Neurology perspectives最新文献

{"title":"Paroxysmal tonic upgaze with epileptiform discharges and calcarine sulcus lesion","authors":"Nazaret Peláez Viña , Dennis Dunlop Bórquez , Eva Negro Moral , Maite Cáceres","doi":"10.1016/j.neurop.2025.100185","DOIUrl":"10.1016/j.neurop.2025.100185","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immune evolution in neurological/psychiatric patients during the COVID-19 pandemic","authors":"A. Toledo ,&nbsp;M.A. Gaona ,&nbsp;T. Delgadillo ,&nbsp;C.T. Arellano ,&nbsp;A. Padilla ,&nbsp;S. Bravo ,&nbsp;H. Alipi ,&nbsp;V. Toledo ,&nbsp;M.A. Del Rio Quiñones ,&nbsp;D.L. De la Cruz-Aguilera ,&nbsp;L. Aguirre-Cruz ,&nbsp;A. Fleury","doi":"10.1016/j.neurop.2025.100189","DOIUrl":"10.1016/j.neurop.2025.100189","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic has had a disastrous impact on the world's population. Its effects were mainly respiratory, but resulting neurological damage has also been described. In this context, we evaluated the effects of COVID-19 on the subjective perception of neurological and psychiatric symptoms in patients with pre-pandemic neuropsychiatric diseases, as well as the possible association between the evolution of these symptoms and immunological factors.</div></div><div><h3>Methods</h3><div>A cohort of neurological/psychiatric patients with (n = 99) or without (n = 42) a history of COVID-19 was included. Inclusion took place 7 months after COVID-19 infection, and follow-up was performed 14 months after inclusion. At both assessments, included subjects were asked whether they considered their neurological/psychiatric symptoms to be stable, worsened or improved compared with the situation before COVID-19, or compared with the first assessment. A blood sample of all subjects was taken at both assessments to determine levels of several cytokines<strong>.</strong></div></div><div><h3>Results</h3><div>A worsening of neurological/psychiatric symptoms was reported by 36.9% of patients, when comparing the situation at follow-up with that prior to COVID-19. Comparing with controls, patients with history of COVID-19 had significantly higher levels of IL-6 and IFN-γ, and patients with a history of symptomatic COVID-19 presented a significant higher level of IL-10. IFN-γ was significantly associated with COVID-19 severity, and its decrease during follow-up was associated with improvement of neurological/psychiatric symptoms in neurological patients with a history of COVID-19, but not in control patients.</div></div><div><h3>Conclusions</h3><div>More than 35% of included neuropsychiatric patients have reported worsening of symptoms after non-severe COVID-19. IFN-γ seems to be a marker linked to COVID-19 pathogeny and its evaluation might be useful for monitoring affected patients.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on physiotherapy for patients with multiple sclerosis in Spain: Adaptation and challenges in the implementation of telerehabilitation","authors":"I. Yeregui-Prieto ,&nbsp;R. Berriozabalgoitia Etxaniz ,&nbsp;N. Martínez Lerín ,&nbsp;G. Yaya-Tur ,&nbsp;G. Loyola ,&nbsp;E.R. Meza-Murillo ,&nbsp;C. Santoyo-Medina","doi":"10.1016/j.neurop.2025.100188","DOIUrl":"10.1016/j.neurop.2025.100188","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic, declared in March 2020, had a profound impact on health services in Spain, especially on physiotherapy for people with multiple sclerosis (PwMS). The health reorganization forced the suspension of rehabilitation services, affecting millions of people with disabilities in Europe.</div></div><div><h3>Objective</h3><div>To evaluate the impact of the pandemic on the clinical practice of the Physiotherapy Collective (CF) specialized in multiple sclerosis (MS) in Spain, highlighting the changes in interventions and the use of telerehabilitation (TRHB).</div></div><div><h3>Materials and methods</h3><div>An international survey was designed and disseminated in Spain through MS associations. The sample included 32 physiotherapists. The statistical analysis was performed with IBM SPSS, with a significance level of <em>p</em> ≤ 0.05.</div></div><div><h3>Results</h3><div>A total of 78% of physiotherapists worked with PwMS before the pandemic, and the use of TRHB increased to 29.24%. A reduction in face-to-face interventions, especially in manual therapies, was observed, mainly affecting patients with severely impaired mobility (SIM). However, 81.3% kept aerobic training sessions online. The main barriers were the lack of devices and the difficulty in conducting adequate assessments.</div></div><div><h3>Conclusions</h3><div>The pandemic not only underscored the importance of TRHB but also exposed key limitations. Future research should focus on improving its feasibility and providing appropriate training to optimize care for PwMS.