OBM neurobiology最新文献

{"title":"Autistic Traits Correlate with Chronic Musculoskeletal Pain: A Self-Selected Population Based Survey","authors":"Laura Ryan, Harriet Beer, Ella Thomson, Edward Philcox, C. Kelly","doi":"10.21926/obm.neurobiol.2301155","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301155","url":null,"abstract":"Chronic musculoskeletal pain is an increasingly frequent feature in young people. Many exhibit a range of additional physical and psychological features and fulfil criteria for fibromyalgia. Hypermobility, irritable bowel syndrome and migraine are frequent comorbid conditions. These are all in part mediated by dysfunction of the autonomic nervous system and commonly include fatigue, poor sleep and brain fog. Anxiety, social withdrawal and a range of autistic traits are frequently described by those with chronic musculoskeletal pain, and autistic people are over-represented among patients attending pain clinics. This study was designed to explore the correlation between the degree of pain and autistic traits described within a self-selected community-based population. The study used a nonexperimental, correlational design with data collected from a volunteer sample of 448 adults (aged 18-60) who completed online self-report questionnaires assessing each of autistic traits (RAADS-R score), fibromyalgia symptoms (ACR criteria) and hypermobility (Beighton’s test). Correlation analysis and linear regressions were used to test the relationships between each disorder. Data was analysed using parametric and non-parametric techniques to assess prevalence, strength and significance of relationships, causes of variance within populations and mediations. Our self-selected community population had a mean age of 24 years and was 77% female. The prevalence of significant autistic traits, fibromyalgia and hypermobility were all much greater than expected at 63.4%, 40.6% and 43.7% respectively. Those identifying as non-binary or trans had the highest rates. Fibromyalgia was significantly associated with autistic traits, with dysautonomia a stronger predictor than chronic pain. Regression analyses revealed hypermobility partially mediated the relationship between autistic traits and fibromyalgia. This is the first community study to provide evidence for a direct association between fibromyalgia and autistic traits. Although self-selected, the findings in our predominantly young female population confirm that these conditions are common and that those with autistic traits are at significantly increased risk of developing fibromyalgia, especially if they are hypermobile.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41582701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Coping Mechanism and Its Associated Factors Following Perinatal Loss in Hospitals of Wolaita Zone, South Ethiopia 2021","authors":"Addisu Yeshambel, Tamiru Alene, Getachew Asmare, Gedion Asnake, Wallilign Anmut, Kelemu Abebe, Belete Birhan","doi":"10.21926/obm.neurobiol.2301154","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301154","url":null,"abstract":"Perinatal loss is the most painful and unanticipated experience for those who conceived and it is a major global concern worldwide, especially in developed countries like Ethiopia. Women who lost their pregnancy are believed to be at higher risk of developing severe grief following a loss. To reduce the risk of complications after perinatal loss, healthcare providers need to appreciate the grieving process and identify grief factors in mothers for early copying and to be managed promptly by providing adequate emotional, social, and psychological support. This study aimed to assess the level of maternal coping mechanisms and associated factors following perinatal loss in Hospitals of Wolaita Zone, Ethiopia, 2021. A hospital-based cross-sectional study design was conducted from June 30/2021-August15/2021. Study participants were selected through systematic random sampling. Epi-data manager version 4.6 was used for template preparation and data entry and SPSS version 25 was used for analysis. Logistic regression was employed. The strength of association was declared at a p-value < 0.05 with 95% CI. Out of the total 393 participants, 51.4% had positive coping mechanisms whereas the rest, 48.6% had a poor coping mechanism following perinatal loss. Participants who have been satisfied with marriage (AOR = 5.64, 95% CI(3.10-10.29)), history of Antenatal care(ANC) follow-up(AOR = 2.52, 95% CI(1.39-4.57)), profession-based support(AOR = 2.91, 95% CI(1.64-5.15)), support from their own spiritual belief (AOR = 3.87, 95% CI(2.33-6.43)), support from their parents(AOR = 8.11, 95% CI(3.94-16.69)), support from their husband(AOR = 3.2, 95% CI (1.74-5.89)) and discussed/received information from those who had a history of loss(AOR = 2.65, 95% CI (1.31-5.32)) were some of the factors associated with positive maternal copying following perinatal loss. Maternal coping following the perinatal loss was relatively low. Thus, healthcare providers need to be more cautious and ensure mothers receive adequate care, and giving adequate emotional, social, and psychological support for them during grieving moments is essential.