Medicine international最新文献_第8页

Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report. 甲状腺转移的非小细胞肺癌癌症靶向治疗的问题：一例病例报告。

Medicine international Pub Date : 2023-10-17 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.117

Ertugrul Bayram, Tugba Toyran, Burak Güney, Aysun Hatice Uguz, Derya Gümürdülü, Semra Paydas

引用次数: 0

Castleman disease: Experience from a single institution. Castleman病：单一机构的经验。

Medicine international Pub Date : 2023-10-06 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.116

Sherry S Abraham, Geetha Narayanan, Sugeeth Mangalapilly Thambi, Jayasudha Arundhathi Vasudevan, Deepa Susan Joy Philip, Prakash N Purushothaman, Sreejith G Nair, Rekha Nair

{"title":"Castleman disease: Experience from a single institution.","authors":"Sherry S Abraham, Geetha Narayanan, Sugeeth Mangalapilly Thambi, Jayasudha Arundhathi Vasudevan, Deepa Susan Joy Philip, Prakash N Purushothaman, Sreejith G Nair, Rekha Nair","doi":"10.3892/mi.2023.116","DOIUrl":"https://doi.org/10.3892/mi.2023.116","url":null,"abstract":"Castleman disease (CD) describes a group of rare heterogeneous lymphoproliferative disorders characterized by enlarged hyperplastic lymph nodes. It is classified into unicentric CD (UCD) and multicentric CD (MCD). The present retrospective study examined the data of 11 patients with CD diagnosed and treated at a tertiary cancer center from 2017 to 2022. The median age of the study group was 41 years (range, 24 to 68 years). There were 8 males and 3 females. In total, 7 patients were diagnosed with UCD and 4 patients with MCD. The hyaline-vascular variant was the most common histology in both UCD and MCD. Among the 7 patients with UCD, 5 patients underwent excision, 1 patient underwent debulking followed by radiotherapy and 1 patient received single agent rituximab. Of the patients with UCD, 6 had a complete response (CR) and 1 patient had a partial response (PR). All 4 patients with MCD received systemic treatment, which included single agent rituximab (2 patients), rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (RCHOP) (1 patient) and CHOP (1 patient). Among the patients with MCD, 1 patient attained a CR, 2 patients had a PR and 1 patient succumbed. The 3-year survival rate for the study population was 91%. In summary, CD is a rare disease occurring in immunodeficient patients. UCD is more common and is associated with better outcomes. Surgery is the mainstay of management in UCD whereas MCD requires combination chemotherapy.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 6","pages":"56"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of increasing levels of exposure therapy in the treatment of maladaptive behaviors and anxiety. 提高暴露治疗水平对适应不良行为和焦虑的疗效。

Medicine international Pub Date : 2023-10-03 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.115

Fatih Bal

{"title":"Efficacy of increasing levels of exposure therapy in the treatment of maladaptive behaviors and anxiety.","authors":"Fatih Bal","doi":"10.3892/mi.2023.115","DOIUrl":"https://doi.org/10.3892/mi.2023.115","url":null,"abstract":"The present study examined the effectiveness of increasing levels of exposure therapy, which is applied for the treatment of maladaptive behaviors and anxiety. A total of 16 sessions were applied to the study group in the experimental group three times a week for 10 weeks. Patients aged ≥18 years whom the referring clinician evaluated as meeting the criteria for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-V-TR) Generalized Anxiety Disorder were included in the study. For the control group, demographic characteristics and Spielberger's State-Trait Anxiety Inventory were applied in the first session, followed by Spielberger's State-Trait Anxiety Inventory as a post-test and follow-up. Electroencephalography (EEG) recordings of the study group were obtained at the cortical level. Electrodes for EEG measurements were recorded using the International 10/20 Electrode Placement System. EEG data were obtained using the EEG Analysis Program software. Following the data collection phase, all data were entered into cells based on items using SPSS 25 software. When the findings obtained in the study were examined, it was determined that the increasing levels of exposure and behavioral therapy applied for maladaptive anxiety decreased the anxiety levels compared to those before therapy. This finding can be interpreted as that the cortical function-oriented application method for anxiety effectively reduced the anxiety levels of the study group. However, EEG asymmetry revealed a change in the data before and after the application. These findings demonstrate that the application affects the EEG asymmetry changes at the cortical level.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"55"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet and metabolism are back: The oldest known Islamic medical manuscript bridges the gap from ancient to modern gout management. 饮食和新陈代谢又回来了：已知最古老的伊斯兰医学手稿弥合了从古代到现代痛风管理的差距。

