Phenomics (Cham, Switzerland)最新文献

{"title":"Better BMI: Novel Digital Anthropometry Equations for Adiposity Assessment in the Chinese Population.","authors":"Jialu Zhao, Xia Hu, Shujing Fu, Jialin Wang, Yan Zheng, Chen Chen, Jingchun Luo","doi":"10.1007/s43657-026-00314-4","DOIUrl":"https://doi.org/10.1007/s43657-026-00314-4","url":null,"abstract":"<p><p>The global obesity epidemic necessitates improved adiposity assessment alternatives beyond conventional anthropometric indices such as body mass index (BMI), particularly given their limitations in characterizing fat distribution. This study aimed to (1) develop adiposity assessment equations based on digital anthropometry and (2) systematically evaluate our equations against conventional anthropometric indices. We analyzed 1294 participants from the <i>International Human Phenome Project</i>, leveraging 151 digital anthropometric phenotypes and eight DXA-derived adiposity relative indices capturing adiposity from multiple distinct aspects. After training and comparing seven machine learning algorithms, the final equations were subjected to variance inflation factor (VIF) analysis to optimize predictor selection. A systematic evaluation was conducted, comparing the newly developed equations with both BMI and conventional alternative indices via Pearson correlation analysis. The forward stepwise linear regression (FSLR) model achieved superior or comparable accuracy ([Formula: see text]) to the other six machine learning algorithms. Eight ethnicity-specific equations were derived via FSLR and VIF selection, incorporating 10.25 predictors on average. Systematic evaluation demonstrated that our equations outperformed BMI and conventional alternative indices by 2.3-63.0% across key adiposity metrics. Moreover, the results highlight the complementary value of combining BMI with alternative measures for comprehensive adiposity assessment. We developed adiposity assessment equations in the Chinese population using digital anthropometry, which significantly improved upon BMI-based evaluations. Furthermore, our findings provide concrete evidence for combining BMI with supplementary indices, as recently recommended by <i>The Lancet Diabetes & Endocrinology Commission</i>.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-026-00314-4.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 2","pages":"117-136"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations of Red Cell Distribution Width with Rheumatoid Arthritis and Congestive Heart Failure: A Phenome-Wide Mendelian Randomization Study.","authors":"Jing Lei, Zhenqiu Liu, Renjia Zhao, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Chen Suo, Xingdong Chen","doi":"10.1007/s43657-024-00172-y","DOIUrl":"https://doi.org/10.1007/s43657-024-00172-y","url":null,"abstract":"<p><p>Red cell distribution width (RDW) has been reported to be associated with many diseases, but there is no conclusive evidence for any causal relationship. This study aims to explore to determine the causal effects of high RDW on health with the help of phenome-wide association study (PheWAS), genome-wide association study (GWAS), and Mendelian randomization (MR). The data was derived from the UK Biobank and the population was selected to include white British with complete RDW data at baseline and similar genetic ancestry. The eligible subjects were divided into two non-overlapping groups using random sampling in a ratio of 8:2, with the former for PheWAS and the latter for GWAS. MR analysis was performed to determine whether there was a causal association between RDW and disease outcomes. After multiple corrections, 222 phenotypes associated with RDW were identified with PheWAS. According to GWAS, RDW was associated with 29 independent genetic signals. MR analysis confirmed that RDW had a statistically significant causal association with rheumatoid arthritis and congestive heart failure. Our study provides new evidence that sheds light on the controversial question of whether RDW is associated with disease risk.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00172-y.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"39-49"},"PeriodicalIF":6.