Neurology perspectives最新文献

{"title":"Descriptive study of the activity at a headache day hospital","authors":"Á.J. Morales Lahoz, A.I. Dengra Maldonado, Á. Gómez Camello","doi":"10.1016/j.neurop.2024.100166","DOIUrl":"10.1016/j.neurop.2024.100166","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bálint syndrome in dementia with lewy bodies: A new phenotypic variant with progression implications?","authors":"R. Ghosh , M. León-Ruiz , S. Dubey , J. Benito-León","doi":"10.1016/j.neurop.2024.100171","DOIUrl":"10.1016/j.neurop.2024.100171","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000280/pdfft?md5=9497cb449cf05e69364b34dacc5dc920&pid=1-s2.0-S2667049624000280-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stroke in SARS-CoV-2 positive people is not necessarily caused by the virus","authors":"J. Finsterer , S. Mehri","doi":"10.1016/j.neurop.2024.100170","DOIUrl":"10.1016/j.neurop.2024.100170","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000279/pdfft?md5=4cb2727755b4accd5b2e3ab00e04e8f7&pid=1-s2.0-S2667049624000279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 disease severity and affectations in electroneuromyographic studies","authors":"E.A. Torres-Carranza ,&nbsp;S. Reyes-Bravo ,&nbsp;G. Hernández-Torres ,&nbsp;A.Y. Longoria-Castro ,&nbsp;O. Torres-Pineda ,&nbsp;G Marin","doi":"10.1016/j.neurop.2024.100169","DOIUrl":"10.1016/j.neurop.2024.100169","url":null,"abstract":"<div><h3>Introduction</h3><p>Emerging research has highlighted COVID-19's profound impact on the nervous system, with ongoing debate regarding its severity and the emergence of peripheral neurological disorders. This study delves into the correlation between COVID-19 severity and electromyographic abnormalities in hospitalized patients, aiming to elucidate the nature and extent of neuromuscular dysfunction associated with the disease.</p></div><div><h3>Methods</h3><p>In a retrospective, cross-sectional, observational study, we analyzed data from 170 patients treated at the North Physical Medicine and Rehabilitation Unit between July 2020 and April 2021. Post-COVID-19 patients underwent comprehensive motor and sensory nerve conduction studies. Spearman's correlation and Kruskal–Wallis tests were used to examine the relationship between disease severity and electromyographic findings.</p></div><div><h3>Results</h3><p>Of the 170 patients in the study, 71.17% were male and 28.82% female, with an average age of 48 years; the subgroup of patients with severe clinical classification predominated at 68.23%. Spearman's correlation yielded values higher than 0.5 for all parameters analyzed concerning severity classification. A significant difference was found in the average of non-evoked motor and sensory nerves, motor nerves with latency, amplitude, and conduction velocity impairment, and affected muscles regarding critical classification.</p></div><div><h3>Conclusion</h3><p>Our study showed a relationship between the severity of COVID-19 and an increase in non-evoked motor and sensory nerves, impaired motor nerve latency, amplitude, and velocity, and more affected muscles, particularly in critical cases.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000267/pdfft?md5=e9ddaa323060f407f0b6aeb6fe625061&pid=1-s2.0-S2667049624000267-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of the ocular movements test (HINTS) in the detection of central acute vestibular syndrome","authors":"Issa Layka ,&nbsp;Mostafa Ibrahim ,&nbsp;Ahmed Issa","doi":"10.1016/j.neurop.2024.100167","DOIUrl":"10.1016/j.neurop.2024.100167","url":null,"abstract":"<div><h3>Background</h3><p>Acute vestibular syndrome may seem intimidating due to the large overlap of symptoms between vestibular and non-vestibular causes, including serious and benign causes. In addition, there is no diagnostic method to differentiate between central and peripheral causes early.</p></div><div><h3>Objective</h3><p>This study aimed to evaluate the sensitivity and specificity of the ocular movements test (HINTS) in the detection of central acute vestibular syndrome.