Precision nutrition最新文献

{"title":"Effect of nutrition education based on IIFAR regimen on patients with gastrointestinal cancer complicated with diabetes mellitus","authors":"Xiaoling Li, Weijing Qi, Chun-Wei Chen, Feng Yang, Yanhong Ge, Zengning Li","doi":"10.1097/PN9.0000000000000045","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000045","url":null,"abstract":"Background: For patients with gastrointestinal cancer complicated with diabetes, carrying out more effective nutrition education is recommended. However, the current nutrition education protocol is ineffective, resulting in patients suffering from malnutrition and poor blood glucose control. The best education strategy for dietary behavior change in patients with gastrointestinal cancer complicated with diabetes is still unclear. Objective: This article aimed to determine the feasibility, acceptability, and preliminary efficacy of IIFAR (initial check, information exchange, final accuracy check, and response) based nutrition education protocol in patients of gastrointestinal cancer complicated with diabetes. Method: A total of 80 patients with gastrointestinal cancer complicated with diabetes during chemotherapy were recruited from June 2021 to June 2022. They were randomly divided into control group and intervention group with 40 cases each. The control group received routine nutrition education. The intervention group received nutrition education based on the IIFAR regimen. The dietary structure, nutritional status, and blood glucose level before and after intervention were compared between the two groups. Result: The nutritional status and blood glucose control in the intervention group were better than those in the control group. Dietary surveys in the intervention group showed a healthier diet. Nutrition knowledge–attitude–behavior survey showed that the intervention group scored higher than the control group. Conclusion: Nutrition education based on the IIFAR program is feasible and effective for this population. In particular, IIFAR-based nutrition education during the active phase of patients’ cancer treatment provides health benefits. Further translational research is also needed to determine the feasibility, enablers, and barriers for clinicians embedding this approach into routine cancer survivorship care.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 1","pages":"e00045"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46675351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of consuming a Mediterranean-style diet during pregnancy on neurodevelopmental disabilities in offspring: results from the Boston Birth Cohort.","authors":"Xiaoyu Che, Susan M Gross, Guoying Wang, Xiumei Hong, Colleen Pearson, Tami Bartell, Xiaobin Wang","doi":"10.1097/PN9.0000000000000047","DOIUrl":"10.1097/PN9.0000000000000047","url":null,"abstract":"<p><strong>Background: </strong>While consuming a Mediterranean-style diet (MSD) among pregnant women is expected to affect offspring neurodevelopment, the current evidence is limited. This prospective birth cohort study aimed to explore the association of maternal MSD with neurodevelopmental disabilities (NDD) in offspring, especially among children born to mothers with overweight or obesity (OWO) and/or diabetes mellitus (DM) since they have a higher risk for oxidative stress and immune/metabolic disturbances.</p><p><strong>Methods: </strong>We analyzed data from a subgroup of mother-child dyads enrolled in the Boston Birth Cohort. Maternal dietary information (<i>via</i> food frequency questionnaires, Food frequency questionnaires [FFQ]) and sociodemographic information were obtained <i>via</i> in-person interviews within 24 to 72 hours postpartum. Maternal clinical information and child diagnosis of NDD including autism, attention-deficit/hyperactivity disorder (ADHD), and other developmental disabilities (DD) were extracted from medical records. A Mediterranean-style diet score (MSDS) was calculated using the FFQ. The association of maternal MSDS with NDD, autism, ADHD, and other DD was evaluated using multivariable logistic regression models adjusted for pertinent covariates.</p><p><strong>Results: </strong>This study included 3153 mother-child pairs, from which we identified diagnoses of 1362 (43.2%) NDD, including 123 (3.9%) case of autism, 445 (14.1%) ADHD, and 794 (25.2%) other DD. In the overall sample, women with a higher maternal MSDS (per standard deviation increase) were less likely to have offspring with NDD (adjusted odds ratio [OR]: 0.904, 95% confidence interval [CI]: 0.817-1.000; <i>P</i> value: 0.049). Using MSDS quintile 1 as the reference, being in the combined group of quintiles 3-5 was associated with a 26% lower likelihood of NDD (adjusted OR: 0.738, 95% CI: 0.572-0.951; <i>P</i> value: 0.019). When stratified by mothers with OWO/DM <i>vs.