Neurology perspectives最新文献

{"title":"Retrospective, multi-centre, open-label study on the use of alemtuzumab for relapsing–remitting multiple sclerosis in clinical practice: A 4-year follow-up","authors":"A. Pato-Pato ,&nbsp;P. Gabeiras-Araujo ,&nbsp;M. Lorenzo-García ,&nbsp;C. Hernandez-Cerón ,&nbsp;J.R. Lorenzo-González ,&nbsp;D.A. García-Estévez","doi":"10.1016/j.neurop.2025.100192","DOIUrl":"10.1016/j.neurop.2025.100192","url":null,"abstract":"<div><h3>Introduction</h3><div>The efficacy and safety of alemtuzumab for patients with relapsing–remitting multiple sclerosis (RRMS) have been demonstrated in clinical trials. However, due to the limitations of these studies, it is important to assess the effects of the drug in clinical practice. The purpose of this study is to describe the effectiveness of alemtuzumab in terms of the number of relapses per year in patients with RRMS in the clinical setting. As secondary objectives, we evaluated its impact on disability and neuroimaging findings, as well as its tolerability and safety following administration.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, multi-centre, open-label study by reviewing the clinical records of patients receiving alemtuzumab for RRMS treatment.</div></div><div><h3>Results</h3><div>A total of 32 patients were included at the beginning of the 4-year follow-up period. The mean number of relapses per year remained below 0.35 during follow-up, compared to 1.25 per year before treatment. Disability, as measured with the Expanded Disability Status Scale, improved during the first 2 years, and remained stable thereafter. Neuroimaging revealed a decrease in disease activity. The most frequent adverse effects were infusion-related reactions and infections.</div></div><div><h3>Conclusions</h3><div>Alemtuzumab has been shown to be effective in clinical practice in reducing the number of relapses per year, improving disability and decreasing disease activity on brain MRI in patients with MS, with adequate tolerability and safety. However, prevention and monitoring strategies continue to be necessary.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 3","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Findings in orofacial praxis in clinical swallow examination in patients with neurogenic oropharyngeal dysphagia","authors":"J.C. Suárez-Escudero ,&nbsp;V. De Alba-Higuita ,&nbsp;J. Bareño-Silva","doi":"10.1016/j.neurop.2025.100191","DOIUrl":"10.1016/j.neurop.2025.100191","url":null,"abstract":"<div><h3>Introduction</h3><div>Praxis facilitate the execution of learned motor acts, including swallowing. Inability to perform praxis movements, or apraxia, may be classified according to different criteria. Buccopharyngeal apraxia includes orofacial apraxia. Clinical swallow evaluation does not typically include assessment of oropharyngeal/orofacial praxes; however, this would be of great semiological value, particularly in patients with neurological and neuromuscular disorders who present with dysphagia. The objective of this study was to explore and compare findings from the assessment of 3 orofacial praxis in healthy individuals without dysphagia and in patients with neurogenic oropharyngeal dysphagia, as part of the clinical swallow examination.</div></div><div><h3>Methods</h3><div>We designed a case–control study based on a clinical swallow examination that included an assessment of 3 orofacial praxis. Comparisons were made, and odds ratios with 95% confidence intervals were calculated. Non-performance of the 3 orofacial praxis was recorded separately and jointly, adjusting for sex and age in both groups, as well as for other clinical variables of interest in the patient group.</div></div><div><h3>Results</h3><div>Our study included 86 patients and 80 controls. Oral motor apraxia was associated with oropharyngeal dysphagia; more specifically, the presence of neurogenic oropharyngeal dysphagia was found to be associated with difficulty in moving both lips together to either side, as well as with such other physical examination findings as tongue fasciculations and atrophy, and impaired tongue coordination. No statistically significant association was observed with age or sex in either group.</div></div><div><h3>Conclusion</h3><div>Assessment of orofacial praxes can help to identify patients with neurogenic oropharyngeal dysphagia.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 3","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myasthenic crisis probably triggered by local lidocaine infiltration unveiling generalized myasthenia gravis without extraocular muscle involvement","authors":"M. León-Ruiz ,&nbsp;C. Rízea ,&nbsp;J. Álvarez-Troncoso ,&nbsp;M. Quintana-Díaz ,&nbsp;G. Zmork-Martínez ,&nbsp;J. Benito-León ,&nbsp;J. Rodríguez-Pardo","doi":"10.1016/j.neurop.2025.100193","DOIUrl":"10.1016/j.neurop.2025.100193","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 3","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxysmal tonic upgaze with epileptiform discharges and calcarine sulcus lesion","authors":"Nazaret Peláez Viña ,&nbsp;Dennis Dunlop Bórquez ,&nbsp;Eva Negro Moral ,&nbsp;Maite Cáceres","doi":"10.1016/j.neurop.2025.100185","DOIUrl":"10.1016/j.neurop.2025.100185","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immune evolution in neurological/psychiatric patients during the COVID-19 pandemic","authors":"A. Toledo ,&nbsp;M.A. Gaona ,&nbsp;T. Delgadillo ,&nbsp;C.T. Arellano ,&nbsp;A. Padilla ,&nbsp;S. Bravo ,&nbsp;H. Alipi ,&nbsp;V. Toledo ,&nbsp;M.A. Del Rio Quiñones ,&nbsp;D.L. De la Cruz-Aguilera ,&nbsp;L. Aguirre-Cruz ,&nbsp;A. Fleury","doi":"10.1016/j.neurop.2025.100189","DOIUrl":"10.1016/j.neurop.2025.100189","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic has had a disastrous impact on the world's population. Its effects were mainly respiratory, but resulting neurological damage has also been described. In this context, we evaluated the effects of COVID-19 on the subjective perception of neurological and psychiatric symptoms in patients with pre-pandemic neuropsychiatric diseases, as well as the possible association between the evolution of these symptoms and immunological factors.