{"title":"Electric Scooters: A Modern Method of Trauma.","authors":"Ryan Hoffman, James O'Brien, Matthew Cook","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electric scooters (e-scooters) have become a popular means of short-distance transportation for major metropolitan areas in several countries over the past decade. Their eco-friendliness, affordability, and ease of operation are selling points to people of all ages, particularly youth and young adults. Societal normalization has unfortunately overshadowed the risks entailed with their operation including severe injury and death. Alcohol, lack of protective equipment, and inadequate infrastructure appear to be common preventable risk factors. Emergency clinicians and trauma teams experience the aftermath of e-scooter injuries, which promise a rising trajectory. Common injury patterns have been identified by researchers around the world, most notably orthopedic, head, and maxillofacial in nature. Becoming familiar with these injury patterns and risk factors contributing to e-scooter accidents can be advantageous to the emergency physician's preparedness and public officials' approach to injury prevention.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 2","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ulnar Collateral Ligament Injuries in Youth Throwing Athletes.","authors":"Matthew J Steffes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The medial ulnar collateral ligament (UCL) of the elbow is a vital structure for the overhead throwing motion. Injuries to this ligament are becoming increasingly common and specifically in youth baseball players. Significant work has been done to provide pitch count guidelines to monitor workload and prevent UCL injuries. Yet despite these efforts, injuries to the ulnar collateral ligament continue to occur at an alarming rate, leading to lost playing time and impacting player development. Complete tears of the UCL have traditionally been addressed surgically by reconstructing the ligament with a tendon graft, known as Tommy John Surgery. Newer techniques have allowed for repair of the native UCL tissue in many cases, drastically changing the treatment paradigm and subsequent rehabilitation.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 2","pages":"162-165"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrase Inhibitors: Redefining HIV-1 Treatment and Future Challenges.","authors":"Krishan K Pandey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The discovery and development of HIV-1 integrase strand transfer inhibitors (INSTIs) represent one of the remarkable success stories in antiviral drug discovery, transforming fundamental insights of retroviral enzymology into highly effective first-line therapies for HIV-1/AIDS patients. Currently there are five INSTIs approved for clinical use. Among these, second generation drugs Dolutegravir, Bictegravir and Cabotegravir offer excellent virologic suppression, favorable tolerability and a high genetic barrier to resistance. The long-acting formulation of the most recent INSTI Cabotegravir has also been approved for pre-exposure prophylaxis in high-risk populations. Apart from inhibiting the active site of integrase, a new class of allosteric integrase inhibitors (ALLINIs), which target integrase multimerization affecting multiple steps in viral life cycle, are in the advanced phases of clinical trials. The mechanisms of HIV-1 integration, development of integrase inhibitors, structural biology breakthroughs that guided inhibitor optimization and clinical use of INSTIs, their successes and challenges for HIV/1AIDS management are reviewed here.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 2","pages":"142-148"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shaping the Future: Why Physician Advocacy Matters for Patients, Physicians, and the Health System.","authors":"David O Barbe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"21-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren Landfried, Jess Watson, Maggie McCoy, Anna Chott
{"title":"Food Dating: What Does it Really Mean?","authors":"Lauren Landfried, Jess Watson, Maggie McCoy, Anna Chott","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"18-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Partner in Healing: Our Lives Together in Medicine.","authors":"Kathy Perryman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"They Stole Your Umbrella: Why Healthcare Professionals Should Support Stronger Fraud Controls.","authors":"Malcolm K Sparrow","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}