Muhammad Aziz, Sachit Sharma, Sami Ghazaleh, Rawish Fatima, Ashu Acharya, Marcel Ghanim, Taha Sheikh, Wade Lee-Smith, Syed U Hamdani, Ali Nawras
{"title":"The anti-spasmodic effect of peppermint oil during colonoscopy: a systematic review and meta-analysis.","authors":"Muhammad Aziz, Sachit Sharma, Sami Ghazaleh, Rawish Fatima, Ashu Acharya, Marcel Ghanim, Taha Sheikh, Wade Lee-Smith, Syed U Hamdani, Ali Nawras","doi":"10.23736/S1121-421X.20.02652-5","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02652-5","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple pharmacological agents have been studied in literature with antispasmodic effect during colonoscopy. Peppermint oil, with its relaxing effect on colon has demonstrated varying results. We therefore conducted a systematic review and meta-analysis of the available literature to evaluate its role during colonoscopy.</p><p><strong>Evidence acquisition: </strong>Literature search of the following databases was undertaken: PubMedMedline, Embase, Cochrane, Web of Science, and CINAHL. Outcomes that were evaluated included incidence of any spasticity, severe spasticity, and peristalsis during examination. Adenoma detection rate (ADR) was evaluated as a quality outcome metric. Risk ratios (RR), risk difference (RD) and mean difference (MD) were calculated using the DerSimonian-Laird method and random effects where applicable.</p><p><strong>Evidence synthesis: </strong>Overall, six studies (with one abstract) were included in this review. Peppermint oil resulted in overall lower incidence for spasticity (RD: -0.39, P=0.02), severe spasticity (RD: -0.15, P=0.04), and peristalsis (-0.27, P≤0.001) during colonoscopy examination. An improved ADR (RR: 1.31, P=0.01) was also noted, however only two studies evaluated this effect.</p><p><strong>Conclusions: </strong>Peppermint oil resulted in relaxation of colon during colonoscopy with decrease incidence of spasticity, severe spasticity, peristalsis and improved ADR. These results are encouraging however results are limited due to significant heterogeneity found in the outcomes. Larger studies with standardized dosing are needed to evaluate this effect. Furthermore, studies evaluating additional colonoscopy outcomes such as polyp detection rate, advanced adenoma detection rate, and serrated adenoma detection rate are needed.</p>","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"66 2","pages":"164-171"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37590042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-cirrhotic portal hypertension in inflammatory bowel disease.","authors":"Adil S Mir, D. Sorrentino","doi":"10.23736/S1121-421X.20.02684-7","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02684-7","url":null,"abstract":"With the increasing incidence and prevalence of IBD, its complications and associated morbidity also continue to rise. One of these is non-cirrhotic portal hypertension. There is an increasing need of recognizing and understanding the pathophysiology of this condition in the clinical setting of IBD, especially in long standing cases. Due to multiple potential factors, patients with IBD appear to be at a higher risk of developing portal hypertension even in the absence of liver cirrhosis. Portal hypertension is usually diagnosed when complications (such as ascites, variceal bleeding) develop, especially when patients have already experienced multiple complications of the disease. Hence, a high level of vigilance for the detection of portal hypertension at an early stage is needed. This review discusses the known epidemiology, clinical characteristics, clinical presentation, modalities of diagnosis and the potential treatments of the different forms of non-cirrhotic portal hypertension associated with IBD. The concomitant presence of portal hypertension can significantly impact the overall clinical picture and disease burden in IBD. Hence, increased awareness of this condition at an early stage might help tailor a comprehensive and individualized therapeutic plan of care for these patients.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"46 33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89585908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Vernero, Ilaria Di Leo, Matteo Givone, Alessandro Adriani, Alessandro Bergamaschi, Mauro Fanelli, Marco Astegiano