</i> without OWO/DM, the association between maternal MSDS and offspring NDD was greater in children born to mothers with OWO/DM.</p><p><strong>Conclusions: </strong>In this prospective birth cohort, a higher maternal MSDS was associated with a lower likelihood of NDD in the offspring. Furthermore, this association of maternal MSDS with offspring NDD was greater in children born to women with OWO/DM. More studies are needed to replicate the findings and further analyze NDD subgroups and explore underlying molecular pathways.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 3","pages":"e00047"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/7d/pn9-2-e00047.PMC10513021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamical monitoring and causal inference for respiratory metabolic indicators of septic patients","authors":"Mei G Sun, Yunhan Wang, Han-yang Yue, Jianguo Hou, Jun Li, Qiyu Wu, Hua Jiang, Qi Wang","doi":"10.1097/PN9.0000000000000042","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000042","url":null,"abstract":"Background: The objective of this study is to develop monitoring and predictive models for respiratory dynamics of sepsis to improve the emergency medical care of septic shock patients. Methods: We develop two patient-specific models to recognize and forecast the respiratory dynamics of a septic shock patient using the patient’s longitudinal data of three respiratory metabolic indicators PO2, PCO2, and SpO2, obtained from the arterial blood gas analysis over 8 days. The first is based on the neural dynamical system architecture while the second is on the long and short-term memory (LSTM) recurrent neural network (RNN) architecture. The causal relations among the indicators are inferred via information flow theory from the dynamical system models. Results: The models recognize the respiratory dynamics of the septic patient very well and can make short-term predictions with clinically acceptable relative errors of less than 5.2% in the L1 and L2 norm and less than 8.2% in the L norm, attesting to the effectiveness of the models. The subsequent causal analysis shows that SpO2 or PO2 is, respectively, the cause of PCO2, while there exist mutually causal relationships between SpO2 and PO2, consistent with the clinical experience. Conclusions: These models provide useful quantitative tools for physicians to make critical diagnostic and treatment decisions for septic shock patients in emergency situations.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 1","pages":"e00042"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48430825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Smoking-Hypertension Paradox in Pregnancy: Insight from a Multiethnic US Birth Cohort.","authors":"H M Garrison-Desany,&nbsp;C Ladd-Acosta,&nbsp;X Hong,&nbsp;G Wang,&nbsp;I Burd,&nbsp;Z M Sanchez,&nbsp;X Wang,&nbsp;P J Surkan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Smoking during pregnancy has been associated with reduced risk of a spectrum of hypertensive (HTN) disorders, known as the \"smoking-hypertension paradox.\"</p><p><strong>Objective: </strong>We sought to test potential epidemiologic explanations for the smoking-hypertension paradox.</p><p><strong>Methods: </strong>We analyzed 8,510 pregnant people in the Boston Birth Cohort, including 4,027 non-Hispanic Black and 2,428 Hispanic pregnancies. Study participants self-reported tobacco, alcohol, cannabis, opioids, or cocaine use during pregnancy. We used logistic regression to assess effect modification by race/ethnicity, and confounding of concurrent substances on hypertensive disorders or prior pregnancy. We also investigated early gestational age as a collider or competing risk for pre-eclampsia, using cause-specific Cox models and Fine-Gray models, respectively.</p><p><strong>Results: </strong>We replicated the paradox showing smoking to be protective against hypertensive disorders among Black participants who used other substances as well (aOR: 0.61, 95% CI: 0.41, 0.93), but observed null effects for Hispanic participants (aOR: 1.14, 95% CI: 0.55, 2.36). In our cause-specific Cox regression, the effects of tobacco use were reduced to null effects with pre-eclampsia (aOR: 0.81, 95% CI: 0.63, 1.04) after stratifying for preterm birth. For the Fine-Gray competing risk analysis, the paradoxical associations remained. The smoking paradox was either not observed or reversed after accounting for race/ethnicity, other substance use, and collider-stratification due to preterm birth.