Progress in biomedical engineering (Bristol, England)最新文献_第6页

Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements 水凝胶和纳米颗粒载体用于肾脏疾病治疗:趋势和最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-05-09 DOI: 10.1088/2516-1091/ac6e18

Xurui Gu, Zhen Liu, Yi-fan Tai, Ling-yun Zhou, Kun Liu, D. Kong, Adam C. Midgley, Xiao-cong Zuo

{"title":"Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements","authors":"Xurui Gu, Zhen Liu, Yi-fan Tai, Ling-yun Zhou, Kun Liu, D. Kong, Adam C. Midgley, Xiao-cong Zuo","doi":"10.1088/2516-1091/ac6e18","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6e18","url":null,"abstract":"Achieving local therapeutic agent concentration in the kidneys through traditional systemic administration routes have associated concerns with off-target drug effects and toxicity. Additionally, kidney diseases are often accompanied by co-morbidities in other major organs, which negatively impacts drug metabolism and clearance. To circumvent these issues, kidney-specific targeting of therapeutics aims to achieve the delivery of controlled doses of therapeutic agents, such as drugs, nucleic acids, peptides, or proteins, to kidney tissues in a safe and efficient manner. Current carrier material approaches implement macromolecular and polyplex hydrogel constructs, prodrug strategies, and nanoparticle (NP)-based delivery technologies. In the context of multidisciplinary and cross-discipline innovations, the medical and bioengineering research fields have facilitated the rapid development of kidney-targeted therapies and carrier materials. In this review, we summarize the current trends and recent advancements made in the development of carrier materials for kidney disease targeted therapies, specifically hydrogel and NP-based strategies for acute kidney disease, chronic kidney disease, and renal cell carcinoma. Additionally, we discuss the current limitations in carrier materials and their delivery mechanisms.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41536559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Physiological closed-loop control in critical care: opportunities for innovations 重症监护中的生理闭环控制:创新的机会

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-05-05 DOI: 10.1088/2516-1091/ac6d36

J. Hahn, O. Inan

{"title":"Physiological closed-loop control in critical care: opportunities for innovations","authors":"J. Hahn, O. Inan","doi":"10.1088/2516-1091/ac6d36","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6d36","url":null,"abstract":"Physiological closed-loop control (PCLC) systems are a key enabler for automation and clinician support in medicine, including, but not limited to, patient monitoring, diagnosis, clinical decision making, and therapy delivery. Existing body of work has demonstrated that PCLC systems hold the promise to advance critical care as well as a wide range of other domains in medicine bearing profound implications in quality of life, quality of care, and human wellbeing. However, the state-of-the-art PCLC technology in critical care is associated with long-standing limitations related to its development and assessment, including (a) isolated and loop-by-loop PCLC design without sufficient account for multi-faceted patient physiology, (b) suboptimal choice of therapeutic endpoints, (c) concerns related to collective safety originating from multi-PCLC interferences, and (d) premature PCLC assessment methodology. Such limitations naturally motivate research to generate new knowledge and create innovative methods. In this perspective, we propose several high-reward opportunities that can accelerate the advances in PCLC systems, which may be explored by deep fusion and collaboration among multiple disciplines including physiological systems and signals analysis, control and estimation, machine learning and artificial intelligence, and wearable sensing and embedded computing technologies.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44952674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Recent progress in the use of thermogelling polymers for treatment of ophthalmic conditions 热凝胶聚合物用于眼科疾病治疗的最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-04-11 DOI: 10.1088/2516-1091/ac6641

Jasmin Omar, C. A. Dreiss, X. Loh

引用次数: 0

3D Coaxial Bioprinting: Process Mechanisms, Bioinks and Applications. 三维同轴生物打印：工艺机制、生物墨水和应用。

IF 5

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-04-01 Epub Date: 2022-04-20 DOI: 10.1088/2516-1091/ac631c

Tarun Shyam Mohan, Pallab Datta, Sepehr Nesaei, Veli Ozbolat, Ibrahim T Ozbolat

{"title":"3D Coaxial Bioprinting: Process Mechanisms, Bioinks and Applications.","authors":"Tarun Shyam Mohan, Pallab Datta, Sepehr Nesaei, Veli Ozbolat, Ibrahim T Ozbolat","doi":"10.1088/2516-1091/ac631c","DOIUrl":"10.1088/2516-1091/ac631c","url":null,"abstract":"In the last decade, bioprinting has emerged as a facile technique for fabricating tissues constructs mimicking the architectural complexity and compositional heterogeneity of native tissues. Amongst different bioprinting modalities, extrusion-based bioprinting (EBB) is the most widely used technique. Coaxial bioprinting, a type of EBB, enables fabrication of concentric cell-material layers and enlarges the scope of EBB to mimic several key aspects of native tissues. Over the period of development of bioprinting, tissue constructs integrated with vascular networks, have been one of the major achievements made possible largely by coaxial bioprinting. In this review, current advancements in biofabrication of constructs with coaxial bioprinting are discussed with a focus on different bioinks that are particularly suitable for this modality. This review also expounds the properties of different bioinks suitable for coaxial bioprinting and then analyses the key achievements made by the application of coaxial bioprinting in tissue engineering, drug delivery and in-vitro disease modelling. The major limitations and future perspectives on the critical factors that will determine the ultimate clinical translation of the versatile technique are also presented to the reader.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"4 2","pages":""},"PeriodicalIF":5.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103990/pdf/nihms-1800053.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9327461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in bioactive gas delivery for cancer immunotherapy 癌症免疫治疗中生物活性气体输送的最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-18 DOI: 10.1088/2516-1091/ac4c43

