Progress in biomedical engineering (Bristol, England)最新文献_第8页

Challenges of continuum robots in clinical context: a review 连续体机器人在临床环境中的挑战:综述

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-08-03 DOI: 10.1088/2516-1091/ab9f41

Tomás da Veiga, J. Chandler, P. Lloyd, G. Pittiglio, N. J. Wilkinson, A. K. Hoshiar, R. Harris, P. Valdastri

{"title":"Challenges of continuum robots in clinical context: a review","authors":"Tomás da Veiga, J. Chandler, P. Lloyd, G. Pittiglio, N. J. Wilkinson, A. K. Hoshiar, R. Harris, P. Valdastri","doi":"10.1088/2516-1091/ab9f41","DOIUrl":"https://doi.org/10.1088/2516-1091/ab9f41","url":null,"abstract":"With the maturity of surgical robotic systems based on traditional rigid-link principles, the rate of progress slowed as limits of size and controllable degrees of freedom were reached. Continuum robots came with the potential to deliver a step change in the next generation of medical devices, by providing better access, safer interactions and making new procedures possible. Over the last few years, several continuum robotic systems have been launched commercially and have been increasingly adopted in hospitals. Despite the clear progress achieved, continuum robots still suffer from design complexity hindering their dexterity and scalability. Recent advances in actuation methods have looked to address this issue, offering alternatives to commonly employed approaches. Additionally, continuum structures introduce significant complexity in modelling, sensing, control and fabrication; topics which are of particular focus in the robotics community. It is, therefore, the aim of the presented work to highlight the pertinent areas of active research and to discuss the challenges to be addressed before the potential of continuum robots as medical devices may be fully realised.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab9f41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43917656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 100

Biochemomechanics of the thoracic aorta in health and disease 健康与疾病中胸主动脉的生物化学力学

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-07-07 DOI: 10.1088/2516-1091/ab9a29

Selda Sherifova and, G. Holzapfel

{"title":"Biochemomechanics of the thoracic aorta in health and disease","authors":"Selda Sherifova and, G. Holzapfel","doi":"10.1088/2516-1091/ab9a29","DOIUrl":"https://doi.org/10.1088/2516-1091/ab9a29","url":null,"abstract":"Aneurysms and dissections of the thoracic aorta are life threatening events with poorly understood pathophysiologies which may have genetic origins. By starting with an introduction to these pathologies, we focus on the biochemomechanics of the healthy thoracic aorta. Specifically, we describe the microstructure and the mechanics of the aortic tissue since it is known that the microstructure strongly influences the biomechanical behavior. This relationship is then complemented by providing more detailed information on the selected extracellular matrix components (collagen, elastic fibers and proteoglycans) and smooth muscle cells. More specifically, we introduce the roles smooth muscle cells play in the function of the aortic wall: actively (mechanically) with their contractile abilities and passively by regulating the composition of the extracellular matrix they are embedded in, in particular via the transforming growth factor β (TGF-β) pathway. Subsequently, we summarize the microstructural changes in thoracic aortic aneurysms and dissections in connection with selected risk factors and genetic mutations, and couple these changes with the findings on the biomechanical behavior of the pathological tissues. Finally, we provide a summary and concluding remarks.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab9a29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44075097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Catheter-based optical approaches for cardiovascular medicine: progress, challenges and new directions 基于导管的心血管医学光学方法:进展、挑战和新方向

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-06-12 DOI: 10.1088/2516-1091/ab8af8

