Neurocirugia (English Edition)最新文献

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Direct puncture embolization of intracranial solitary fibrous tumor with SQUID 用SQUID直接穿刺栓塞颅内孤立性纤维性肿瘤。
Neurocirugia (English Edition) Pub Date : 2025-11-01 Epub Date: 2025-06-02 DOI: 10.1016/j.neucie.2025.500700
Dixit Varma, Avinash A. Gutte, Snehal Kose, Abin Jose
{"title":"Direct puncture embolization of intracranial solitary fibrous tumor with SQUID","authors":"Dixit Varma,&nbsp;Avinash A. Gutte,&nbsp;Snehal Kose,&nbsp;Abin Jose","doi":"10.1016/j.neucie.2025.500700","DOIUrl":"10.1016/j.neucie.2025.500700","url":null,"abstract":"<div><div>Solitary fibrous tumors<span> (SFTs) are rare intracranial neoplasms that are highly vascular, making surgical resection challenging due to significant intraoperative blood loss. Preoperative embolization is commonly performed via the transarterial route; however, this approach has limitations, including difficulty in accessing multiple feeders, prolonged procedural time, and the risk of embolic material reflux into the intracranial circulation.</span></div><div>Here, we report the case of a 19-year-old male with a large intracranial SFT, initially treated with transarterial embolization using polyvinyl alcohol<span> (PVA) particles, which failed to achieve proper devascularization of the tumor. Consequently, direct puncture embolization using the SQUID 12 agent was performed. Following successful embolization, complete tumor resection was achieved with significantly reduced intraoperative blood loss and no postoperative neurological deficits.</span></div><div>This case highlights the effectiveness of direct puncture embolization as a viable alternative to traditional transarterial approaches for managing highly vascular intracranial tumors.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 6","pages":"Article 500700"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is monopolar electrocautery use in vagus nerve stimulator revision surgery a risk to avoid or a safe surgical option? 在迷走神经刺激器翻修手术中使用单极电是一种需要避免的风险还是一种安全的手术选择?
Neurocirugia (English Edition) Pub Date : 2025-11-01 Epub Date: 2025-05-13 DOI: 10.1016/j.neucie.2025.500674
Cezmi Çağrı Türk , Umut Ogün Mutlucan , Orhan Günay , Fatma Genç , Meltem Korucuk , Gültekin Kutluk
{"title":"Is monopolar electrocautery use in vagus nerve stimulator revision surgery a risk to avoid or a safe surgical option?","authors":"Cezmi Çağrı Türk ,&nbsp;Umut Ogün Mutlucan ,&nbsp;Orhan Günay ,&nbsp;Fatma Genç ,&nbsp;Meltem Korucuk ,&nbsp;Gültekin Kutluk","doi":"10.1016/j.neucie.2025.500674","DOIUrl":"10.1016/j.neucie.2025.500674","url":null,"abstract":"<div><h3>Background</h3><div>The use of monopolar electrocautery<span> in vagal nerve stimulator (VNS) revision surgeries has been debated due to concerns about device interference. Thus, herein, we aimed to evaluate the safety and efficacy of monopolar electrocautery during VNS generator replacement surgeries, particularly its impact on seizure control and battery performance.</span></div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted on 30 patients who underwent VNS generator revision at a tertiary care center. Patients were divided into two groups: those in whom monopolar electrocautery was used (n = 18) and those in whom it was not used (n= = 12). Pre- and postoperative data were collected, including seizure frequency, VNS settings, and operative time. The McHugh Outcome Classification was used to assess seizure control.</div></div><div><h3>Results</h3><div>The surgeries were significantly shorter in the electrocautery group than in the nonelectrocautery group (20.06 ± 2.29 vs. 51.83 ± 12.76 min, p &lt; 0.001). Furthermore, there was no significant difference in seizure control between the two groups (p &gt; 0.05). In two patients, a decline in seizure control classification was noted. However, this did not reach statistical significance. No lead damage or major complications developed in either group.</div></div><div><h3>Conclusion</h3><div>Monopolar electrocautery significantly reduces the operative time during VNS generator revisions without compromising seizure control or increasing the risk of complications. Thus, monopolar electrocautery can be safely used in VNS revision surgeries, potentially streamlining the procedure and improving patient outcomes. However, further studies with larger populations are needed to confirm these findings.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 6","pages":"Article 500674"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy surgery in children: Outcomes of patients with drug-resistant epilepsy at a paediatric hospital in Bogotá, Colombia, with 10 years of follow-up 儿童癫痫手术:哥伦比亚波哥大<e:1>一家儿科医院耐药癫痫患者随访10年的结果
