Progress in biomedical engineering (Bristol, England)最新文献

{"title":"A comprehensive review of computational diagnostic techniques for lymphedema.","authors":"Jayasree K R, Vijaykumar D K, Vijayan Sugumaran, Rahul Krishnan Pathinarupothi","doi":"10.1088/2516-1091/ada85a","DOIUrl":"https://doi.org/10.1088/2516-1091/ada85a","url":null,"abstract":"<p><p>Lymphedema is localized swelling due to lymphatic system dysfunction, often affecting arms and legs due to fluid accumulation. It occurs in 20% to 94% of patients within 2 to 5 years after breast cancer treatment, with around 20% of women developing breast cancer-related lymphedema (BCRL). This condition involves the accumulation of protein-rich fluid in interstitial spaces, leading to symptoms like swelling, pain, and reduced mobility that significantly impact quality of life. The early diagnosis of lymphedema helps mitigate the risk of deterioration and prevent its progression to more severe stages. Healthcare providers can reduce risks through exercise prescriptions and self-manual lymphatic drainage techniques. Lymphedema diagnosis currently relies on physical examinations and limb volume measurements, but challenges arise from a lack of standardized criteria and difficulties in detecting early stages. Recent advancements in computational imaging and decision support systems have improved diagnostic accuracy through enhanced image reconstruction and real-time data analysis. The aim of this comprehensive review is to provide an in-depth overview of the research landscape in computational diagnostic techniques for lymphedema. The computational techniques primarily include imaging-based, electrical, and machine learning approaches, which utilize advanced algorithms and data analysis. These modalities were compared based on various parameters to choose the most suitable techniques for their applications. Lymphedema detection faces challenges like subtle symptoms and inconsistent diagnostics. The research identifies Bioimpedance Spectroscopy (BIS), Kinect sensor and Machine Learning integration as the promising modalities for early lymphedema detection. BIS can effectively identify lymphedema as early as four months post-surgery with sensitivity of 44.1% and specificity of 95.4% in diagnosing lymphedema whereas in Machine learning, Artificial Neural Network (ANN) achieved an impressive average cross-validation accuracy of 93.75%, with sensitivity at 95.65% and specificity at 91.03%. Machine learning and imaging can be integrated into clinical practice to enhance diagnostic accuracy and accessibility.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human motor performance assessment with lower limb exoskeletons as a potential strategy to support healthy aging-a perspective article.","authors":"Tobias Moeller, Melina Beyerlein, Michael Herzog, Bettina Barisch-Fritz, Charlotte Marquardt, Miha Dežman, Katja Mombaur, Tamim Asfour, Alexander Woll, Thorsten Stein, Janina Krell-Roesch","doi":"10.1088/2516-1091/ada333","DOIUrl":"https://doi.org/10.1088/2516-1091/ada333","url":null,"abstract":"<p><p>With increasing age, motor performance declines. This decline is associated with less favorable health outcomes such as impaired activities of daily living, reduced quality of life, or increased mortality. Through regular assessment of motor performance, changes over time can be monitored, and targeted therapeutic programs and interventions may be informed. This can ensure better individualization of any intervention approach (e.g. by considering the current motor performance status of a person) and thus potentially increase its effectiveness with regard to maintaining current performance status or delaying further decline. However, in older adults, motor performance assessment is time consuming and requires experienced examiners and specific equipment, amongst others. This is particularly not feasible in care facility/nursing home settings. Wearable robotic devices, such as exoskeletons, have the potential of being used to assess motor performance and provide assistance during physical activities and exercise training for older adults or individuals with mobility impairments, thereby potentially enhancing motor performance. In this manuscript, we aim to (1) provide a brief overview of age-related changes of motor performance, (2) summarize established clinical and laboratory test procedures for the assessment of motor performance, (3) discuss the possibilities of translating established test procedures into exoskeleton-based procedures, and (4) highlight the feasibility, technological requirements and prerequisites for the assessment of human motor performance using lower limb exoskeletons.