</p><p><strong>Conclusions: </strong>These findings offer new insights into this paradox and underscore the importance of considering multiple sources of bias in assessing the smoking-hypertension association in pregnancy.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the smoking-hypertension paradox in pregnancy: insight from a multiethnic US birth cohort.","authors":"Henri M Garrison-Desany,&nbsp;Christine Ladd-Acosta,&nbsp;Xiumei Hong,&nbsp;Guoying Wang,&nbsp;Irina Burd,&nbsp;Zila van der Meer Sanchez,&nbsp;Xiaobin Wang,&nbsp;Pamela J Surkan","doi":"10.1097/PN9.0000000000000035","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000035","url":null,"abstract":"<p><strong>Background: </strong>Smoking during pregnancy has been associated with reduced risk of a spectrum of hypertensive (HTN) disorders, known as the \"smoking-hypertension paradox.\"</p><p><strong>Objective: </strong>We sought to test potential epidemiologic explanations for the smoking-hypertension paradox.</p><p><strong>Methods: </strong>We analyzed 8510 pregnant people in the Boston Birth Cohort, including 4027 non-Hispanic Black and 2428 Hispanic pregnancies. Study participants self-reported tobacco, alcohol, cannabis, opioids, or cocaine use during pregnancy. We used logistic regression to assess effect modification by race/ethnicity, and confounding of concurrent substances on hypertensive disorders or prior pregnancy. We also investigated early gestational age as a collider or competing risk for pre-eclampsia, using cause-specific Cox models and Fine-Gray models, respectively.</p><p><strong>Results: </strong>We replicated the paradox showing smoking to be protective against hypertensive disorders among Black participants who used other substances as well (aOR: 0.61, 95% CI: 0.41, 0.93), but observed null effects for Hispanic participants (aOR: 1.14, 95% CI: 0.55, 2.36). In our cause-specific Cox regression, the effects of tobacco use were reduced to null effects with pre-eclampsia (aOR: 0.81, 95% CI: 0.63, 1.04) after stratifying for preterm birth. For the Fine-Gray competing risk analysis, the paradoxical associations remained. The smoking paradox was either not observed or reversed after accounting for race/ethnicity, other substance use, and collider-stratification due to preterm birth.</p><p><strong>Conclusions: </strong>These findings offer new insights into this paradox and underscore the importance of considering multiple sources of bias in assessing the smoking-hypertension association in pregnancy.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 2","pages":"e00035"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, biosafety, and metabolic impacts of feeding mice egg yolks enriched with three bioactive nutrients in different combinations","authors":"Keith J. Ou, A. Magnuson, X. Lei","doi":"10.1097/PN9.0000000000000039","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000039","url":null,"abstract":"Background: Docosahexaenoic acid (DHA), 25-hydroxyvitamin D3 (25-OH D3), and astaxanthin (AST) are three bioactive and health-promoting nutrients. We previously enriched eggs with DHA alone and in combination with 25-OH D3 and (or) AST as a novel food source of these nutrients by the public. This study was to determine dietary efficacy, biosafety, and metabolic impacts and mechanisms of feeding these egg yolks with four different enrichments of the three nutrients in mice. Methods: Eighty mice (23- to 40-week-old, n = 8, four males and females each) were divided into two experiments and were fed a sucrose-yeast basal diet with control egg yolk (BD) or one of the four types of enriched yolks (BD + DHA, BD + DHA + 25-OH D3, BD + DHA + AST, and BD + DHA + 25-OH D3 + AST) at recommended (1X, Experiment I) and high dose (5X, Experiment II) for 6 weeks. Concentrations of fatty acids, 25-OH D3, AST, and lipids and expression of genes and proteins related to lipid and vitamin D metabolism in the plasma, liver, and (or) heart were determined. Data within each experiment were analyzed by one-way ANOVA. Results: Compared with BD, the four diets with enriched yolks at the 1X level elevated (P < 0.001, up to 61%) hepatic DHA concentrations. Feeding the enriched yolks at either dose did not affect body weights or plasma glucose and triacylglycerol concentrations. In Experiment I, total cholesterol concentrations were 40% higher (P < 0.05) in the liver of BD + DHA than BD and were 1.5-fold higher (P < 0.05) in the heart of BD + DHA + 25-OH D3 + AST than BD + DHA + 25-OH D3. Compared with BD + DHA, BD + DHA + 25-OH D3 upregulated (P < 0.05) hepatic Dgat1 gene expression by 1.4-fold and hepatic DGAT1 protein expression by 1.7-fold. Conclusions: Feeding mice egg yolks enriched with DHA alone or with other nutrients at two doses (1X and 5X) improved hepatic DHA status and exerted moderate impacts on tissue lipid profiles and the related gene expressions. These eggs may be safe for future human trials.