Minerva gastroenterologica e dietologica最新文献

Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations. 嗜酸性粒细胞性食管炎:关于发病机制和临床表现的新概念。

Minerva gastroenterologica e dietologica Pub Date : 2021-01-01 DOI: 10.23736/S1121-421X.20.02807-X

G. Sciumè, P. Visaggi, A. Sostilio, L. Tarducci, C. Pugno, M. Frazzoni, A. Ricchiuti, M. Bellini, E. Giannini, S. Marchi, V. Savarino, N. de Bortoli

{"title":"Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.","authors":"G. Sciumè, P. Visaggi, A. Sostilio, L. Tarducci, C. Pugno, M. Frazzoni, A. Ricchiuti, M. Bellini, E. Giannini, S. Marchi, V. Savarino, N. de Bortoli","doi":"10.23736/S1121-421X.20.02807-X","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02807-X","url":null,"abstract":"Eosinophilic esophagitis is a chronic disease whose incidence and prevalence are increasing, based on a genetic-driven interaction between environment and immune system. Several gene loci involved in the development of the disease have been identified. A two-step mechanism has been hypothesized: a TSLP-induced allergic sensitization followed by upregulation of CAPNA14-related esophageal-specific pathways. Environment seems to have a larger effect than genetic variants. Factors that could play a role are allergens, drugs, colonizing bacteria and possibly Helicobacter Pylori infection. Acting on these modifiable risk factors may be a tool to prevent the disease. EoE is characterized by a typical eosinophilic infiltrate limited to the esophageal epithelium, supported by a Th2-mediated immune response, found in other atopic conditions. The key of the pathogenesis is the disfunction of the epithelial barrier which allow the interaction between allergens and inflammatory cells. Eosinophilic-predominant inflammation leads to the typical wall remodeling, histologically characterized by epithelial and smooth muscle hyperplasia, lamina propria fibrosis and neo-angiogenesis. These alterations find their clinical expression in the pattern of symptoms: dysphagia, food impaction, chest pain, heartburn.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77386517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Liver and spleen elastography as predictor of portal hypertension and esophageal varices. 肝脾弹性图作为门脉高压和食管静脉曲张的预测指标。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-18 DOI: 10.23736/S1121-421X.20.02779-8

J. Aquino-Matus, M. Uribe, N. Chavez-Tapia

引用次数: 1

Bleeding peptic ulcer disease: over or through the scope clipping? 出血性消化性溃疡:过镜还是过镜?

Minerva gastroenterologica e dietologica Pub Date : 2020-12-03 DOI: 10.23736/S1121-421X.20.02810-X

W. Sbeit, A. Mari, R. Pellicano, T. Khoury

引用次数: 0

Liver fibrosis in NAFLD patients: examining the opportunity to find a non-invasive, accurate and low-cost tool. NAFLD患者肝纤维化:寻找一种无创、准确和低成本工具的机会。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-03 DOI: 10.23736/S1121-421X.20.02813-5

C. Sanna

引用次数: 1

What does liver elastography measure? Technical aspects and methodology. 肝弹性成像测量什么?技术方面和方法。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-03 DOI: 10.23736/S1121-421X.20.02787-7

C. Dietrich, Long Shi, Qi Wei, Yi Dong, X. Cui, Axel Löwe, M. Worni, G. Ferraioli

引用次数: 5

COVID-19 and obesity. COVID-19和肥胖。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-07-16 DOI: 10.23736/S1121-421X.20.02748-8

Andrea Devecchi, Mirko Ippolito, Fabio D Merlo, Costanza Pira, Farnaz Rahimi

引用次数: 1

The role of endoscopy in eosinophilic esophagitis: from diagnosis to therapy. 内镜在嗜酸性粒细胞性食管炎中的作用:从诊断到治疗。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02786-5