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of optical and thermal eye tissue parameters for improved computational models in retinal laser therapy.","authors":"G Zanellati, D Allegrini, F Auricchio, M R Romano, A Cattenone, G Alaimo, S Marconi","doi":"10.1088/2516-1091/ad9aec","DOIUrl":"10.1088/2516-1091/ad9aec","url":null,"abstract":"<p><p>Laser surgery is recognized as a highly effective method for managing retinal diseases. However, the thermal effects of the laser on different eye tissues are not entirely understood yet. In this context, computational modeling can be a useful tool to predict therapy outcomes. Accurate optical and thermal parameters of ocular tissues are crucial to correctly modeling the laser-tissue interactions. The present work aims to provide an easily accessible list of optical and thermal parameters for developing computational models involving ocular tissues. An extensive literature review was conducted to gather data on these parameters. The sources of data and the methodology used to calculate these parameters are analyzed in detail to ensure the reliability of the proposed values. In particular, this review focuses on density, specific heat, thermal conductivity, refractive index, and absorption coefficient, with optical properties referring to the 577 nm wavelength. The review underscores a common tendency to rely on pre-existing values when developing new computational models, often lacking clarity regarding selection criteria and data sources. This emphasizes the necessity for new experimental studies to improve the accuracy of ocular tissue properties.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of bioengineered 3D patient derived breast cancer organoid model focusing dynamic fibroblast-stem cell reciprocity.","authors":"Nakka Sharmila Roy, Mamta Kumari, Kamare Alam, Anamitra Bhattacharya, Santanu Kaity, Kulwinder Kaur, Velayutham Ravichandiran, Subhadeep Roy","doi":"10.1088/2516-1091/ad9dcb","DOIUrl":"10.1088/2516-1091/ad9dcb","url":null,"abstract":"<p><p>Three-dimensional (3D) models, such as tumor spheroids and organoids, are increasingly developed by integrating tissue engineering, regenerative medicine, and personalized therapy strategies. These advanced 3D<i>in-vitro</i>models are not merely endpoint-driven but also offer the flexibility to be customized or modulated according to specific disease parameters. Unlike traditional 2D monolayer cultures, which inadequately capture the complexities of solid tumors, 3D co-culture systems provide a more accurate representation of the tumor microenvironment. This includes critical interactions with mesenchymal stem/stromal cells (MSCs) and induced pluripotent stem cells (iPSCs), which significantly modulate cancer cell behavior and therapeutic responses. Most of the findings from the co-culture of Michigan Cancer Foundation-7 breast cancer cells and MSC showed the formation of monolayers. Although changes in the plasticity of MSCs and iPSCs caused by other cells and extracellular matrix (ECM) have been extensively researched, the effect of MSCs on cancer stem cell (CSC) aggressiveness is still controversial and contradictory among different research communities. Some researchers have argued that CSCs proliferate more, while others have proposed that cancer spread occurs through dormancy. This highlights the need for further investigation into how these interactions shape cancer aggressiveness. The objective of this review is to explore changes in cancer cell behavior within a 3D microenvironment enriched with MSCs, iPSCs, and ECM components. By describing various MSC and iPSC-derived 3D breast cancer models that replicate tumor biology, we aim to elucidate potential therapeutic targets for breast cancer. A particular focus of this review is the Transwell system, which facilitates understanding how MSCs and iPSCs affect critical processes such as migration, invasion, and angiogenesis. The gradient formed between the two chambers is based on diffusion, as seen in the human body. Once optimized, this Transwell model can serve as a high-throughput screening platform for evaluating various anticancer agents. In the future, primary cell-based and patient-derived 3D organoid models hold promise for advancing personalized medicine and accelerating drug development processes.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomedical applications of the engineered AIEgen-lipid nanostructure<i>in vitro</i>and<i>in vivo</i>.","authors":"Meng Suo, Tianfu Zhang, Xing-Jie Liang","doi":"10.1088/2516-1091/ad9aeb","DOIUrl":"10.1088/2516-1091/ad9aeb","url":null,"abstract":"<p><p>Since the concept of aggregation-induced emission (AIE) was first coined by Tang and co-workers, AIE-active luminogens (AIEgens) have drawn widespread attention among chemists and biologists due to their unique advantages such as high fluorescence efficiency, large Stokes shift, good photostability, low background noise, and high biological visualization capabilities in the aggregated state, surpassing conventional fluorophores. A growing number of AIEgens have been engineered to possess multifunctional properties, including near-infrared emission, two-photon absorption, reactive oxygen species (ROS) generation and photothermal conversion, making them suitable for deep-tissue