenesis. Cell-matrix and signaling biomolecule interactions that initiate and promote formation of vasculature in vivo can often be mimicked in biomaterial platforms. Hydrogels are frequently used in these applications because they are soft and hydrated with mechanical properties similar to soft tissues and because many synthetic hydrogels are essentially bioinert, allowing one to engineer in specific cell-material interactions. A variety of both naturally-derived and synthetic hydrogel bases are used for supporting vascularization, and these gels are tailored to possess mechanical properties, biodegradation, cell adhesive interactions, biochemical signaling, and/or architectural properties that can promote assembly and tubulogenesis by vascular cells. This article serves to review current hydrogel materials and the innovative design modifications implemented to guide and support the vascularization process.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45706070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}