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inulin-Type Hexasaccharide Improves Vascular Dementia by Modulating Sphingomyelin Lipid Metabolism.","authors":"Jiayao Liu, Jinghuan Wang, Jialin Zhao, Yunzhi Wang, Huibin Wang, Yuyu Zhang, Yinglie Xu, Chunxiang Fan, Xinhua Liu, Jun Chang","doi":"10.1007/s43657-025-00262-5","DOIUrl":"https://doi.org/10.1007/s43657-025-00262-5","url":null,"abstract":"<p><p>Vascular dementia (VaD) is the second most common type of dementia lacking effective treatments. Inulin-type hexasaccharide (IHS) extracted from traditional Chinese herbal medicine <i>BaJiTian</i> (<i>Morinda officinalis</i>) has antidepressant effects in many animal models. In this study, we aimed to investigate the therapeutic effects and potential mechanisms of IHS in VaD. Our results showed that IHS could effectively improve cognitive impairment in VaD mice, alleviate histological changes, and promote cerebral blood flow recovery. In addition, we observed that IHS could reduce neuroinflammation and apoptosis in VaD mice. The comprehensive characterization analysis of the serum, fecal, and brain tissue metabolites revealed that IHS regulates multiple metabolic pathways including sphingolipid metabolism, glycerophospholipid metabolism, and pyruvate metabolism in VaD mice. Furthermore, integrative analysis of metabolomics and brain proteomics found that IHS modulates the sphingolipid metabolism pathway to decrease accumulation of ceramide in the brains of VaD mice. Based on the role of ceramide in VaD development and cognitive impairment, IHS improves the pathology of VaD mice at least partially through the sphingolipid metabolism pathway. These results provide a framework for better understanding the mechanisms of the therapeutic effects of IHS in VaD.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-025-00262-5.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"15-28"},"PeriodicalIF":6.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct T Cell Repertoires in Spinal Entheses and Synovial Fluids in Ankylosing Spondylitis.","authors":"Hongzi Zhu, Yulong Tang, Yuexin Yu, Qi Zhu, Li Jin, Jiucun Wang, Mark Hwang, Jing Liu","doi":"10.1007/s43657-025-00292-z","DOIUrl":"https://doi.org/10.1007/s43657-025-00292-z","url":null,"abstract":"<p><p>Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily impacting the spine and sacroiliac joints, driven by immune dysregulation. While T cells are known contributors to AS, the specific cellular and molecular changes within affected tissues, especially in the spine, remain to be fully elucidated. We conducted single-cell RNA (scRNA-seq) and T cell receptor (TCR) sequencing on synovial fluids and spinal ligament samples from AS patients, supplemented by public AS and healthy control data. The analysis identified nine T cell clusters, with CD8 + memory T cells enriched in spine ligaments (SL), while mucosal-associated invariant T lymphocytes (MAIT) cells and regulatory T lymphocytes (Tregs) were enriched in synovial fluids. Differential expression and pathway analyses revealed that senescence-related genes, such as calmodulin 1 (<i>CALM1</i>) and cyclin-dependent kinase inhibitor 1A (<i>CDKN1A</i>), were enriched in SL, suggesting the presence of senescent T cells, and cytotoxic genes, including natural killer cell granule protein 7 (<i>NKG7</i>), were enriched in synovial fluids. Furthermore, TCR repertoire analysis uncovered biased usage of T cell receptor gamma variable (<i>TRGV</i>) genes in SL and T cell receptor beta variable 9 (<i>TRBV9</i>) in synovial fluid, indicating tissue-specific clonal expansion. Lastly, peptide prediction identified potential human leukocyte antigen-B27 (HLA-B27)-presented peptides, highlighting their contribution to inflammation. Our study demonstrates a unique immune landscape in AS, characterized by differential clonal expansion in peripheral and axial joints. These findings underscore T cell-mediated immune responses in AS pathology, contributing to the understanding of the immunological mechanisms of AS and potential immune-focused therapies.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-025-00292-z.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 2","pages":"137-149"},"PeriodicalIF":6.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Elements and Urinary Arsenic Species with Esophageal Cancer Risk in a Low Metal Exposure Area: A Case-Cohort Study in China.","authors":"Qingling Su, Zesen Gao, Yan Wu, Yang Ouyang, Shanshan Du, Hongwei Zhao, Weidong Qu, Yanfeng Jiang, Chen Suo, Ziyu Yuan, Xingdong Chen, Ruimei Feng, Weimin Ye","doi":"10.1007/s43657-025-00269-y","DOIUrl":"https://doi.org/10.1007/s43657-025-00269-y","url":null,"abstract":"<p><p>The role of multiple elements in esophageal cancer (EC) remains unclear, especially in low-level metal exposure area. To investigate the causal relationship between elements and EC risk, we conducted a case-cohort study nested within the Taizhou Longitudinal Study, in which the baseline fasting serum concentrations of 21 elements in a subcohort of 926 randomly selected subjects and 256 participants with incident EC were measured. Baseline urine levels of four arsenic species were also measured among 826 subcohort subjects and 232 EC cases to further elucidate the