Nucleus (Austin, Tex.)最新文献

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease. 血管机械转导中的核膜成分：在血管健康和疾病中的新作用。

Nucleus (Austin, Tex.) Pub Date : 2025-12-01 Epub Date: 2025-01-19 DOI: 10.1080/19491034.2025.2453752

Tung D Nguyen, Michael A Winek, Mihir K Rao, Shaiva P Dhyani, Monica Y Lee

{"title":"Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease.","authors":"Tung D Nguyen, Michael A Winek, Mihir K Rao, Shaiva P Dhyani, Monica Y Lee","doi":"10.1080/19491034.2025.2453752","DOIUrl":"https://doi.org/10.1080/19491034.2025.2453752","url":null,"abstract":"The vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli. Recently, the nuclear envelope (NE) has emerged as a key regulator of vascular cell function. Studies implicate nucleoskeletal elements (e.g. nuclear lamina) and the linker of nucleoskeleton and cytoskeleton (LINC) complex in force transmission, emphasizing nucleo-cytoskeletal communication in mechanotransduction. The nuclear pore complex (NPC) and its component proteins (i.e. nucleoporins) also play roles in cardiovascular disease (CVD) progression. We herein summarize evidence on the roles of nuclear lamina proteins, LINC complex members, and nucleoporins in endothelial and vascular cell mechanotransduction. Numerous studies attribute NE components in cytoskeletal-related cellular behaviors to insinuate dysregulation of nucleocytoskeletal feedback and nucleocytoplasmic transport as a mechanism of endothelial and vascular dysfunction, and hence implications for aging and vascular pathophysiology.","PeriodicalId":74323,"journal":{"name":"Nucleus (Austin, Tex.)","volume":"16 1","pages":"2453752"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear envelope and chromatin choreography direct cellular differentiation.

Nucleus (Austin, Tex.) Pub Date : 2025-12-01 Epub Date: 2025-02-12 DOI: 10.1080/19491034.2024.2449520

Anjitha Nair, Jayati Khanna, Jashan Kler, Rohith Ragesh, Kundan Sengupta

{"title":"Nuclear envelope and chromatin choreography direct cellular differentiation.","authors":"Anjitha Nair, Jayati Khanna, Jashan Kler, Rohith Ragesh, Kundan Sengupta","doi":"10.1080/19491034.2024.2449520","DOIUrl":"10.1080/19491034.2024.2449520","url":null,"abstract":"The nuclear envelope plays an indispensable role in the spatiotemporal organization of chromatin and transcriptional regulation during the intricate process of cell differentiation. This review outlines the distinct regulatory networks between nuclear envelope proteins, transcription factors and epigenetic modifications in controlling the expression of cell lineage-specific genes during differentiation. Nuclear lamina with its associated nuclear envelope proteins organize heterochromatin via Lamina-Associated Domains (LADs), proximal to the nuclear periphery. Since nuclear lamina is mechanosensitive, we critically examine the impact of extracellular forces on differentiation outcomes. The nuclear envelope is spanned by nuclear pore complexes which, in addition to their central role in transport, are associated with chromatin organization. Furthermore, mutations in the nuclear envelope proteins disrupt differentiation, resulting in developmental disorders. Investigating the underlying nuclear envelope controlled regulatory mechanisms of chromatin remodelling during lineage commitment will accelerate our fundamental understanding of developmental biology and regenerative medicine.","PeriodicalId":74323,"journal":{"name":"Nucleus (Austin, Tex.)","volume":"16 1","pages":"2449520"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closing the loops: chromatin loop dynamics after DNA damage. 闭合环：DNA损伤后染色质环动力学。

Nucleus (Austin, Tex.) Pub Date : 2025-12-01 Epub Date: 2024-12-25 DOI: 10.1080/19491034.2024.2438633

Pierre-Alexandre Vidi, Jing Liu, Keith Bonin, Kerry Bloom

引用次数: 0

Correction. 修正。

Nucleus (Austin, Tex.) Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/19491034.2024.2443274

引用次数: 0

Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation. 核周细胞器损伤是由功能丧失引起的心肌病发病机制的纽带。

Nucleus (Austin, Tex.) Pub Date : 2025-12-01 Epub Date: 2025-01-09 DOI: 10.1080/19491034.2024.2449500

Jason C Choi

引用次数: 0

Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts. 通过比较重编码位点与不可编辑的对应位点，缩小有益的 A 到 I RNA 编辑的候选范围。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2024-01-29 DOI: 10.1080/19491034.2024.2304503

Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan

{"title":"Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts.","authors":"Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan","doi":"10.1080/19491034.2024.2304503","DOIUrl":"10.1080/19491034.2024.2304503","url":null,"abstract":"Adar-mediated adenosine-to-inosine (A-to-I) RNA editing mainly occurs in nucleus and diversifies the transcriptome in a flexible manner. It has been a challenging task to identify beneficial editing sites from the sea of total editing events. The functional Ser>Gly auto-recoding site in insect Adar gene has uneditable Ser codons in ancestral nodes, indicating the selective advantage to having an editable status. Here, we extended this case study to more metazoan species, and also looked for all Drosophila recoding events with potential uneditable synonymous codons. Interestingly, in D. melanogaster, the abundant nonsynonymous editing is enriched in the codons that have uneditable counterparts, but the Adar Ser>Gly case suggests that the editable orthologous codons in other species are not necessarily edited. The use of editable versus ancestral uneditable codon is a smart way to infer the selective advantage of RNA editing, and priority might be given to these editing sites for functional studies due to the feasibility to construct an uneditable allele. Our study proposes an idea to narrow down the candidates of beneficial recoding sites. Meanwhile, we stress that the matched transcriptomes are needed to verify the conservation of editing events during evolution.","PeriodicalId":74323,"journal":{"name":"Nucleus (Austin, Tex.)","volume":"15 1","pages":"2304503"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensing the squeeze: nuclear mechanotransduction in health and disease. 感知挤压：健康和疾病中的核机械传导。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/19491034.2024.2374854

Luv Kishore Srivastava, Allen J Ehrlicher

引用次数: 0

Long non-coding RNAs: roles in cellular stress responses and epigenetic mechanisms regulating chromatin. 长非编码 RNA：在细胞应激反应和调节染色质的表观遗传机制中的作用。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI: 10.1080/19491034.2024.2350180

Jeffrey A Nickerson, Fatemeh Momen-Heravi

引用次数: 0

PML Nuclear bodies: the cancer connection and beyond. PML 核体：与癌症的联系及其他。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2024-02-27 DOI: 10.1080/19491034.2024.2321265

Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach

{"title":"PML Nuclear bodies: the cancer connection and beyond.","authors":"Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach","doi":"10.1080/19491034.2024.2321265","DOIUrl":"10.1080/19491034.2024.2321265","url":null,"abstract":"Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal structure analyses revealed essential self-interacting domains, while liquid-liquid phase separation contributes to their formation. PML bodies orchestrate post-translational modifications, particularly stress-induced SUMOylation, impacting target protein functions. Serving as hubs in multiple signaling pathways, they influence cellular processes like senescence. Dysregulation of PML expression contributes to diseases, including cancer, highlighting their significance. Therapeutically, PML bodies are promising targets, exemplified by successful acute promyelocytic leukemia treatment with arsenic trioxide and retinoic acid restoring PML bodies. Understanding their functions illuminates both normal and pathological cellular physiology, guiding potential therapies. This review explores recent advancements in PML body biogenesis, biochemical activity, and their evolving biological roles.","PeriodicalId":74323,"journal":{"name":"Nucleus (Austin, Tex.)","volume":"15 1","pages":"2321265"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction. 凋亡诱导的 nesprin-2 从核包膜转位到线粒体与线粒体功能障碍有关。

Nucleus (Austin, Tex.) Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1080/19491034.2024.2413501

Hila Zohar, Liora Lindenboim, Oren Gozlan, Gregg G Gundersen, Howard J Worman, Reuven Stein

{"title":"Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction.","authors":"Hila Zohar, Liora Lindenboim, Oren Gozlan, Gregg G Gundersen, Howard J Worman, Reuven Stein","doi":"10.1080/19491034.2024.2413501","DOIUrl":"https://doi.org/10.1080/19491034.2024.2413501","url":null,"abstract":"Accumulating evidence suggests that the nuclear envelope (NE) is not just a target, but also a mediator of apoptosis. We showed recently that the NE protein nesprin-2 has pro-apoptotic activity, which involves its subcellular redistribution and Bcl-2 proteins. Here we further characterize the pro-apoptotic activity of nesprin-2 focusing on its redistribution. We assessed the redistribution kinetics of endogenous nesprin-2 tagged with GFP relative to apoptosis-associated mitochondrial dysfunction. The results show apoptosis-induced GFP-nesprin-2G redistribution occurred by two different modes - complete and partial, both lead to appearance of nesprin-2G near the mitochondria. Moreover, GFP-nesprin-2 redistribution is associated with reduction in mitochondrial membrane potential and mitochondrial outer membrane permeabilization and precedes the appearance of morphological features of apoptosis. Our results show that nesprin-2G redistribution and translocation near mitochondria is an early apoptotic effect associated with mitochondrial dysfunction, which may be responsible for the pro-apoptotic function of nesprin-2.","PeriodicalId":74323,"journal":{"name":"Nucleus (Austin, Tex.)","volume":"15 1","pages":"2413501"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0