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A Crossroad for Physician-Led Care in Missouri. 密苏里州医生主导医疗的十字路口。
Missouri medicine Pub Date : 2026-01-01
Jacob Scott
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引用次数: 0
Excessive Exercise Unenviable Victim of Irony. 过度运动是讽刺的受害者。
Missouri medicine Pub Date : 2026-01-01
Charles Lederer
{"title":"Excessive Exercise Unenviable Victim of Irony.","authors":"Charles Lederer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Empty Promises of Medical Marijuana. 医用大麻的空洞承诺。
Missouri medicine Pub Date : 2026-01-01
Gary A Salzman
{"title":"The Empty Promises of Medical Marijuana.","authors":"Gary A Salzman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"12-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 20th Century Historical Perspective on Congenital Syphilis and Lessons for Today. 20世纪先天性梅毒的历史透视及对今天的教训。
Missouri medicine Pub Date : 2026-01-01
Jane F Knapp, Robert D Schremmer
{"title":"A 20th Century Historical Perspective on Congenital Syphilis and Lessons for Today.","authors":"Jane F Knapp, Robert D Schremmer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"15-17"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A History of Biostatistics and Data Science at Washington University School of Medicine. 华盛顿大学医学院生物统计学和数据科学史。
Missouri medicine Pub Date : 2026-01-01
Charles W Goss, Daberru C Rao
{"title":"A History of Biostatistics and Data Science at Washington University School of Medicine.","authors":"Charles W Goss, Daberru C Rao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biostatistics at Washington University School of Medicine has evolved from a modest component of pharmacology in the 1940s into a nationally recognized leader in quantitative biomedical research. In this perspective we trace the development of the biostatistics program from its early incorporation into medical education through the formal establishment of the Division of Biostatistics in 1966 and its subsequent expansion in scope and impact. The Division's transformation into the Center for Biostatistics and Data Science (CBDS) marks a new era that integrates traditional biostatistics with modern data science, including machine learning and other advanced computational methods. Guided by three strategic pillars-team science and collaborative research, innovative methods, and education and training-CBDS continues to advance biomedical discovery through rigorous quantitative science. This historical reflection connects the early foundations to the questions and methods that define biostatistics and data science at Washington University today.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"36-39"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and Determinants of Blood Pressure Control in US Hypertensive Patients: Insights from NHANES 1999-2021. 美国高血压患者血压控制的趋势和决定因素：来自NHANES 1999-2021的见解
Missouri medicine Pub Date : 2026-01-01
Yiming Shi, Ke Xie, Zhichen Xu, Jingyi Zhang, Lei Liu
{"title":"Trends and Determinants of Blood Pressure Control in US Hypertensive Patients: Insights from NHANES 1999-2021.","authors":"Yiming Shi, Ke Xie, Zhichen Xu, Jingyi Zhang, Lei Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study analyzes trends and determinants of blood pressure control among hypertensive patients in the United States (US) using National Health and Nutrition Examination Survey NHANES data from 1999 to 2021. Blood pressure control rates improved through 2013 but declined thereafter. Applying machine learning methods such as XGBoost, we identify hypertension awareness and antihypertensive medication use as the strongest predictors of successful control. In contrast, resistant hypertension, chronic kidney disease, and elevated low-density lipoprotein (LDL) levels are associated with poorer control. The shift from JNC7 to JNC8 hypertension guidelines reclassified some individuals from uncontrolled to controlled, influencing observed trends. Additionally, a reduction in antihypertensive medication use among female patients may have contributed to the recent decline. These findings highlight the critical role of medication adherence and patient awareness in maintaining blood pressure control.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1 Picture = 1,000 Words. 1张图片= 1000字
Missouri medicine Pub Date : 2026-01-01
{"title":"1 Picture = 1,000 Words.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Decision Support Systems with Data, Informatics, and Learning Health Systems in a Post-Meaningful Use Era. 推进决策支持系统与数据，信息学和学习卫生系统在后有意义的使用时代。
Missouri medicine Pub Date : 2026-01-01
Adam Wilcox
{"title":"Advancing Decision Support Systems with Data, Informatics, and Learning Health Systems in a Post-Meaningful Use Era.","authors":"Adam Wilcox","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The HITECH Act and Meaningful Use (MU) successfully drove widespread EHR adoption but largely missed the strategic goal of healthcare transformation. While EHRs are now ubiquitous, few institutions have transitioned to a true Learning Health System (LHS). To support achieving transformative impact, this article proposes an extension of a previously-described quality improvement life cycle model, aligning it with modern informatics and artificial intelligence (AI) capabilities. We detail how the stages of DMAIC (Define, Measure, Analyze, Improve, Control) provide the necessary structured framework for advancing decision support within a post-MU environment. We argue that by integrating AI-driven tools into each step of the DMAIC cycle, healthcare organizations can effectively leverage their vast stores of electronic clinical data. This structured approach offers a pathway to establishing agile, data-driven learning health systems necessary to fulfill the latent promise of health information technology.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"40-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI for Scientific Discovery in Omics Data-Driven Precision Medicine. 人工智能在组学数据驱动的精准医学中的科学发现。
Missouri medicine Pub Date : 2026-01-01
Fuhai Li, Heming Zhang, Di Huang, Hao Li, Wenyu Li, Tianqi Xu, Yixin Chen, Michael Province, Philip R O Payne
{"title":"AI for Scientific Discovery in Omics Data-Driven Precision Medicine.","authors":"Fuhai Li, Heming Zhang, Di Huang, Hao Li, Wenyu Li, Tianqi Xu, Yixin Chen, Michael Province, Philip R O Payne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, the rapid advancement of high-throughput technologies has led to the generation of vast and complex multi-omics datasets that are valuable for characterizing and understanding complex cell signaling network systems. On the other hand, large language models (LLMs), domain-specific foundation models (FMs) and AI agents, have achieved significant breakthroughs and have been revolutionizing scientific research. The convergence of these two trends is catalyzing a new era for biomedical research to augment and speed up scientific discovery and the development of precision medicine. In this study, we examine the large-scale omics datasets, emerging applications, and challenges at the intersection of massive omic datasets and related AI models and agents, highlighting how their integration is reshaping the landscape of biomedical research and precision medicine.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"55-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence as a Catalyst for Quality, Safety, and Value in Healthcare Delivery. 人工智能作为医疗保健服务质量、安全和价值的催化剂。
Missouri medicine Pub Date : 2026-01-01
Philip R O Payne
{"title":"Artificial Intelligence as a Catalyst for Quality, Safety, and Value in Healthcare Delivery.","authors":"Philip R O Payne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Artificial intelligence (AI) has the potential to transform healthcare by enhancing quality, improving safety, and increasing value. However, achieving these benefits requires navigating a complex interplay between data quality, interoperability, computability, workflow integration, and governance, as well as the need to create and sustain what have been described as learning health systems. The full promise of AI will only be realized through rigorous data stewardship, the design and demonstration of novel computational methods, cross-disciplinary collaboration, and a commitment to responsible and equitable technology implementation. Substantial work remains to address these challenges and capitalize on these opportunities, which can and should lead to significant improvements in human health and well-being.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":"123 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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