Medicine international Pub Date : 2023-10-02 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.114

Styliani Geronikolou, George P Chrousos, Demetrios A Spandidos, Athanasios Diamantopoulos

{"title":"Diet and metabolism are back: The oldest known Islamic medical manuscript bridges the gap from ancient to modern gout management.","authors":"Styliani Geronikolou, George P Chrousos, Demetrios A Spandidos, Athanasios Diamantopoulos","doi":"10.3892/mi.2023.114","DOIUrl":"https://doi.org/10.3892/mi.2023.114","url":null,"abstract":"Gout is a chronic disease frequently associated with lifestyle; its prevalence is increasing in Western societies, as well as in the Middle East. Apart from its partial genetic features, diet accounts for 12% of the causality of the disease, while purine-rich foods contribute decisively to its development and evaluation. The influential Persian physician of the medieval ages, Abu Bakr Muhammad Ibn Zakariya al-Razi (or by his Latin name Rhazes; 860-925 AD), wrote a short book (20 chapters) entitled 'Treatise on gout'. Rhazes adopted the Hippocratic humoralism, and suggested that the disease results from metabolic excess in the peripheral blood, presenting sex dimorphism and age-dependence. His therapeutic guidelines include a diet prescribed by a physician, the use of laxatives and emetics, counter-balancing excess or deficiency of bile or phlegm and analgesics, bloodletting, foot and steam baths, as well as salves and poultices as preventive measures. He appends differential dietary restrictions/suggestions for phlegmatic or choleric patients: Small rations and intake of good quality foods low in purine by 20% for phlegmatic and 28% for choleric patients, as well as the restriction of foods high in purine by 27% for phlegmatic and 22% for the choleric patients. Finally, the acidic to alkaloid food intake ratio suggested is 2/5 for choleric and 3/7 for phlegmatic patients. His suggested foods and drugs are vitamin C and B-rich complexes, thereby inhibiting the accumulation of tophi.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and successful management of subglottic tracheal stenosis in a 2‑year‑old child: A case report and a mini‑review of the literature. 2岁儿童声门下气管狭窄的挑战和成功治疗：一例病例报告和文献综述。

Medicine international Pub Date : 2023-09-20 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.113

Fahmi H Kakamad, Mariwan L Fatah, Rezheen J Rashid, Karzan M Hasan, Bilal A Mohammed, Honar Othman Kareem, Sarwat T San Ahmed, Khdir Hussein Hamad Khoshnaw, Sanaa O Karim, Berun A Abdalla, Sarhang Sedeeq Abdullah

{"title":"Challenges and successful management of subglottic tracheal stenosis in a 2‑year‑old child: A case report and a mini‑review of the literature.","authors":"Fahmi H Kakamad, Mariwan L Fatah, Rezheen J Rashid, Karzan M Hasan, Bilal A Mohammed, Honar Othman Kareem, Sarwat T San Ahmed, Khdir Hussein Hamad Khoshnaw, Sanaa O Karim, Berun A Abdalla, Sarhang Sedeeq Abdullah","doi":"10.3892/mi.2023.113","DOIUrl":"10.3892/mi.2023.113","url":null,"abstract":"Tracheal stenosis is a narrowing of the windpipe that can lead to shortness of breath, stridor and even suffocation. The present study reports the clinical course of a patient with this condition in an aim to help clinicians obtain more information about this rare condition and identify potential treatment options. A 2-year-old female child presented with progressive shortness of breath and stridor. She was initially managed with tracheostomy; however, this was unsuccessful in relieving the stenosis. Subsequent interventions, including rigid bronchoscopy and dilatation were successful in relieving the condition. A benign hypertrophy of the bronchial wall was identified through biopsy. The patient was treated with steroids and antibiotics, and she experienced a marked improvement in symptoms and remained asymptomatic after a 1-year follow-up. Tracheal stenosis is a rare, yet serious condition that may be life-threatening. Thus, the early diagnosis and treatment of this condition are essential in order to improve outcomes.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"53"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review). 入住重症监护室的COVID-19危重患者实验室特征的时间演变（综述）。

