PNAS nexusPub Date : 2024-11-19eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae442
Marisa Abrajano, Marianna Garcia, Aaron Pope, Robert Vidigal, Joshua A Tucker, Jonathan Nagler
{"title":"How reliance on Spanish-language social media predicts beliefs in false political narratives amongst Latinos.","authors":"Marisa Abrajano, Marianna Garcia, Aaron Pope, Robert Vidigal, Joshua A Tucker, Jonathan Nagler","doi":"10.1093/pnasnexus/pgae442","DOIUrl":"10.1093/pnasnexus/pgae442","url":null,"abstract":"<p><p>False political narratives are nearly inescapable on social media in the United States. They are a particularly acute problem for Latinos, and especially for those who rely on Spanish-language social media for news and information. Studies have shown that Latinos are vulnerable to misinformation because they rely more heavily on social media and messaging platforms than non-Hispanic whites. Moreover, fact-checking algorithms are not as robust in Spanish as they are in English, and social media platforms put far more effort into combating misinformation on English-language media than Spanish-language media, which compounds the likelihood of being exposed to misinformation. As a result, we expect that Latinos who use Spanish-language social media to be more likely to believe in false political narratives when compared with Latinos who primarily rely on English-language social media for news. To test this expectation, we fielded the largest online survey to date of social media usage and belief in political misinformation of Latinos. Our study, fielded in the months leading up to and following the 2022 midterm elections, examines a variety of false political narratives that were circulating in both Spanish and English on social media. We find that social media reliance for news predicts one's belief in false political stories, and that Latinos who use Spanish-language social media have a higher probability of believing in false political narratives, compared with Latinos using English-language social media.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae442"},"PeriodicalIF":2.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-19eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae481
Hause Lin, Marlyn Thomas Savio, Xieyining Huang, Miriah Steiger, Rachel L Guevara, Dali Szostak, Gordon Pennycook, David G Rand
{"title":"Accuracy prompts protect professional content moderators from the illusory truth effect.","authors":"Hause Lin, Marlyn Thomas Savio, Xieyining Huang, Miriah Steiger, Rachel L Guevara, Dali Szostak, Gordon Pennycook, David G Rand","doi":"10.1093/pnasnexus/pgae481","DOIUrl":"10.1093/pnasnexus/pgae481","url":null,"abstract":"<p><p>Content moderators review problematic content for technology companies. One concern is that repeated exposure to false claims could cause moderators to come to believe the very claims they are supposed to moderate, via the \"illusory truth effect.\" In a first lab-in-field experiment (<i>N</i> = 199) with a global content moderation company, we found that exposure to false claims while working as moderators increased subsequent belief among (mostly Indian and Philippine) employees by 7.1%. We tested an intervention to mitigate this effect: inducing an accuracy mindset. In both general population samples (<i>N</i> <sub>India</sub> = 997; <i>N</i> <sub>Philippines</sub> = 1,184) and a second lab-in-field experiment with professional moderators (<i>N</i> = 239), inducing participants to consider accuracy when first exposed to the claims eliminates the negative effects of exposure on belief in falsehoods. Our results show that the illusory truth effect and the protective power of an accuracy mindset generalize to non-Western populations and professional moderators.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae481"},"PeriodicalIF":2.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-12eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae456
Frank Emmert-Streib, Hocine Cherifi, Kimmo Kaski, Stuart Kauffman, Olli Yli-Harja
{"title":"Complexity data science: A spin-off from digital twins.","authors":"Frank Emmert-Streib, Hocine Cherifi, Kimmo Kaski, Stuart Kauffman, Olli Yli-Harja","doi":"10.1093/pnasnexus/pgae456","DOIUrl":"https://doi.org/10.1093/pnasnexus/pgae456","url":null,"abstract":"<p><p>Digital twins offer a new and exciting framework that has recently attracted significant interest in fields such as oncology, immunology, and cardiology. The basic idea of a digital twin is to combine simulation and learning to create a virtual model of a physical object. In this paper, we explore how the concept of digital twins can be generalized into a broader, overarching field. From a theoretical standpoint, this generalization is achieved by recognizing that the duality of a digital twin fundamentally connects complexity science with data science, leading to the emergence of complexity data science as a synthesis of the two. We examine the broader implications of this field, including its historical roots, challenges, and opportunities.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae456"},"PeriodicalIF":2.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-11eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae504
