Parasites, hosts and diseases最新文献_第9页

Eight cases of canine thelaziosis found in two localities in Korea. 在韩国两个地方发现8例犬血吸虫病。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.23031

Seongjun Choe, Sunmin Kim, Tilak Chandra Nath, Jeong-Ho Kim

引用次数: 0

A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea. 在韩国生活的中国妇女声带舌口病的病理切片诊断。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.23065

Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh

{"title":"A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea.","authors":"Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh","doi":"10.3347/PHD.23065","DOIUrl":"https://doi.org/10.3347/PHD.23065","url":null,"abstract":"This study aimed to describe a rare case of gnathostomiasis in the vocal cord. A 54-year-old Chinese woman living in Korea visited with a chief complaint of voice change at the outpatient department of otorhinolaryngology in Hallym Sacred Heart Hospital, Hallym University on August 2, 2021. She had eaten raw conger a few weeks before the voice change developed, but her medical history and physical examinations demonstrated neither gastrointestinal symptoms nor other health problems. A round and red cystic lesion, recognized in the anterior part of the right vocal cord, was removed using forceps and scissors through laryngeal microsurgery. The histopathological specimen of the cyst revealed 3 cross-sections of a nematode larva in the lumen of the cyst wall composed of inflammatory cells and fibrotic tissues. They differ in diameter, from 190 μm to 235 μm. They showed characteristic cuticular layers with tegumental spines, somatic muscle layers, and gastrointestinal tracts such as the esophagus and intestine. Notably, intestinal sections consisted of 27-28 lining cells containing 0-4 nuclei per cell. We tentatively identified the nematode larva recovered from the vocal cord cystic lesion as the third-stage larva of Gnathostoma, probably G. nipponicum or G. hispidum, based on the sectional morphologies.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 3","pages":"298-303"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/a0/phd-23065.PMC10471466.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in vaccine development targeting pre-clinical human toxoplasmosis. 针对临床前人类弓形虫病疫苗开发的最新进展。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.22097

Ki-Back Chu, Fu-Shi Quan

引用次数: 0

Evaluating the activity of N-89 as an oral antimalarial drug. 口服抗疟药N-89的活性评价。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.23044

Nagwa S M Aly, Hiroaki Matsumori, Thi Quyen Dinh, Akira Sato, Shin-Ichi Miyoshi, Kyung-Soo Chang, Hak Sun Yu, Takaaki Kubota, Yuji Kurosaki, Duc Tuan Cao, Gehan A Rashed, Hye-Sook Kim

{"title":"Evaluating the activity of N-89 as an oral antimalarial drug.","authors":"Nagwa S M Aly, Hiroaki Matsumori, Thi Quyen Dinh, Akira Sato, Shin-Ichi Miyoshi, Kyung-Soo Chang, Hak Sun Yu, Takaaki Kubota, Yuji Kurosaki, Duc Tuan Cao, Gehan A Rashed, Hye-Sook Kim","doi":"10.3347/PHD.23044","DOIUrl":"https://doi.org/10.3347/PHD.23044","url":null,"abstract":"Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t1/2 was 0.97 h, Tmax was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED50) and ED90 values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89- treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic characteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 3","pages":"282-291"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/7e/phd-23044.PMC10471475.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenetic and phylogeographic analyses of Anisakis simplex sensu stricto (Nematoda: Anisakidae) from the common minke whale in Korean waters. 韩国水域普通小须鲸的严格单感异尖线虫(线虫纲:异尖线虫科)系统发育和系统地理分析。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.23046