Medicine international Pub Date : 2023-09-14 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.112

Stelios Kokkoris, Angeliki Kanavou, Panagiotis Kremmydas, Dimitrios Katsaros, Stavros Karageorgiou, Aikaterini Gkoufa, Vasiliki Epameinondas Georgakopoulou, Demetrios A Spandidos, Charalampos Giannopoulos, Marina Kardamitsi, Christina Routsi

{"title":"Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review).","authors":"Stelios Kokkoris, Angeliki Kanavou, Panagiotis Kremmydas, Dimitrios Katsaros, Stavros Karageorgiou, Aikaterini Gkoufa, Vasiliki Epameinondas Georgakopoulou, Demetrios A Spandidos, Charalampos Giannopoulos, Marina Kardamitsi, Christina Routsi","doi":"10.3892/mi.2023.112","DOIUrl":"10.3892/mi.2023.112","url":null,"abstract":"In the context of coronavirus disease 2019 (COVID-19), laboratory medicine has played a crucial role in both diagnosis and severity assessment. Although the importance of baseline laboratory findings has been extensively reported, data regarding their evolution over the clinical course are limited. The aim of the present narrative review was to provide the dynamic changes of the routine laboratory variables reported in patients with severe COVID-19 over the course of their critical illness. A search was made of the literature for articles providing data on the time-course of routine laboratory tests in patients with severe COVID-19 during their stay in the intensive care unit (ICU). White blood cell, neutrophil and lymphocyte counts, neutrophil to lymphocyte ratio, platelet counts, as well as D-dimer, fibrinogen, C-reactive protein, lactate dehydrogenase and serum albumin levels were selected as disease characteristics and routine laboratory parameters. A total of 25 research articles reporting dynamic trends in the aforementioned laboratory parameters over the clinical course of severe COVID-19 were identified. During the follow-up period provided by each study, the majority of the laboratory values remained persistently abnormal in both survivors and non-survivors. Furthermore, in the majority of studies, the temporal trends of laboratory values distinctly differentiated patients between survivors and non-survivors. In conclusion, there are distinct temporal trends in selected routine laboratory parameters between survivors and non-survivors with severe COVID-19 admitted to the ICU, indicating their importance in the prognosis of clinical outcome.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spermatocytic tumor of the testis: A case report and mini‑review of the literature. 睾丸精细胞肿瘤：一例报告和文献综述。

Medicine international Pub Date : 2023-09-11 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.111

Rawa Bapir, Ismaeel Aghaways, Rawa M Ali, Saman S Fakhralddin, Rebaz M Ali, Rezheen J Rashid, Ari M Abdullah, Muhammed Bag A Ali, Karukh K Mohammed, Hiwa O Abdullah, Fahmi H Kakamad

{"title":"Spermatocytic tumor of the testis: A case report and mini‑review of the literature.","authors":"Rawa Bapir, Ismaeel Aghaways, Rawa M Ali, Saman S Fakhralddin, Rebaz M Ali, Rezheen J Rashid, Ari M Abdullah, Muhammed Bag A Ali, Karukh K Mohammed, Hiwa O Abdullah, Fahmi H Kakamad","doi":"10.3892/mi.2023.111","DOIUrl":"10.3892/mi.2023.111","url":null,"abstract":"Spermatocytic tumors are a rare type of testicular cancer, comprising <1% of all testicular malignancies. This type of cancer typically affects males in their 60s and 70s and rarely metastasizes; however, it poses a threat to the health of affected individuals if left untreated. The present study describes the case of a 68-year-old male patient with this type of tumor, including a presentation of his initial symptoms, treatment and subsequent monitoring. A male patient, aged 68 years, visited the authors' clinic with an asymptomatic mass in the right testicle. The mass had been progressively increasing in size for a duration of 5 years following a history of blunt injury. During the examination, a noticeable, painless enlargement was detected in the right testis, whereas the left testis appeared to be in a normal state. Tumor markers were within normal limits. Imaging revealed a complex mass (11x8x7 cm) almost replacing the right testis, with no detectable lymph nodes. A right radical orchidectomy was performed under spinal anesthesia. A histopathological examination revealed a spermatocytic tumor. The post-operative period was uneventful, with no metastasis detected in the CT scans. The patient was discharged with instructions for regular follow-up appointments. The case presented herein highlights a rare spermatocytic tumor in a 68-year-old male. The early detection and treatment of testicular tumors, regardless of age, are crucial for a good prognosis.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"51"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic neutrophilic granulomatous mastitis: A case report and review of the literature. 囊性中性粒细胞肉芽肿性乳腺炎：一例报告并文献复习。