Neurocirugia (English Edition) Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1016/j.neucie.2025.500701
Kevin José Navarro Jaime , Bryan Gómez Cristancho , David C. Gómez Cristancho , Nelson Andres Cuevas Morales , Armando Rojas Calderon , Oscar Fernando Zorro Guio
{"title":"Epilepsy surgery in children: Outcomes of patients with drug-resistant epilepsy at a paediatric hospital in Bogotá, Colombia, with 10 years of follow-up","authors":"Kevin José Navarro Jaime ,&nbsp;Bryan Gómez Cristancho ,&nbsp;David C. Gómez Cristancho ,&nbsp;Nelson Andres Cuevas Morales ,&nbsp;Armando Rojas Calderon ,&nbsp;Oscar Fernando Zorro Guio","doi":"10.1016/j.neucie.2025.500701","DOIUrl":"10.1016/j.neucie.2025.500701","url":null,"abstract":"<div><h3>Introduction</h3><div>Drug-resistant epilepsy is defined as the lack of response to two appropriately selected antiepileptic drugs that the patient has tolerated properly. Epilepsy is a common neurological disorder in the paediatric population, with an estimated prevalence ranging from 4.3 to 9.3 cases per 1000 children, affecting 1.2% of the global population. Despite pharmacological treatment, between 30% and 40% of patients fail to achieve adequate seizure control, and approximately half of these become candidates for epilepsy surgery.</div></div><div><h3>Objective</h3><div>To determine the incidence of seizure freedom, considering the Engel classification, in paediatric patients undergoing epilepsy surgery at a level IV paediatric hospital in Bogotá, Colombia.</div></div><div><h3>Methodology</h3><div>A retrospective observational cohort study was conducted with paediatric patients treated at a level IV paediatric hospital by the epilepsy surgery team between January 1, 2013, and July 31, 2024.</div></div><div><h3>Results</h3><div>Between 2013 and 2024, a total of 326 patients were evaluated through the epilepsy surgery programme. Of these, 154 underwent surgery. The median postoperative follow-up was 40<!--> <!-->months. The type of surgery was significantly associated with a higher likelihood of achieving favourable outcomes at 6<!--> <!-->months (RR<!--> <!-->=<!--> <!-->3.54; 95%<!--> <!-->CI: 1.86–6.77; <em>p</em> <!-->&lt;<!--> <!-->.001) and 12<!--> <!-->months of follow-up (RR<!--> <!-->=<!--> <!-->4; 95%<!--> <!-->CI: 1.96–8.08; <em>p</em> <!-->&lt;<!--> <!-->.001). The presence of daily seizures and the need for treatment with more than three medications were associated with a lower likelihood of achieving favourable outcomes during the follow-up period.</div></div><div><h3>Conclusions</h3><div>The loss of years of healthy life since the diagnosis of epilepsy and the type of surgery performed (palliative or curative) were identified as independent factors strongly associated with favourable outcomes in the treatment of drug-resistant epilepsy.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 6","pages":"Article 500701"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fully percutaneous posterior transarticular C1-C2 stand-alone screw instrumentation: A case series and technical note 完全经皮后路经关节C1-C2独立螺钉内固定:一个病例系列和技术说明。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-05 DOI: 10.1016/j.neucie.2025.500665
Ivan Lvov, Andrey Grin, Anton Kordonskiy, Zaali Barbakadze, Aleksandr Talypov, Aleksandr Tupikin
{"title":"Fully percutaneous posterior transarticular C1-C2 stand-alone screw instrumentation: A case series and technical note","authors":"Ivan Lvov,&nbsp;Andrey Grin,&nbsp;Anton Kordonskiy,&nbsp;Zaali Barbakadze,&nbsp;Aleksandr Talypov,&nbsp;Aleksandr Tupikin","doi":"10.1016/j.neucie.2025.500665","DOIUrl":"10.1016/j.neucie.2025.500665","url":null,"abstract":"<div><div>Magerl’s technique remains a widely accepted method for achieving C1-C2 fusion. Although two approaches using intermuscular corridors and biplanar X-ray guidance have been reported, there are no published studies dedicated to fully percutaneous techniques employing cannulated screws.</div></div><div><h3>Objective</h3><div>To demonstrate the feasibility of a fully percutaneous C1-C2 fixation technique using cannulated screws and to analyze the short- and long-term outcomes of the initial case series.</div></div><div><h3>Material and methods</h3><div>This case series included patients over 15 years of age who were presented with acute or subacute atlantoaxial instability at C1-C2 due to fractures of the odontoid process<span>, C1 vertebra<span>, or C2 vertebral body. Surgical details and fusion criteria were described. Due to the absence of comparison groups, only descriptive statistical methods were employed.