Yuting Jin, Keqiang Rao, Jiaojiao Zheng, Xinchao Zhang, Yi Luo, Jing He
{"title":"Deficiency of TET2-mediated KMT2D self-transcription confers a targetable vulnerability in hepatocellular carcinoma.","authors":"Yuting Jin, Keqiang Rao, Jiaojiao Zheng, Xinchao Zhang, Yi Luo, Jing He","doi":"10.1093/pnasnexus/pgae504","DOIUrl":"10.1093/pnasnexus/pgae504","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related mortality worldwide. Conventional therapies tend to exacerbate comorbidities, liver dysfunction, and relapse, rendering an urgent demand for novel strategy for management of HCC. Here, we reported that DNA dioxygenase TET2 collaborates with histone methyltransferase KMT2D to enable transcription of <i>KMT2D</i> and <i>ARID1A</i> in HCC. Mechanistically, <i>KMT2D</i> and <i>ARID1A</i> are the major epigenetic targets of TET2 through RNA-seq analysis. Moreover, KMT2D recruits TET2 to facilitate self-transcription via oxidation of 5-methylcytosine in promoter, thereby maintaining expression of ARID1A. Physiologically, KMT2D was identified as a tumor suppressor and mediates the antitumor effect of vitamin C in HCC. Tumors with depleted KMT2D present growth advantage over control group. Vitamin C is able to impair tumor growth, which is compromised by deficiency of KMT2D. Furthermore, loss of KMT2D sensitizes HCC tumors to cisplatin with reduced tumor weight and high level of DNA damage. Ultimately, TET2-KMT2D axis correlates with prognosis of patients with HCC. Patients with high amounts of TET2 and KMT2D present better outcome. Our findings not only put forth a heretofore unrecognized mechanism underlying cross-talk between TET2 and KMT2D in mediating self-transcription of KMT2D, but also propose a targetable vulnerability for HCC therapy on the basis of TET2-KMT2D axis.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae504"},"PeriodicalIF":2.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-11eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae506
Jonas Stein, Marc Keuschnigg, Arnout van de Rijt
{"title":"Partisan belief in new misinformation is resistant to accuracy incentives.","authors":"Jonas Stein, Marc Keuschnigg, Arnout van de Rijt","doi":"10.1093/pnasnexus/pgae506","DOIUrl":"10.1093/pnasnexus/pgae506","url":null,"abstract":"<p><p>One explanation for why people accept ideologically welcome misinformation is that they are insincere. Consistent with the insincerity hypothesis, past experiments have demonstrated that bias in the veracity assessment of publicly reported statistics and debunked news headlines often diminishes considerably when accuracy is incentivized. Many statements encountered online, however, constitute previously unseen claims that are difficult to evaluate the veracity of. We hypothesize that when confronted with unfamiliar content, unsure partisans will form sincere beliefs that are ideologically aligned. Across three experimental studies, 1,344 conservative and liberal US participants assessed the veracity of 20 politically sensitive statements that either confirmed or contradicted social science evidence only known to experts. As hypothesized, analyses show that incentives failed to correct most ideological differences in the perceived veracity of statements. Sixty six to 78% of partisan differences in accuracy assessment persisted even when monetary stakes were raised beyond levels in prior studies. Participants displayed a surprising degree of confidence in their erroneous beliefs, as bias was not reduced when participants could safely avoid rating statements they were unsure about, without monetary loss. These findings suggest limits to the ability of disciplining interventions to reduce the expression of false statements, because many of the targeted individuals sincerely believe them to be true.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae506"},"PeriodicalIF":2.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-06eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae498
Yilin Bi, Xinshan Jiao, Yan-Li Lee, Tao Zhou
{"title":"Inconsistency among evaluation metrics in link prediction.","authors":"Yilin Bi, Xinshan Jiao, Yan-Li Lee, Tao Zhou","doi":"10.1093/pnasnexus/pgae498","DOIUrl":"10.1093/pnasnexus/pgae498","url":null,"abstract":"<p><p>Link prediction is a paradigmatic and challenging problem in network science, which aims to predict missing links, future links, and temporal links based on known topology. Along with the increasing number of link prediction algorithms, a critical yet previously ignored risk is that the evaluation metrics for algorithm performance are usually chosen at will. This paper implements extensive experiments on hundreds of real networks and 26 well-known algorithms, revealing significant inconsistency among evaluation metrics, namely different metrics probably produce remarkably different rankings