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From Aspiration to Impact: Paving the Path in Healthcare and Inspiring Future Generations. 从愿望到影响：为医疗保健事业铺平道路，激励后人。
Missouri medicine Pub Date : 2024-01-01
April Tyus-Myles
{"title":"From Aspiration to Impact: Paving the Path in Healthcare and Inspiring Future Generations.","authors":"April Tyus-Myles","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain Imaging in Routine Psychiatric Practice. 常规精神病治疗中的脑成像。
Missouri medicine Pub Date : 2024-01-01
Alecia C Vogel, Kevin J Black
{"title":"Brain Imaging in Routine Psychiatric Practice.","authors":"Alecia C Vogel, Kevin J Black","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Technologies in the 21st century provide increasingly detailed and accurate maps of brain structure and function. So why don't psychiatrists order brain imaging on all our patients? Here we briefly review major neuroimaging methods and some of their findings in psychiatry. As clinicians and neuroimaging researchers, we are eager to bring brain imaging into daily clinical practice. However, to be clinically useful, any test in medicine must demonstrate adequate test statistics, and show proven benefits that outweigh its risks and costs. In 2024, beyond certain limited circumstances, we have no imaging tests that can meet those standards to provide diagnosis or guide treatment. This cold fact explains why for most psychiatric patients, neuroimaging is not currently recommended by professional organizations or the National Institute of Mental Health.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Neurochemistry of Depression: The Good, The Bad and The Ugly. 抑郁症的神经化学：好、坏、丑》。
Missouri medicine Pub Date : 2024-01-01
Kami Pearson, Kimberley Beier, Thornton Mardis, Bryan Munoz, Asma Zaidi
{"title":"The Neurochemistry of Depression: The Good, The Bad and The Ugly.","authors":"Kami Pearson, Kimberley Beier, Thornton Mardis, Bryan Munoz, Asma Zaidi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A large constellation of experimental evidence suggests that neuroinflammation is involved in the onset of depression and neurodegenerative disorders. Many studies have shown impairments in tryptophan metabolism, the major pathway for the synthesis of serotonin, the mood regulating neurotransmitter. This article reviews the various metabolites generated in the competing pathways of tryptophan metabolism including the kynurenine pathway. Increased synthesis of the neurotoxic compound quinolinic acid occurs at the expense of the synthesis of the neuroprotective metabolite kynurenic acid. This shift in equilibrium plays a critical role in the induction of oxidative stress, neuroinflammation, and neurotoxicity. Sufficient protein intake with adequate amounts of tryptophan along with dietary antioxidants and flavonoids may offer protection against major depressive and neurodegenerative disorders.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home Sleep Apnea Testing for Obstructive Sleep Apnea. 首页 阻塞性睡眠呼吸暂停测试。
Missouri medicine Pub Date : 2024-01-01
Omar Hussein, Aseel Alkhader, Ashraf Gohar, Abid Bhat
{"title":"Home Sleep Apnea Testing for Obstructive Sleep Apnea.","authors":"Omar Hussein, Aseel Alkhader, Ashraf Gohar, Abid Bhat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obstructive Sleep Apnea (OSA) is a major public health problem affecting almost one billion individuals worldwide. Ninety percent of patients with OSA are still undiagnosed. Although an attended polysomnography (PSG) testing is the gold standard to diagnose OSA, it is time-consuming and is associated with higher costs. The Home Sleep Apnea Testing (HSAT) is now available to diagnose OSA. Understanding the indications and limitations of HSAT is important to avoid misdiagnosis and improve patient outcomes.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasally Delivered 0.5% Timolol Beta Blocker Successfully Treats Acute Migraines in a Referral Headache Clinic: A Case Series. 鼻腔给药 0.5% 噻吗洛尔β受体阻滞剂成功治疗头痛转诊诊所的急性偏头痛：病例系列。
Missouri medicine Pub Date : 2024-01-01
Steven C Kosa, John C Hagan
{"title":"Nasally Delivered 0.5% Timolol Beta Blocker Successfully Treats Acute Migraines in a Referral Headache Clinic: A Case Series.","authors":"Steven C Kosa, John C Hagan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is the first reported case series of nasally delivered beta blocker (timolol 0.5%) for the treatment of acute migraine. In a retrospective chart review, 16 patients were found who had received intranasal timolol for sub-optimally treated acute migraines. Of these, 10 (62.5%) reported to their provider that the medication was helpful. Encouragingly, the treatment was beneficial even for patients previously refractory to other medications. Intranasal timolol was well tolerated, with only one patient reporting mild nasal congestion and no other side effects reported. These findings suggest the need for a prospective pilot study followed by a larger double-blind randomized placebo-controlled trial to determine the overall efficacy and safety of nasally delivered beta blockers for acute migraine treatment.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insomnia: A Current Review. 失眠：当前综述。
Missouri medicine Pub Date : 2024-01-01
Sowjanya Naha, Manjamalai Sivaraman, Pradeep Sahota
{"title":"Insomnia: A Current Review.","authors":"Sowjanya Naha, Manjamalai Sivaraman, Pradeep Sahota","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Insomnia is a prevalent sleep disorder with pervasive effects on quality of life. The deleterious effects of insomnia are largely preventable with appropriate therapeutic interventions. Pharmacotherapy should be initiated in patients with inadequate response to CBT-I and tailored to comorbidities. Referral to a sleep medicine specialist should be considered in patients with a suboptimal response.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10887463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for Cognitive Impairment in Primary Care: Rationale and Tools. 初级保健中的认知障碍筛查：原理与工具。
Missouri medicine Pub Date : 2023-11-01
Mehwish Siddiqui, Tarisai Nyahoda, Christina Traber, Susan Elliott, Veena Wang, Lina Toledo-Franco, Miriam B Rodin
{"title":"Screening for Cognitive Impairment in Primary Care: Rationale and Tools.","authors":"Mehwish Siddiqui, Tarisai Nyahoda, Christina Traber, Susan Elliott, Veena Wang, Lina Toledo-Franco, Miriam B Rodin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cognitive impairment is common and often under diagnosed in the early stages. Patients and family caregivers benefit from early diagnosis of reversible causes and longer lead time for care planning in primary dementia diagnoses. Primary care physicians are the first and best providers for diagnosing common, serious, and progressive cognitive disorders.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andrew Conway Ivy, MD: The Missouri Physician Who Coauthored the Nuremberg Code. 安德鲁-康威-艾维（Andrew Conway Ivy）医学博士：与人合著《纽伦堡法典》的密苏里医生。
Missouri medicine Pub Date : 2023-11-01
Arthur Gale
{"title":"Andrew Conway Ivy, MD: The Missouri Physician Who Coauthored the Nuremberg Code.","authors":"Arthur Gale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moral Injury and Preserving Our Profession. 道德伤害和保护我们的职业。
Missouri medicine Pub Date : 2023-11-01
Wendy Dean
{"title":"Moral Injury and Preserving Our Profession.","authors":"Wendy Dean","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1 Picture = 1,000 Words. 1 张图片 = 1,000 字。
Missouri medicine Pub Date : 2023-11-01
{"title":"1 Picture = 1,000 Words.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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