</span></span></div></div><div><h3>Results</h3><div><span>A total of 11 patients (8 men, 3 women; mean age 41.5 ± 18.2 years) underwent fully percutaneous transarticular C1-C2 fixation. The mean operative time was 115.0 ± 30.8 min for patients stabilized using a Halo device and 80.6 ± 33.2 min for those immobilized with a Mayfield clamp. The mean blood loss across all cases was 38.8 ± 8.7 mL. One patient died from concurrent cardiac pathology. Two patients were lost to follow-up due to relocation, leaving 8 patients for final assessment. At final follow-up, the mean VAS score was 2 ± 1.5 and the mean </span>NDI<span> score was 5.3 ± 5.2. All patients with preoperative neurological deficits improved by one level on the ASIA scale. Fusion was achieved in 7 of 8 cases (87.5%), and 1 patient (12.5%) developed a stable C1-C2 pseudoarthrosis.</span></div></div><div><h3>Conclusion</h3><div>Our initial clinical experience demonstrated that fully percutaneous posterior transarticular C1-C2 stand-alone screw fixation using cannulated instruments could be a feasible and safe procedure. Critical requirements for this technique include complete reduction of atlantoaxial dislocation, compression in the lateral joint region, adequate intraoperative visualization, and strict adherence to specific screw trajectories.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500665"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALIF in a Spanish female cohort: No urinary and sexual complications or a gender bias? ALIF在西班牙女性队列中:没有泌尿和性并发症还是性别偏见?
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-05 DOI: 10.1016/j.neucie.2025.500662
Cristina Romero-López , Santiago Rocha-Romero , María de los Ángeles Cañizares-Méndez , Julio Valencia-Anguita
{"title":"ALIF in a Spanish female cohort: No urinary and sexual complications or a gender bias?","authors":"Cristina Romero-López ,&nbsp;Santiago Rocha-Romero ,&nbsp;María de los Ángeles Cañizares-Méndez ,&nbsp;Julio Valencia-Anguita","doi":"10.1016/j.neucie.2025.500662","DOIUrl":"10.1016/j.neucie.2025.500662","url":null,"abstract":"<div><h3>Background</h3><div>The objective of the present study is to analyze urinary and sexual functions in females treated with ALIF and to describe possible complications not previously reported in the literature.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of urinary and sexual functions in females treated with this technique in our hospital between 2019 and 2022. Inclusion criteria were: females treated with ALIF who provided informed consent.</div></div><div><h3>Results</h3><div><span><span>22 patients consented to participate. The median age was 51.5 years, the median follow-up was 11.5 months, and there was an improvement in low back pain of 4 points on the postoperative (postop) visual analogue scale (VAS). Overall, 36.3% of patients reported postoperative urinary deterioration, including 27.3% with new-onset </span>urinary incontinence. The international consultation on incontinence questionnaire-short form score worsened by 3.5 points. 77.2% maintained an active sexual life; within this group, there was a worsening of 2.4 points in the postop female sexual function index and 35.2% described worsening in sexual function. We hypothesized that age, underlying lumbar pathology and changes in postoperative VAS scores could be confounding factors; however, only the relationship between age and postoperative urinary deterioration reached statistical significance (</span><em>p</em> = 0.034).</div></div><div><h3>Conclusions</h3><div>The present study describes deterioration in urinary function in 36.3% and in sexual function in 35.2% after the procedure, findings also supported by specific scales. In view of the above, we cannot discount a possible gender bias in the literature. Despite that, we believe that ALIF is still an adequate technique, but studies of higher level of evidence should be conducted to improve the information process of our patients.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500662"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous sitting position during the postoperative period as an intervention to reduce risk of cerebrospinal fluid leak after endoscopic endonasal surgery 内镜鼻内窥镜手术后持续坐位作为降低脑脊液漏风险的干预措施。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-04 DOI: 10.1016/j.neucie.2025.500658
José de Jesús Martínez-Manrique , Ricardo A. Palacios-Rodríguez , Luis A. Rodríguez-Hernández , Jorge F. Aragón-Arreola , Marcos V. Sangrador-Deitos , Juan Luis Gómez-Amador
