Pediatric health, medicine and therapeutics最新文献

{"title":"Impact of Delay Prior to Treatment in Ethiopian Children with Acute Lymphoblastic Leukemia.","authors":"Abel Hailu,&nbsp;Amha Mekasha,&nbsp;Daniel Hailu,&nbsp;Atalay Mulu Fentie,&nbsp;David N Korones,&nbsp;Abdulkadir Mohammedsaid Gidey","doi":"10.2147/PHMT.S406181","DOIUrl":"https://doi.org/10.2147/PHMT.S406181","url":null,"abstract":"<p><strong>Introduction: </strong>More than 85% of childhood malignancies occur in developing countries with less than a 30% cure rate as opposed to more than 80% cure rate in developed countries. This disproportionately significant difference might be due to delays in diagnosis, treatment initiation, lack of adequate supportive care, and treatment abandonment. We aimed to determine the impact of overall treatment delay on induction mortality of children with acute lymphoblastic leukemia treated at Tikur Anbessa specialized hospital (TASH).</p><p><strong>Methods: </strong>A cross-sectional study was conducted among children who were treated from 2016 to 2019. Children with Down syndrome and relapsed leukemia were excluded from this study.</p><p><strong>Results: </strong>A total of 166 children were included; most patients were males (71.7%). The mean age at diagnosis was 5.9 years. The median time interval from the onset of symptoms to the first TASH visit was 30 days and the median period from TASH's first clinic visit to diagnosis was 11 days. The median time to initiate chemotherapy after diagnosis was 8 days. The total median time from the first onset of symptoms to chemotherapy initiation was 53.5 days. Induction mortality was 31.3%. High-risk ALL and patients with an overall delay between 30 and 90 days were more likely to experience induction mortality.</p><p><strong>Discussion: </strong>Patient and healthcare system delay is high compared to most studies done and a significant association has been noted with induction mortality. Efforts to expand the pediatric oncology service in the country and efficient diagnostic and treatment approach need to be established to reduce mortality associated with overall delay.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"14 ","pages":"147-157"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/e4/phmt-14-147.PMC10184856.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9486966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurofibromatosis Type 1 (NF1): Addressing the Transition from Pediatric to Adult Care.","authors":"Heather B Radtke,&nbsp;Angela Berger,&nbsp;Tammi Skelton,&nbsp;Allison Goetsch Weisman","doi":"10.2147/PHMT.S362679","DOIUrl":"https://doi.org/10.2147/PHMT.S362679","url":null,"abstract":"<p><p>Health care transition, or HCT, is the process of adolescents and young adults moving from a child/family-centered model of health care to an adult/patient-centered model of health care. Healthcare providers have an essential role in this process which can be especially challenging for individuals with medical or special healthcare needs. Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring lifelong medical surveillance, education, and psychosocial support. This review highlights the transition needs of NF1 patients and provides resources for both clinicians and families to facilitate HCT in this population. The authors propose a framework for the development of an effective NF1 transition program by using the Six Core Elements model of the Got Transition program, reviewing existing literature, and incorporating author experiences in the care and transition of NF1 patients.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"14 ","pages":"19-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/b9/phmt-14-19.PMC9925753.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10748487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Anti-Vascular Endothelial Growth Factor (Anti-VEGF) in the Treatment of Retinopathy of Prematurity: A Narrative Review in the Context of Middle-Income Countries.","authors":"Mangat Ram Dogra,&nbsp;Anand Vinekar","doi":"10.2147/PHMT.S391591","DOIUrl":"https://doi.org/10.2147/PHMT.S391591","url":null,"abstract":"<p><p>The rise in preterm births and higher survival rates of premature infants have led to a global increase in retinopathy of prematurity (ROP), a vasoproliferative retinal disorder common in premature infants. ROP is one of the leading causes of childhood blindness. Clinical manifestation of ROP ranges from mild abnormal retinal neovascularization to bilateral retinal detachment and vision loss. The incidence of ROP is higher in middle income countries, including India, which has the highest number of global preterm births. Low birth weight and low gestational age are the primary risk factors for ROP; however, anemia, cardiac defects, blood transfusion, apnea, sepsis, respiratory distress syndrome, high exposure to oxygen and poor postnatal weight gain may also contribute to its development. India has stringent ROP screening guidelines revised in 2018, and screening of infants with either birth weight <2000 grams or gestational age <34 weeks is mandated. With an improved understanding of the pathogenesis of ROP in the past decades and advances in clinical research, treatment for ROP has evolved from cryotherapy to laser retinal ablation. Most recently, anti-vascular endothelial growth factor (anti-VEGF) drugs have emerged as a favorable treatment option for zone-I and II ROP. This article reviews the current approaches for ROP treatment in India with a particular focus on anti-VEGF drugs. The article also integrates the understanding of safety and risk-benefit evaluation of the current approaches in ROP management. The review concluded that there is a need to increase the ROP screening not only for preterm and low birth weight but also for optimal gestational age infants with healthy birth weight. Anti-VEGF therapies have shown improved efficacy, although studies are required to establish the long-term safety.