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 1","pages":"e00039"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46850517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-hydroxybutyrate inhibits cellular proliferation, EMT, stemness, migration, and invasion in glioma cells","authors":"Junrong Yang, Ning Zhang, Zhengping Wang, Qingpeng Wang, Jun Han, Muhammad Akram Khan, Aayesha Riaz, Chongfei Chang","doi":"10.1097/PN9.0000000000000038","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000038","url":null,"abstract":"Glioma is the most common and account for 81% of intracranial malignancies. Ketogenic dietary intervention in patients with glioma has been more and more popular. However, the current research mechanism on β-hydroxybutyrate (BHB) and glioma is not clear, and we have explored the mechanism of BHB inhibiting glioma. Western blot, polymerase chain reaction (PCR), and immunofluorescence were used to study the relationship between BHB and proliferation, stemness, epithelial mesenchymal transformation, migration, and invasion of glioma U251 cells. In the present study, our results showed that BHB treatment downregulated the expressions of epithelial-to-mesenchymal transition (EMT)-related proteins including N-cadherin and vimentin, while upregulated the expression of E-cadherin in U251 glioma cells, when compared with control group. Meanwhile, the expressions of matrix metallopeptidase (MMP)2, MMP9, and vascular endothelial growth factor A (VEGFA) proteins were decreased in BHB-treated group. The expression levels of TGF-β, p-phosphatidylinositol-3-kinase (PI3K), p-protein kinase B (Akt), p-glycogen synthase kinase 3β (GSK-3β), Wnt5a, β-catenin, and Snail were decreased in the BHB-treated group, as our results showed. Additionally, BHB treatment downregulated the expressions of p-Janus kinase 2 (JAK2) and p-signal transducer and activator of transcription 3 (STAT3) proteins, which are related to migration of glioma cells, respectively. In addition, BHB inhibited glioma stemness genes such as CD133, ALDH1, SOX2, and Olig2. Altogether, present study concluded that BHB inhibited proliferation, EMT, and migration of glioma cells by inhibiting transforming growth factor (TGF)-β/PI3K/Akt/GSK-3β, Wnt5a/β-catenin/Snail, and interleukin (IL)-6/JAK2/STAT3 signaling pathways, therefore, with a diet containing BHB will benefit the glioma patients.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 1","pages":"e00038"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45229993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Nutrition and Developmental Origins of Health and Disease.","authors":"Xiaobin Wang","doi":"10.1097/PN9.0000000000000040","DOIUrl":"10.1097/PN9.0000000000000040","url":null,"abstract":"","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 2","pages":"e00040"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/e1/pn9-2-e00040.PMC10599801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and joint association of cord plasma pantothenate and cysteine levels with autism spectrum disorders and other neurodevelopmental disabilities in children born term and preterm.","authors":"Ramkripa Raghavan, Guoying Wang, Xiumei Hong, Colleen Pearson, Hehuang Xie, William G Adams, Marilyn Augustyn, Xiaobin Wang","doi":"10.1097/PN9.0000000000000036","DOIUrl":"10.1097/PN9.0000000000000036","url":null,"abstract":"<p><strong>Background: </strong>Pantothenate (vitamin B5) is a precursor for coenzyme A (CoA) synthesis, which serves as a cofactor for hundreds of metabolic reactions. Cysteine is an amino acid in the CoA synthesis pathway. To date, research on the combined role of early life pantothenate and cysteine levels in childhood neurodevelopmental disabilities is scarce.</p><p><strong>Objective: </strong>To study the association between cord pantothenate and cysteine levels and risk of autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and other developmental disabilities (DD) in children born term and preterm.