Nature synthesis最新文献_第6页

Scale-aware self-driving laboratories for multiscale process development 多尺度过程开发的规模感知自动驾驶实验室

IF 22.6

Nature synthesis Pub Date : 2026-07-29 DOI: 10.1038/s44160-026-01125-1

Zhihao Wang, Xiaonan Wang

引用次数: 0

Orbital order observation in intermetallic crystals 金属间晶体的轨道序观测

IF 22.6

Nature synthesis Pub Date : 2026-07-29 DOI: 10.1038/s44160-026-01136-y

Bei Zhang

引用次数: 0

Guiding principles for seeded electrochemical synthesis of multimetallic nanocrystals 多金属纳米晶体种子电化学合成的指导原则

Nature synthesis Pub Date : 2026-07-27 DOI: 10.1038/s44160-026-01119-z

Nilotpal Kapuria, Ekta Verma, Nabojit Kar, Xingchen Ye, Sara E. Skrabalak

{"title":"Guiding principles for seeded electrochemical synthesis of multimetallic nanocrystals","authors":"Nilotpal Kapuria, Ekta Verma, Nabojit Kar, Xingchen Ye, Sara E. Skrabalak","doi":"10.1038/s44160-026-01119-z","DOIUrl":"https://doi.org/10.1038/s44160-026-01119-z","url":null,"abstract":"Electrodeposition offers control over nanocrystal growth through modulation of applied current or potential, which governs precursor reduction kinetics, nucleation behaviour and local ion concentrations. However, conventional electrodeposition often yields ill-defined morphologies and aggregated nanocrystals. Here seed-assisted electrodeposition is used to overcome these limitations, enabling growth of structurally complex and compositionally well-defined multimetallic nanocrystals. We identify lattice mismatch and metal–metal bond dissociation energy as key parameters dictating the growth mode; high values of either parameter promote island-like overgrowth, while low lattice-mismatch favours layer-by-layer growth. Guided by these mechanistic insights, uniform metal shell deposition is achieved across diverse bimetallic systems, including those with substantial interfacial strain, enabling synthesis of multilayered trimetallic nanocrystals. Furthermore, the formation of hollow-shell nanocrystals is demonstrated by selective interfacial etching achieved by dynamically modulating the redox environment during growth. Collectively, these findings establish design principles for the electrochemical synthesis of core–shell nanocrystals, including multimetallic variants and hollow architectures.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective pore modulation in layered molecular crystals 层状分子晶体中的选择性孔调制

Nature synthesis Pub Date : 2026-07-27 DOI: 10.1038/s44160-026-01123-3

Qiang Gao, Guoxing Jiang, Xiang Liu, Mingzi Sun, Cheng Qian, Chuting Yuan, Walter P. D. Wong, Jing Niu, Yipu Xu, Shutao Xu, Guijun Ma, Ziyi Li, Jia-Wei Hu, Peiyu Zhang, Bolong Huang, Wei Wei, Xing Li

{"title":"Selective pore modulation in layered molecular crystals","authors":"Qiang Gao, Guoxing Jiang, Xiang Liu, Mingzi Sun, Cheng Qian, Chuting Yuan, Walter P. D. Wong, Jing Niu, Yipu Xu, Shutao Xu, Guijun Ma, Ziyi Li, Jia-Wei Hu, Peiyu Zhang, Bolong Huang, Wei Wei, Xing Li","doi":"10.1038/s44160-026-01123-3","DOIUrl":"https://doi.org/10.1038/s44160-026-01123-3","url":null,"abstract":"Multi-porous reticular materials, featuring various pore sizes and shapes, have gained increasing attention due to their structural properties that facilitate mass transport. However, the rational design of such materials remains challenging, particularly when selectively modulating pore sizes. Here we present a synthesis strategy that enables selective pore modulation in dual-porous layered double-walled hydrogen-bonded organic frameworks using triskele-shaped building units. We uncovered an unusual syn conformation of acylhydrazone, which forms hydrogen bonding with carboxyl groups, thereby allowing the rapid, scalable synthesis of a series of single crystals with exceptional stability, including resistance to aqua regia. Harnessing the enriched proton-hopping sites and acid robustness of the double-walled framework, we demonstrate that incorporating superacids into these dual-porous crystals effectively enhances proton conductivity, which reaches 4.25 × 10−3 S cm−1 at 30 °C. Furthermore, we elucidate the formation mechanism of double-walled hydrogen-bonded organic frameworks via a combination of experimental and computational approaches. This work opens avenues for the tailored design of multi-porous materials with independently tunable pore architectures and functionalities.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical C(sp3)–C(sp3) cross-coupling of alcohols 醇的电化学C(sp3) -C （sp3）交叉偶联