imaging and phototherapy. AIEgens show great potential in biomedical applications<i>in vitro</i>and<i>in vivo</i>. However, despite the favorable photophysical stability and ROS/heat generation capability in the aggregated state, limitations including uncontrolled size, low targeting efficiency, and unexpected dispersion in physiological environments have hindered their biomedical applications. The combination of AIEgens with lipids offers a simple, promising, and widely adopted solution to these challenges. This review article provides an overview of the synthesis methods of AIEgen-lipid nanostructures and their applications in the biomedical engineering field, aiming to serve as a guideline for developing these AIEgens-lipid nanostructures with promising biological applications.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell stretching devices integrated with live cell imaging: a powerful approach to study how cells react to mechanical cues.","authors":"Beatrice Bighi, Gregorio Ragazzini, Alessia Gallerani, Andrea Mescola, Chiara Scagliarini, Chiara Zannini, Martina Marcuzzi, Elena Olivi, Claudia Cavallini, Riccardo Tassinari, Michele Bianchi, Lorenzo Corsi, Carlo Ventura, Andrea Alessandrini","doi":"10.1088/2516-1091/ad9699","DOIUrl":"10.1088/2516-1091/ad9699","url":null,"abstract":"<p><p>Mechanical stimuli have multiple effects on cell behavior, affecting a number of cellular processes including orientation, proliferation or apoptosis, migration and invasion, the production of extracellular matrix proteins, the activation and translocation of transcription factors, the expression of different genes such as those involved in inflammation and the reprogramming of cell fate. The recent development of cell stretching devices has paved the way for the study of cell reactions to stretching stimuli<i>in-vitro</i>, reproducing physiological situations that are experienced by cells in many tissues and related to functions such as breathing, heart beating and digestion. In this work, we review the highly-relevant contributions cell stretching devices can provide in the field of mechanobiology. We then provide the details for the in-house construction and operation of these devices, starting from the systems that we already developed and tested. We also review some examples where cell stretchers can supply meaningful insights into mechanobiology topics and we introduce new results from our exploitation of these devices.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical models on bone cell homeostasis and kinetics in the presence of electric fields: a review.","authors":"Poh Soo Lee, Kiran K Sriperumbudur, Jonathan Dawson, Ursula van Rienen, Revathi Appali","doi":"10.1088/2516-1091/ad9530","DOIUrl":"10.1088/2516-1091/ad9530","url":null,"abstract":"<p><p>The role of bioelectricity in regulating various physiological processes has attracted increasing scientific interest in implementing exogenous electrical stimulations as a therapeutic approach. In particular, electrical stimuli are used clinically in pre-/post-surgery patient care for the musculoskeletal tissues. The reported potential of electric fields (EF) to regulate bone cell homeostasis and kinetics<i>in vitro</i>has further provoked more studies in this field of research. Various customised apparatuses have been developed, and a range of parameters for the applied EFs have been investigated<i>in vitro</i>with bone cells or mesenchymal stem cells. Additionally, biomaterials with conductive or piezo-electric properties have been designed to complement the enhancing effects of the EF on bone regeneration. Despite much research, there remained a significant gap in knowledge due to the diverse range of EF parameters available. Mathematical models are built to facilitate further understanding and zero in on an effective range of EF parameters<i>in silico</i>. However, the diverse range of EF parameters, experimental conditions, and reported analytical output of different works of literature were reported to possess significant variance, making it challenging to accurately model the field<i>in silico</i>. This review categorises the existing experimental approaches and the parameters used to distinguish the potential variables that apply to mathematical modelling. Furthermore, we will discuss existing modelling approaches and models available in the literature. With this, we will concisely highlight the need to categorise EF parameters, osteogenic differentiation initiators and research output.