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"14 ","pages":"59-69"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/fe/phmt-14-59.PMC9939806.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' Readiness to Vaccinate Their Children Aged 5 to 17 Years Against Covid-19 and Its Associated Factors in Lira District, Uganda.","authors":"Sean Steven Puleh,&nbsp;Eustes Kigongo,&nbsp;Innocent Ojok Opio,&nbsp;Stella Immaculate Akech,&nbsp;Marc Sam Opollo,&nbsp;Everlyne Achan,&nbsp;Joy Acen,&nbsp;Maxson Kenneth Anyolitho,&nbsp;Walter Acup,&nbsp;Amir Kabunga","doi":"10.2147/PHMT.S404620","DOIUrl":"https://doi.org/10.2147/PHMT.S404620","url":null,"abstract":"<p><strong>Background: </strong>Data on parents' readiness to vaccinate their children aged 5 to 17 years against COVID-19 is still scarce. This study assessed parents' readiness to vaccinate their children aged 5 to 17 years against COVID-19 and factors associated in Lira district, Uganda.</p><p><strong>Methods and materials: </strong>A cross-sectional survey employing quantitative methods was conducted between October and November 2022 among 578 parents of children aged 5-17 years in 3 sub-counties in Lira district. An interviewer-administered questionnaire was used to collect data. Data was analyzed using descriptive statistics including means, percentages, frequencies, and odds ratios. Logistic regression was used to determine associations between the factors and the readiness of parents at a 95% level of significance.</p><p><strong>Results: </strong>Out of 634 participants, 578 responded to the questionnaire, giving a response rate of 91.2%. The majority of the parents (327, 56.8%) were female, had children aged between 12 and 15 years (266, 46.4%), and had completed primary education (351, 60.9%). Most of the parents were Christian (565, 98.4%), married (499, 86.6%), and had been vaccinated against COVID-19 (535, 92.6%). Results also indicated that 75.6% (ranging from 71.9% to 78.9%) of the parents were unwilling to vaccinate their children for the COVID-19 virus. The predictors of readiness were the age of the child (AOR: 2.02; 95% CI: 0.97-4.20; p=0.05) and lack of trust in the vaccine (AOR: 3.33; 95% CI: 1.95-5.71; p0.001).</p><p><strong>Conclusion: </strong>Our study shows that parents' readiness to vaccinate their children aged 5 to 17 years was only 24.6%, which is suboptimal. The predictors of hesitancy were the age of the child and a lack of trust in the vaccine. Based on our results, the Ugandan authorities should provide health education interventions targeting parents to combat mistrust with respect to COVID-19 and the COVID-19 vaccine and highlight the benefits of the vaccines.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"14 ","pages":"131-139"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/f0/phmt-14-131.PMC10124741.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B430 Disparities in paediatric fracture treatment in the United States","authors":"JM Ruby, H. Zhong, KR DelPizzo, A. Illescas, J. Poeran, J. Liu, C. Cozowicz, S. Memtsoudis","doi":"10.1136/rapm-2022-esra.506","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.506","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77527780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B437 Dexamethasone as adjuvant in upper extremity peripheral nerve blocks in pediatric patients","authors":"L. Mikjunovikj Derebanova, V. Demjanski, V. Ognjanova, S. Golubic, H. Lazarevska, E. Jankulovska Vlahovikj","doi":"10.1136/rapm-2022-esra.513","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.513","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78462205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B438 Dural puncture epidural for caesarean delivery in a patient with recently unstable multiple sclerosis","authors":"M. Sharapi, J. Loughrey","doi":"10.1136/rapm-2022-esra.514","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.514","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81020637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B442 Regional analgesia via continuouserector spinaeplane (ESP) catheters for thoracic outlet decompression surgery in children – a retrospective case series","authors":"A. Koka, BP Modi, EA Nir, C. Sullivan","doi":"10.1136/rapm-2022-esra.518","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.518","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84158643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B429 An audit of single shot regional techniques in paediatric patients at a tertiary orthopaedic hospital","authors":"SL Dsouza, Mark Cooper","doi":"10.1136/rapm-2022-esra.505","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.505","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74062905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B436 Regional anesthesia in surgery of pediatric patients with congenital syndromes – case series","authors":"E. Bosinci","doi":"10.1136/rapm-2022-esra.512","DOIUrl":"https://doi.org/10.1136/rapm-2022-esra.512","url":null,"abstract":"","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74401973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}