Nature synthesis Pub Date : 2026-07-24 DOI: 10.1038/s44160-026-01128-y

Yanwei Wang, Yushi Jiang, Weikang Qi, Youai Qiu

引用次数: 0

Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water 中性水中铁氰化物介导的肽酰肼直接连接

Nature synthesis Pub Date : 2026-07-24 DOI: 10.1038/s44160-026-01121-5

Dongyang Han, Xianglai Zhu, Guiyu Deng, Wei He, Tianyi Zhang, Huasong Ai, Guo-Chao Chu, Lei Liu

{"title":"Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water","authors":"Dongyang Han, Xianglai Zhu, Guiyu Deng, Wei He, Tianyi Zhang, Huasong Ai, Guo-Chao Chu, Lei Liu","doi":"10.1038/s44160-026-01121-5","DOIUrl":"https://doi.org/10.1038/s44160-026-01121-5","url":null,"abstract":"Hydrazide-based native chemical ligation has emerged as one of the most widely used methods in modern chemical protein synthesis, but its traditional two-step, dual-environment workflow complicates operations and limits small-scale reactions. Here we present a ferricyanide-mediated system that enables chemoselective activation of peptide hydrazides and their ligation with N-terminal cysteine peptides in a single neutral buffer. This approach obviates the need for pH adjustment and intermediate isolation, thereby reducing labour, minimizing operational errors and expanding compatibility across a broader range of synthetic scales. We validate this method via the streamlined synthesis of biochemically or pharmaceutically relevant targets, including the antimicrobial protein Dptb, D-enantiomer of human interleukin-8 and glycosylated histone H4. In addition, this versatile chemistry can be repurposed for rapid one-step peptide cyclization and efficient C-terminal functionalization of recombinant proteins. Collectively, ferricyanide-mediated hydrazide ligation establishes a robust and generalizable platform for chemical protein synthesis.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148587335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical cross-electrophile coupling for carbon–heteroatom and heteroatom–heteroatom bond formation 碳杂原子和杂原子-杂原子键形成的电化学亲电偶联

IF 22.6

Nature synthesis Pub Date : 2026-07-23 DOI: 10.1038/s44160-026-01112-6

Wan-Chen Cindy Lee, Yi Wang, Andrew J. Ressler, Song Lin

{"title":"Electrochemical cross-electrophile coupling for carbon–heteroatom and heteroatom–heteroatom bond formation","authors":"Wan-Chen Cindy Lee, Yi Wang, Andrew J. Ressler, Song Lin","doi":"10.1038/s44160-026-01112-6","DOIUrl":"10.1038/s44160-026-01112-6","url":null,"abstract":"Electrochemical cross-electrophile coupling (eXEC), the union of two distinct electrophiles by means of electrochemical activation, has experienced substantial growth in recent years. This Review specifically focuses on eXEC reactions that enable C–X and X–X bond formation (X = heteroatom), providing an overview of recent advances in synthetic strategies and reaction development. We also discuss remaining challenges and future opportunities in this rapidly growing subarea of organic electrosynthesis, including broadening the scope of electrophile partners, enhancing selectivity, enabling scalable processes and expanding catalytic systems. The sections are organized according to the types of bond formed, as classified by the heteroatom elements involved. Overall, this Review outlines the current state of the field and offers perspectives on future directions for the development and application of eXEC in synthetic chemistry. Electrochemical cross-electrophile coupling (eXEC) has expanded the scope of available reaction tools for carbon–heteroatom and heteroatom–heteroatom bond formation. This Review surveys recent advances in methodology development, catalysis design and mechanistic investigation, while highlighting future opportunities in unconventional electrophile activation, asymmetric synthesis and scalable applications.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 8","pages":"1144-1158"},"PeriodicalIF":22.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cations control CO2 electroreduction 阳离子控制CO2电还原

IF 22.6

Nature synthesis Pub Date : 2026-07-23 DOI: 10.1038/s44160-026-01135-z

Eric Piechota

引用次数: 0

Self-driving laboratories need an autonomy safety harness 自动驾驶实验室需要一个自动安全装置

IF 22.6

Nature synthesis Pub Date : 2026-07-22 DOI: 10.1038/s44160-026-01120-6

Linjiang Chen, Xiaobo Li, Quan Lin, Jun Jiang

引用次数: 0

Membranes tame methanol in yeast 膜抑制酵母中的甲醇