{"title":"Continuous sitting position during the postoperative period as an intervention to reduce risk of cerebrospinal fluid leak after endoscopic endonasal surgery","authors":"José de Jesús Martínez-Manrique ,&nbsp;Ricardo A. Palacios-Rodríguez ,&nbsp;Luis A. Rodríguez-Hernández ,&nbsp;Jorge F. Aragón-Arreola ,&nbsp;Marcos V. Sangrador-Deitos ,&nbsp;Juan Luis Gómez-Amador","doi":"10.1016/j.neucie.2025.500658","DOIUrl":"10.1016/j.neucie.2025.500658","url":null,"abstract":"<div><h3>Introduction/objectives</h3><div><span>In recent decades, endoscopic endonasal surgery<span> for skull base tumours<span> has modified the way in which this region is approached. One of the most feared complications is the cerebrospinal fluid leak. It has been shown in different publications about </span></span></span>CSF<span> physiology that changes in the position modify the pressure of the CSF (pCSF). With this background, it is proposed as a viable, noninvasive, and very low-risk option, the continuous sitting position in patients during their hospital stay after endoscopic endonasal surgery as an adjuvant intervention to reduce the risk of CSF leak in patients considered to be at high risk. The objective is to demonstrate that the continuous sitting position in the postoperative period is a useful adjuvant intervention for the prevention of CSF leak in endoscopic endonasal surgery.</span></div></div><div><h3>Methods</h3><div>This is a retrospective, observational, cross-sectional, comparative study. It included patients over 18 years of either sex, intervened by endoscopic endonasal surgery with intraoperative CSF leak observed and with advanced reconstruction technique realized. A continuous sitting position (between 70 ° and 90 °) was considered when the patient remained in this position from the immediate postoperative period until the hospital discharge.</div></div><div><h3>Results</h3><div>A total of 60 patients were included. No statistically significant difference was found on all the variables studied, except when patients were stratified into sitting and non-sitting patients (p = 0.045). OR of 0.12 (95% CI 0.002–1.03) was observed. In the sitting group, only 1 patient (6.67%) had CSF leak, which was resolved with non-surgical treatment. The average length of hospital stay was 18 days (7–38) for sitting patients and 14 days (5–80) for non-sitting patients, with statistical significance stablished by the dispersion of the data (p = 0.023).</div></div><div><h3>Conclusions</h3><div>The continuous sitting position during the immediate postoperative period is an intervention that shows a decrease in the risk of CSF leak in patients intervened by endoscopic endonasal approach, included extended routes.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500658"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genesis of Academic Neurosurgery. Part II: The contribution of Johns Hopkins School of Medicine leaders 学术神经外科的起源。第二部分:约翰霍普金斯医学院领导的贡献。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-07-01 DOI: 10.1016/j.neucie.2025.500672
Ramiro D. Lobato , Alfonso Lagares , Igor Paredes , Ana M. Castaño-Leon , Pablo M. Munarriz , Irene Panero
{"title":"The genesis of Academic Neurosurgery. Part II: The contribution of Johns Hopkins School of Medicine leaders","authors":"Ramiro D. Lobato ,&nbsp;Alfonso Lagares ,&nbsp;Igor Paredes ,&nbsp;Ana M. Castaño-Leon ,&nbsp;Pablo M. Munarriz ,&nbsp;Irene Panero","doi":"10.1016/j.neucie.2025.500672","DOIUrl":"10.1016/j.neucie.2025.500672","url":null,"abstract":"<div><div>This paper describes the influence of the Jonhs Hopkins School of Medicine on the origin of academic neurosurgery in America. The impact, arising from two of the founders, W Osler and W Halsted, was vehiculated by their direct pupils Harvey Cushing and Walter Dandy. The relationships between all these pioneers (sometimes stormy) are analized along with the development of the primitive residency program and the efforts to create the first neurosurgical society (the Society of Neurological Surgeons).</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500672"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ossification of posterior longitudinal ligament of the cervical spine: A review article 颈椎后纵韧带骨化:一篇综述文章。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-24 DOI: 10.1016/j.neucie.2025.500668
Shengyu Cui , Jinze Li , Xiaoxu Yu , Hongyu Zhao , Fengzeng Jian
