Progress in biomedical engineering (Bristol, England)最新文献_第5页

Advances in visual prostheses: engineering and biological challenges 视觉假体的进展:工程和生物学的挑战

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-07-14 DOI: 10.1088/2516-1091/ac812c

Eleonora Borda, D. Ghezzi

引用次数: 12

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-06-13 DOI: 10.1088/2516-1091/ac7833

Defne Yigci, M. R. Sarabi, M. Ustun, Nazente Atçeken, Emel Sokullu, T. Bagci-Onder, S. Tasoglu

{"title":"3D bioprinted glioma models","authors":"Defne Yigci, M. R. Sarabi, M. Ustun, Nazente Atçeken, Emel Sokullu, T. Bagci-Onder, S. Tasoglu","doi":"10.1088/2516-1091/ac7833","DOIUrl":"https://doi.org/10.1088/2516-1091/ac7833","url":null,"abstract":"Glioma is one of the most malignant types of cancer and most gliomas remain incurable. One of the hallmarks of glioma is its invasiveness. Furthermore, glioma cells tend to readily detach from the primary tumor and travel through the brain tissue, making complete tumor resection impossible in many cases. To expand the knowledge regarding the invasive behavior of glioma, evaluate drug resistance, and recapitulate the tumor microenvironment, various modeling strategies were proposed in the last decade, including three-dimensional (3D) biomimetic scaffold-free cultures, organ-on-chip microfluidics chips, and 3D bioprinting platforms, which allow for the investigation on patient-specific treatments. The emerging method of 3D bioprinting technology has introduced a time- and cost-efficient approach to create in vitro models that possess the structural and functional characteristics of human organs and tissues by spatially positioning cells and bioink. Here, we review emerging 3D bioprinted models developed for recapitulating the brain environment and glioma tumors, with the purpose of probing glioma cell invasion and gliomagenesis and discuss the potential use of 4D printing and machine learning applications in glioma modelling.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44184333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Advances in engineered exosomes towards cancer diagnosis and therapeutics 工程外泌体在癌症诊断和治疗中的研究进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-05-26 DOI: 10.1088/2516-1091/ac73c9

Tanziela Tanziela, Xiawei Dong, Jing Ye, Zengchao Guo, Hui Jiang, Zuhong Lu, Xiaohui Liu, Xuemei Wang

{"title":"Advances in engineered exosomes towards cancer diagnosis and therapeutics","authors":"Tanziela Tanziela, Xiawei Dong, Jing Ye, Zengchao Guo, Hui Jiang, Zuhong Lu, Xiaohui Liu, Xuemei Wang","doi":"10.1088/2516-1091/ac73c9","DOIUrl":"https://doi.org/10.1088/2516-1091/ac73c9","url":null,"abstract":"Exosomes have emerged as natural nanocarriers and are advantageous in the field of nanomedicine due to their lipid bilayer membrane comprising many proteins, nucleic acids and cell debris. Exosomes are secreted from all types of living cells and play a role in cancer diagnosis and therapy because of their biological properties, such as intercellular communication, modulation of immune responses, biocompatibility and target specificity. Many studies have shown that exosomes can be engineered or modified with different therapeutic substances, including nucleic acids, proteins, drugs and other nanomaterials, to improve their specificity, efficiency and safety in nanomedicine. In this review, we summarize the methodologies of exosome biogenesis, purification, the possible mechanisms of cellular uptake and the important role of exosomes in cancer diagnosis, followed by the role of engineered exosomes in cancer therapy. Also, future trends and challenges are discussed. We strongly suggest that a clear articulation of the fundamental principles for the creation of exosome-based theranostic platforms will help reveal the unique powers of exosomes in early cancer diagnosis and therapeutics, including chemotherapy, gene therapy, immunotherapy and phototherapy.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43818913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements 水凝胶和纳米颗粒载体用于肾脏疾病治疗:趋势和最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-05-09 DOI: 10.1088/2516-1091/ac6e18

Xurui Gu, Zhen Liu, Yi-fan Tai, Ling-yun Zhou, Kun Liu, D. Kong, Adam C. Midgley, Xiao-cong Zuo