</p></div><div><h3>Materials and methods</h3><p>A prospective cross-sectional study was conducted, which included (<em>n</em> <!-->=<!--> <!-->58) patients admitted with a complaint of acute vestibular syndrome to Tishreen University Hospital in Latakia during the period from April 14, 2021 to July 1, 2022. Patients with acute vestibular syndrome (according to the definition of the International Classification of Vestibular Disorders) who were admitted to the hospital and who had at least one risk factor for stroke were included. Patients with a history of recurrent vertigo, those with diseases that would preclude HINTS testing, such as cervical or ocular diseases, and those for whom MRI was contraindicated were excluded. HINTS testing and brain CT were performed on admission. A brain MRI was performed 48 h after the onset of symptoms. The central lesion was diagnosed with a positive CT scan or MRI.</p></div><div><h3>Results</h3><p>Out of the 58 patients, 23 were diagnosed with a central lesion and 35 with a peripheral lesion. We found that in patients with a central lesion, with ischemic stroke being the most common cause. Cerebellar infarction was the most common, with a rate of 34.78%. We found bulbar infarction in 5 patients with a rate of 21.74%, pontine infarction in 4 with a rate of 17.39%, cerebellar metastasis in 3 with a rate of 13.04%, cerebellar peduncle infarction in 2 with a rate of 8.70%, and cerebellar hemorrhage in 1 with a rate of 4.35%. The HINTS test was positive (i.e., indicated a central lesion) in 22 patients with a central lesion and negative (i.e., indicated a peripheral lesion) in 33 patients with a peripheral lesion. Thus, the sensitivity of the HINTS test in detecting central acute vestibular syndrome was found to be 95.65%, and its specificity was 94.29%.</p></div><div><h3>Conclusion</h3><p>The HINTS test is a simple and cost-effective clinical tool that can be used to accurately diagnose central acute vestibular syndrome.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000243/pdfft?md5=6f56295acec35b39f116171b4cfbd2e6&pid=1-s2.0-S2667049624000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching of monoclonal antibodies against the calcitonin gene-related peptide or its receptor in migraine. Results from a Spanish Cohort","authors":"J. Arzalluz-Luque ,&nbsp;M. Millán Vázquez ,&nbsp;R. Lamas Pérez ,&nbsp;N. Sánchez Rodríguez ,&nbsp;P. Gómez López ,&nbsp;F.J. Gómez Fernández ,&nbsp;J. Viguera Romero ,&nbsp;C. Jurado Cobo ,&nbsp;M. Fernández Recio ,&nbsp;C. González Oria","doi":"10.1016/j.neurop.2024.100168","DOIUrl":"10.1016/j.neurop.2024.100168","url":null,"abstract":"<div><h3>Background</h3><p>Switching between calcitonin gene-related peptide (CGRP) and monoclonal antibodies (mAbs) may be a beneficial strategy after discontinuation. The aim of this study was to evaluate switching outcomes of effectiveness/tolerability.</p></div><div><h3>Methods</h3><p>Retrospective multicentric study of migraine patients who switched to another CGRP–mAb due to lack of tolerability or effectiveness (defined as &lt;<!--> <!-->30% reduction of monthly headache days [MHD]). Assessment was performed before and 3 months after switch. The main outcome was the response rate of MHD. Secondary outcomes included other effectiveness/tolerability measures.</p></div><div><h3>Results</h3><p>90patients were included: 75(83.3%) women, 72(80%) chronic, and 18(20%) episodic migraine. Mean age was 45.9<!--> <!-->±<!--> <!-->11 years and mean duration of migraine was 29.2<!--> <!-->±<!--> <!-->12.4 years. Mean time under first mAb prior to switch was 10.4<!--> <!-->±<!--> <!-->4.9 months. Most frequent switches were erenumab-galcanezumab 38 (42.2%) and erenumab–fremanezumab 21 (23.3%). Lack of effectiveness (50/90, 55.6%) or tolerability (40/90, 44.4%) provoked switching. Most common adverse events (AEs) leading to discontinuation were constipation and flu-like syndrome in 16 (40%) patients each. Response rate (RR) of MHD 30%–50% occurred in 10 patients (11.1%), ≥<!