Precision nutrition最新文献

{"title":"Association of ω-3 and ω-6 polyunsaturated fatty acids with tumors: a scoping review","authors":"Fangqi Li, Jiuwei Cui","doi":"10.1097/PN9.0000000000000072","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000072","url":null,"abstract":"ω-3 polyunsaturated fatty acids (PUFAs) and ω-6 PUFAs are two types of essential PUFAs that must be obtained from food. They are metabolized by the same enzyme system to produce different cytokines, performing different functions. Previous studies have suggested that ω-3 PUFAs have anti-inflammatory, while ω-6 PUFAs have the pro-inflammatory effect on humans. However, there is growing recognition that this view may be too simple. Using tumor as an example, numerous preclinical studies have found that both ω-3 PUFAs and ω-6 PUFAs are associated with tumors, including tumor metabolism and tumor microenvironment. However, their role in tumors may vary, depending on their relative balance. This is in part because they undergo the same enzymatic metabolism. Notably, the ratio of ω-6/ω-3 PUFAs in the diet affects the anti-inflammatory and anti-tumor effects, and ω-6 PUFAs, although regarded as pro-inflammatory, may also have anti-tumor properties under certain conditions. This scoping review aims to summarize the latest literature regarding the metabolic pathways of ω-3 and ω-6 PUFAs and their relationships with tumors. Such updated information will be helpful to clinical and public health professionals regarding the role of ω-3 and ω-6 PUFAs in the prevention and treatment of tumors.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"122 5","pages":"e00072"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific association of serum cystatin C with the risks of 24 type of cancer: pan-cancer analyses in the UK Biobank","authors":"Yuanyuan Zhang, Yanjun Zhang, Z. Ye, Sisi Yang, Mengyi Liu, Qimeng Wu, Chun Zhou, P. He, Xiaoqin Gan","doi":"10.1097/PN9.0000000000000073","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000073","url":null,"abstract":"Background: We aim to investigate the associations of circulating cystatin C (Cyst-C) concentrations with the risk of different cancers in men and women, using a pan-cancer approach, including 24 cancers in UK Biobank. Methods: A total of 421,867 cancer-free participants from the UK Biobank study were included. We restricted analyses to cancers with a minimum of 100 recorded cases in men or women. Results: During a median follow-up of 10.7 years, in both men and women, circulating Cyst-C concentrations (per standard deviation [SD] increment) were significantly and positively associated with the risks of kidney cancer, lung cancer, leukemia, mesothelial and soft tissue cancer, multiple myeloma, non-Hodgkin lymphoma and liver cancer, with a range of adjusted hazard ratios (HR) from 1.09 (95% confidence interval [CI]: 1.01–1.18) for kidney cancer in women to 1.27 (95% CI: 1.17–1.38) for liver cancer in women. In addition, only in men, higher Cyst-C concentrations (per SD increment) were associated with higher risks of head and neck cancer (adjusted HR, 1.10; 95% CI: 1.02–1.21), esophagus cancer (adjusted HR, 1.09; 95% CI: 1.01–1.17), and pancreas cancer (adjusted HR, 1.15; 95% CI: 1.07–1.24), as well as a lower risk of prostate cancer (adjusted HR, 0.95; 95% CI: 0.93–0.98). Meanwhile, only in women, higher Cyst-C concentrations (per SD increment) were related to higher risks of brain or central nervous system or intracranial cancer (adjusted HR, 1.18; 95% CI: 1.09–1.27) and urinary tract cancer (adjusted HR, 1.10; 95% CI: 1.02–1.19). Conclusions: Circulating Cyst-C was significantly associated with multiple human cancers in men or women. Our results suggest that circulating Cyst-C may serve as a potential biomarker for identifying multiple human cancers.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"210 1","pages":"e00073"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and correlates of plasma folate, vitamin B12, and homocysteine in a sample of low-income minority children aged 6 months to 9 years in the U.S.","authors":"Yuyi Chen, Xiaoyu Che, Ramkripa Raghavan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Precision nutrition emphasizes tailoring dietary requirements across populations and life stages. Optimal folate and vitamin B12 levels are important for normal growth and development, but data are lacking for low-income minority U.S. children during early life periods. This study aimed to describe folate, vitamin B12, homocysteine (Hcy) levels, and influencing factors to address the gaps.