potential impact of arsenic on EC risk. Cox proportional hazards regression was used to estimate adjusted hazard ratios for EC associated with elements and false discovery rate (FDR) correction was performed for multiple testing. The results indicated that elevated serum level of arsenic was associated with a reduced risk of EC, with a p-value for trend of 0.002 after FDR correction. When analyzing urinary arsenic species, we found urinary dimethylarsinic acid (DMA) was weakly correlated with serum arsenic. DMA was inversely associated with EC risk after excluding the first two years of follow-up and showed a significant interaction with smoking. Overall, this case-cohort study did not suggest positive associations between any of serum elements examined and EC risk. Nevertheless, the inverse associations of serum arsenic and urinary DMA with EC risk should be interpreted cautiously. Further population-based and experimental studies that incorporate metabolome and consider multiple biomarkers of exposure are required.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-025-00269-y.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"86-90"},"PeriodicalIF":6.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Immune Dysfunction in ESCC with Lymph Node Metastasis: Implications for Preoperative Diagnosis and Prognosis.","authors":"Yingcen Li, Bin Li, Helian Li, Jingyan Xu, Yali Luo, Jian Gao, Jingxuan Han, Xuling Han, Yiran Zhao, Alin Zhang, Feng Qian","doi":"10.1007/s43657-025-00291-0","DOIUrl":"https://doi.org/10.1007/s43657-025-00291-0","url":null,"abstract":"<p><p>Lymph node metastasis (LNM) indicates aggressive tumor biology, which is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC). However, comprehensive and in-depth research on the immunophenotyping of ESCC patients with LM remains limited, and effective indicators for the preoperative LNM diagnosis and prognosis assessment in ESCC are urgently needed in clinical practice. Therefore, we performed deep immunophenotyping of peripheral blood samples from ESCC patients and age- and sex-matched healthy controls, revealing a distinct landscape of immune dysfunction in peripheral blood of ESCC patients with LNM. Specifically, innate immunity exhibited impaired antigen presentation capacity, evidenced by decreased CD86 and HLADR expression on monocytes and mDCs. Compromised innate immune response was demonstrated by significantly attenuated IL-6 production following toll-like receptor 2 agonist stimulation in ESCC patients with LNM. Furthermore, adaptive immunity displayed increased CD38⁺ T cells concurrent with decreased CD28⁺ T cells and CD8⁺ T_CM cells, indicating T cell hyporesponsiveness. Decreased Tconv/Treg and Tfh/Tfr ratios revealed an immunosuppressive state. Notably, an integrated three-parameter random forest model presented considerable discriminatory power for preoperative LNM diagnosis (AUC = 0.96), with Tfh cells providing the highest contribution to diagnostic accuracy. Moreover, a nomogram incorporating memory Treg cells demonstrated excellent predictive capacity for 3-year mortality (AUC = 0.94). These findings demonstrate that peripheral blood immune phenotypes could serve as effective indicators for both preoperative LNM diagnosis and postoperative prognosis in ESCC, potentially improving clinical decision-making.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-025-00291-0.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 2","pages":"101-116"},"PeriodicalIF":6.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of High-Performing Blood Metabolite Biomarkers of Lung Cancer in a Chinese Population.","authors":"Zhenpu Chen, Lun Zhang, Kaining Mao, Jia Li, Yongchun Zhou, Jiamin Zheng, Marcia LeVatte, David S Wishart, Youguang Huang, Yunchao Huang, Jie Chen","doi":"10.1007/s43657-024-00206-5","DOIUrl":"10.1007/s43657-024-00206-5","url":null,"abstract":"<p><p>Lung cancer is the world's leading cause of cancer deaths. Early detection through low-cost metabolite screening approaches could reduce lung cancer mortality. Here we report the results of a large-scale, quantitative metabolomics study aimed at identifying plasma biomarkers for lung cancer detection in a Chinese population. A cohort of 410 patients, including 137 healthy controls, 189 biopsy-confirmed individuals with stage I/II lung cancer, and 84 individuals with biopsy-confirmed stage III/IV cancer, were studied. Plasma samples were collected and analyzed using an in-house-developed, targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics method that detects and quantifies 138 metabolites. Logistic regression was used to develop an optimal biomarker panel that could distinguish all-stage lung cancer patients from healthy controls. The resulting six-metabolite panel achieved an area under the curve (AUC) of 95.0%. A second biomarker panel was developed to distinguish early-stage lung cancer from healthy controls and reached an AUC of 94.3%. All models were developed on an initial training set and then fully validated on a separate holdout set. Our proposed biomarker models show significant improvements over previously published models for metabolite-based lung cancer diagnosis and detection. These metabolite biomarker panels are intended for the development of a low-cost, minimally invasive blood test for lung cancer screening in China.