</div></div><div><h3>Methods</h3><div>A cohort of neurological/psychiatric patients with (n = 99) or without (n = 42) a history of COVID-19 was included. Inclusion took place 7 months after COVID-19 infection, and follow-up was performed 14 months after inclusion. At both assessments, included subjects were asked whether they considered their neurological/psychiatric symptoms to be stable, worsened or improved compared with the situation before COVID-19, or compared with the first assessment. A blood sample of all subjects was taken at both assessments to determine levels of several cytokines<strong>.</strong></div></div><div><h3>Results</h3><div>A worsening of neurological/psychiatric symptoms was reported by 36.9% of patients, when comparing the situation at follow-up with that prior to COVID-19. Comparing with controls, patients with history of COVID-19 had significantly higher levels of IL-6 and IFN-γ, and patients with a history of symptomatic COVID-19 presented a significant higher level of IL-10. IFN-γ was significantly associated with COVID-19 severity, and its decrease during follow-up was associated with improvement of neurological/psychiatric symptoms in neurological patients with a history of COVID-19, but not in control patients.</div></div><div><h3>Conclusions</h3><div>More than 35% of included neuropsychiatric patients have reported worsening of symptoms after non-severe COVID-19. IFN-γ seems to be a marker linked to COVID-19 pathogeny and its evaluation might be useful for monitoring affected patients.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on physiotherapy for patients with multiple sclerosis in Spain: Adaptation and challenges in the implementation of telerehabilitation","authors":"I. Yeregui-Prieto ,&nbsp;R. Berriozabalgoitia Etxaniz ,&nbsp;N. Martínez Lerín ,&nbsp;G. Yaya-Tur ,&nbsp;G. Loyola ,&nbsp;E.R. Meza-Murillo ,&nbsp;C. Santoyo-Medina","doi":"10.1016/j.neurop.2025.100188","DOIUrl":"10.1016/j.neurop.2025.100188","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic, declared in March 2020, had a profound impact on health services in Spain, especially on physiotherapy for people with multiple sclerosis (PwMS). The health reorganization forced the suspension of rehabilitation services, affecting millions of people with disabilities in Europe.</div></div><div><h3>Objective</h3><div>To evaluate the impact of the pandemic on the clinical practice of the Physiotherapy Collective (CF) specialized in multiple sclerosis (MS) in Spain, highlighting the changes in interventions and the use of telerehabilitation (TRHB).</div></div><div><h3>Materials and methods</h3><div>An international survey was designed and disseminated in Spain through MS associations. The sample included 32 physiotherapists. The statistical analysis was performed with IBM SPSS, with a significance level of <em>p</em> ≤ 0.05.</div></div><div><h3>Results</h3><div>A total of 78% of physiotherapists worked with PwMS before the pandemic, and the use of TRHB increased to 29.24%. A reduction in face-to-face interventions, especially in manual therapies, was observed, mainly affecting patients with severely impaired mobility (SIM). However, 81.3% kept aerobic training sessions online. The main barriers were the lack of devices and the difficulty in conducting adequate assessments.</div></div><div><h3>Conclusions</h3><div>The pandemic not only underscored the importance of TRHB but also exposed key limitations. Future research should focus on improving its feasibility and providing appropriate training to optimize care for PwMS.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré syndrome following acute hepatitis E virus infection: A novel Indian case report with acute inflammatory demyelinating polyneuropathy pattern and anti-GM1 antibodies","authors":"R. Ghosh ,&nbsp;M. León-Ruiz ,&nbsp;A.S. Mondal ,&nbsp;S. Dubey ,&nbsp;J. Benito-León","doi":"10.1016/j.neurop.2025.100187","DOIUrl":"10.1016/j.neurop.2025.100187","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset cerebral X-linked adrenoleukodystrophy presenting with frontal lobe syndrome caused by a de novo ABCD1 gene mutation (c.1415_1416delAG, p.Gln472fs*83)","authors":"R. Ghosh ,&nbsp;M. León-Ruiz ,&nbsp;A. Jana ,&nbsp;S. Dubey ,&nbsp;J. Benito-León","doi":"10.1016/j.neurop.2025.100186","DOIUrl":"10.1016/j.neurop.2025.100186","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke machine learning for discharge planning: A pilot implementation study","authors":"S. Bacchi ,&nbsp;R. Goh ,&nbsp;J. Kovoor ,&nbsp;S. Gluck ,&nbsp;L. Oakden-Rayner ,&nbsp;S. Koblar ,&nbsp;T. Kleinig ,&nbsp;J. Jannes","doi":"10.1016/j.neurop.2025.100183","DOIUrl":"10.1016/j.neurop.2025.100183","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset myoclonic epilepsy in Down syndrome (LOMEDS) and efficacy of perampanel","authors":"Nazaret Peláez Vina ,&nbsp;D.D. Bórquez ,&nbsp;E.N. Moral ,&nbsp;M. Cáceres","doi":"10.1016/j.neurop.2025.100184","DOIUrl":"10.1016/j.neurop.2025.100184","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}