Molecular and cellular pediatrics最新文献

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Ultrasound elastography in children — nice to have for scientific studies or arrived in clinical routine? 儿童超声弹性成像-用于科学研究还是临床常规?
Molecular and cellular pediatrics Pub Date : 2022-06-06 DOI: 10.1186/s40348-022-00143-1
H. Mentzel, K. Glutig, Stephanie Gräger, Paul C. Krüger, M. Waginger
{"title":"Ultrasound elastography in children — nice to have for scientific studies or arrived in clinical routine?","authors":"H. Mentzel, K. Glutig, Stephanie Gräger, Paul C. Krüger, M. Waginger","doi":"10.1186/s40348-022-00143-1","DOIUrl":"https://doi.org/10.1186/s40348-022-00143-1","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47122683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Long noncoding RNAs as regulators of pediatric acute myeloid leukemia. 长链非编码rna作为儿童急性髓性白血病的调节因子
IF 2.4
Molecular and cellular pediatrics Pub Date : 2022-05-20 DOI: 10.1186/s40348-022-00142-2
Sina Neyazi, Michelle Ng, Dirk Heckl, Jan-Henning Klusmann
{"title":"Long noncoding RNAs as regulators of pediatric acute myeloid leukemia.","authors":"Sina Neyazi, Michelle Ng, Dirk Heckl, Jan-Henning Klusmann","doi":"10.1186/s40348-022-00142-2","DOIUrl":"10.1186/s40348-022-00142-2","url":null,"abstract":"<p><p>Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights into the contribution of lncRNAs to AML development and revealed connections between lncRNA expression and clinical parameters in AML patients. In this mini review, we illustrate the versatile functions of lncRNAs in AML, with a focus on pediatric AML, and present examples that may serve as future therapeutic targets or predictive factors.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47297273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How peritoneal dialysis transforms the peritoneum and vasculature in children with chronic kidney disease—what can we learn for future treatment? 腹膜透析如何改变儿童慢性肾脏疾病的腹膜和血管系统——我们对未来的治疗有什么了解?
Molecular and cellular pediatrics Pub Date : 2022-05-05 DOI: 10.1186/s40348-022-00141-3
M. Bartosova, S. Zarogiannis, C. Schmitt, Klaus Gema Aysun K. Rainer Salim Rimante Dorota Sahar Gü Arbeiter Ariceta Bayazit Büscher Caliskan Cerkausk, K. Arbeiter, G. Ariceta, A. Bayazıt, R. Büscher, S. Çalışkan, R. Čerkauskienė, D. Drożdż, S. Fathallah-Shaykh, G. Klaus, R. Krmar, J. Oh, V. Peters, U. Querfeld, B. Ranchin, P. Sallay, B. Schaefer, C. Taylan, S. Testa, J. Vandewalle, E. Verrina, K. Vondrák, B. Warady, Y. Yap, A. Zaloszyc
{"title":"How peritoneal dialysis transforms the peritoneum and vasculature in children with chronic kidney disease—what can we learn for future treatment?","authors":"M. Bartosova, S. Zarogiannis, C. Schmitt, Klaus Gema Aysun K. Rainer Salim Rimante Dorota Sahar Gü Arbeiter Ariceta Bayazit Büscher Caliskan Cerkausk, K. Arbeiter, G. Ariceta, A. Bayazıt, R. Büscher, S. Çalışkan, R. Čerkauskienė, D. Drożdż, S. Fathallah-Shaykh, G. Klaus, R. Krmar, J. Oh, V. Peters, U. Querfeld, B. Ranchin, P. Sallay, B. Schaefer, C. Taylan, S. Testa, J. Vandewalle, E. Verrina, K. Vondrák, B. Warady, Y. Yap, A. Zaloszyc","doi":"10.1186/s40348-022-00141-3","DOIUrl":"https://doi.org/10.1186/s40348-022-00141-3","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41895546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia 当炎症与肺发育相结合——支气管肺发育不良发病机制的最新进展
Molecular and cellular pediatrics Pub Date : 2022-04-20 DOI: 10.1186/s40348-022-00137-z
Lena Holzfurtner, T. Shahzad, Ying Dong, Lisa Rekers, Ariane Selting, B. Staude, Tina Lauer, A. Schmidt, S. Rivetti, K. Zimmer, Judith Behnke, S. Bellusci, H. Ehrhardt
{"title":"When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia","authors":"Lena Holzfurtner, T. Shahzad, Ying Dong, Lisa Rekers, Ariane Selting, B. Staude, Tina Lauer, A. Schmidt, S. Rivetti, K. Zimmer, Judith Behnke, S. Bellusci, H. Ehrhardt","doi":"10.1186/s40348-022-00137-z","DOIUrl":"https://doi.org/10.1186/s40348-022-00137-z","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43276843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Implementation of exclusive enteral nutrition in pediatric patients with Crohn's disease-results of a survey of CEDATA-GPGE reporting centers. 儿童克罗恩病患者独家肠内营养的实施- CEDATA-GPGE报告中心的调查结果
IF 2.4
Molecular and cellular pediatrics Pub Date : 2022-04-05 DOI: 10.1186/s40348-022-00139-x
Sarah Peters, Serdar Cantez, Jan De Laffolie
