{"title":"Innovations In Physical Medicine and Rehabilitation: Advances in the Diagnosis, Treatment, and Care of Amyotrophic Lateral Sclerosis.","authors":"W David Arnold, Ryan Castoro, Smita Saxena","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that causes loss of upper and lower motor neurons, leading to muscle weakness and ultimately death. This review highlights recent advancements in Neuromuscular Medicine and Physical Medicine and Rehabilitation (PM&R), emphasizing innovations in the diagnosis, treatment, and care delivery for ALS. The field of PM&R emphasizes a multidisciplinary, patient-centered approach, incorporating advanced diagnostic tools, therapeutic strategies, adaptive equipment, and telerehabilitation to optimize function. Neuromuscular PM&R physicians play a key role in managing symptoms and maximizing functional independence. Current disease-modifying therapies include riluzole and edaravone which provide only modest benefits, but emerging gene therapies like tofersen for SOD1-related ALS offer promise for targeted treatment for genetic forms of ALS. Future advancements in regenerative therapies, biotechnologies, and digital health integration hold the potential to improve care and enhance the quality of life and functional independence of individuals living with ALS.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Summary of Council Actions: 2024-2025.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"234-237"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stroke and Spasticity: Identifying Risk Factors and Optimizing Patient Function.","authors":"Bryan Wacker, Hannah Farmer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the United States, there are almost one million strokes per year creating a significant burden on the healthcare system. With risk factors and complications of strokes being numerous, it is no surprise it takes a multidisciplinary team to treat and manage this mosaic disease process. Physical Medicine and Rehabilitation physicians (physiatrists) play a large role in management of post-stroke complications and aim to optimize and return the patients to their functional baseline. One specific complication well known to physiatrists is post-stroke spasticity. This article looks to shed light on the stroke burden in Missouri and how physiatrists contribute to post-stroke care with a highlight on spasticity management.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"189-192"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges in Objectively Assessing Merit in the Modern World.","authors":"John B Holds","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"177-178"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ChatGPT4, Perplexity, and Copilot Artificial Intelligence Rank <i>Missouri Medicine</i> Top State Medical Journal.","authors":"John C Hagan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"160-161"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reports of the Delegate Handbook: 2024-2025.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"238-244"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chrissa McClellan, Christian van Doren, Ben Washburn
{"title":"Making Waves: Improving Electrodiagnostics with Integration of Ultrasound for Entrapment and Traumatic Neuropathies.","authors":"Chrissa McClellan, Christian van Doren, Ben Washburn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electrodiagnostic studies (including nerve conduction studies and electromyography) are the most common diagnostic tests utilized in entrapment and traumatic neuropathies, including carpal tunnel and cubital tunnel syndromes. Electrodiagnostic studies evaluate the function of the nerves and give essential information about the location and severity of the lesion, but they provide little information about the structure of the nerve or any other structural abnormalities that may be contributing to the cause of the neuropathy. With improving technology, ultrasound has been increasingly used to image nerves and muscles. Due to its accessibility and portability, ultrasound has been integrated into electrodiagnostic laboratories and equipment, allowing for additional structural information to be obtained, which can alter management and improve patient outcomes.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"211-214"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whooping Cough: A Rising Risk for All Ages.","authors":"Farzana Hoque","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 3","pages":"184"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}