Nature synthesis最新文献_第7页

Building bridged bicyclic scaffolds 搭建桥式双环脚手架

IF 2

Nature synthesis Pub Date : 2025-05-12 DOI: 10.1038/s44160-025-00798-4

Stacey Brenner-Moyer

引用次数: 0

Publisher Correction: Regulation of Pd single-atom coordination for enhanced photocatalytic oxidation of toluene to benzaldehyde 出版者更正：Pd单原子配位对增强甲苯光催化氧化生成苯甲醛的调节

IF 2

Nature synthesis Pub Date : 2025-05-12 DOI: 10.1038/s44160-025-00820-9

Ruiyi Sun, Xing Cao, Junguo Ma, Hsiao-Chien Chen, Chen Chen, Qing Peng, Yadong Li

引用次数: 0

Single molecule chemistry for cyclic carbon synthesis 环碳合成的单分子化学

IF 2

Nature synthesis Pub Date : 2025-05-08 DOI: 10.1038/s44160-025-00804-9

Pascal Ruffieux

引用次数: 0

Crystallizing ion conduction pathways 结晶离子传导途径

IF 2

Nature synthesis Pub Date : 2025-05-06 DOI: 10.1038/s44160-025-00811-w

Jet-Sing M. Lee

引用次数: 0

Allosteric regulation in metal–organic cages 金属有机笼的变构调节

IF 2

Nature synthesis Pub Date : 2025-05-02 DOI: 10.1038/s44160-025-00799-3

Yuchong Yang, Yuyin Du, Andrew W. Heard, Jonathan R. Nitschke

{"title":"Allosteric regulation in metal–organic cages","authors":"Yuchong Yang, Yuyin Du, Andrew W. Heard, Jonathan R. Nitschke","doi":"10.1038/s44160-025-00799-3","DOIUrl":"10.1038/s44160-025-00799-3","url":null,"abstract":"Synthetic molecular systems with allosteric regulation capabilities find applications in purification, sensing, molecular delivery and catalysis. Allosteric regulation, often observed in enzymes, involves the binding of an effector at an allosteric site, which results in the modulation of the function of an active site. Recent efforts have produced synthetic systems that exhibit allostery. Metal–organic cages (MOCs) offer a versatile platform for this purpose due to their three-dimensional structures and simple preparation through self-assembly, enabling the incorporation of multiple binding sites within a single structure. Their structural diversity, tunable cavity sizes and functional adaptability allow effective encapsulation of various guest molecules. Allosteric effectors can serve as chemical triggers to induce structural changes in MOCs through reversible post-assembly modifications, using dynamic covalent bonds or intermolecular interactions. Here we highlight recent advances in using MOCs for allosteric regulation, focusing on design principles, applications and future challenges in this emerging field. Synthetic molecular systems exhibiting allosteric regulation are used in purification, sensing, delivery and catalysis. Metal–organic cages provide a versatile platform for allosteric regulation due to their structural diversity and tunable cavities. This Review discusses recent advances in allosteric regulation with metal–organic cages, emphasizing design principles, applications and future challenges.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"4 5","pages":"537-551"},"PeriodicalIF":20.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered dielectrics for high energy 高能工程电介质

IF 2

Nature synthesis Pub Date : 2025-05-01 DOI: 10.1038/s44160-025-00813-8

Alexandra R. Groves

引用次数: 0

Ionic liquids for fluoride-ion shuttling 氟离子穿梭用离子液体

IF 2

Nature synthesis Pub Date : 2025-05-01 DOI: 10.1038/s44160-025-00810-x

Sara Renfrew

引用次数: 0

Designing current collector interphases 设计集流器界面

IF 2

Nature synthesis Pub Date : 2025-05-01 DOI: 10.1038/s44160-025-00812-9

Peter W. Seavill

引用次数: 0

Elucidation of the final steps in Taxol biosynthesis and its biotechnological production 紫杉醇生物合成的最后步骤及其生物技术生产