{"title":"Implementation of exclusive enteral nutrition in pediatric patients with Crohn's disease-results of a survey of CEDATA-GPGE reporting centers.","authors":"Sarah Peters, Serdar Cantez, Jan De Laffolie","doi":"10.1186/s40348-022-00139-x","DOIUrl":"10.1186/s40348-022-00139-x","url":null,"abstract":"<p><strong>Background: </strong>Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric-onset Crohn's disease (CD) patients. CEDATA-GPGE® is the largest patient registry for children and adolescents with inflammatory bowel disease (IBD) in Europe, collecting data from over 5000 patients since 2004 in Germany and Austria. Since the application of EEN over 8 weeks is difficult and a high dropout rate is often described, the mode of application including a supporting structure is crucial for success. The aim of this study was to ascertain the variation in the application of EEN across the participating centers and to associate these with the outcome.</p><p><strong>Results: </strong>Thirty-one centers responded to the survey (81.6%). 88.5% of CD patients were recommended EEN for induction therapy, 71.8% actually started with EEN, and 22.1% terminated the EEN prematurely. The duration of EEN typically lasted 6 to 8 weeks, and the polymeric formula was mainly used. 80.6% of the clinics added flavorings to the formulas. After EEN, the most preferred diet for maintenance therapy was a healthy, well-balanced diet considering individual intolerances.</p><p><strong>Conclusions: </strong>EEN is widely recommended as an induction therapy by the German and Austrian pediatric gastroenterologists for children and adolescents with CD. However, this questionnaire-based study has shown a wide variation in EEN protocols used by the different pediatric clinics of CEDATA-GPGE®.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47855012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response 单心室缓解vs双心室修复:不同的炎症反应
Molecular and cellular pediatrics Pub Date : 2022-03-20 DOI: 10.1186/s40348-022-00138-y
M. Sigler, H. Rouatbi, J. Vázquez-Jiménez, M. Seghaye
{"title":"Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response","authors":"M. Sigler, H. Rouatbi, J. Vázquez-Jiménez, M. Seghaye","doi":"10.1186/s40348-022-00138-y","DOIUrl":"https://doi.org/10.1186/s40348-022-00138-y","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44725631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Precision medicine in pediatric oncology 更正:儿科肿瘤学中的精准医学
Molecular and cellular pediatrics Pub Date : 2022-03-10 DOI: 10.1186/s40348-022-00140-4
S. Burdach, M. Westhoff, M. Steinhauser, K. Debatin
{"title":"Correction to: Precision medicine in pediatric oncology","authors":"S. Burdach, M. Westhoff, M. Steinhauser, K. Debatin","doi":"10.1186/s40348-022-00140-4","DOIUrl":"https://doi.org/10.1186/s40348-022-00140-4","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48599681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine DMBT1在囊性纤维化中上调,影响纤毛运动,并被乙酰半胱氨酸降低
Molecular and cellular pediatrics Pub Date : 2022-03-05 DOI: 10.1186/s40348-022-00136-0
Alexander Kiefer, Erika Plattner, R. Ruppel, C. Weiss, Z. Zhou-Suckow, M. Mall, M. Renner, H. Müller
{"title":"DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine","authors":"Alexander Kiefer, Erika Plattner, R. Ruppel, C. Weiss, Z. Zhou-Suckow, M. Mall, M. Renner, H. Müller","doi":"10.1186/s40348-022-00136-0","DOIUrl":"https://doi.org/10.1186/s40348-022-00136-0","url":null,"abstract":"","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49654119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
PTEN hamartoma tumor syndrome in childhood and adolescence-a comprehensive review and presentation of the German pediatric guideline. 儿童和青少年PTEN错构瘤肿瘤综合征-德国儿科指南的综合回顾和介绍。
Molecular and cellular pediatrics Pub Date : 2022-02-21 DOI: 10.1186/s40348-022-00135-1
Michaela Plamper, Bettina Gohlke, Joachim Woelfle
{"title":"PTEN hamartoma tumor syndrome in childhood and adolescence-a comprehensive review and presentation of the German pediatric guideline.","authors":"Michaela Plamper,&nbsp;Bettina Gohlke,&nbsp;Joachim Woelfle","doi":"10.1186/s40348-022-00135-1","DOIUrl":"https://doi.org/10.1186/s40348-022-00135-1","url":null,"abstract":"<p><strong>Background: </strong>The PTEN hamartoma tumor syndrome (PHTS) encompasses several different syndromes, which are linked to an autosomal-dominant mutation of the tumor suppressor PTEN gene on chromosome 10. Loss of PTEN activity leads to an increased phosphorylation of different cell proteins, which may have an influence on growth, migration, and apoptosis. Excessive activity of the PI3K/AKT/mTOR pathway due to PTEN deficiency may lead to the development of benign and malignant tumors and overgrowth. Diagnosis of PHTS in childhood can be even more challenging than in adulthood because of a lack of well-defined diagnostic criteria. So far, there are no official recommendations for cancer surveillance in affected children and adolescents.