</p><p><strong>Methods: </strong>Blood samples from children aged 6 months to 9 years and mothers 48-72 hours postpartum in the Boston Birth Cohort (BBC) were tested for folate, vitamin B12, and Hcy. Maternal and child characteristics, sociodemographic factors, and feeding status were obtained from a standard maternal questionnaire interview at the enrollment and follow-up, and medical records. The distribution of children's folate, vitamin B12, and Hcy were described and factors influencing these biomarkers were analyzed.</p><p><strong>Results: </strong>A wide distribution of folate, vitamin B12, and Hcy levels was observed in this sample, with longitudinal trends consistent with National Health and Nutrition Examination Survey (NHANES) data. Multivariate analysis showed that very preterm birth correlated with higher folate levels (adjusted β 4.236; 95% CI: 1.218, 7.253; p=0.006). Children aged 1-2 years and 3-8 years had lower folate levels compared to those <1 year (adjusted β -10.191 and -7.499 respectively; p<0.001). Vitamin B12 levels were higher in Black children (adjusted fold change 1.139; 95% CI: 1.052, 1.233; p=0.001) and those children whose mothers' B12 levels were at the highest quartile (Q4) (adjusted fold change 1.229; 95% CI: 1.094, 1.380; p=0.001). Delayed solid food introduction (> 6 months) correlated with lower children's B12 levels (adjusted fold change 0.888; 95% CI: 0.809, 0.975; p=0.013). Hcy levels were lower in Black children (adjusted fold change 0.962; 95% CI: 0.932, 0.993; p=0.018), higher in children with maternal Hcy levels in Q4 (adjusted fold change 1.081; 95% CI: 1.03, 1.135; p=0.002) and in children aged 3-8 years (adjusted fold change 1.084; 95% CI: 1.040, 1.131; p< 0.001).</p><p><strong>Conclusions: </strong>This study revealed wide variations in plasma folate, vitamin B12, and Hcy levels among low-income minority U.S. children and identified race, maternal levels, child's age, prematurity, and timing of solid food introduction as significant correlates.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folic acid supplementation and serum trimethylamine oxide (TMAO) lowering: new insight from the post hoc analysis of Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy)","authors":"Ziheng Tan, C. Ding, Junpei Li, T. Cao, Lishun Liu, Yun Song, Ping Chen, Yan Zhang, Jianping Li, Y. Huo, Hong Wang, H. Bao, Xiao Huang, Xiaoshu Cheng","doi":"10.1097/PN9.0000000000000075","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000075","url":null,"abstract":"Background: The impact of folic acid supplementation on trimethylamine oxide (TMAO) levels in hypertensive patients have not been well-studied. This study sought to investigate the association between folic acid supplementation in a range of doses and corresponding change in serum TMAO levels among Chinese hypertensive patients. Methods: This is a post hoc analysis of 1562 hypertensive patients from Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy) who were randomly assigned to one of eight folic acid daily treatment groups ranging from 0 to 2.4 mg (0, 0.4, 0.6, 0.8, 1.2, 1.6, 2.0, 2.4 mg). The duration of the treatment was 8 weeks. The endpoint of this study was the reduction in TMAO levels by the end of 8-week treatment compared to the baseline level. Results: In the overall sample, as the dosage of folic acid supplementation escalated from 0 to 2.4 mg, there was no statistically significant association between folic acid supplementation and TMAO changes. However, subgroup analysis revealed that the association between folic acid supplementation and TMAO lowering differed by the baseline TMAO levels. When baseline TMAO was in the lowest tertile (<1.4 μmol/L) or the middle tertile (1.4–2.5 μmol/L), there was no association between folic acid supplementation and TMAO changes. However, among those with baseline TAMO in the highest tertile (>2.5 μmol/L), there was a significant inverse association between folic acid supplementation dosage and TMAO changes, the adjusted β (95% confidence interval [CI]) among those with the highest TMAO tertile was −0.58 (−1.10, −0.06); (P for interaction, 0.009). In this subgroup, we further observed that those with baseline elevated total homocysteine (tHcy) levels benefited even more from folic acid supplementation (P for interaction: 0.047). Conclusions: In this sample of Chinese adults with hypertension, folic acid supplementation can significantly lower serum TMAO levels in the subgroup with elevated serum TMAO levels (>2.5 μmol/L), and within this subgroup, those with concomitantly elevated tHcy benefited even more.