Chao Huang, Nathan J. Knighton, L. Timmins, F. Sachse

{"title":"Catheter-based optical approaches for cardiovascular medicine: progress, challenges and new directions","authors":"Chao Huang, Nathan J. Knighton, L. Timmins, F. Sachse","doi":"10.1088/2516-1091/ab8af8","DOIUrl":"https://doi.org/10.1088/2516-1091/ab8af8","url":null,"abstract":"Catheterization of the heart is crucial for many diagnostic and therapeutic procedures in cardiovascular medicine. In this review, we discussed developments of catheter-based optical tools and approaches for cardiovascular medicine. We provided a background in gross and microscopic anatomy of the normal and diseased heart. We overviewed optical properties of cardiac tissues, such as scattering, absorption and fluorescence, and related optical properties to tissues constituents. Furthermore, we introduced optical modalities for tissue characterization, in particular, spectroscopy, confocal, multi-photon and light sheet fluorescence microcopy, and optical coherence tomography. We then surveyed example applications in cardiovascular medicine and contrasted established clinical tools and approaches with catheter-based optical approaches and tools. First, we explored assessment of heart transplant rejection and reviewed alternative catheterized optical approaches. Rejection is commonly assessed using endomyocardial biopsy, i.e. the excision and histological assessment of tissue samples. A further application is atrial fibrosis mapping. Atrial fibrosis is an important predictor for prognosis of atrial fibrillation patients, yet clinical tools for fibrosis mapping in patients are lacking. We surveyed clinical tools for assessing catheter ablation of the heart, which is an indispensable therapy for arrhythmia. Last, we discussed methods and protocols for guiding coronary angioplasty and stent placement. For all applications, we explored the current and potential role of catheterized optical tools. We concluded with a discussion of technical challenges and open questions related to clinical translation of the catheter-based optical approaches. Our review stressed the potential of catheterized optical tools to improve diagnosis and treatment of patients with heart disease.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab8af8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48416984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Introducing Progress in Biomedical Engineering; Issue 2 Vol 2 生物医学工程进展介绍；第2期第2卷

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-05-27 DOI: 10.1088/2516-1091/ab871a

M. Sitti

{"title":"Introducing Progress in Biomedical Engineering; Issue 2 Vol 2","authors":"M. Sitti","doi":"10.1088/2516-1091/ab871a","DOIUrl":"https://doi.org/10.1088/2516-1091/ab871a","url":null,"abstract":"Progress in Biomedical Engineering is a new interdisciplinary journal publishing high-quality authoritative reviews and opinion pieces in the most significant and exciting areas of biomedical engineering research. Invited content by leading experts on the current state of the science and emerging trends aims to fuel discussion on the future direction of research. In our first and second issues this year, we have four topical review articles. In the first review article related to medical devices, Xia et al present and discuss intravascular sensors to assess unstable plaques and their compositions. Vulnerable atherosclerotic plaques can rapture, which can create acute cardiovascular events and sudden cardiac deaths as a major health issue all around the world. Existing methods such as coronary angiography lacks the capacity to provide detailed information about exact lipid-rich, fibrotic or calcified type of properties of the lesion. Therefore, novel catheter technologies have been proposed for the assessment of atherosclerotic plaques, which integrates intravascular ultrasound with photoacoustic microscopy or optical coherence tomography and utilizes stretchable electrodes for electrochemical impedance spectroscopy. While these technologies are promising for the identification of the complexity and composition of potentially unstable plaques in animal and human trials, real-time detection of such plaques in clinics is still a significant challenge. This article highlights existing and emerging intravascular sensors to assess unstable plaques and their compositions. The authors report the advantages, limitations, future directions, and potential clinical applications of such sensors. the fundamentals and state-of-the-art the future of vascularization of engineered tissues, which is a grand challenge in engineering regenerative A new recent tissue engineering sub-field, called vascular tissue engineering, to a","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab871a","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46570735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches 用于体外临床前药物测试的高通量生理微模型：工程系统方法综述

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-05-22 DOI: 10.1088/2516-1091/ab7cc4

Huagui Zhang, R. Whalley, A. Ferreira, K. Dalgarno

{"title":"High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches","authors":"Huagui Zhang, R. Whalley, A. Ferreira, K. Dalgarno","doi":"10.1088/2516-1091/ab7cc4","DOIUrl":"https://doi.org/10.1088/2516-1091/ab7cc4","url":null,"abstract":"To address the low success rate of new drug discovery, there has been significant growth of in vitro physiological micro-models based on human cells. These may be in the form of cell spheroids, organs-on-a-chip, or multi-cellular tissue cultures, and it is expected that the more biomimetic environment they create will be more accurate than standard cell culture in drug screening prior to clinical testing. However, commercial use of complex co-cultures is still limited. This is due to a lack of validation, low throughput rates, and a lack of compatibility with standard assessment techniques. This review paper focusses specifically on the different engineering approaches used to create, mature and analyse these micro-models, with the aim of exploring which approaches have the potential for high throughput. Active and passive pumping and nozzle based dispensing techniques are considered for fluid handling, with transwells, cell patterning, spheroid cultures and microfluidics considered for establishing and maintaining co-cultures, together with conventional analysis techniques (proteomic and genomic approaches, and immunohistochemistry) and novel sensor systems for downstream analysis are considered. It is concluded that (i) throughput is essential for validation as well as exploitation of the models, and (ii) an integrated approach to model re-design for high throughput is key, with the limitations on throughput at each stage considered in order to develop a system which can deliver and analyse at high throughput rates at all stages of the process.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab7cc4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41418861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Vascularization in tissue engineering: fundamentals and state-of-art. 组织工程中的血管化:基础与现状。