Sunmin Kim, Bom Sok Lee, Seongjun Choe

{"title":"Phylogenetic and phylogeographic analyses of Anisakis simplex sensu stricto (Nematoda: Anisakidae) from the common minke whale in Korean waters.","authors":"Sunmin Kim, Bom Sok Lee, Seongjun Choe","doi":"10.3347/PHD.23046","DOIUrl":"https://doi.org/10.3347/PHD.23046","url":null,"abstract":"The genus Anisakis is among the most significant parasites to public health, as it causes anisakiasis, a parasitic infection in humans resulting from consuming raw or undercooked seafood. Although the infection status of i>Anisakis in second intermediate hosts, such as marine fishes and cephalopods, and humans have been severally reported in Korea, no information about the definitive host in Korean waters is available. In 2014, 2 adult gastric nematodes were collected from a common minke whale (Balaenoptera acutorostrata) found in the East Sea, Korea. These worms were identified as A. simplex sensu stricto (s.s.) by comparing the mitochondrial COX2 marker with previously deposited sequences. Phylogenetic and phylogeographic analyses of A. simplex (s.s.) worldwide revealed 2 distinct populations: the Pacific population and the European waters population. This is the first report on adult i>Anisakis and its definitive host species in Korea. Further studies on Anisakis infection in other cetacean species and marine mammals in Korean seas are warrantedi>Anisakis.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 3","pages":"240-250"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/7d/phd-23046.PMC10471470.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic diversity of Plasmodium falciparum erythrocyte membrane protein 1 in field isolates: Correspondence. 野外分离株中恶性疟原虫红细胞膜蛋白 1 的遗传多样性：通信。

Parasites, hosts and diseases Pub Date : 2023-08-01 Epub Date: 2023-08-21 DOI: 10.3347/PHD.23058

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

Disease vector occurrence and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019. 2001 - 2019年西南地区板栗白腹鼠恙虫病媒发生及生态特征

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.22044

Yan-Ling Chen, Xian-Guo Guo, Wen-Yu Song, Tian-Guang Ren, Lei Zhang, Rong Fan, Cheng-Fu Zhao, Zhi-Wei Zhang, Wen-Ge Dong, Xiao-Bin Huang, Dao-Chao Jin

{"title":"Disease vector occurrence and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019.","authors":"Yan-Ling Chen, Xian-Guo Guo, Wen-Yu Song, Tian-Guang Ren, Lei Zhang, Rong Fan, Cheng-Fu Zhao, Zhi-Wei Zhang, Wen-Ge Dong, Xiao-Bin Huang, Dao-Chao Jin","doi":"10.3347/PHD.22044","DOIUrl":"https://doi.org/10.3347/PHD.22044","url":null,"abstract":"Chigger mites are the vector of scrub typhus. This study estimates the infestation status and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019. Chiggers were identified under the microscope, and infestation indices were calculated. The Preston's log-normal model was used to fit the curve of species abundance distribution. A total of 6,557 chiggers were collected in 136 of 342 N. fulvescens rats, showing high overall infestation indices (prevalence=39.8%, mean abundance=19.2, mean intensity=48.2) and high species diversity (S=100, H'=3.0). Leptotrombidium cangjiangense, Neotrombicula japonica, and Ascoschoengastia sifanga were the three dominant chigger species (constituent ratio=42.9%; 2,736/6,384) and exhibited an aggregated distribution among different rat individuals. We identified 100 chigger species, with 3 of them (Leptotrombidium scutellare, Leptotrombidium wenense, and Leptotrombidium deliense) as the main vectors of scrub typhus in China and nine species as potential vectors of this disease. Disease vector occurrence on N. fulvescens may increase the risk of spreading scrub typhus from rats to humans. Chigger infestation on N. fulvescens varied significantly in different environments. The species abundance distribution showed a log-normal distribution pattern. The estimated number of chigger species on N. fulvescens was 126 species.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 3","pages":"272-281"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/5a/phd-22044.PMC10471469.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni. 血吸虫肺抗原制备及可溶性蛋抗原疫苗对实验性曼氏血吸虫病的疗效评价。

Parasites, hosts and diseases Pub Date : 2023-08-01 DOI: 10.3347/PHD.22154

Nagwa S M Aly, Hye-Sook Kim, Maysa A Eraky, Asmaa A El Kholy, Basma T Ali, Shin-Ichi Miyoshi, Rabab E Omar