--> <!-->50% in 32 (35.6%) and &lt;<!--> <!-->30% in 48 (53.3%) patients. Significant reduction was proved after switch in MHD (20 [IQR:15–29] vs 13 [IQR:7–23]; <em>p</em> <!-->&lt;<!--> <!-->.001) and monthly migraine days (15 [IQR:12–20] vs 10 [IQR:7–16]; <em>p</em> <!-->&lt;<!--> <!-->.001). After switching, 38 (42.2%) experienced AEs, but tolerability improved in 50% of patients who discontinued due to lack of tolerability. RR compared between switches to different CGRP-mAb classes showed no differences.</p></div><div><h3>Conclusion</h3><p>Switching may become an individualized strategy in migraine refractory patients who discontinue CGRP–mAbs due to lack of effectiveness/tolerability. In this study, supportive data are provided to the growing evidence of switch and future needs are highlighted.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 4","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000255/pdfft?md5=ada1201f651792129ddd40e7444e7615&pid=1-s2.0-S2667049624000255-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of and factors associated with underdosing of direct oral anticoagulants in patients with ischaemic stroke and atrial fibrillation","authors":"E.M. Bacas ,&nbsp;J.C.P. Cuenca ,&nbsp;L.L. Gata ,&nbsp;M.M. Acevedo ,&nbsp;A.F. García ,&nbsp;I.C. Naranjo","doi":"10.1016/j.neurop.2024.100160","DOIUrl":"10.1016/j.neurop.2024.100160","url":null,"abstract":"<div><h3>Introduction</h3><p>Direct oral anticoagulants (DOACs) are the first line of stroke prevention treatment in patients with non-valvular atrial fibrillation (NVAF). However, their inappropriate use is associated with increased risk of stroke, haemorrhagic complications, and mortality. The aim of this study is to analyse the factors associated with the non-prescription of anticoagulants and the underdosing of DOACs.</p></div><div><h3>Methods</h3><p>We conducted a descriptive study of a prospective registry of patients admitted to a stroke unit due to ischaemic stroke or transient ischaemic attack (TIA) during an 1-year period. We included consecutive patients with history of NVAF with indication for anticoagulant therapy (ACT), according to the CHA₂DS₂-VASc scale. We analysed demographic factors, exposure to vascular risk factors, kidney function, polymedication, and short- and medium-term stroke progression.</p></div><div><h3>Results</h3><p>Data were obtained from 60 patients admitted due to TIA or ischaemic stroke, with a previous diagnosis of NVAF, of whom 13 (21.7%) were not receiving ACT. Of the remaining 47, 25 (53.2%) were under treatment with DOACs, 21 (44.7%) with vitamin K antagonists, and 1 (2.1%) with heparin. Among patients on DOACs, 8 (32%) were receiving inappropriately low doses, with no differences between drugs.</p><p>Age (80.8 vs 74.9 years, <em>p</em> <!-->=<!--> <!-->.05) and female sex (75% vs 35.3%, <em>p</em> <!-->=<!--> <!-->.05) were associated with underdosing of DOACs. Paroxysmal atrial fibrillation (46.2% vs 14.9%, <em>p</em> <!-->&lt;<!--> <!-->.005) and antiplatelet therapy (61.5% vs 8.5%, <em>p</em> <!-->&lt;<!--> <!-->.005) were associated with non-prescription of ACT.</p></div><div><h3>Conclusions</h3><p>Inappropriate use of ACT, including underdosing, is frequent in our setting, occurring in up to one-third of patients admitted due to ischaemic stroke.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 3","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000164/pdfft?md5=d632caec40de5f883f6e402417db3c20&pid=1-s2.0-S2667049624000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area postrema syndrome and longitudinally extensive transverse myelitis in neuromyelitis optica","authors":"D. López de Mota Sánchez,&nbsp;L. Maure Blesa,&nbsp;M.T. Montojo Villasanta,&nbsp;A. Herranz Bárcenas","doi":"10.1016/j.neurop.2024.100162","DOIUrl":"10.1016/j.neurop.2024.100162","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 3","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000188/pdfft?md5=3dd48bdb176433a98acdfaae6a2e732f&pid=1-s2.0-S2667049624000188-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of