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré syndrome following acute hepatitis E virus infection: A novel Indian case report with acute inflammatory demyelinating polyneuropathy pattern and anti-GM1 antibodies","authors":"R. Ghosh ,&nbsp;M. León-Ruiz ,&nbsp;A.S. Mondal ,&nbsp;S. Dubey ,&nbsp;J. Benito-León","doi":"10.1016/j.neurop.2025.100187","DOIUrl":"10.1016/j.neurop.2025.100187","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset cerebral X-linked adrenoleukodystrophy presenting with frontal lobe syndrome caused by a de novo ABCD1 gene mutation (c.1415_1416delAG, p.Gln472fs*83)","authors":"R. Ghosh ,&nbsp;M. León-Ruiz ,&nbsp;A. Jana ,&nbsp;S. Dubey ,&nbsp;J. Benito-León","doi":"10.1016/j.neurop.2025.100186","DOIUrl":"10.1016/j.neurop.2025.100186","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke machine learning for discharge planning: A pilot implementation study","authors":"S. Bacchi ,&nbsp;R. Goh ,&nbsp;J. Kovoor ,&nbsp;S. Gluck ,&nbsp;L. Oakden-Rayner ,&nbsp;S. Koblar ,&nbsp;T. Kleinig ,&nbsp;J. Jannes","doi":"10.1016/j.neurop.2025.100183","DOIUrl":"10.1016/j.neurop.2025.100183","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset myoclonic epilepsy in Down syndrome (LOMEDS) and efficacy of perampanel","authors":"Nazaret Peláez Vina ,&nbsp;D.D. Bórquez ,&nbsp;E.N. Moral ,&nbsp;M. Cáceres","doi":"10.1016/j.neurop.2025.100184","DOIUrl":"10.1016/j.neurop.2025.100184","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 2","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibero-American consensus statement on migraine treatment","authors":"José Miguel Láinez ,&nbsp;Oscar Pradilla ,&nbsp;Pablo Irimia ,&nbsp;Fidel Sobrino ,&nbsp;Michel Volcy ,&nbsp;Pedro Kowaks ,&nbsp;Ildefonso Rodríguez Leyva ,&nbsp;Fiorella Martín ,&nbsp;Lucía Zavala ,&nbsp;Alex Espinoza","doi":"10.1016/j.neurop.2024.100182","DOIUrl":"10.1016/j.neurop.2024.100182","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Migraine is the most common reason for neurology outpatient consultation; more than 80% of patients with migraine suffer some degree of associated disability. Migraine is an underdiagnosed disorder and patients frequently receive inappropriate treatment, which is why it is necessary to establish recommendations to improve patient management. The objective of this document is to establish a consensus position on the pharmacological treatment of migraine, including general measures and detailed analysis of the different options for the treatment of attacks and their prevention, from the perspective of Ibero-American countries.</div></div><div><h3>Methods and results</h3><div>Based on the recommendation documents published by the scientific societies of different Ibero-American countries, 2 surveys were prepared; through the application of the Delphi methodology and discussions in subsequent meetings, a document was developed in consensus format, supported by evidence from the literature and expert recommendations.</div></div><div><h3>Conclusions</h3><div>A series of recommendations were agreed upon for the treatment of episodic migraine and chronic migraine, both for the acute management of attacks and for their prevention. These recommendations are based on the consensus process and a literature review, and are adapted to the regional conditions of the Ibero-American countries.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 1","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain","authors":"M. Llaneza ,&nbsp;G. Fontes ,&nbsp;L. Benedito-Palos ,&nbsp;E. Moral","doi":"10.1016/j.neurop.2024.100178","DOIUrl":"10.1016/j.neurop.2024.100178","url":null,"abstract":"<div><h3>Introduction</h3><div>Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood.</div></div><div><h3>Methods</h3><div>Based on a review of the literature and the experience of a scientific committee made up by 2 neurologists, an ad hoc survey was developed and distributed to Spanish neurologists. It included 22 questions related to the first-line therapeutic management of RRMS.</div></div><div><h3>Results</h3><div>Sixty neurologists (mean age: 45.6 years, 60% women, mean of 16.0 years of experience, mean of 93.8 patients with RRMS attended/month) participated in the study. Neurologists considered that the 3 most important treatment characteristics (1–8 points, with higher scores denoting greater relevance) in treatment decision-making were efficacy in disease control (7.8<!--> <!-->±<!--> <!-->0.5), safety/tolerability (6.7<!--> <!-->±<!--> <!-->0.9), and improvements in patient quality of life (5.0<!--> <!-->±<!--> <!-->1.5); regarding patient characteristics, the 3 most important (1–7 points) were disease activity (6.9<!--> <!-->±<!--> <!-->0.5), intention to become pregnant (5.0<!--> <!-->±<!--> <!-->1.0), and level of disability (4.3<!--> <!-->±<!--> <!-->1.8). Dimethyl fumarate (32.6%) was the most frequently prescribed treatment, followed by teriflunomide (24.8%) and glatiramer acetate (17.6%). According to over 87% of the specialists, the latter drug was considered the most appropriate treatment for patients with liver disorders, who intended to become pregnant, and who presented low disease activity.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence on the first-line therapeutic management of non-aggressive forms of RRMS and the factors influencing decision-making in routine clinical practice.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 1","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20886. EFECTIVIDAD DEL TRATAMIENTO CON TOXINA BOTULÍNICA Y ANTICUERPOS MONOCLONALES ANTI-CGRP EN LA MIGRAÑA ASOCIADA A LA MENSTRUACIÓN","authors":"L. Gómez Dabó,&nbsp;R. Mas de les Valls,&nbsp;V. Gallardo Gómez-Dabó,&nbsp;A. Alpuente,&nbsp;M. Torres Ferrús,&nbsp;E. Caronna,&nbsp;E. Giné Ciprés,&nbsp;P. Pozo Rosich","doi":"10.1016/S2667-0496(24)00052-8","DOIUrl":"10.1016/S2667-0496(24)00052-8","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Pages 4-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}