E. Arsiè, P. Cantù, R. Penagini

{"title":"The role of endoscopy in eosinophilic esophagitis: from diagnosis to therapy.","authors":"E. Arsiè, P. Cantù, R. Penagini","doi":"10.23736/S1121-421X.20.02786-5","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02786-5","url":null,"abstract":"Endoscopy plays an important role in the management of eosinophilic esophagitis (EoE), since it is involved in the diagnosis, follow up and treatment of this condition. In patients presenting with food impaction, dysphagia and other symptoms of suspected EoE, esophago-gastric-duodenoscopy (EGD) with multiple esophageal biopsies should be performed to confirm or rule out the diagnosis of EoE. The EREFS system, a validated instrument for assessment of the endoscopically-identified esophageal features in EoE (edema, rings, exudates, longitudinal furrows and strictures), is currently used in the clinical practice for the evaluation of the macroscopic aspects of esophageal mucosa during EGD. Multiple esophageal biopsies are mandatory to further confirm EoE diagnosis and subsequent response to treatement, since symptoms reported by patients do not always correlate with histological activity, and considering the low sensitivity of endoscopic assessment; a cut-off of ≥ 15 eosinophils in at least one high power field is the density threshold considered the standard for diagnosis (sensitivity 100%, specificity 96%). Other histological features, included in the EoE histologic scoring system (EoEHSS), are supportive for the diagnosis and for the assessment of inflammatory activity during follow-up. Esophageal dilation, performed either with Savary dilators/bougie or hydrostatic baloon, is an effective and safe treatment in both adult and pediatric EoE patients with fibrostenotic features, mainly in association with other therapeutic strategies which can control eosinophilic inflammation.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81849562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nutritional approach to eosinophilic esophagitis: which diet and when. 嗜酸性粒细胞性食管炎的营养方法:哪种饮食和何时。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02797-X

A. Lucendo

{"title":"Nutritional approach to eosinophilic esophagitis: which diet and when.","authors":"A. Lucendo","doi":"10.23736/S1121-421X.20.02797-X","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02797-X","url":null,"abstract":"Dietary elimination therapy has long been an option for patients with eosinophilic esophagitis (EoE) and remains the only therapy targeting the cause of the disease. Different dietary approaches have been described along the last 3 decades, and cumulative evidence has defined the effectiveness and usefulness of each approach. Elemental diets are highly effective to induce EoE remission, but unpractical in the vast majority of patients. Allergy testing-directed food restrictions resulted inefficient to induce remission in a significant proportion of patients (specially adults) and show a low concordance with the dietary causes of EoE. Empiric elimination diets are currently considered the most effective drug-free treatment for patients of all ages with EoE, after providing widely reproducible results. Highly restrictive empiric six-food elimination diets have paved the way to most efficient and less restrictive step-up approaches, which now include four-food and two-food elimination diets. The potential role of milk-elimination, especially in children, should be also considered. Multiple factors including demographics, nutritional status, patient and family lifestyles, social and financial support, and acceptance of repeated endoscopies influence the results of dietary therapy. Dietary therapy in EoE should be patient centered, and the patients and/or their families together with the medical provider should participate in the decision to set up this treatment. This article updates recent knowledge on dietary therapy for EoE and provides guideline to choose the most suitable alternative for patients with EoE, as well as practical tips to achieve the best results in clinical practice.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84198173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Open challenges in the management of autoimmune hepatitis. 自身免疫性肝炎管理中的公开挑战。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02805-6

A. Gerussi, N. Halliday, M. Carbone, P. Invernizzi, D. Thorburn

{"title":"Open challenges in the management of autoimmune hepatitis.","authors":"A. Gerussi, N. Halliday, M. Carbone, P. Invernizzi, D. Thorburn","doi":"10.23736/S1121-421X.20.02805-6","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02805-6","url":null,"abstract":"Autoimmune Hepatitis (AIH) is a rare autoimmune disease of the liver with many open questions as regards its aetiopathogenesis, natural history and clinical management. The classical picture of AIH is chronic hepatitis with fluctuating elevation of serum transaminases and Immunoglobulin G levels, the presence of circulating autoantibodies and typical histological features. However, atypical presentations do occur and are not well captured by current diagnostic scores, with important consequences in terms of missed diagnoses and delayed treatments. AIH is treated with corticosteroids and immunosuppressive drugs but up to 40% of patients do not achieve full biochemical response and are at risk of progressing to cirrhosis and liver failure. Moreover, standard therapies are associated by significant side-effects which may impair the quality of life of patients living with AIH. However, advances in the understanding of the underlying immunology of AIH is raising the prospect of novel therapies and optimisation of existing therapeutic approaches to reduce side-effect burdens and potentially restore immunological tolerance. In this review we outline the clinical characteristics, aetiopathogenesis and management of AIH and current challenges in the diagnosis and management of AIH and provide evidence underlying the evolution of diagnostic and clinical management protocols.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85052167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Eosinophilic esophagitis and biologics. 嗜酸性食管炎与生物制剂。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02780-4

M. Ghisa, G. Laserra, D. Maniero, E. Marabotto, B. Barberio, F. Pelizzaro, I. Barbuscio, F. Zingone, V. Savarino, E. Savarino

引用次数: 0