{"title":"Role of Compositum Zeolite® in management of inflammatory bowel disease: a pilot study.","authors":"Marta Vernero, Ilaria Di Leo, Matteo Givone, Alessandro Adriani, Alessandro Bergamaschi, Mauro Fanelli, Marco Astegiano","doi":"10.23736/S1121-421X.20.02682-3","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02682-3","url":null,"abstract":"<p><strong>Background: </strong>Zeolites are crystalline mineral aluminosilicate compounds with microporous structures of tetrahedrons and huge porosity. In the gut, these silicates act as adsorbents, ion-exchangers, catalysts, detergents or antidiarrheic agents. In addition to its well-known antioxidant effect, a new potential advantage of Zeolite could be the microbiome modulation. In this scenery, we aimed to investigate the effect of this compound on inflammation among inflammatory bowel disease patients, assessing both clinical activity and inflammatory markers.</p><p><strong>Methods: </strong>This was an open one branch pilot study involving 20 IBD patients, both affected with Crohn's disease and ulcerative colitis affering to San Giovanni Antica Sede Hospital, Città della Salute e della Scienza in Turin. Each patient was given Compositum Zeolite® 6 g/die for 56 days; follow-up time was 60 days from the end of Zeolite therapy. Primary outcomes of the study were to evaluate the improvement of the quality of life (Partial Mayo score or Harvey Bradshaw Index) and the compliance to therapy, while secondary outcome was the reduction of calprotectin value.</p><p><strong>Results: </strong>Of the twenty patients enrolled, 4 did not attend the scheduled check-up visit and 2 reported non-adherence to the therapy with Compositum Zeolite® so these 6 patients were considered as drop out and their data were not included in statistical analysis. So, compliance rate was 70%, that is similar to general adherence to therapy in our setting. Regarding Ulcerative Colitis patients, at the moment of enrolment mean Mayo Partial Score (MPS) was 3.09 (CI: 1.76-4.41) while after 8 weeks of Compositum Zeolite® supplementation the mean MPS was 2.72 (CI: 1.45-4.00) (P=0.57) and after 60 days of follow-up mean MPS was 1.9 (CI: 0.85-2.97) (P=0.24). As Crohn's disease patients are concerned, HBI Score at enrolment was 5.3 (CI: 3.38-7.29) while mean score after 8 week of therapy was 4 (CI: 2.85-5.15) (P=0.042) and after 60 days of follow-up mean score was 3.1 (CI: 1.48-4.87) (P=0.18). Mean calprotectin value at enrolment was 925.64 (CI: 451.83-1399.45). while after 2 months of Compositum Zeolite® addon therapy was 952.72 (CI: 492.73-1412.73); P value 0.93. After 2 months of follow-up mean value was 724.45 (CI: 240.15-1208.73) P value 0.3.</p><p><strong>Conclusions: </strong>Compositum Zeolite® has a compliance rate similar to the other prescribed therapies and is a good addon therapy to improve activity indexes, mainly in Crohn's disease. It also seems to improve inflammatory indexes, even if maybe dose or time of therapy were insufficient to reach a full negativization of these parameters.</p>","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"66 2","pages":"113-116"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38030737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Accardi, Isabella Cammarata, F. Canaletti, I. Bachini, A. Demagistris
{"title":"Management of nutritional consultations in local clinics during SARS-CoV-2 pandemic.","authors":"F. Accardi, Isabella Cammarata, F. Canaletti, I. Bachini, A. Demagistris","doi":"10.23736/S1121-421X.20.02716-6","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02716-6","url":null,"abstract":"","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"257 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91325033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential role of fecal gluten immunogenic peptides to assess dietary compliance in celiac patients.","authors":"T. Larussa, L. Boccuto, F. Luzza, L. Abenavoli","doi":"10.23736/S1121-421X.20.02710-5","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02710-5","url":null,"abstract":"","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88955877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic resection of a giant colonic lipoma with endoloop-assisted-snare polypectomy.","authors":"G. Valentini, M. Surace, D. Mazzucco","doi":"10.23736/S1121-421X.20.02701-4","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02701-4","url":null,"abstract":"","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"217 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79663075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One