Minerva gastroenterologica e dietologica最新文献_第2页

Noninvasive diagnosis of fibrosis in non-alcoholic fatty liver disease: diagnostic accuracy of different scores. 非酒精性脂肪肝纤维化的无创诊断:不同评分的诊断准确性。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-07-22 DOI: 10.23736/S1121-421X.20.02753-1

Marilena Durazzo, Letizia Marzari, Silvia Bonetto, Arianna Ferro, Maria C Ghigo, Paola Belci, Alessandro Collo, Sharmila Fagoonee

{"title":"Noninvasive diagnosis of fibrosis in non-alcoholic fatty liver disease: diagnostic accuracy of different scores.","authors":"Marilena Durazzo, Letizia Marzari, Silvia Bonetto, Arianna Ferro, Maria C Ghigo, Paola Belci, Alessandro Collo, Sharmila Fagoonee","doi":"10.23736/S1121-421X.20.02753-1","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02753-1","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of pathologies characterized by liver damage without history of excessive alcohol intake. Advanced fibrosis, generally detected by transient elastography (TE), is the most significant predictor of poor prognosis and mortality among these patients. This study aimed at assessing the accuracy of five noninvasive methods, compared to TE, for the evaluation of severity of liver fibrosis in patients with NAFLD.Methods: The cohort included 41 patients, in whom the result of TE was compared to AST/ALT ratio, BARD Score (Body Mass Index, AST/ALT ratio, diabetes), AST To Platelet Ratio Index (APRI), Fibrosis-4 Index (FIB-4 Index) and NAFLD Fibrosis Score (NFS).Results: The severity of fibrosis, assessed by TE, was the following: F0 (absence of fibrosis): 17%, F1 (mild): 39%, F2 (moderate): 17%, F3 (advanced): 10%, F4 (cirrhosis): 17%. Performances of the diagnostic scores were: 49% for AST/ALT ratio, 68% for BARD Score, 73% for APRI, 59% and 71% for the lower and upper cut-off of FIB-4 Index, 61% and 76% for the lower and upper cut-off of NFS.Conclusions: Considering the scores compared to TE, AST/ALT ratio was not enough sensitive, while BARD Score had better diagnostic performance and APRI had a superior accuracy than the formers. However, FIB-4 and NFS were the most useful tests and their performance could be improved through the use of a single cut-off. These findings demonstrated that the most accurate scores, compared to TE, were NFS and FIB-4.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38191244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Safety profile of intravenous iron in inflammatory bowel disease: an up-to-date overview. 静脉注射铁治疗炎症性肠病的安全性:最新综述

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02819-6

R. Spagnuolo, L. Abenavoli, T. Larussa, C. Iannelli, R. Pellicano, S. Fagoonee, P. Doldo, F. Luzza

引用次数: 0

The relationship between Helicobacter pylori and chronic kidney disease: update 2020. 幽门螺杆菌与慢性肾脏疾病的关系:更新2020。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-07-03 DOI: 10.23736/S1121-421X.20.02729-4

Carlotta F Zizzi, Rinaldo Pellicano, Luigi Biancone

{"title":"The relationship between Helicobacter pylori and chronic kidney disease: update 2020.","authors":"Carlotta F Zizzi, Rinaldo Pellicano, Luigi Biancone","doi":"10.23736/S1121-421X.20.02729-4","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02729-4","url":null,"abstract":"A number of studies has confirmed that the epidemiology of Helicobacter pylori is changing worldwide, with a decrease especially in developed countries. Nevertheless, since this gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Beyond its role in the pathogenesis of the main gastroduodenal diseases, including gastritis, peptic ulcer and gastric cancer, Helicobacter pylori has been suspected to be involved in several extra-gastroduodenal disorders. Patients with chronic kidney disease (CKD) present gastric mucosal injuries and dyspepsia more often than the general population. However, the reported relationship between CKD and Helicobacter pylori infection is conflicting. In fact, in this population these conditions have a multifactorial pathogenesis and Helicobacter pylori infection could play a limited role in their development. Nevertheless, while it seems that the prevalence of the bacterium is lower in patients with CKD than in controls, Helicobacter pylori has been shown to be associated to an increased occurrence of proteinuria in patients with type 2 diabetes mellitus. This narrative review analyzes the results of recent literature in this field with particular focus on data reported by meta-analyses.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38123602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Eosinophilic esophagitis: definition, epidemiology and quality of life. 嗜酸性粒细胞性食管炎:定义、流行病学和生活质量。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02798-1