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"94 3","pages":"e00075"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141411344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and correlates of plasma folate, vitamin B12, and homocysteine in a sample of low-income minority children aged 6 months to 9 years in the U.S.","authors":"Yuyi Chen, Xiaoyu Che, Ramkripa Raghavan","doi":"10.1097/PN9.0000000000000074","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000074","url":null,"abstract":"Background: Precision nutrition emphasizes tailoring dietary requirements across populations and life stages. Optimal folate and vitamin B12 levels are important for normal growth and development, but data are lacking for low-income minority U.S. children during early life periods. This study aimed to describe folate, vitamin B12, homocysteine (Hcy) levels, and influencing factors to address the gaps. Methods: Blood samples from children aged 6 months to 9 years and mothers 48 to 72 hours postpartum in the Boston Birth Cohort (BBC) were tested for folate, vitamin B12, and Hcy. Maternal and child characteristics, sociodemographic factors, and feeding status were obtained from a standard maternal questionnaire interview at the enrollment and follow-up, and medical records. The distribution of children’s folate, vitamin B12, and Hcy were described and factors influencing these biomarkers were analyzed. Results: A wide distribution of folate, vitamin B12, and Hcy levels was observed in this sample, with longitudinal trends consistent with National Health and Nutrition Examination Survey (NHANES) data. Multivariate analysis showed that very preterm birth correlated with higher folate levels (adjusted β = 4.236; 95% confidence interval [CI]: 1.218, 7.253; P = 0.006). Children aged 1 to 2 years and 3 to 8 years had lower folate levels compared to those <1 year (adjusted β = −10.191 and −7.499 respectively; P < 0.001). Vitamin B12 levels were higher in Black children (adjusted fold change 1.139; 95% CI: 1.052, 1.233; P = 0.001) and those children whose mothers’ B12 levels were at the highest quartile (Q4) (adjusted fold change 1.229; 95% CI: 1.094, 1.380; P = 0.001). Delayed solid food introduction (>6 months) correlated with lower children’s B12 levels (adjusted fold change 0.888; 95% CI: 0.809, 0.975; P = 0.013). Hcy levels were lower in Black children (adjusted fold change 0.962; 95% CI: 0.932, 0.993; P = 0.018), but higher in children with maternal Hcy levels in Q4 (adjusted fold change 1.081; 95% CI: 1.03, 1.135; P = 0.002) and in children aged 3 to 8 years (adjusted fold change 1.084; 95% CI: 1.040, 1.131; P < 0.001). Conclusions: This study revealed wide variations in plasma folate, vitamin B12, and Hcy levels among low-income minority U.S. children and identified race, maternal levels, child’s age, prematurity, and timing of solid food introduction as significant correlates.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"23 8","pages":"e00074"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Life Origins of Neurodevelopmental Disabilities in the Boston Birth Cohort: Research findings and future directions.","authors":"Ramkripa Raghavan, Xiaobin Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neurodevelopmental disabilities (NDD) are a group of conditions with onset in early development period and is characterized by limitations in several functional domains. Autism spectrum disorder (ASD) and Attention-Deficit Hyperactivity Disorders (ADHD), the most common NDDs, have complex etiologies and possibly multiple pathways leading up to the manifestation of these disorders. Boston Birth Cohort (BBC) is a preterm enriched birth cohort, and over the years, researchers have used the BBC dataset to study a broad spectrum of early life protective and risk factors in the context of NDDs. Broadly, some of them include: 1) nutrition (e.g. maternal folate, vitamin B12, cord folate species, selenium), 2) metabolic factors (e.g. role of maternal diabetes, obesity, branched chain amino acids and other essential amino acids), 3) lipid metabolism (e.g. maternal cholesterol), 4) immune activation and/or systematic inflammation (including maternal immune activation, inflammation of the placenta, inflammatory markers, maternal antibiotic use and acetaminophen use), and 5) other factors associated with NDDs (e.g. maternal stress, sickle cell disease). The findings from these studies are discussed in this review. BBC studies have advanced the field of NDD in the following important ways: 1) generating evidence that sheds light on new exposures, 2) furthering the existing knowledge using better methodological approaches, 3) analyzing novel mechanistic pathways on already proven relationship, and 4) advancing knowledge on the under-studied minority population in the U.S. BBC researchers are involved in ongoing efforts to characterize NDD developmental trajectories across the life stages by integrating multi-omics data (genome, epigenome, and metabolome) to gain a deeper understanding of the molecular pathways by which early life factors drive or shape the developmental trajectories of NDDs.