Yang Liu, Tiandong Chen, N. Gu, Fang Yang

引用次数: 0

Spike sorting: new trends and challenges of the era of high-density probes 尖峰分选：高密度探针时代的新趋势和挑战

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-07 DOI: 10.1088/2516-1091/ac6b96

A. P. Buccino, Samuel Garcia, P. Yger

{"title":"Spike sorting: new trends and challenges of the era of high-density probes","authors":"A. P. Buccino, Samuel Garcia, P. Yger","doi":"10.1088/2516-1091/ac6b96","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6b96","url":null,"abstract":"Recording from a large neuronal population of neurons is a crucial challenge to unravel how information is processed by the brain. In this review, we highlight the recent advances made in the field of ‘spike sorting’, which is arguably a very essential processing step to extract neuronal activity from extracellular recordings. More specifically, we target the challenges faced by newly manufactured high-density multi-electrode array devices (HD-MEA), e.g. Neuropixels probes. Among them, we cover in depth the prominent problem of drifts (movements of the neurons with respect to the recording devices) and the current solutions to circumscribe it. In addition, we also review recent contributions making use of deep learning approaches for spike sorting, highlighting their advantages and disadvantages. Next, we highlight efforts and advances in unifying, validating, and benchmarking spike sorting tools. Finally, we discuss the spike sorting field in terms of its open and unsolved challenges, specifically regarding scalability and reproducibility. We conclude by providing our personal view on the future of spike sorting, calling for a community-based development and validation of spike sorting algorithms and fully automated, cloud-based spike sorting solutions for the neuroscience community.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44093658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Protein Based Biomaterials for Therapeutic and Diagnostic Applications. 用于治疗和诊断的蛋白质生物材料。

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-01 Epub Date: 2021-10-26 DOI: 10.1088/2516-1091/ac2841

Stanley Chu, Andrew L Wang, Aparajita Bhattacharya, Jin Kim Montclare

{"title":"Protein Based Biomaterials for Therapeutic and Diagnostic Applications.","authors":"Stanley Chu, Andrew L Wang, Aparajita Bhattacharya, Jin Kim Montclare","doi":"10.1088/2516-1091/ac2841","DOIUrl":"10.1088/2516-1091/ac2841","url":null,"abstract":"Proteins are some of the most versatile and studied macromolecules with extensive biomedical applications. The natural and biological origin of proteins offer such materials several advantages over their synthetic counterparts, such as innate bioactivity, recognition by cells and reduced immunogenic potential. Furthermore, proteins can be easily functionalized by altering their primary amino acid sequence and can often be further self-assembled into higher order structures either spontaneously or under specific environmental conditions. This review will feature the recent advances in protein-based biomaterials in the delivery of therapeutic cargo such as small molecules, genetic material, proteins, and cells. First, we will discuss the ways in which secondary structural motifs, the building blocks of more complex proteins, have unique properties that enable them to be useful for therapeutic delivery. Next, supramolecular assemblies, such as fibers, nanoparticles, and hydrogels, made from these building blocks that are engineered to behave in a cohesive manner, are discussed. Finally, we will cover additional modifications to protein materials that impart environmental responsiveness to materials. This includes the emerging field of protein molecular robots, and relatedly, protein-based theranostic materials that combine therapeutic potential with modern imaging modalities, including near-infrared fluorescence spectroscopy (NIRF), single-photo emission computed tomography/computed tomography (SPECT/CT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasound/photoacoustic imaging (US/PAI).","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691744/pdf/nihms-1755309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10806603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Wave-based optical coherence elastography: The 10-year perspective. 基于波的光学相干弹性成像:十年展望。

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-01 DOI: 10.1088/2516-1091/ac4512