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48020246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Lexical Intentionality and the Mathematics of Homomorphism","authors":"H. Moisl","doi":"10.21926/obm.neurobiol.2301152","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301152","url":null,"abstract":"Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account of the distance structure preservation that underlies the proposed mechanism of intrinsic intentionality. The three-layer autoassociative multilayer perceptron (aMLP) architecture with nonlinear hidden and linear output layers is the component in the model which generates representations homomorphic with the environment. The discussion first cites existing work which identifies the aMLP as an implementation architecture for principal component analysis (PCA), and then goes on to argue that the homomorphism characteristic of linear functions like PCA extends to aMLPs with nonlinear activation functions in the hidden layer. The discussion is in two main parts: the first part outlines the model, and the second presents the mathematical account.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43702835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who Believes in Fake News: A Study on the Relationship between Affective Temperament, Cyberchondria and Problematic Use of the Internet during the COVID-19 Pandemic","authors":"C. Mento, Maria Catena Silvestri, C. Lombardo, Lucrezia Neri, M. Campolo, Francesco Pira","doi":"10.21926/obm.neurobiol.2301151","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301151","url":null,"abstract":"The COVID-19 outbreak has been associated with various psychological problems, such as Cyberchondria, constant research for information online, to obtain health-related information. This was associated with problematic social media use and various psychological problems. This study aimed to measure the characteristics of fear and anxiety of COVID-19, the generalized approach to online searching and the use of the Internet about the perception of health, during a pandemic. The online survey was disseminated from April to June 2021 on available social media channels. We found that the pandemic was associated with depression, anxiety, cyberchondria, and cognitive preoccupation. We reported an increase in cyberchondria, depression, stress, low mood, and anxiety during the Covid outbreak. The Internet plays a vital role in everyday life in this period, because it has become a popular source of accessing health-related information.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42472641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective Assessments of the Pandemic Situation and Academic Adaptation of University Students","authors":"R. Shamionov, M. Grigoryeva, E. Grinina, A. Sozonnik, Bolshakova Alina","doi":"10.21926/obm.neurobiol.2301150","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301150","url":null,"abstract":"Students’ academic adaptation during the pandemic is the key problem for the educational system. Even though certain success has been achieved in the organization of education with distance learning technologies and additional learning tools, there are still plenty of other difficulties that affect students’ adaptation. The purpose of the study is to conduct a comparative analysis of academic adaptation’s structure during and before the pandemic and to study the role of subjective assessments of the pandemic situation in university students’ academic adaptation. Nine hundred nineteen university students took part in the study. М = 19.54; SD = 2.47 (17.5% male). The following methods were used within the framework of the study: the method for assessing academic adaptation components developed by the authors, the direct scaling method via a questionnaire used to analyze subjective assessments of the pandemic situation, social frustration [1] assessment method and a differential 1uestionnaire used to assess the experience of loneliness [2]. The study established certain differences in the level of manifestation for emotional, motivational, and psychophysiological components of students' academic adaptation before and during the pandemic. The hypotheses were tested regarding the role of subjective assessment of the pandemic situation, social frustration, and experience of loneliness under academic adaptation-related changes. Structural modeling allowed testing of the hypothesis concerning the direction of relations between variables. The pandemic situation is an important factor in reducing psycho-emotional and motivational components of academic adaptation. Interpersonal relations among students are the most important predictors of their academic adaptation. Assessment of the pandemic situation (29% variation), social frustration (49%), and loneliness (22%) are significant predictors of academic adaptation. The presence of diseases and attitudes regarding health risks, and satisfaction with relations with other educational process participants largely determines students' academic adaptation during the pandemic. At the same time, the direct effect of academic adaptation and the indirect one through the positive perception of distance learning is a more positive perception of Covid-19consequences.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43973094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment to Reviewers of OBM Neurobiology in 2022","authors":"Obm Neurobiology Editorial Office","doi":"10.21926/obm.neurobiol.2301149","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2301149","url":null,"abstract":"The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2022. