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CRISPR Advancements for Human Health. CRISPR 促进人类健康。
Missouri medicine Pub Date : 2024-03-01
Daniel J Davis, Sai Goutham Reddy Yeddula
{"title":"CRISPR Advancements for Human Health.","authors":"Daniel J Davis, Sai Goutham Reddy Yeddula","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has emerged as a powerful gene editing technology that is revolutionizing biomedical research and clinical medicine. The CRISPR system allows scientists to rewrite the genetic code in virtually any organism. This review provides a comprehensive overview of CRISPR and its clinical applications. We first introduce the CRISPR system and explain how it works as a gene editing tool. We then highlight current and potential clinical uses of CRISPR in areas such as genetic disorders, infectious diseases, cancer, and regenerative medicine. Challenges that need to be addressed for the successful translation of CRISPR to the clinic are also discussed. Overall, CRISPR holds great promise to advance precision medicine, but ongoing research is still required to optimize delivery, efficacy, and safety.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
My Story. 我的故事
Missouri medicine Pub Date : 2024-03-01
Charles Van Way
{"title":"My Story.","authors":"Charles Van Way","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Cranial Surgery. 颅骨外科进展。
Missouri medicine Pub Date : 2024-03-01
Farzana Tariq, Fareed Jumah, Kaushik Ravipati, Michael Ortiz-Torres, Steven B Carr, Michael R Chicoine
{"title":"Advances in Cranial Surgery.","authors":"Farzana Tariq, Fareed Jumah, Kaushik Ravipati, Michael Ortiz-Torres, Steven B Carr, Michael R Chicoine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The landscape of the cranial neurosurgery has changed tremendously in past couple of decades. The main frontiers including introduction of neuro-endoscopy, minimally invasive skull base approaches, SRS, laser interstitial thermal therapy and use of tubular retractors have revolutionized the management of intracerebral hemorrhages, deep seated tumors other intracranial pathologies. Introduction of these novel techniques is based on smaller incisions with maximal operative corridors, decreased blood loss, shorter hospital stays, decreased post-operative pain and cosmetically appealing scars that improves patient satisfaction and clinical outcomes. The sophisticated tools like neuroendoscopy have improved light source, and better visualization around the corners. Advanced navigated tools and channel-based retractors help us to target deeply seated lesions with increased precision and minimal disruption of the surrounding neurovascular tissues. Advent of stereotactic radiosurgery has provided us alternative feasible, safe and effective options for treatment of patients who are otherwise not medically stable to undergo complex cranial surgical interventions. This paper review advances in treatment of intracranial pathologies, and how the neurosurgeons and other medical providers at the University of Missouri-Columbia (UMC) are optimizing these treatments for their patients.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why I Carry Naloxone. 我为何随身携带纳洛酮
Missouri medicine Pub Date : 2024-03-01
William V Stoecker
{"title":"Why I Carry Naloxone.","authors":"William V Stoecker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity and Anesthesia: Challenges in the Perioperative Period. 肥胖与麻醉：围手术期的挑战。
Missouri medicine Pub Date : 2024-03-01
Sarah Von Thaer, Janette McVey, James Shelton, Quinn Johnson
{"title":"Obesity and Anesthesia: Challenges in the Perioperative Period.","authors":"Sarah Von Thaer, Janette McVey, James Shelton, Quinn Johnson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The obesity epidemic has significant implications for all aspects of healthcare. The physiological changes of obesity affect every area of perioperative medicine. In this article, we discuss several anesthetic concerns regarding obesity. We will specifically discuss preoperative evaluation, perioperative challenges, and postoperative pain control and monitoring.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Generous Reimbursement of Non-Physician Clinical Services: Part I: A Deep Dive into the Resource-Based Relative Value Scale. 非医生临床服务的慷慨报销：第一部分：深入探讨基于资源的相对价值表。
Missouri medicine Pub Date : 2024-03-01
Gary Gaddis
{"title":"The Generous Reimbursement of Non-Physician Clinical Services: Part I: A Deep Dive into the Resource-Based Relative Value Scale.","authors":"Gary Gaddis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New MSMA Members! MSMA 新会员！
Missouri medicine Pub Date : 2024-03-01
{"title":"New MSMA Members!","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MSMA & MAOPS: Pitching Our Advocacy Tent. MSMA 和 MAOPS：搭建我们的宣传帐篷。
Missouri medicine Pub Date : 2024-03-01
Lancer G Gates, Victoria Damba
{"title":"MSMA & MAOPS: Pitching Our Advocacy Tent.","authors":"Lancer G Gates, Victoria Damba","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutting Edge Developments in Spine Surgery at the University of Missouri. 密苏里大学脊柱外科的前沿发展。
Missouri medicine Pub Date : 2024-03-01
Ravi Nunna, Farzana Tariq, Michael Ortiz, Inamullah Khan, Sabrina Genovese, Paul Santiago
{"title":"Cutting Edge Developments in Spine Surgery at the University of Missouri.","authors":"Ravi Nunna, Farzana Tariq, Michael Ortiz, Inamullah Khan, Sabrina Genovese, Paul Santiago","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The treatment of spinal pathologies has evolved significantly from the times of Hippocrates and Galen to the current era. This evolution has led to the development of cutting-edge technologies to improve surgical techniques and patient outcomes. The University of Missouri Health System is a high-volume, tertiary care academic medical center that serves a large catchment area in central Missouri and beyond. The Department of Neurosurgery has sought to integrate the best available technologies to serve their spine patients. These technological advancements include intra-operative image guidance, robotic spine surgery, minimally invasive techniques, motion preservation surgery, and interdisciplinary care of metastatic disease to the spine. These advances have resulted in safer surgeries with enhanced outcomes at the University of Missouri. This integration of innovation demonstrates our tireless commitment to ensuring excellence in the comprehensive care of a diverse range of patients with complex spinal pathologies.</p>","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seven Decades of Neurosurgery at MU Columbia. 哥伦比亚大学神经外科七十年。
Missouri medicine Pub Date : 2024-03-01
Michael Chicoine
{"title":"Seven Decades of Neurosurgery at MU Columbia.","authors":"Michael Chicoine","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74203,"journal":{"name":"Missouri medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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