minute liver \"digitopsy\" for point of care risk stratification of fibrosis in non alcoholic fatty liver disease.","authors":"A. Salmi","doi":"10.23736/S1121-421X.20.02700-2","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02700-2","url":null,"abstract":"","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"41 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78205986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Something new in management of acute pancreatitis: brief review of recent guidelines and practical tips.","authors":"G. Valentini, M. Surace, I. Andria, D. Mazzucco","doi":"10.23736/S1121-421X.20.02699-9","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02699-9","url":null,"abstract":"Improvement in diagnostic and therapeutic techniques has led to revision of past guidelines on the management of Acute Pancreatitis (AP), still not uniformely applied on the territory, partly due to the different distribution of resources to the various centers, partly due to the lack of unequivocal conduct in the approach itself. We had tried to outline most important changes emerged from the revision of recent and authoritative guidelines, focusing on what we believe are still critical points and identifying attitudes more equally shared than others. Based also on the experience of our small center, which however manages numerous cases of AP and their complications, we finally proposed a simple decision algorithm, which does not claim to be a codified recommendation, but only a small and concrete suggestion.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"304 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77930448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Lombardo, C. Bellia, Giovanni Aulisa, Antonio Pratesi, M. Perrone, E. Padua, F. Iellamo, M. Caprio, A. Bellia
{"title":"The different daily distribution of proteins does not influence the variations in body composition in a sample of subjects undergoing a low-calorie mediterranean-type diet.","authors":"M. Lombardo, C. Bellia, Giovanni Aulisa, Antonio Pratesi, M. Perrone, E. Padua, F. Iellamo, M. Caprio, A. Bellia","doi":"10.23736/S1121-421X.20.02694-X","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02694-X","url":null,"abstract":"BACKGROUND\u0000Controversy exists regarding whether the different daily balances of proteins between meals and snacks in a low-calorie diet may influence the effects on body composition (BC) results. Aim of this study is to evaluate BC changes made by a lifestyle intervention in a randomised homogeneous sample of two groups with equal daily caloric reduction but different protein distributions between meals.\u0000\u0000\u0000METHODS\u0000Forty-seven men and women (mean ± SD age: 32 ± 10 y; body mass index: 28.4 ± 2.4) consumed an energy-restricted diet (788 kcal/d below the requirement) for eight weeks in a free- living contest. Subjects consumed 90.1 g protein/d (1.10 ± 0.16 g · kg-1· d-1 ) and were randomised in an EVEN (16.7% at breakfast, 32.8% at lunch, 31.3% at dinner, 19.2% at snacks;n= 23) or UNEVEN (15.4% at breakfast, 36.6% at lunch, 34.9% at dinner, 12.4% at snacks;n= 24) distribution pattern. The nutritional characteristics and caloric deficit of the two diets were similar.\u0000\u0000\u0000RESULTS\u0000The total sample had an overall improvement in both BMI (-0.9 ± 0.6) and fat mass (FM: -2.3 ± 1.5), while lean body mass was preserved (LBM: 0.0 ± 0.7). There were no significant differences between the two groups in variations in BC.\u0000\u0000\u0000CONCLUSIONS\u0000In overweight and obese subjects undergoing a Mediterranean-type low-calorie diet, a different distribution of daily protein intake between meals and snacks does not result in significant differences in terms of FM loss and LBM maintenance. This is one of the first studies showing that nutritional dietary plans with different daily protein distribution show no particular differences in fat loss and lean mass maintenance.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87054234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inflammatory bowel disease and pancreatic diseases.","authors":"Davide G Ribaldone","doi":"10.23736/S1121-421X.20.02668-9","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02668-9","url":null,"abstract":"","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":"66 1","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37830011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}