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of computational optimization of bone scaffold architecture: methods, challenges, and perspectives.","authors":"Ali H Foroughi, Caleb Valeri, Mir Jalil Razavi","doi":"10.1088/2516-1091/ad879a","DOIUrl":"10.1088/2516-1091/ad879a","url":null,"abstract":"<p><p>The design and optimization of bone scaffolds are critical for the success of bone tissue engineering (BTE) applications. This review paper provides a comprehensive analysis of computational optimization methods for bone scaffold architecture, focusing on the balance between mechanical stability, biological compatibility, and manufacturability. Finite element method (FEM), computational fluid dynamics (CFD), and various optimization algorithms are discussed for their roles in simulating and refining scaffold designs. The integration of multiobjective optimization and topology optimization has been highlighted for developing scaffolds that meet the multifaceted requirements of BTE. Challenges such as the need for consideration of manufacturing constraints and the incorporation of degradation and bone regeneration models into the optimization process have been identified. The review underscores the potential of advanced computational tools and additive manufacturing techniques in evolving the field of BTE, aiming to improve patient outcomes in bone tissue regeneration. The reliability of current optimization methods is examined, with suggestions for incorporating non-deterministic approaches and<i>in vivo</i>validations to enhance the practical application of optimized scaffolds. The review concludes with a call for further research into artificial intelligence-based methods to advance scaffold design and optimization.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of paliperidone nanocrystals for the treatment of schizophrenia.","authors":"Phattalapol Lhaglham, Luksika Jiramonai, Xing-Jie Liang, Bingchuan Liu, Fangzhou Li","doi":"10.1088/2516-1091/ad8fe7","DOIUrl":"10.1088/2516-1091/ad8fe7","url":null,"abstract":"<p><p>Schizophrenia is a complex and chronic psychiatric disorder that significantly impacts patients' quality of life. Ranking 12th among 310 diseases and injuries that result in disability, the number of patients suffering from schizophrenia continues to rise, emphasizing the urgent need for developing effective treatments. Despite the availability of effective antipsychotic drugs, over 80% of patients taking oral antipsychotics experience relapses, primarily caused by non-adherence as the high dosing frequency is required. In this review, we discuss about schizophrenia, its incidence, pathological causes, influencing factors, and the challenges of the current medications. Specifically, we explore nanocrystal technology and its application to paliperidone, making it one of the most successful long-acting antipsychotic drugs introduced to the market. We highlight the clinical advantages of paliperidone nanocrystals, including improved adherence, efficacy, long-term outcomes, patient satisfaction, safety, and cost-effectiveness. Additionally, we address the physicochemical factors influencing the drug's half-life, which crucially contribute to long-acting medications. Further studies on nanocrystal-based long-acting medications are crucial for enhancing their effectiveness and reliability. The successful development of paliperidone nanocrystals holds great promise as a significant approach for drug development, with potential applications for other chronic disease management.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harms associated with retinal implantation of a stimulating electrode array to treat outer-retinal degeneration: a systematic review and meta-analysis of safety.","authors":"Luke E Hallum, Shaun L Cloherty","doi":"10.1088/2516-1091/ad811e","DOIUrl":"10.1088/2516-1091/ad811e","url":null,"abstract":"<p><p>Retinal implantation of an electrode array is an emerging treatment for vision loss caused by outer-retinal degeneration. This article collects and analyses harms associated with the treatment reported in the peer-reviewed literature, thus enabling informed decision-making by patients, clinicians, researchers, engineers, and policymakers. We searched MEDLINE, Embase, and clinical trials registries for peer-reviewed journal articles reporting harms outcomes. We extracted data from articles including study design, definitions of 'serious adverse event', and timing of adverse events. We applied the McMaster tool to these articles to assess the risk of bias in harms assessment and reporting. Our searches returned 585 abstracts. We reviewed the full text of 59 articles describing 11 different devices. McMaster scores ranged from 3 to 12 (maximum 15; higher scores indicate less risk). We compiled a comprehensive list of all serious and non-serious adverse events associated with retinal implantation. Several harms were common across devices. Our meta-analysis showed that serious adverse events are log-uniformly distributed throughout follow-up. Improved reporting and further clinical studies are needed to develop a reliable safety profile of retinal implantation. Our findings will help guide the design, conduct, and reporting of future clinical trials of retinal implantation and other emerging treatments for vision loss. (PROSPERO registration: CRD42022308123.).</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"7 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}