{"title":"Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements","authors":"Xurui Gu, Zhen Liu, Yi-fan Tai, Ling-yun Zhou, Kun Liu, D. Kong, Adam C. Midgley, Xiao-cong Zuo","doi":"10.1088/2516-1091/ac6e18","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6e18","url":null,"abstract":"Achieving local therapeutic agent concentration in the kidneys through traditional systemic administration routes have associated concerns with off-target drug effects and toxicity. Additionally, kidney diseases are often accompanied by co-morbidities in other major organs, which negatively impacts drug metabolism and clearance. To circumvent these issues, kidney-specific targeting of therapeutics aims to achieve the delivery of controlled doses of therapeutic agents, such as drugs, nucleic acids, peptides, or proteins, to kidney tissues in a safe and efficient manner. Current carrier material approaches implement macromolecular and polyplex hydrogel constructs, prodrug strategies, and nanoparticle (NP)-based delivery technologies. In the context of multidisciplinary and cross-discipline innovations, the medical and bioengineering research fields have facilitated the rapid development of kidney-targeted therapies and carrier materials. In this review, we summarize the current trends and recent advancements made in the development of carrier materials for kidney disease targeted therapies, specifically hydrogel and NP-based strategies for acute kidney disease, chronic kidney disease, and renal cell carcinoma. Additionally, we discuss the current limitations in carrier materials and their delivery mechanisms.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41536559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Physiological closed-loop control in critical care: opportunities for innovations 重症监护中的生理闭环控制:创新的机会

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-05-05 DOI: 10.1088/2516-1091/ac6d36

J. Hahn, O. Inan

{"title":"Physiological closed-loop control in critical care: opportunities for innovations","authors":"J. Hahn, O. Inan","doi":"10.1088/2516-1091/ac6d36","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6d36","url":null,"abstract":"Physiological closed-loop control (PCLC) systems are a key enabler for automation and clinician support in medicine, including, but not limited to, patient monitoring, diagnosis, clinical decision making, and therapy delivery. Existing body of work has demonstrated that PCLC systems hold the promise to advance critical care as well as a wide range of other domains in medicine bearing profound implications in quality of life, quality of care, and human wellbeing. However, the state-of-the-art PCLC technology in critical care is associated with long-standing limitations related to its development and assessment, including (a) isolated and loop-by-loop PCLC design without sufficient account for multi-faceted patient physiology, (b) suboptimal choice of therapeutic endpoints, (c) concerns related to collective safety originating from multi-PCLC interferences, and (d) premature PCLC assessment methodology. Such limitations naturally motivate research to generate new knowledge and create innovative methods. In this perspective, we propose several high-reward opportunities that can accelerate the advances in PCLC systems, which may be explored by deep fusion and collaboration among multiple disciplines including physiological systems and signals analysis, control and estimation, machine learning and artificial intelligence, and wearable sensing and embedded computing technologies.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44952674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Recent progress in the use of thermogelling polymers for treatment of ophthalmic conditions 热凝胶聚合物用于眼科疾病治疗的最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-04-11 DOI: 10.1088/2516-1091/ac6641

Jasmin Omar, C. A. Dreiss, X. Loh

引用次数: 0

3D Coaxial Bioprinting: Process Mechanisms, Bioinks and Applications. 三维同轴生物打印：工艺机制、生物墨水和应用。

IF 5

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-04-01 Epub Date: 2022-04-20 DOI: 10.1088/2516-1091/ac631c

Tarun Shyam Mohan, Pallab Datta, Sepehr Nesaei, Veli Ozbolat, Ibrahim T Ozbolat

{"title":"3D Coaxial Bioprinting: Process Mechanisms, Bioinks and Applications.","authors":"Tarun Shyam Mohan, Pallab Datta, Sepehr Nesaei, Veli Ozbolat, Ibrahim T Ozbolat","doi":"10.1088/2516-1091/ac631c","DOIUrl":"10.1088/2516-1091/ac631c","url":null,"abstract":"In the last decade, bioprinting has emerged as a facile technique for fabricating tissues constructs mimicking the architectural complexity and compositional heterogeneity of native tissues. Amongst different bioprinting modalities, extrusion-based bioprinting (EBB) is the most widely used technique. Coaxial bioprinting, a type of EBB, enables fabrication of concentric cell-material layers and enlarges the scope of EBB to mimic several key aspects of native tissues. Over the period of development of bioprinting, tissue constructs integrated with vascular networks, have been one of the major achievements made possible largely by coaxial bioprinting. In this review, current advancements in biofabrication of constructs with coaxial bioprinting are discussed with a focus on different bioinks that are particularly suitable for this modality. This review also expounds the properties of different bioinks suitable for coaxial bioprinting and then analyses the key achievements made by the application of coaxial bioprinting in tissue engineering, drug delivery and in-vitro disease modelling. The major limitations and future perspectives on the critical factors that will determine the ultimate clinical translation of the versatile technique are also presented to the reader.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"4 2","pages":""},"PeriodicalIF":5.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103990/pdf/nihms-1800053.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9327461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in bioactive gas delivery for cancer immunotherapy 癌症免疫治疗中生物活性气体输送的最新进展