L. Frazzoni, S. Tolone

引用次数: 1

The small intestine: barrier, permeability and microbiota. Key messages for clinicians. 小肠:屏障、渗透性和微生物群。给临床医生的关键信息。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02808-1

F. Stalla, M. Astegiano, D. Ribaldone, G. Saracco, R. Pellicano

{"title":"The small intestine: barrier, permeability and microbiota. Key messages for clinicians.","authors":"F. Stalla, M. Astegiano, D. Ribaldone, G. Saracco, R. Pellicano","doi":"10.23736/S1121-421X.20.02808-1","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02808-1","url":null,"abstract":"In recent years, there has been growing interest in the comprehension of the physiology of intestinal permeability and microbiota and how these elements could influence the pathogenesis of diseases. The term intestinal permeability describes all the processes that allow the passage of molecules as water, electrolytes and nutrients through the intestinal barrier by the para-cellular or the trans-cellular transport systems with several implications for self-tolerance and not-self immunity. An increased permeability might induce a more significant interaction of the immune system with unknown external antigens. This might favour the onset of several immune-related extra-intestinal diseases including coeliac disease, diabetes mellitus type 1, bronchial asthma and inflammatory bowel diseases. Furthermore, the intestinal permeability interacts every day with microbiota, the complex system of mutualistic inhabitants and commensal microorganisms living in the healthy gut. Microbiota is implicated in physiological functions by actively participating in digestion, absorption, synthesis of vitamins and protection from external aggressions. The critical site where these processes occur is the small intestine to which this updated review is dedicated. Understanding its anatomy, its barrier structure and permeability modulation and its microbiota composition is the essential skill to comprehend the complex pathogenesis of several - not only gastroenterological - diseases.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80638240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diet high in protein-rich foods with structured sport activity may be useless to lose fat mass and maintain fat-free mass. 富含蛋白质的饮食和有组织的运动可能对减少脂肪量和保持无脂肪量是无用的。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-04-23 DOI: 10.23736/S1121-421X.20.02704-X

Mauro Lombardo, Marco A Perrone, Giovanni Aulisa, Paola Pellegrini, Elvira Padua, Chiara Bellia, Giuseppe Annino, Alfonso Bellia, Massimo Federici, Ferdinando Iellamo

{"title":"Diet high in protein-rich foods with structured sport activity may be useless to lose fat mass and maintain fat-free mass.","authors":"Mauro Lombardo, Marco A Perrone, Giovanni Aulisa, Paola Pellegrini, Elvira Padua, Chiara Bellia, Giuseppe Annino, Alfonso Bellia, Massimo Federici, Ferdinando Iellamo","doi":"10.23736/S1121-421X.20.02704-X","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02704-X","url":null,"abstract":"Background: The aim of this study was to demonstrate that a normal protein diet along with minimal sports activity can be enough to lose fat mass and maintain muscle mass.Methods: All participants were prescribed a hypocaloric nutritionally balanced Mediterranean-style diet tailored to the individual for 8 weeks. Body composition and energy expenditure were measured. Sedentary patients (G1) were only recommended to perform minimal aerobic training, while sport subjects (G2) were prescribed structured physical activity and higher calorie and protein contents in the diet.Results: There were no significant differences between the two groups for any of the measured parameters.Conclusions: The models of lifestyle changes that are currently circulating were for the most part ineffective. It does not appear to be necessary to increase the protein content of the diet above that recommended by guidelines in order to lose weight. Even prescribing specific physical activity is not necessary to maintain muscle mass.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37866856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-07-16 DOI: 10.23736/S1121-421X.20.02749-X

Gianni Testino, Alessandro Adriani

引用次数: 1

IgG4-related autoimmune liver disease. igg4相关的自身免疫性肝病。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02794-4

