Risk Analysis of Atrial Fibrillation Based on ECG Phenotypes: The RAF-ECP Study Protocol.

IF 3.7 Q2 GENETICS & HEREDITY
Phenomics (Cham, Switzerland) Pub Date : 2024-11-19 eCollection Date: 2024-12-01 DOI:10.1007/s43657-023-00151-9
Aiguo Wang, Jiacheng He, Xujian Feng, Jingchun Luo, Wei Chen, Yong Wei, Cuiwei Yang
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Abstract

Atrial fibrillation (AF) is the most common supraventricular arrhythmia in clinical practice, and many patients exhibit silent AF. Variables based on Electrocardiogram (ECG) have shown promise in assessing AF risk in the previous study. This study protocol proposes a systematic approach, named RAF-ECP, to evaluate the role of ECG phenotypes in assessing the risk of AF. The protocol aims to standardize the definition and calculation of ECG phenotypes, ensuring consistency and comparability across different research studies and healthcare settings. Data will be collected from multiple clinical laboratories, with an anticipated sample size of 10,000 cases (lead I and II, 10 s) evenly distributed between subjects with and without AF events in one-year time frame. By analyzing ECG data and baseline information, statistical tests and machine learning classifiers will be employed to identify significant risk factors and develop a comprehensive risk assessment model for AF. The anticipated outcomes include hazard ratio values, confidence intervals, p values, as well as accuracy, sensitivity, and specificity measures. The study also discusses the clinical relevance and potential benefits of standardizing ECG phenotypes, emphasizing the need for collaboration between multiple centers to obtain diverse and representative datasets. The proposed RAF-ECP study protocol offers a novel and significant approach to understanding the impact of ECG phenotypes on AF risk assessment. Its integration of statistical analysis and machine learning techniques has the potential to advance AF research and contribute to the development of improved risk prediction models and clinical decision support tools.

基于ECG表型的房颤风险分析:RAF-ECP研究方案。
房颤(AF)是临床上最常见的室上性心律失常,许多患者表现为无症状房颤。在先前的研究中,基于心电图(ECG)的变量在评估房颤风险方面显示出前景。本研究方案提出了一种名为RAF-ECP的系统方法来评估ECG表型在评估房颤风险中的作用。该方案旨在标准化ECG表型的定义和计算,确保不同研究和医疗保健环境之间的一致性和可比性。数据将从多个临床实验室收集,预计样样量为10,000例(铅I和II, 10 s),在一年的时间框架内均匀分布在有和没有房颤事件的受试者之间。通过分析心电图数据和基线信息,采用统计检验和机器学习分类器来识别重要的危险因素,并建立房颤的综合风险评估模型。预期结果包括风险比值、置信区间、p值以及准确性、敏感性和特异性措施。该研究还讨论了标准化ECG表型的临床相关性和潜在益处,强调需要多个中心之间的合作,以获得多样化和代表性的数据集。提出的RAF-ECP研究方案为了解ECG表型对房颤风险评估的影响提供了一种新颖而重要的方法。它整合了统计分析和机器学习技术,有可能推进房颤研究,并有助于改进风险预测模型和临床决策支持工具的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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