</p><p><strong>Main body: </strong>All individuals with PHTS are at high risk for tumor development and thus might benefit from cancer surveillance strategies. In childhood, macrocephaly may be the only evident symptom, but developmental delay, behavioral problems, dermatological features (e.g., penile freckling), vascular anomalies, lipoma, or enlarged perivascular spaces in cerebral magnetic resonance imaging (cMRI) may help to establish the diagnosis. Regular psychomotor assessment and assistance in subjects with neurological impairment play an important role in the management of affected children. Already in early childhood, affected patients bear a high risk to develop thyroid pathologies. For that reason, monitoring of thyroid morphology and function should be established right after diagnosis. We present a detailed description of affected organ systems, tools for initiation of molecular diagnostic and screening recommendations for patients < 18 years of age.</p><p><strong>Conclusion: </strong>Affected families frequently experience a long way until the correct diagnosis for their child's peculiarity is made. Even after diagnosis, it is not easy to find a physician who is familiar with this rare group of diseases. Because of a still-limited database, it is not easy to establish evidence-based (cancer) surveillance recommendations. The presented screening recommendation should thus be revised regularly according to the current state of knowledge.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39940726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Evaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals. 从儿科和综合医院收集的革兰氏阴性菌氨基糖苷耐药表型和基因型模式的评估。
Molecular and cellular pediatrics Pub Date : 2022-02-04 DOI: 10.1186/s40348-022-00134-2
Leila Azimi, Shahnaz Armin, Hossein Samadi Kafil, Nafiseh Abdollahi, Kiarash Ghazvini, Sepide Hasanzadeh, Shahram Shahraki Zahedani, Sedigheh Rafiei Tabatabaei, Fatemeh Fallah
{"title":"Evaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals.","authors":"Leila Azimi,&nbsp;Shahnaz Armin,&nbsp;Hossein Samadi Kafil,&nbsp;Nafiseh Abdollahi,&nbsp;Kiarash Ghazvini,&nbsp;Sepide Hasanzadeh,&nbsp;Shahram Shahraki Zahedani,&nbsp;Sedigheh Rafiei Tabatabaei,&nbsp;Fatemeh Fallah","doi":"10.1186/s40348-022-00134-2","DOIUrl":"https://doi.org/10.1186/s40348-022-00134-2","url":null,"abstract":"<p><p>The purpose of the current study was to evaluate the phenotypic and genotypic patterns of aminoglycoside resistance among the Gram-negative bacteria (GNB) isolates collected from pediatric and general hospitals in Iran. A total of 836 clinical isolates of GNB were collected from pediatric and general hospitals from January 2018 to the end of December 2019. The identification of bacterial isolates was performed by conventional biochemical tests. Susceptibility to aminoglycosides was evaluated by the disk diffusion method (DDM). The frequency of genes encoding aminoglycoside-modifying enzymes (AMEs) was screened by the PCR method via specific primers. Among all pediatric and general hospitals, the predominant GNB isolates were Acinetobacter spp. (n = 327) and Escherichia coli (n = 144). However, E. coli (n = 20/144; 13.9%) had the highest frequency in clinical samples collected from pediatrics. The DDM results showed that 64.3% of all GNB were resistant to all of the tested aminoglycoside agents. Acinetobacter spp. and Klebsiella pneumoniae with 93.6%, Pseudomonas aeruginosa with 93.4%, and Enterobacter spp. with 86.5% exhibited very high levels of resistance to gentamicin. Amikacin was the most effective antibiotic against E. coli isolates. In total, the results showed that the aac (6')-Ib gene with 59% had the highest frequency among genes encoding AMEs in GNB. The frequency of the surveyed aminoglycoside-modifying enzyme genes among all GNB was found as follows: aph (3')-VIe (48.7%), aadA15 (38.6%), aph (3')-Ia (31.3%), aph (3')-II (14.4%), and aph (6) (2.6%). The obtained data demonstrated that the phenotypic and genotypic aminoglycoside resistance among GNB was quite high and it is possible that the resistance genes may frequently spread among clinical isolates of GNB.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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