of algorithms. Therefore, we conclude that any single metric cannot comprehensively or credibly evaluate algorithm performance. In terms of information content, we suggest the usage of at least two metrics: one is the area under the receiver operating characteristic curve, and the other is one of the following three candidates, say the area under the precision-recall curve, the area under the precision curve, and the normalized discounted cumulative gain. When the data are imbalanced, say the number of negative samples significantly outweighs the number of positive samples, the area under the generalized Receiver Operating Characteristic curve should also be used. In addition, as we have proved the essential equivalence of threshold-dependent metrics, if in a link prediction task, some specific thresholds are meaningful, we can consider any one threshold-dependent metric with those thresholds. This work completes a missing part in the landscape of link prediction, and provides a starting point toward a well-accepted criterion or standard to select proper evaluation metrics for link prediction.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae498"},"PeriodicalIF":2.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An undiscovered circadian clock to regulate phytoplankton photosynthesis.","authors":"Yixi Su, Jingyan Hu, Mengsheng Xia, Jiwei Chen, Weizhao Meng, Cheng Qian, Yuexuan Shu, Chao Wang, Xianwei Wang, Kourosh Salehi-Ashtiani, Sigurður Brynjólfsson, Jianping Lin, Yongquan Li, Haisheng Zhang, Lizhong Wang, Weiqi Fu","doi":"10.1093/pnasnexus/pgae497","DOIUrl":"10.1093/pnasnexus/pgae497","url":null,"abstract":"<p><p>Circadian clocks exist in all types of organisms and coordinate key biological processes, e.g. photosynthesis in phytoplankton (microalgae) and land plants. We asked whether a circadian rhythm sustains in phytoplankton when living under constant illumination without environmental cues. Here, we report the first transcriptomic architecture of persistent oscillatory gene expression in the model marine diatom, <i>Phaeodactylum tricornutum</i> living under constant illumination and temperature without environmental cues. We show that cyclic expression of a considerable number of genes involved in light harvesting and carbon fixation sustained after 24 h of constant illumination (free-running), which could pose additional constraints on cell growth under constant light conditions. Over long-term adaptation to constant illumination, the majority of the rhythmic genes identified under diel light conditions lose their oscillatory expression in the absence of external entrainers, and the genes potentially controlled by persistent circadian clocks are primarily involved in transcriptional regulation and cell division. We find constant illumination leads to an increased average expression of transcription factors and cell division genes, while genes involved in the Calvin-Benson cycle and pigment biosynthesis are kept at low expression levels, which plays a role in the down-regulation of photosynthetic efficiency. By manipulation of the dark rest period, we confirm a fine-tuned light/dark cycle could dramatically improve photosynthetic efficiency in microalgae. Our results unveil a novel persistent circadian rhythm on photosynthetic regulation in marine phytoplankton and provide critical insights into the interaction between environmental signals and inheritable internal circadian clocks in diatoms.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae497"},"PeriodicalIF":2.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-04eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae480
Linyue Gao, Christopher Milliren, Teja Dasari, Alexander A Knoll, Jiarong Hong
{"title":"Catch the wind: Optimizing wind turbine power generation by addressing wind veer effects.","authors":"Linyue Gao, Christopher Milliren, Teja Dasari, Alexander A Knoll, Jiarong Hong","doi":"10.1093/pnasnexus/pgae480","DOIUrl":"10.1093/pnasnexus/pgae480","url":null,"abstract":"<p><p>Wind direction variability with height, known as \"wind veer,\" results in power losses for wind turbines (WTs) that rely on single-point wind measurements at the turbine nacelles. To address this challenge, we introduce a yaw control strategy designed to optimize turbine alignment by adjusting the yaw angle based on specific wind veer conditions, thereby boosting power generation efficiency. This strategy integrates modest yaw offset angles into the existing turbine control systems via a yaw-bias-look-up table, which correlates the adjustments with wind speed, and wind veer data. We evaluated the effectiveness of this control strategy through extensive month-long field campaigns for an individual utility-scale WT and at a commercial wind farm. This included controlling one turbine using our strategy against nine others in the vicinity using standard controls with LiDAR-derived wind veer data and a separate 2.5 MW instrumented research turbine continuously managed using our method with wind profiles provided by meteorological towers. Results from these campaigns demonstrated notable energy gains, with potential net gains exceeding 10% during extreme veering conditions. Our economic analysis, factoring in various elements, suggests an annual net gain of up to approximately $700 K for a 100-MW wind farm, requiring minimal additional investment, with potential for even larger gains in offshore settings with the power of individual turbines exceeding 10 MW nowadays. Overall, our findings underscore the considerable opportunities to improve individual turbine performance under realistic atmospheric conditions through advanced, cost-effective control strategies.