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43657-024-00206-5.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"50-64"},"PeriodicalIF":6.2,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Metabolomic and Adiposity Markers Improve Prediction of Obstructive Sleep Apnea: A Prospective Analysis in the China Human Phenobank.","authors":"Yudan Wu, Yihan Ba, Chen Chen, Qi Wang, Qinsheng Chen, Jinxian Zhang, Longlong Chen, Yining Zhao, Biru Shi, Lisong Ye, Wei Chen, Chengyan Wang, Zixin Hu, Jun Zhang, Kai Feng, Yan Wang, Yuehua Liu, Yuan Qi, Huiru Tang, Jingchun Luo, Mei Tian","doi":"10.1007/s43657-026-00316-2","DOIUrl":"https://doi.org/10.1007/s43657-026-00316-2","url":null,"abstract":"","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"91-95"},"PeriodicalIF":6.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy: A Novel Therapeutic Target for Osteoporosis.","authors":"Li Meng, Zhongkai Zhang, Yufeng Huang, Chengzu Zheng, Lingling Wang, Zhuoran Li, Ying Wang, Yanxia Li, Mingjie Liu, Baobing Zhao, Yuan Li","doi":"10.1007/s43657-025-00244-7","DOIUrl":"https://doi.org/10.1007/s43657-025-00244-7","url":null,"abstract":"<p><p>Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which plays a vital role in the maintenance of cellular homeostasis. The occurrence of autophagy depends on lysosome, which is responsible for eliminating the dysfunctional cellular components, including misfolded proteins, impaired organelles and pathogens. Osteoporosis (OP) is a common bone metabolic disease, and it needs more therapeutic strategies that could restore the imbalance between bone formation and bone resorption, which is the main pathophysiological feature of OP. Interstingly, increasing evidence shows that autophagy is closely involved in bone metabolism, and its aberrant level leads to various skeletal system disorders, including OP. Autophagy regulates the survival, differentiation and function of bone marrow mesenchymal stromal cells (BMSCs), osteoblasts, osteocytes and osteoclasts, which are the major cell types in the bone microenvironment. Herein, we summarized the important advances of autophagy in bone metabolism, and the promising therapeutic strategies for OP by targeting autophagy. This review is aimed at providing novel insights for the prevention and treatment of OP via regulation of autophagy.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 2","pages":"181-199"},"PeriodicalIF":6.2,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Neddylation Beyond Tumor Cells is a Vital Modulator of Anticancer Immunity.","authors":"Mengna Xu, Weixiao Liu, Fan Liu, Ping Xie","doi":"10.1007/s43657-025-00233-w","DOIUrl":"https://doi.org/10.1007/s43657-025-00233-w","url":null,"abstract":"<p><p>Protein neddylation modification involves transfer of neural precursor cell expressed developmentally downregulated protein 8 (NEDD8), a ubiquitin-like protein, to substrates through a three-step enzymatic cascade mediated by NEDD8-activating enzyme (NAE), conjugating enzyme and ligases. Given Cullin-RING ligases (CRLs) as the uppermost substrates which regulate degradation of numerous proteins, neddylation modulates numerous biological functions, including tumor development. MLN4924, a potent NAE inhibitor, has emerged as a promising anti-cancer agent based on neddylation interference. However, resistance to MLN4924 poses a significant challenge. Growing evidence suggests that neddylation directly and indirectly modulates the tumor immune microenvironment (TIME), providing novel insights into its impact on tumor dynamics and the development of resistance to MLN4924. This understanding indicates that targeting neddylation could potentially be combined with immunotherapies for more effective treatment strategies. Here, we briefly outline how neddylation is organized and its modulatory roles in both tumor cells and intertumoral immune cells, proposing an optimistic outlook for neddylation-targeted therapy.</p>","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"6 1","pages":"65-81"},"PeriodicalIF":6.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}