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-01-01 Epub Date: 2020-01-09 DOI: 10.1088/2516-1091/ab5637

Guang Yang, Bhushan Mahadik, Ji Young Choi, John P Fisher

引用次数: 48

Emerging Embolic Agents in Endovascular Embolization: An Overview. 血管内栓塞新出现的栓塞剂:综述。

Progress in biomedical engineering (Bristol, England) Pub Date : 2020-01-01 Epub Date: 2020-02-12 DOI: 10.1088/2516-1091/ab6c7d

Courtney Y Wang, Jingjie Hu, Rahul A Sheth, Rahmi Oklu

引用次数: 15

Intravascular sensors to assess unstable plaques and their compositions: a review 评估不稳定斑块及其组成的血管内传感器：综述

Progress in biomedical engineering (Bristol, England) Pub Date : 2019-11-04 DOI: 10.1088/2516-1091/ab5418

Xing Xia, Jimmy Zhang, Gengxi Lu, Wenjie Lai, Sandeep K. Krishnan, T. Hsiai, Qifa Zhou, Anh H. Nguyen, H. Cao

{"title":"Intravascular sensors to assess unstable plaques and their compositions: a review","authors":"Xing Xia, Jimmy Zhang, Gengxi Lu, Wenjie Lai, Sandeep K. Krishnan, T. Hsiai, Qifa Zhou, Anh H. Nguyen, H. Cao","doi":"10.1088/2516-1091/ab5418","DOIUrl":"https://doi.org/10.1088/2516-1091/ab5418","url":null,"abstract":"Atherosclerosis and its thrombotic complications plague developed countries. The rupture of vulnerable atherosclerotic plaques contributes to acute cardiovascular events and sudden cardiac deaths. Historically, coronary angiography has proved an invaluable tool for the detection and treatment of coronary stenoses that may cause myocardial ischemia; however, the method lacks the capacity to provide thorough information about properties of the lesion (i.e. whether it is lipid-rich, fibrotic, or calcified). Recent advances in electronics, biomaterials and microfabrication techniques have enabled novel multimodality catheters for the assessment of atherosclerotic plaques, such as the integration of intravascular ultrasound with photoacoustic microscopy or optical coherence tomography as well as the utilization of stretchable electrodes for electrochemical impedance spectroscopy. These technologies enable the identification of the complexity and composition of potentially unstable plaques as well as investigations of stenosis severity, plaque formation, and remodeling in both humans and studied animal models. However, real-time detection of vulnerable atherosclerotic lesions prepared for clinical trials remains an unmet challenge. In this context, this review highlights existing and newly-emerged intravascular sensors to assess unstable plaques and their compositions. Advantages and limitations, as well as further development and potential clinical applications, will be thoroughly discussed.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab5418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48026164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatibility in clinical practice: predictable and unpredictable outcomes 临床实践中的生物相容性:可预测和不可预测的结果

Progress in biomedical engineering (Bristol, England) Pub Date : 2019-07-16 DOI: 10.1088/2516-1091/ab22cc

David F. Williams

{"title":"Biocompatibility in clinical practice: predictable and unpredictable outcomes","authors":"David F. Williams","doi":"10.1088/2516-1091/ab22cc","DOIUrl":"https://doi.org/10.1088/2516-1091/ab22cc","url":null,"abstract":"At the present time, there is a significant public and political debate about the safety of implantable medical devices. The debate has centered on the biocompatibility of materials that are used in such devices. It has become clear that, whether the concerns expressed about adverse events in patients are actually caused by the devices or just coincidentally arise in these patients, we are usually unable to address and explain the phenomena that are described. This is very damaging to the medical device industry and the relevant clinical disciplines; it is, however, not surprising, since current ideas about the mechanisms of biocompatibility and the development of the host response are well out-of-date and do not take into account knowledge about inflammation, immunity and fibrosis. This perspectives paper discusses this new knowledge and presents the outline of new biocompatibility paradigms, involving mechanotransduction and sterile inflammation. Based on these ideas, totally new procedures for the determination of biological safety are proposed which, if implemented, could improve patient safety and confidence in the performance of implanted devices.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1088/2516-1091/ab22cc","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47755865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Welcome to Progress in Biomedical Engineering 欢迎来到生物医学工程进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2019-07-16 DOI: 10.1088/2516-1091/ab280b

M. Sitti

引用次数: 0