IF 2

Nature synthesis Pub Date : 2025-04-30 DOI: 10.1038/s44160-025-00800-z

Feiyan Liang, Yuman Xie, Chi Zhang, Yong Zhao, Mohammed S. Motawia, Sotirios C. Kampranis

{"title":"Elucidation of the final steps in Taxol biosynthesis and its biotechnological production","authors":"Feiyan Liang, Yuman Xie, Chi Zhang, Yong Zhao, Mohammed S. Motawia, Sotirios C. Kampranis","doi":"10.1038/s44160-025-00800-z","DOIUrl":"10.1038/s44160-025-00800-z","url":null,"abstract":"Taxol (paclitaxel) is a widely used anti-cancer drug with a complex biosynthetic pathway that has puzzled biochemists for decades. Owing to inefficient chemical synthesis, Taxol supply depends on costly semi-synthesis. Elucidating the Taxol biosynthesis will solve a long-standing question in biochemistry and enable cost-effective production using biotechnological methods. While recent advances have improved our understanding of the steps leading up to the intermediate baccatin III, the final steps of the pathway remain elusive. Here we use gene co-expression analysis, chemically synthesized intermediates and a stepwise learning-by-building approach to reveal the enzymes that catalyse the final two modifications, that is, C2′α hydroxylation and 3′-N benzoylation, which are essential for Taxol’s bioactivity. To replace the current semi-synthetic method of Taxol production, we reconstruct the late pathway in yeast and synthesize Taxol from the readily available intermediate baccatin III. This work provides a complete understanding of Taxol biosynthesis and establishes a foundation for its biotechnological production. In Taxol biosynthesis, the steps leading up to the intermediate baccatin III are understood, however, the final steps remain elusive. Here elucidation of the final steps of Taxol biosynthesis enables the reconstruction of the pathway in yeast and the synthesis of Taxol from baccatin III, paving the way for the biotechnological production of Taxol.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"4 10","pages":"1212-1222"},"PeriodicalIF":20.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and reactivity of nitrogen-containing strained cyclic 1,2,3-trienes 含氮应变环1,2,3-三烯的合成及其反应性

IF 2

Nature synthesis Pub Date : 2025-04-30 DOI: 10.1038/s44160-025-00793-9

Dominick C. Witkowski, Daniel W. Turner, Ana S. Bulger, K. N. Houk, Neil K. Garg

{"title":"Synthesis and reactivity of nitrogen-containing strained cyclic 1,2,3-trienes","authors":"Dominick C. Witkowski, Daniel W. Turner, Ana S. Bulger, K. N. Houk, Neil K. Garg","doi":"10.1038/s44160-025-00793-9","DOIUrl":"10.1038/s44160-025-00793-9","url":null,"abstract":"Cyclic 1,2,3-trienes are a class of intermediates that confine a functional group with a preferred linear geometry into a ring. When the ring is sufficiently small, the 1,2,3-triene geometry becomes bent, leading to substantial strain and high reactivity. Whereas advances in cyclic 1,2,3-triene chemistry have focused on carbocyclic derivatives, the corresponding chemistry of their heteroatom-containing counterparts remains unexplored. Here we report the fluoride-mediated generation and trapping of six-membered azacyclic 1,2,3-trienes in a host of reactions, including (4 + 2) and (3 + 2) cycloadditions and σ-bond insertions, allowing for the synthesis of annulated pyridones. Moreover, computational studies provide insight into their structure and reactivity. This study pushes the limits of strained intermediate chemistry, while also laying the foundation for the further strategic use of strained cyclic 1,2,3-trienes as unconventional, but useful synthetic building blocks. Six-membered cyclic 1,2,3-trienes are geometrically distorted, short-lived intermediates that have high reactivity. Now, azacyclic 1,2,3-trienes can be generated and trapped, allowing for the synthesis of annulated pyridones.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"4 8","pages":"1009-1016"},"PeriodicalIF":20.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0