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae480"},"PeriodicalIF":2.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-04eCollection Date: 2024-11-01DOI: 10.1093/pnasnexus/pgae492
Alveena Zulfiqar, Beenish J Azhar, Samina N Shakeel, William Thives Santos, Theresa D Barry, Dana Ozimek, Kim DeLong, Ruthie Angelovici, Kathleen Greenham, Craig A Schenck, G Eric Schaller
{"title":"Molecular basis for thermogenesis and volatile production in the titan arum.","authors":"Alveena Zulfiqar, Beenish J Azhar, Samina N Shakeel, William Thives Santos, Theresa D Barry, Dana Ozimek, Kim DeLong, Ruthie Angelovici, Kathleen Greenham, Craig A Schenck, G Eric Schaller","doi":"10.1093/pnasnexus/pgae492","DOIUrl":"10.1093/pnasnexus/pgae492","url":null,"abstract":"<p><p>The titan arum (<i>Amorphophallus titanum</i>), commonly known as the corpse flower, produces the largest unbranched inflorescence in the world. Its rare blooms last only a few days and are notable both for their burst of thermogenic activity and for the odor of rotting flesh by which they attract pollinators. Studies on the titan arum can therefor lend insight into the mechanisms underlying thermogenesis as well as the production of sulfur-based volatiles, about which little is known in plants. Here, we made use of transcriptome and metabolite analyses to uncover underlying mechanisms that enable thermogenesis and volatile production in the titan arum. The ability to perform thermogenesis correlated with the expression of genes involved in bypass steps for the mitochondrial electron transport chain, in particular alternative oxidase expression, and through our analysis is placed within the context of sugar transport and metabolism. The major odorants produced by the titan arum are dimethyl disulfide and dimethyl trisulfide, and we identified pathways for sulfur transport and metabolism that culminate in the production of methionine, which our analysis identifies as the amino acid substrate for production of these odorants. Putrescine, derived from arginine, was identified as an additional and previously unrecognized component of the titan arum's odor. Levels of free methionine and putrescine were rapidly depleted during thermogenesis, consistent with roles in production of the titan arum's odor. Models for how tissues of the titan arum contribute to thermogenesis and volatile production are proposed.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae492"},"PeriodicalIF":2.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PNAS nexusPub Date : 2024-11-01DOI: 10.1093/pnasnexus/pgae490
Michael S Cohen, Victoria Halewicz, Ece Yildirim, Joseph W Kable
{"title":"Continued influence of false accusations in forming impressions of political candidates.","authors":"Michael S Cohen, Victoria Halewicz, Ece Yildirim, Joseph W Kable","doi":"10.1093/pnasnexus/pgae490","DOIUrl":"10.1093/pnasnexus/pgae490","url":null,"abstract":"<p><p>Previous work has shown that false information affects decision-making even after being corrected, a phenomenon known as \"continued influence effects\" (CIEs). Using mock social media posts about fictional political candidates, we observe robust within-participant CIEs: candidates targeted by corrected accusations are rated more poorly than candidates not targeted by allegations. These effects occur both immediately and after as much as a 2-day delay. We further demonstrate that vulnerability to CIEs in a political context varies systematically between individuals. We found that certain groups are more susceptible to CIEs on immediate candidate ratings (i) those who rely more on intuitive feelings, (ii) those with lower digital literacy knowledge, and (iii) younger individuals. These individuals' judgments appear to be relatively more influenced by the refuted accusations and/or less influenced by the factual refutations. Interestingly, political orientation did not affect CIEs, despite its influence on explicitly identifying misinformation. Moreover, people recalled accusation stimuli better than refutations at a delay, suggesting that emotions may drive the prioritized processing of accusations. Our results indicate that analytic thinking could be protective when people judge political candidates targeted by refuted false information.</p>","PeriodicalId":74468,"journal":{"name":"PNAS nexus","volume":"3 11","pages":"pgae490"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}