Fernando Zvietcovich, Kirill V Larin

{"title":"Wave-based optical coherence elastography: The 10-year perspective.","authors":"Fernando Zvietcovich, Kirill V Larin","doi":"10.1088/2516-1091/ac4512","DOIUrl":"https://doi.org/10.1088/2516-1091/ac4512","url":null,"abstract":"After 10 years of progress and innovation, optical coherence elastography (OCE) based on the propagation of mechanical waves has become one of the major and the most studied OCE branches, producing a fundamental impact in the quantitative and nondestructive biomechanical characterization of tissues. Preceding previous progress made in ultrasound and magnetic resonance elastography; wave-based OCE has pushed to the limit the advance of three major pillars: (1) implementation of novel wave excitation methods in tissues, (2) understanding new types of mechanical waves in complex boundary conditions by proposing advance analytical and numerical models, and (3) the development of novel estimators capable of retrieving quantitative 2D/3D biomechanical information of tissues. This remarkable progress promoted a major advance in answering basic science questions and the improvement of medical disease diagnosis and treatment monitoring in several types of tissues leading, ultimately, to the first attempts of clinical trials and translational research aiming to have wave-based OCE working in clinical environments. This paper summarizes the fundamental up-to-date principles and categories of wave-based OCE, revises the timeline and the state-of-the-art techniques and applications lying in those categories, and concludes with a discussion on the current challenges and future directions, including clinical translation research.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856668/pdf/nihms-1771742.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Ethical and social aspects of neural prosthetics 神经修复术的伦理和社会方面

Progress in biomedical engineering (Bristol, England) Pub Date : 2021-10-26 DOI: 10.1088/2516-1091/ac23e6

W. Glannon

{"title":"Ethical and social aspects of neural prosthetics","authors":"W. Glannon","doi":"10.1088/2516-1091/ac23e6","DOIUrl":"https://doi.org/10.1088/2516-1091/ac23e6","url":null,"abstract":"Neural prosthetics are devices or systems that bypass, modulate, supplement, or replace regions of the brain and its connections to the body that are damaged and dysfunctional from congenital abnormalities, brain and spinal cord injuries, limb loss, and neuropsychiatric disorders. Some prosthetics are implanted in the brain. Others consist of implants and systems outside the brain to which they are connected. Still others are completely external to the brain. But they all send inputs to and receive outputs from neural networks to modulate or improve connections between the brain and body. As artificial systems, neural prosthetics can improve but not completely restore natural sensory, motor and cognitive functions. This review examines the main ethical and social issues generated by experimental and therapeutic uses of seven types of neural prosthetics: auditory and visual prosthetics for deafness and blindness; deep brain stimulation for prolonged disorders of consciousness; brain-computer and brain-to-brain interfaces to restore movement and communication; memory prosthetics to encode and retrieve information; and optogenetics to modulate or restore neural function. The review analyzes and discusses how recipients of neural prosthetics can benefit from them in restoring autonomous agency, how they can be harmed by trying and failing to use or adapt to them, how these systems affect their identities, how to protect people with prosthetics from external interference, and how to ensure fair access to them. The review concludes by emphasizing the control these systems provide for people and a brief exploration of the future of neural prosthetics.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46874639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Magnetic nanomaterials-mediated cancer diagnosis and therapy 磁性纳米材料介导的癌症诊断与治疗

Progress in biomedical engineering (Bristol, England) Pub Date : 2021-10-19 DOI: 10.1088/2516-1091/ac3111

Xiaoli Liu, Huan Zhang, Tingbin Zhang, Yanyun Wang, W. Jiao, Xiaofeng Lu, Xiao Gao, Mengmeng Xie, Qingfeng Shan, Nana Wen, Chen Liu, Wee Siang Vincent Lee, Haiming Fan

{"title":"Magnetic nanomaterials-mediated cancer diagnosis and therapy","authors":"Xiaoli Liu, Huan Zhang, Tingbin Zhang, Yanyun Wang, W. Jiao, Xiaofeng Lu, Xiao Gao, Mengmeng Xie, Qingfeng Shan, Nana Wen, Chen Liu, Wee Siang Vincent Lee, Haiming Fan","doi":"10.1088/2516-1091/ac3111","DOIUrl":"https://doi.org/10.1088/2516-1091/ac3111","url":null,"abstract":"Magnetic nanomaterials have been widely used in various biomedical applications, which have seen accelerating interest since the breakthrough in the chemical synthesis of monodispersed iron oxide nanoparticles. Magnetic iron oxide nanoparticles (MIONs) possess excellent biocompatibility, and they can produce multiple physicochemical effects when exposed to magnetic fields. Due to this rapid development in MIONs for cancer diagnosis and therapy, it becomes necessary to present a comprehensive review paper from the biomedical engineering perspective. This review will present an overview of the recent synthesis methods used in the preparation of magnetic nanomaterials. We will then focus on the application of magnetic nanomaterials in imaging and therapy technology, and we will also evaluate their biosafety in vitro, in vivo, and clinical aspects. The therapeutic effects of magnetic theranostics, magnetocatalytic therapy, magnetically targeted therapy, and magnetothermal therapy under the guidance of imaging diagnosis will also be discussed in this review. Finally, we will briefly analyze the challenges of implementing magnetic nanomaterials as a nano-platform for imaging diagnosis and treatment, and we will also offer suggestions for future research in this field.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48845047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14