</p><p><strong>Methods: </strong>The study sample (<i>n</i> = 996, 177 born preterm) derived from the Boston Birth Cohort included 416 neurotypical children, 87 ASD, 269 ADHD, and 224 other DD children, who were mutually exclusive. Participants were enrolled at birth and were followed up prospectively (from October 1, 1998, to June 30, 2018) at the Boston Medical Center. Cord blood sample was collected at birth. Plasma pantothenate and cysteine levels were measured using liquid chromatography-tandem mass spectrometry.</p><p><strong>Results: </strong>Higher cord pantothenate (≥50th percentile <i>vs.</i> <50th percentile) was associated with a greater risk of ASD (adjusted odds ratio [aOR]: 1.94, 95% confidence interval [CI]: 1.06, 3.55) and ADHD (aOR: 1.66, 95% CI: 1.14, 2.40), after adjusting for potential confounders. However, cord cysteine alone was not associated with risk of ASD, ADHD, or other DD. When considering the joint association, greater ASD risk was noted when both cord pantothenate and cysteine levels were elevated (≥50th percentile) (aOR: 3.11, 95% CI: 1.24, 7.79), when compared to children with low cord pantothenate (<50th percentile) and high cysteine. Even though preterm and higher pantothenate independently increased the ASD risk, the greatest risk was found in preterm children who also had elevated pantothenate (≥50th percentile), which was true for all three outcomes: ASD (aOR: 5.36, 95% CI: 2.09, 13.75), ADHD (aOR: 3.31, 95% CI: 1.78, 6.16), and other DD (aOR: 3.39, 95% CI: 1.85, 6.24).</p><p><strong>Conclusions: </strong>In this prospective birth cohort, we showed that higher cord pantothenate individually and in combination with higher cysteine or preterm birth were associated with increased risk of ASD and ADHD. More study is needed to explore this biologically plausible pathway.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 2","pages":"e00036"},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/3c/pn9-2-e00036.PMC10513014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining longitudinal trajectory of body mass index percentile and predicting childhood obesity: methodologies and findings in the Boston Birth Cohort.","authors":"Wanyu Huang,&nbsp;Anat Yaskolka Meir,&nbsp;Bolanle Olapeju,&nbsp;Guoying Wang,&nbsp;Xiumei Hong,&nbsp;Maya Venkataramani,&nbsp;Tina L Cheng,&nbsp;Tak Igusa,&nbsp;Liming Liang,&nbsp;Xiaobin Wang","doi":"10.1097/PN9.0000000000000037","DOIUrl":"10.1097/PN9.0000000000000037","url":null,"abstract":"<p><strong>Background: </strong>Overweight or obesity (OWO) in school-age childhood tends to persist into adulthood. This study aims to address a critical need for early identification of children at high risk of developing OWO by defining and analyzing longitudinal trajectories of body mass index percentile (BMIPCT) during early developmental windows.</p><p><strong>Methods: </strong>We included 3029 children from the Boston Birth Cohort (BBC) with repeated BMI measurements from birth to age 18 years. We applied locally weighted scatterplot smoothing with a time-limit scheme and predefined rules for imputation of missing data. We then used time-series <i>K</i>-means cluster analysis and latent class growth analysis to define longitudinal trajectories of BMIPCT from infancy up to age 18 years. Then, we investigated early life determinants of the BMI trajectories. Finally, we compared whether using early BMIPCT trajectories performs better than BMIPCT at a given age for predicting future risk of OWO.</p><p><strong>Results: </strong>After imputation, the percentage of missing data ratio decreased from 36.0% to 10.1%. We identified four BMIPCT longitudinal trajectories: early onset OWO; late onset OWO; normal stable; and low stable. Maternal OWO, smoking, and preterm birth were identified as important determinants of the two OWO trajectories. Our predictive models showed that BMIPCT trajectories in early childhood (birth to age 1 or 2 years) were more predictive of childhood OWO (age 5-10 years) than a single BMIPCT at age 1 or 2 years.</p><p><strong>Conclusions: </strong>Using longitudinal BMIPCT data from birth to age 18 years, this study identified distinct BMIPCT trajectories, examined early life determinants of these trajectories, and demonstrated their advantages in predicting childhood risk of OWO over BMIPCT at a single time point.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"2 2","pages":"e00037"},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/e2/pn9-2-e00037.PMC10513013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}