G. Capurso, F. Pedica, D. Palumbo, E. Della Torre

{"title":"IgG4-related autoimmune liver disease.","authors":"G. Capurso, F. Pedica, D. Palumbo, E. Della Torre","doi":"10.23736/S1121-421X.20.02794-4","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02794-4","url":null,"abstract":"The term IgG4-related autoimmune liver disease (AILD) refers to hepato-biliary manifestations of IgG4-related disease (IgG4-RD) including IgG4-related sclerosing cholangitis and IgG4-related pseudotumors. The association of some forms of autoimmune hepatitis to IgG4-RD remains controversial. Although autoimmune phenomena have not been clearly observed in IgG4-AILD, perturbation of the adaptive immune system and activation of the humoral response represent established pathophysiological hallmarks and potential therapeutic targets. Clinical manifestations of IgG4-AILD are virtually indistinguishable from bile duct cancer or primary sclerosing cholangitis, and are due to mass forming lesions and thickening of the biliary tract that progressively lead to biliary ducts obstruction. There are no current reliable biomarkers for IgG4-AILD and diagnosis should rely on the integration of clinical, serological, radiological, and histological findings. In analogy to most IgG4-RD manifestations, and in contrast to its major mimickers, IgG4-AILD promptly responds to glucocorticoids but frequently relapses, thus requiring long-term maintenance therapy to avoid progressive fibrosclerotic disease and liver cirrhosis. Accumulating evidence on the efficacy of B-cell depletion therapy in patients with systemic IgG4-RD is gradually changing the treatment paradigm of IgG4-AILD and biologics will be increasingly used also for gastroenterological manifestations of IgG4-RD to spare glucocorticoids and traditional immunosuppressive agents. Looking ahead, identification of reliable biomarkers and of miniinvasive strategies to obtain informative biopsies from the biliary tree represent unavoidable priorities to optimize diagnosis and management of IgG4-AILD.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73575302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Proteins daily distribution and body composition changes in weight-loss. 减肥过程中蛋白质的日常分布和身体成分的变化。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 Epub Date: 2020-07-03 DOI: 10.23736/S1121-421X.20.02731-2

Umberto Aimasso, Mirko Ippolito, Costanza Pira, Andrea Devecchi

引用次数: 0

Hepatic steatosis integrated approach: nutritional guidelines and joined nutraceutical administration. 肝脂肪变性综合治疗方法：营养指南和联合营养品管理。

Minerva gastroenterologica e dietologica Pub Date : 2020-12-01 DOI: 10.23736/S1121-421X.20.02738-5

Beniamino Palmieri, Veronica Corazzari, Diana G Panariello Brasile, Vincenzo Sangiovanni, Maria VadalÀ

{"title":"Hepatic steatosis integrated approach: nutritional guidelines and joined nutraceutical administration.","authors":"Beniamino Palmieri, Veronica Corazzari, Diana G Panariello Brasile, Vincenzo Sangiovanni, Maria VadalÀ","doi":"10.23736/S1121-421X.20.02738-5","DOIUrl":"https://doi.org/10.23736/S1121-421X.20.02738-5","url":null,"abstract":"Background: The nonalcoholic fat liver disease (NAFLD) progresses in 30% of the patients to not alcoholic steatohepatitis (NASH) and subsequently in liver fibrosis and even primary cancer and death. Due to the complex physiopathology of the liver steatosis, NASH is an area orphan of specific drugs, but many authors suggest an integrated treatment based upon diet, lifestyle change, and pharmacology.Methods: Our clinical study selected from a wider patient cohort, 13 subjects, appealing to the Second Opinion Medical Consulting Network, for liver and nutritional problems. The diet was integrated with regular prescription of an herbal derivative based on Chrysanthellum americanum and Pistacia lentiscus L. extracts. Clinical data of the recruited patients including body weight, Body Mass Index, were recorded before and after treatment. Each patient underwent pre-post accurate clinical examination and lab exams. The liver stiffness and liver steatosis were evaluated by a trained hepatologist with FibroScan®.Results: A significant reduction of anthropometric parameters was detected in all the patients at the end of the study; liver fibrosis and steatosis were instrumentally decreased in 8 subjects, but not significant changes in lab exams and no adverse effects were reported.Conclusions: Chrysanthellum americanum and Pistacia lentiscus L. extracts were absolutely safe and effective and gave a substantial contribution to the life quality benefit, metabolic balance and gut function in patients with hepatic steatosis.","PeriodicalId":74201,"journal":{"name":"Minerva gastroenterologica e dietologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38820886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0