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-18 DOI: 10.1088/2516-1091/ac4c43

Yang Liu, Tiandong Chen, N. Gu, Fang Yang

引用次数: 0

Spike sorting: new trends and challenges of the era of high-density probes 尖峰分选：高密度探针时代的新趋势和挑战

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-07 DOI: 10.1088/2516-1091/ac6b96

A. P. Buccino, Samuel Garcia, P. Yger

{"title":"Spike sorting: new trends and challenges of the era of high-density probes","authors":"A. P. Buccino, Samuel Garcia, P. Yger","doi":"10.1088/2516-1091/ac6b96","DOIUrl":"https://doi.org/10.1088/2516-1091/ac6b96","url":null,"abstract":"Recording from a large neuronal population of neurons is a crucial challenge to unravel how information is processed by the brain. In this review, we highlight the recent advances made in the field of ‘spike sorting’, which is arguably a very essential processing step to extract neuronal activity from extracellular recordings. More specifically, we target the challenges faced by newly manufactured high-density multi-electrode array devices (HD-MEA), e.g. Neuropixels probes. Among them, we cover in depth the prominent problem of drifts (movements of the neurons with respect to the recording devices) and the current solutions to circumscribe it. In addition, we also review recent contributions making use of deep learning approaches for spike sorting, highlighting their advantages and disadvantages. Next, we highlight efforts and advances in unifying, validating, and benchmarking spike sorting tools. Finally, we discuss the spike sorting field in terms of its open and unsolved challenges, specifically regarding scalability and reproducibility. We conclude by providing our personal view on the future of spike sorting, calling for a community-based development and validation of spike sorting algorithms and fully automated, cloud-based spike sorting solutions for the neuroscience community.","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44093658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Protein Based Biomaterials for Therapeutic and Diagnostic Applications. 用于治疗和诊断的蛋白质生物材料。

Progress in biomedical engineering (Bristol, England) Pub Date : 2022-01-01 Epub Date: 2021-10-26 DOI: 10.1088/2516-1091/ac2841

Stanley Chu, Andrew L Wang, Aparajita Bhattacharya, Jin Kim Montclare

{"title":"Protein Based Biomaterials for Therapeutic and Diagnostic Applications.","authors":"Stanley Chu, Andrew L Wang, Aparajita Bhattacharya, Jin Kim Montclare","doi":"10.1088/2516-1091/ac2841","DOIUrl":"10.1088/2516-1091/ac2841","url":null,"abstract":"Proteins are some of the most versatile and studied macromolecules with extensive biomedical applications. The natural and biological origin of proteins offer such materials several advantages over their synthetic counterparts, such as innate bioactivity, recognition by cells and reduced immunogenic potential. Furthermore, proteins can be easily functionalized by altering their primary amino acid sequence and can often be further self-assembled into higher order structures either spontaneously or under specific environmental conditions. This review will feature the recent advances in protein-based biomaterials in the delivery of therapeutic cargo such as small molecules, genetic material, proteins, and cells. First, we will discuss the ways in which secondary structural motifs, the building blocks of more complex proteins, have unique properties that enable them to be useful for therapeutic delivery. Next, supramolecular assemblies, such as fibers, nanoparticles, and hydrogels, made from these building blocks that are engineered to behave in a cohesive manner, are discussed. Finally, we will cover additional modifications to protein materials that impart environmental responsiveness to materials. This includes the emerging field of protein molecular robots, and relatedly, protein-based theranostic materials that combine therapeutic potential with modern imaging modalities, including near-infrared fluorescence spectroscopy (NIRF), single-photo emission computed tomography/computed tomography (SPECT/CT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasound/photoacoustic imaging (US/PAI).","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691744/pdf/nihms-1755309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10806603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6