Cohort Profile: TRacing Etiology of Non-communicable Diseases (TREND): Rationale, Progress and Perspective.

IF 3.7 Q2 GENETICS & HEREDITY
Phenomics (Cham, Switzerland) Pub Date : 2024-10-16 eCollection Date: 2024-12-01 DOI:10.1007/s43657-024-00196-4
Hui-Ying Ren, Ying Lv, Bei-Ning Ma, Chang Gao, Hong-Mei Yuan, Hai-Hong Meng, Zheng-Qian Cao, Ya-Ting Chen, Yan-Xi Zhang, Yu-Ting Zhang, Wei Liu, Yu-Ping Fan, Meng-Han Li, Yu-Xuan Wu, Zhuo-Yue Feng, Xin-Xin Zhang, Zhen-Jian Luo, Qiu-Yi Tang, Anke Wesselius, Jian Chen, Hong-Xing Luo, Qi-Rong Qin, Lianmin Chen, Evan Yi-Wen Yu
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Abstract

The TRacing Etiology of Non-communicable Diseases (TREND) cohort is a prospective longitudinal cohort and biobank that is mainly based in Ma'anshan, Anhui Province, China. The primary aim of the study is to decipher comprehensive molecular characterization and deep phenotyping for a broad spectrum of chronic non-communicable diseases (NCDs), which focuses on providing mechanistic insights with diagnostic, prognostic and therapeutic implications. The recruitment was initiated in 2023 and is expected to complete in 2025 with 20,000 participants originated from urban and rural area. In the first phase, 3360 participants were recruited. Follow-up visits are scheduled annually and intervally for a total of 30 years. The cohort includes individuals aged over 18 years. Two participants with first-degree linkage were recruited from a household. The age distribution of recruited participants was stratified into four categories: 18-45, 45-55, 55-65, and ≥65 years, aligning with the population proportions of Ma'anshan. Meanwhile, the gender distribution was controlled by pairing men and women from the same household. Data collected at baseline includes socio-economic information, medical history, lifestyle and nutritional habits, anthropometrics, blood oxygen, electrocardiogram (ECG), heart sound, as well as blood, urine and feces tests results. Molecular profiling includes genome, proteome, metabolome, microbiome and extracellular vesicles -omics. Blood, urine and fecal samples are collected and stored at -80 °C in a storage facility for future research.

Supplementary information: The online version contains supplementary material available at 10.1007/s43657-024-00196-4.

队列简介:追踪非传染性疾病的病因(趋势):基本原理,进展和前景。
非传染性疾病病原学追踪(TREND)队列是一个主要在中国安徽省马鞍山开展的前瞻性纵向队列和生物库。该研究的主要目的是破译广泛的慢性非传染性疾病(NCDs)的综合分子特征和深度表型,其重点是提供具有诊断、预后和治疗意义的机制见解。此次招募于2023年启动,预计于2025年完成,届时将有2万名来自城乡的参与者。在第一阶段,招募了3360名参与者。每年和每隔一段时间进行随访,共30年。该队列包括18岁以上的个体。从一个家庭中招募了两名具有一级亲缘关系的参与者。根据马鞍山人口比例,将招募的参与者年龄分为18-45岁、45-55岁、55-65岁和≥65岁4类。同时,性别分布由来自同一家庭的男女配对控制。基线时收集的数据包括社会经济信息、病史、生活方式和营养习惯、人体测量、血氧、心电图、心音以及血液、尿液和粪便测试结果。分子分析包括基因组学、蛋白质组学、代谢组学、微生物组学和细胞外囊泡组学。收集血液、尿液和粪便样本,并将其储存在-80°C的储存设施中,以备将来的研究。补充资料:在线版本包含补充资料,网址为10.1007/s43657-024-00196-4。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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