{"title":"Ossification of posterior longitudinal ligament of the cervical spine: A review article","authors":"Shengyu Cui ,&nbsp;Jinze Li ,&nbsp;Xiaoxu Yu ,&nbsp;Hongyu Zhao ,&nbsp;Fengzeng Jian","doi":"10.1016/j.neucie.2025.500668","DOIUrl":"10.1016/j.neucie.2025.500668","url":null,"abstract":"<div><div><span>This article reviews the literature on the status of cervical OPLL in recent years, and reviews the etiology, clinical manifestations, imaging features, treatment and prognosis. Evidence was collected through PubMed and Google Scholar databases. After screening, weight removal and irrelevant articles, 57 articles were finally included in the review. Imaging is the only way to confirm the diagnosis, and </span>CT<span> and MRI are used to assess the patient's ossified material and spinal cord compression. Because there are hundreds of surgical approaches to cervical OPLL, each with advantages and disadvantages, clinicians must develop a personalized surgical plan based on the patient’s preoperative relevant factors to maximize prognosis. Clinicians should also actively follow up on discharged patients, carefully analyze cases with a poor prognosis, and summarize their experiences.</span></div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500668"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical and systemic effects of medical ozone therapy on epidural fibrosis: Experimental research 医用臭氧治疗硬膜外纤维化的局部和全身效应:实验研究。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-05 DOI: 10.1016/j.neucie.2025.500663
Nur Balcin , Mine Ozsen , Pinar Eser , Tamer Kala , Gokhan Ocakoglu , Seref Dogan
{"title":"Topical and systemic effects of medical ozone therapy on epidural fibrosis: Experimental research","authors":"Nur Balcin ,&nbsp;Mine Ozsen ,&nbsp;Pinar Eser ,&nbsp;Tamer Kala ,&nbsp;Gokhan Ocakoglu ,&nbsp;Seref Dogan","doi":"10.1016/j.neucie.2025.500663","DOIUrl":"10.1016/j.neucie.2025.500663","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Epidural fibrosis<span> (EF) causes adhesions in the epidural distance, resulting in chronic low back and leg pain symptoms during the </span></span>postoperative period<span>. Currently, ozone is used for treating lumbar disk herniation and low back pain. However, its effect on epidural fibrosis is largely unknown.</span></div></div><div><h3>Material and methods</h3><div><span>This rodent study examined the histopathological and biochemical effects of ozone therapy on epidural fibrosis. Forty-seven male Sprague–Dawley rats were divided into four groups, as follows: Control Group (CG) (</span><em>n</em><span> = 12): Laminectomy was performed, and no substance was applied. Saline Group (SG) (</span><em>n</em> = 11): Rats underwent intraoperative washing with 50 mL saline after laminectomy. Local Ozone Group (LOG) (<em>n</em> = 12): Rats underwent intraoperative washing with 50 mL ozonated distilled water after laminectomy. Systemic Ozone Group (SOG) (<em>n</em> = 12): Ozone was administered intraperitoneally (0.7 mg/kg) for 7 consecutive days postoperatively. At the end of 4 weeks, all subjects were sacrificed. Histopathological and biochemical data obtained from the tissues were analyzed in terms of EF.</div></div><div><h3>Results</h3><div>No statistically significant differences regarding EF, spinal cord retraction, inflammation, and fibroblast density were observed between the groups (<em>p</em> = 0.728; <em>p</em> = 0.813; <em>p</em> = 0.152; and <em>p</em><span> = 0.226, respectively). Hydroxyproline levels were higher in LOG than in SOG (</span><em>p</em> = 0.007); however, no statistically significant differences were observed among other groups (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>In our study, we could not record the positive effect of ozone therapy in terms of histopathology<span> and biochemistry with the current doses and application methods. We think that caution should be exercised in the ozone dose and method of application in the clinical approach. In addition, we are of the opinion that statistically significant results can be obtained by creating a treatment protocol that includes different dose applications.</span></div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"36 5","pages":"Article 500663"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic thrombosed venous aneurysm after stereotactic radiosurgery for brain arteriovenous malformation: Case report of a late complication mimicking radiation necrosis 立体定向放射治疗脑动静脉畸形后的症状性血栓性静脉动脉瘤:一例模拟放射坏死的晚期并发症。
Neurocirugia (English Edition) Pub Date : 2025-09-01 Epub Date: 2025-03-24 DOI: 10.1016/j.neucie.2025.500669
Gino A. Mendoza-Vega , Jason Riveros-Ruiz , Juan E. Basilio-Flores
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