ultra-longitudinally extensive transverse myelitis in a Peruvian cohort","authors":"E. Guevara-Silva ,&nbsp;C. Caparó-Zamalloa ,&nbsp;V. Osorio-Marcatinco ,&nbsp;K. Álvarez-Toledo ,&nbsp;S. Castro-Suarez","doi":"10.1016/j.neurop.2024.100161","DOIUrl":"10.1016/j.neurop.2024.100161","url":null,"abstract":"<div><h3>Introduction</h3><p>Ultra-longitudinally extensive transverse myelitis (uLETM) is defined as an inflammatory lesion involving 10 or more spinal cord segments. The aim of our study is to describe the clinical and radiological features of this atypical form of myelitis.</p></div><div><h3>Methods</h3><p>We conducted a descriptive cross-sectional study of clinical data from 57 patients older than 18 years diagnosed with longitudinally extensive transverse myelitis. Nineteen cases were classified as uLETM.</p></div><div><h3>Results</h3><p>Twelve of the 19 patients were women, age ranged between 18 and 76 years, and the main aetiology was neuromyelitis optica spectrum disorder (8 patients), followed by anti-MOG antibody myelitis (3 patients). The main region involved was at cervical-thoracic spinal cord. Two patients presented complete spinal cord lesion.</p></div><div><h3>Conclusions</h3><p>Our results are consistent with previous reports suggesting that neuromyelitis optica spectrum disorder remains the main aetiology in uLETM; however, anti-MOG antibodies should be considered within the differential diagnosis.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 3","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000176/pdfft?md5=676772ac11a620cfc1a62e96cf0d2fb1&pid=1-s2.0-S2667049624000176-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141051906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between brain-derived neurotrophic factor and mild to moderate cognitive impairment in the older Mexican population","authors":"E. Rico-Fernández ,&nbsp;C.A. Reyes-Hernandez ,&nbsp;M.P. Rico-Fernández ,&nbsp;F.J. García-Alvarado ,&nbsp;H.A. Delgado-Aguirre","doi":"10.1016/j.neurop.2024.100158","DOIUrl":"https://doi.org/10.1016/j.neurop.2024.100158","url":null,"abstract":"<div><h3>Background</h3><p>Mild–moderate cognitive impairment is a frequent pathology in the adult population. It is important to explore early expression biomarkers that contribute to early detection and benefit the prognostic outlook. Brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, neuronal survival, and differentiation, and even a critical molecular target for drug development in neurological disorders. It is crucial to carry out studies in the early stages that better clarify the landscape of BDNF.</p></div><div><h3>Objective</h3><p>To compare the serum levels of BDNF in healthy adult patients and those with mild to moderate cognitive impairment.</p></div><div><h3>Materials and methods</h3><p>A casecontrol study in patients over 55- years with cognitive impairment, obtained by the MMSE® and MoCA® screening scales. A total of 191 patients, 102 patients with cognitive impairment (cases) and 89 healthy ones (controls) participated in the study. Blood samples were collected to obtain serum, with the determination of BDNF concentrations. For differences in BDNF concentrations, a one-way analysis of variance was used. The significance level of <em>p</em> <!-->&lt;<!--> <!-->.05.</p></div><div><h3>Results</h3><p>The mean serum concentration of BDNF in the case group was 277.68<!--> <!-->±<!--> <!-->75.09 vs. the control group, where the concentration was 354.97<!--> <!-->±<!--> <!-->66.06 pg/ml (<em>p</em> <!-->=<!--> <!-->.001).</p></div><div><h3>Conclusions</h3><p>There is an association between decreased BDNF levels and mild and moderate cognitive impairment in our study population.</p></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 3","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667049624000140/pdfft?md5=82765305e0905015f407c613d27d330d&pid=1-s2.0-S2667049624000140-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}