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46254233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurostimulation for Traumatic Brain Injury: Emerging Innovation.","authors":"Michael Joseph Diaz, Kevin Thomas Root, Alice Beneke, Yordan Penev, Brandon Lucke-Wold","doi":"10.21926/obm.neurobiol.2301161","DOIUrl":"10.21926/obm.neurobiol.2301161","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encouraged deeper investigation of neurostimulation strategies, owed largely to its demonstrated livening of damaged neural circuitry and capacity to stabilize erratic network activity. The objective of the present study is to provide a scoping review of new knowledge in neurostimulation published in the PubMed, Scopus, and Google Scholar databases from inception to November 2022. We critically assess and appraise the available data on primary neurostimulation delivery techniques, with marked emphasis on restorative opportunities for accessory neurostimulation in the interdisciplinary care of moderate-to-severe TBI (msTBI) patients. These data identify two primary future directions: 1) to relate obtained gain-of-function outcomes to hemodynamic and histological changes and 2) to develop a clearer understanding of neurostimulation efficacy, when combined with pharmacologic interventions or other modulatory techniques, for complex brain insult.</p>","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9163083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary Tumors.","authors":"Sai Batchu, Michael J Diaz, Lauren Ladehoff, Brandon Lucke-Wold","doi":"10.21926/obm.neurobiol.2301153","DOIUrl":"10.21926/obm.neurobiol.2301153","url":null,"abstract":"<p><p>Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are commonly used to mimic tumors for <i>in vitro</i> experiments, but the extent to which they resemble GBM tumors in relation to the membranome is unclear. The present study explores the resemblance of GBM cell lines to primary tumors regarding membranome expression. Gene expression data was retrieved from Cancer Cell Line Encyclopedia (CCLE) and The Cancer Genome Atlas (TCGA). Membranomic genes were annotated and tumor purity was accounted for when correlating tumors and cell lines. The results suggest some commonly used cell lines, including AM38 and U87MG, display relatively little resemblance to tumors membranome. Differential gene expression analysis and subsequent gene set enrichment showed numerous genes related to neurexin/neuroligin, ion homeostasis, and synaptic signaling were downregulated in cell lines' membranomes compared to that of GBM tumors. The findings suggest that the membranome of GBM cell lines exhibit pronounced changes in gene expression compared to primary tumors and may not be completely representative of the disease process.</p>","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9276569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections.","authors":"Isabella Zuccaroli, Brandon Lucke-Wold, Adhith Palla, Alexander Eremiev, Zachary Sorrentino, Rasheedat Zakare-Fagbamila, Jack McNulty, Carlton Christie, Vyshak Chandra, David Mampre","doi":"10.21926/obm.neurobiol.2301158","DOIUrl":"10.21926/obm.neurobiol.2301158","url":null,"abstract":"<p><p>Reported neuro-modulation schemes in the literature are typically classified as closed-loop or open-loop. A novel group of recently developed neuro-modulation devices may be better described as a neural bypass, which attempts to transmit neural data from one location of the nervous system to another. The most common form of neural bypasses in the literature utilize EEG recordings of cortical information paired with functional electrical stimulation for effector muscle output, most commonly for assistive applications and rehabilitation in spinal cord injury or stroke. Other neural bypass locations that have also been described, or may soon be in development, include cortical-spinal bypasses, cortical-cortical bypasses, autonomic bypasses, peripheral-central bypasses, and inter-subject bypasses. The most common recording devices include EEG, ECoG, and microelectrode arrays, while stimulation devices include both invasive and noninvasive electrodes. Several devices are in development to improve the temporal and spatial resolution and biocompatibility for neuronal recording and stimulation. A major barrier to entry includes neuroplasticity and current decoding mechanisms that regularly require retraining. Neural bypasses are a unique class of neuro-modulation. Continued advancement of neural recording and stimulating devices with high spatial and temporal resolution, combined with decoding mechanisms uninhibited by neuroplasticity, can expand the therapeutic capability of neural bypassing. Overall, neural bypasses are a promising modality to improve the treatment of common neurologic disorders, including stroke, spinal cord injury, peripheral nerve injury, brain injury and more.</p>","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9168806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Cell Metabolic Landscape of Pituitary Neuroendocrine Tumor Subgroups and Lineages.","authors":"Sai Batchu, Michael Joseph Diaz, Keldon Lin, Namrata Arya, Karan Patel, Brandon Lucke-Wold","doi":"10.21926/obm.neurobiol.2301157","DOIUrl":"10.21926/obm.neurobiol.2301157","url":null,"abstract":"<p><p>Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors comprising numerous subtypes whose metabolic profiles have yet to be fully examined. The present <i>in silico</i> study analyzed single-cell expression profiles from 2311 PitNET cells from various lineages and subtypes to elucidate differences in metabolic activities. Gonadotroph tumors exhibited high activities with histidine metabolism, whose activity is low in lactotroph tumors. Somatotroph tumors enriched for sulfur and tyrosine metabolism, while lactotroph tumors were enriched metabolism of nitrogen, ascorbate, and aldarate. PIT-1 lineage tumors exhibited high sulfur and thiamine metabolism. These results set precedence for further translational studies for subgroup/lineage specific targeted therapies.</p>","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}