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From Serendipity to Scalability in Rare Disease Patient Collaborations.
Missouri medicine Pub Date : 2025-01-01
Kerry Grens, Judith L Weisenberg, Robin C Ryther, Harrison W Gabel
{"title":"From Serendipity to Scalability in Rare Disease Patient Collaborations.","authors":"Kerry Grens, Judith L Weisenberg, Robin C Ryther, Harrison W Gabel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As the rate of diagnosis for rare disease increases, so does the need to develop scalable solutions to address patient community needs. Drawing upon our experiences in rare intellectual and developmental disability research, advocacy, and treatment, we present two examples of how collaboration between patient groups, clinicians, and investigators at Washington University in St. Louis have generated invaluable resources to accelerate toward treatments. These successful partnerships serve as models for building research and clinical infrastructure for rare diseases.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In the News.
Missouri medicine Pub Date : 2025-01-01
{"title":"In the News.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Private Equity and the Ravaging of United States Health Care.
Missouri medicine Pub Date : 2025-01-01
James R Webster
{"title":"Private Equity and the Ravaging of United States Health Care.","authors":"James R Webster","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced Technology Clinic Provides Personalized Approach to Pediatric Epilepsy Surgery: Early Data and Future Directions. 先进技术诊所为小儿癫痫手术提供个性化方法：早期数据与未来方向
Missouri medicine Pub Date : 2025-01-01
Esra Pehlivan, John Zempel, Janette Coble, Sara Graves, Sean McEvoy, Matt Smyth, Kwee Liu Lin Thio, Christina Gurnett, Jarod Roland, Réjean M Guerriero, Stuart R Tomko
{"title":"Advanced Technology Clinic Provides Personalized Approach to Pediatric Epilepsy Surgery: Early Data and Future Directions.","authors":"Esra Pehlivan, John Zempel, Janette Coble, Sara Graves, Sean McEvoy, Matt Smyth, Kwee Liu Lin Thio, Christina Gurnett, Jarod Roland, Réjean M Guerriero, Stuart R Tomko","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative improvement in seizures may impact quality of life. We examined the relationship between reduced seizure burden and quality of life in a surgical epilepsy clinic.</p><p><strong>Methods: </strong>We reviewed data from all children who received epilepsy surgery at our center. Surgeries were classified as palliative or definitive based on the seizure outcome goals. We collected demographics, surgical data, Engel classification, and quality of life outcomes.</p><p><strong>Results: </strong>Between 2016 and 2024, 282 patients underwent 338 surgeries. In the definitive surgery group, 66 patients (58%) attained an Engel 1 outcome at six months and 46 patients (58%) at 24 months. In the palliative surgery group, six patients (7%) attained an Engel 1 outcome at six months. At 12 months, 75% of patients who attained Engel 1 reported lower depression scores.</p><p><strong>Conclusion: </strong>Improvement in seizure burden and quality of life outcomes following epilepsy surgery may be related. Further outcomes research is required.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Patient Education on Cardiovascular Rehabilitation with Large Language Models.
Missouri medicine Pub Date : 2025-01-01
Som Singh, Eric Errampalli, Nathan Errampalli, Mohammed Shah Miran
{"title":"Enhancing Patient Education on Cardiovascular Rehabilitation with Large Language Models.","authors":"Som Singh, Eric Errampalli, Nathan Errampalli, Mohammed Shah Miran","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>There are barriers that exist for individuals to adhere to cardiovascular rehabilitation programs. A key driver to patient adherence is appropriately educating patients. A growing education tool is using large language models to answer patient questions.</p><p><strong>Methods: </strong>The primary objective of this study was to evaluate the readability quality of educational responses provided by large language models for questions regarding cardiac rehabilitation using Gunning Fog, Flesh Kincaid, and Flesch Reading Ease scores.</p><p><strong>Results: </strong>The findings of this study demonstrate that the mean Gunning Fog, Flesch Kincaid, and Flesch Reading Ease scores do not meet US grade reading level recommendations across three models: ChatGPT 3.5, Copilot, and Gemini. The Gemini and Copilot models demonstrated greater ease of readability compared to ChatGPT 3.5.</p><p><strong>Conclusions: </strong>Large language models could serve as educational tools on cardiovascular rehabilitation, but there remains a need to improve the text readability for these to effectively educate patients.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overdose Data to Action in States (OD2A-S): Missouri's Response to the Opioid Epidemic.
Missouri medicine Pub Date : 2025-01-01
Andrew Hunter, Ashley E Douglas, Neann Wedgeworth, Julie M Kapp
{"title":"Overdose Data to Action in States (OD2A-S): Missouri's Response to the Opioid Epidemic.","authors":"Andrew Hunter, Ashley E Douglas, Neann Wedgeworth, Julie M Kapp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Pathophysiology of Traumatic Brain Injuries and the Rationale Behind Creatine Supplementation as a Potential Therapy: A Review.
Missouri medicine Pub Date : 2025-01-01
Faith I Vietor, Kayln Sticher, Komal H Ashraf
{"title":"The Pathophysiology of Traumatic Brain Injuries and the Rationale Behind Creatine Supplementation as a Potential Therapy: A Review.","authors":"Faith I Vietor, Kayln Sticher, Komal H Ashraf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Traumatic brain injuries (TBI) are detrimental to the brain in a variety of ways. Mild traumatic brain injuries (mTBI) are concussions; these are common events that disrupt typical brain functioning and send millions of patients to seek acute care each year globally. Despite the frequency of mTBIs, clinicians have few tools, pharmacologic and nonpharmacologic, to promote recovery and alleviate symptoms. After a TBI, complex biomolecular signaling, diffuse axonal stretching, and glutamate excitotoxicity occur, along with other pathological sequelae. Creatine has been shown to improve cognitive functioning in healthy adults. Burgeoning research is providing evidence that creatine may enhance recovery from TBI, as it directly targets derangements from such trauma.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"122 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Captain John C. Hagan III, USAF Medical Corp 1970-1972. 约翰·c·哈根三世上尉，1970-1972年，美国空军医疗公司。
Missouri medicine Pub Date : 2024-11-01
{"title":"Captain John C. Hagan III, USAF Medical Corp 1970-1972.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"121 6","pages":"451"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Military Medicine and Medical Education in Missouri. 密苏里州的军事医学和医学教育。
Missouri medicine Pub Date : 2024-11-01
Ulysses Fernandez-Miro, Pamala R Huges, Luke F Jett, Craig Krausz, Richard K Newman, Brandon M Parham, Julie K Gammack
{"title":"Military Medicine and Medical Education in Missouri.","authors":"Ulysses Fernandez-Miro, Pamala R Huges, Luke F Jett, Craig Krausz, Richard K Newman, Brandon M Parham, Julie K Gammack","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"121 6","pages":"445-450"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1 Picture = 1,000 Words. 1张图片= 1000字
Missouri medicine Pub Date : 2024-11-01
{"title":"1 Picture = 1,000 Words.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"121 6","pages":"415"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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