</p>","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and status of vitamin B12 in Chinese adults with hypertension: a comprehensive report across 14 provinces","authors":"T. Cao, Xiao Huang, Ping Chen, Zena Huang, Zaihua Cheng, Wenyang Lu, J. Spence, Hanping Shi, Xiaoshu Cheng, Lishun Liu, J. Spence, Liu L. Distribution","doi":"10.1097/PN9.0000000000000060","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000060","url":null,"abstract":"Background: Vitamin B12 (VB12) is an essential biomarker for population health, and its deficiency status leads to severe health burdens. A comprehensive and updated investigation on the distribution of VB12 levels and status is critically needed to address public health and clinical concerns. Methods: We conducted a cross-sectional analysis using data obtained from the Precision Medical Program, which encompassed 14 provinces in China. Specific criteria based on previously published cutoffs and our study population’s characteristics are adopted to define B12 deficiency. Biochemical B12 deficiency was identified with circulating VB12 levels <148 pmol/L. Metabolic B12 deficiency was determined with circulating VB12 levels ≥148 and ≤258 pmol/L with concomitant elevated plasma total homocysteine (tHcy ≥14 µmol/L). Normal B12 status included VB12 levels >258 pmol/L or VB12 levels ranging from 148 to 258 pmol/L with tHcy levels below 14 µmol/L. VB12 levels and status were analyzed and stratified by age, sex, and geographical region. Results: This study enrolled a total of 2174 hypertensive adults, with a mean age of 63.0 years (±13.4) and 45.8% female. The overall mean VB12 levels were 322.3 (85.0) pmol/L. The prevalence rates of B12 biochemical deficiency, metabolic deficiency, metabolic deficiency with excluded renal dysfunction, and adequate status were 0.7%, 13.3%, 11.5%, and 85.9%, respectively. Females exhibited higher VB12 levels than males, with a β value of 19.72 (95% confidence interval [CI], 10.59–28.84) in the multivariate model. The southern population demonstrated higher VB12 levels than people from the north, with a β value of −18.14 (95% CI, −25.72 to −10.76). Males had a higher prevalence of metabolic VB12 deficiency in comparison to females (15.8% vs. 10.4%). Conclusions: Our study revealed that Chinese hypertensive adults exhibit relatively higher levels of VB12. Additionally, while biochemical B12 deficiency is uncommon, a noteworthy proportion of individuals were affected by metabolic VB12 deficiency. This study has important implications for nutritional counseling and vitamin B supplement strategies.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"59 2","pages":"e00060"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of several serum folate forms with the prevalence of hypertension","authors":"Qimeng Wu, Chun Zhou, Z. Ye, Mengyi Liu, Zhuxian Zhang, P. He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin","doi":"10.1097/PN9.0000000000000058","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000058","url":null,"abstract":"Background: The relationship of different serum forms of folate with the prevalence of hypertension remains uncertain. We aim to examine the association of several folate forms (5-methyltetrahydrofolate [5-mTHF], unmetabolized folic acid [UMFA], and MeFox [an oxidation product of 5-mTHF]) with the prevalence of hypertension. Methods: This cross-sectional study included 19,237 participants from the National Health and Nutrition Examination Survey 2011–2018. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or a self-reported diagnosis of hypertension by a physician, or current anti-hypertensive treatment. Results: The prevalence of hypertension was 39.3%. When serum 5-mTHF was assessed as quartiles, a significantly lower prevalence of hypertension was found in participants in quartiles 3 to 4 (≥34.0 nmol/L) (odds ratio [OR], 0.86; 95% confidence interval [CI], 0.76–0.97), compared with those in quartiles 1 to 2. When serum UMFA was assessed as quartiles, a significantly higher prevalence of hypertension was found in participants in quartile 4 (≥1.0 nmol/L) (OR, 1.16; 95% CI, 1.03–1.31), compared with those in quartiles 1 to 3. When serum MeFox was assessed as quartiles, a significantly higher prevalence of hypertension was found in participants in quartiles 3 to 4 (≥1.4 nmol/L) (OR, 1.19; 95% CI, 1.06–1.34), compared with those in quartiles 1 to 2. Conclusions: Higher serum 5-mTHF levels were associated with a lower prevalence of hypertension, while higher serum UMFA and MeFox levels were associated with a higher prevalence of hypertension. If further confirmed, our findings highlight the importance of monitoring different serum forms of folate and may help guide future clinical trials and nutritional guidelines on folic acid supplementation for prevention of hypertension.