{"title":"Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni.","authors":"Nagwa S M Aly, Hye-Sook Kim, Maysa A Eraky, Asmaa A El Kholy, Basma T Ali, Shin-Ichi Miyoshi, Rabab E Omar","doi":"10.3347/PHD.22154","DOIUrl":"https://doi.org/10.3347/PHD.22154","url":null,"abstract":"Schistosomiasis causes significant morbidity and mortality worldwide. This study aimed to assess the effect of schistosomula lung antigen preparation (SLAP) and soluble egg antigen (SEA) on a murine schistosomiasis mansoni model. Ninety laboratory-bred male Swiss albino mice were divided into 6 groups. Two doses of the vaccine were given at 2-week intervals. All mice were subcutaneously infected with 80±10 Schistosoma mansoni cercariae 2 weeks after the last vaccination dose. They were sacrificed 7 weeks post-infection. Parasitological and histopathological studies were conducted to assess the effect of inoculated antigens (single or combined). The results showed that the combination of SLAP and SEA (combination group) led to a significant reduction in worm burden (65.56%), and liver and intestine egg count (59% and 60.59%, respectively). The oogram pattern revealed a reduction in immature and mature eggs (15±0.4 and 10±0.8, respectively) and an increased number of dead eggs in the combination group (P<0.001). In terms of histopathological changes, the combination group showed notably small compact fibrocellular egg granuloma and moderate fibrosis in the liver. A high percentage of destroyed ova was observed in the intestine of the combination group. This study demonstrates for the first time the prophylactic effect of combined SLAP and SEA vaccine. The vaccine induced a significant reduction in the parasitological and pathological impacts of schistosomiasis mansoni in hepatic and intestinal tissues, making it a promising vaccine candidate for controlling schistosomiasis.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 3","pages":"251-262"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/9a/phd-22154.PMC10471471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in Chin State, Myanmar. 缅甸钦邦葡萄糖-6-磷酸脱氢酶缺乏症的患病率和分子分析。

Parasites, hosts and diseases Pub Date : 2023-05-01 DOI: 10.3347/PHD.23004

Ja Moon Aung, Zin Moon, Dorene VanBik, Sylvatrie-Danne Dinzouna-Boutamba, Sanghyun Lee, Zau Ring, Dong-Il Chung, Yeonchul Hong, Youn-Kyoung Goo

引用次数: 1

Trematode metacercariae and adults in cyprinoid fish from Khun Thale Swamp in Surat Thani province, Thailand. 泰国素叻他尼省坤太莱沼泽鲤科鱼类中吸虫和成虫。

Parasites, hosts and diseases Pub Date : 2023-05-01 DOI: 10.3347/PHD.23030

Kanda Kamchoo, Jong-Yil Chai

{"title":"Trematode metacercariae and adults in cyprinoid fish from Khun Thale Swamp in Surat Thani province, Thailand.","authors":"Kanda Kamchoo, Jong-Yil Chai","doi":"10.3347/PHD.23030","DOIUrl":"https://doi.org/10.3347/PHD.23030","url":null,"abstract":"The present study aimed to determine the infection status of trematode metacercariae and adults in cyprinoid fish from the Khun Thale Swamp in Surat Thani, Southern Thailand, with epidemiologic and faunistic viewpoints. In 2020, 577 fish in 15 species were collected in the summer (February-April) and rainy (September-November) seasons. Fish were individually examined for trematode metacercariae in the whole body and adults in the gastrointestinal tract using a stereomicroscope. Three species of digenetic trematode metacercariae, i.e., Haplorchis taichui, Haplorchoides mehrai, and Centrocestus formosanus, were detected in the muscle, fin, and/or scale of fish. Two species of adult flukes, including Rohdella siamensis and Helostomatis cyprinorum, were collected in the intestines. The prevalence of overall trematode infections was 32.4% (187/577 fish), which was higher in the rainy season (41.4%; 118/285) than in the summer season (23.6%; 69/292). The metacercariae of H. taichui and H. mehrai were detected in 7 fish species each, and those of C. formosanus were found only in Rasbora toneri. The aspidogastrean trematode R. siamensis (adult) was detected in Babonymus gonionotus. A digenean species, H. cyprinorum (adult), was found in Labiobarbus siamensis and Osteochilus vittatus. The present study has first confirmed that the metacercariae of heterophyid flukes, including H. taichui, H. mehrai, and C. formosanus, and adults of R. siamensis (Aspidogastrea) and H. cyprinorum (Digenea) are infected in some species of the cyprinoid fish from the Khun Thale Swamp in Surat Thani, Thailand.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 2","pages":"163-171"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/bc/phd-23030.PMC10234818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9620306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0