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"4 1","pages":"e00058"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin E and risk of first stroke in general hypertensive patients: a nested case–control study","authors":"Sultan Mehmood Siddiqi, Ping Chen, Shuqun Li, Yaping Wei, Qiang-Qiang He, Ziyi Zhou, Jiafeng Xu, Jie Bai, Lishun Liu, Bin-yan Wang, Xiping Xu, X. Qin, Anam Mehmood, Yiming Du, Yun Song, Zhijie Zhang","doi":"10.1097/PN9.0000000000000055","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000055","url":null,"abstract":"Background: Epidemiological studies on the association between levels of plasma vitamin E and first stroke risk are inconclusive. Methods: A nested, case–control study was conducted utilizing data on 115,337 hypertensive patients from the H-type Hypertension and Stroke Prevention and Control Project. The current analysis comprised 2193 cases of first stroke and 2193 controls matched for age, sex, and study site. Results: The mean plasma concentration of vitamin E was 12.37 (3.61) μg/mL. The smoothing curve showed a linear correlation between plasma vitamin E levels and the risk of the first stroke. Hypertensive patients with plasma vitamin E levels ≥14.1 μg/mL (Q4) had an increased risk of first stroke (adjusted odds ratios [OR]: 1.18; 95% confidence interval [CI]: 1.01, 1.37) compared with those with plasma vitamin E < 14.1 μg/mL (Q1–Q3). Sub-group analysis revealed that the relationship between plasma vitamin E (≥14.1.1 vs. P interaction = 0.035). Conclusions: This study suggests that higher levels of plasma vitamin E are associated with an elevated risk of first stroke among Chinese hypertensive patients.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"62 23","pages":"e00055"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of cancer nutrition research from 2013 to 2022: a bibliometric and visualized analysis study","authors":"Chuying Zhang, Gege Zhang, Tiantian Wu, Saba Fida, Mingming Zhou, C. Song","doi":"10.1097/PN9.0000000000000054","DOIUrl":"https://doi.org/10.1097/PN9.0000000000000054","url":null,"abstract":"Background: The use of nutrition in cancer treatment has become increasingly widespread in recent decades, and the current stage of nutritional support and assessment has had a positive effect on reducing the side effects of cancer treatment. Based on the analysis of international literature on “tumor nutrition,” we identified the current status of research, research hotspots, and frontiers and provided a theoretical basis and reference for the development of related research in China. This study aimed to conduct a bibliometric analysis of the global literature published from 2013 to 2022 to assess the current research directions. Methods: The Web of Science core collection was searched from 2013 to 2022. The VOSviewer 1.6.19 and CiteSpace 6.2.2 were adopted to conduct the analysis. Results: Following the inclusion and exclusion criteria, a total of 28,245 documents were collected. The number of articles issued annually was fluctuatingly increasing. These articles were written by 124,412 authors from 20,162 affiliations in 166 countries or regions and were published in 3110 journals. The leading authors were Susan M. Gapstur, Heiner Boeing, and Hanping Shi. All publications were taken from 166 countries/regions and 20,162 organizations. The most productive countries were the United States and China. The most active institutions were the Harvard Medical School and University of Alberta. A total of 3110 journals contributed to this field, and the leading journals were Nutrients and Clinical Nutrition. The important author keywords occurred most frequently were cancer, nutrition, risk, survival, mortality, and sarcopenia. Conclusions: This study provided the dynamics and progress of nutrition research field. The studies about nutrition are booming. The current growth trend predicts that the global field of oncology nutrition will still increase. In addition to the traditional research on tumor nutrition, the development of interdisciplinary research should be promoted. Every country should strengthen international cooperation to enhance the influence of research results and solve many common scientific problems in the field of tumor nutrition research in multiple dimensions.","PeriodicalId":74488,"journal":{"name":"Precision nutrition","volume":"75 1","pages":"e00054"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}