Medicine international Pub Date : 2023-09-06 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.110

David Gaskin, Dale Springer, Kandamaran Latha, Pamela S Gaskin, Alain Reid

引用次数: 0

Large bladder flap haematoma following a caesarean section associated with right hydroureteronephrosis: A case report and a mini‑review of the literature. 剖宫产术后大膀胱瓣血肿伴右输尿管积水性肾病：一例病例报告和文献复习。

Medicine international Pub Date : 2023-09-05 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.108

Efthymia Thanasa, Anna Thanasa, Evangelos Kamaretsos, Ioannis Paraoulakis, Vasiliki Grapsidi, Evangelos-Ektoras Gerokostas, Ioannis Thanasas

{"title":"Large bladder flap haematoma following a caesarean section associated with right hydroureteronephrosis: A case report and a mini‑review of the literature.","authors":"Efthymia Thanasa, Anna Thanasa, Evangelos Kamaretsos, Ioannis Paraoulakis, Vasiliki Grapsidi, Evangelos-Ektoras Gerokostas, Ioannis Thanasas","doi":"10.3892/mi.2023.108","DOIUrl":"https://doi.org/10.3892/mi.2023.108","url":null,"abstract":"Post-caesarean section bladder flap haematoma is a rare postpartum complication. There are currently no specific treatment protocols, at least to the best of our knowledge. In general, the failure of conservative treatment with antibiotics requires the re-operation and surgical drainage of the haematoma. The present study describes the case of a primiparous pregnant woman who, at 40 weeks of pregnancy, delivered by caesarean section. On the 3rd post-operative day, the puerperant, haemodynamically stable, developed febrile infection. During the evaluation, the presence of bladder flap haematoma associated with moderate right hydroureteronephrosis was found. The failure of conservative management led to the decision to perform a re-laparotomy 1 week later. During the surgery, a large bladder flap haematoma was found with a retroperitoneal extension into the right parametrium. The surgical drainage of the haematoma and thorough haemostasis in the area of the vesicouterine pouch was performed. The patient was discharged from the clinic on the 5th post-operative day following the re-operation. After 2 weeks, an ultrasound revealed the complete repair of the lesions in the vesicouterine pouch and the right kidney. In the present study, a brief review of literature is also provided regarding the diagnostic and therapeutic management of patients with post-caesarean section bladder flap hematoma.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"48"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculous granulomatous inflammation of parathyroid adenoma manifested as primary hyperparathyroidism: A case report and a review of the literature. 甲状旁腺腺瘤的结核性肉芽肿性炎症表现为原发性甲状旁腺功能亢进：一例报告和文献复习。

Medicine international Pub Date : 2023-09-05 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.109

Abdulwahid M Salih, Aras J Qaradakhy, Shko H Hassan, Ari M Abdullah, Hardi Mohammed Dhahir, Sanaa O Karim, Hawar A Sofi, Berun A Abdalla, Muhammad Hassan Ali, Fahmi H Kakamad

{"title":"Tuberculous granulomatous inflammation of parathyroid adenoma manifested as primary hyperparathyroidism: A case report and a review of the literature.","authors":"Abdulwahid M Salih, Aras J Qaradakhy, Shko H Hassan, Ari M Abdullah, Hardi Mohammed Dhahir, Sanaa O Karim, Hawar A Sofi, Berun A Abdalla, Muhammad Hassan Ali, Fahmi H Kakamad","doi":"10.3892/mi.2023.109","DOIUrl":"https://doi.org/10.3892/mi.2023.109","url":null,"abstract":"Tuberculosis of the thyroid gland is rare, and tuberculous granulomatous inflammation of the parathyroid glands is even rarer. The present study reports a rare case of primary hyperparathyroidism caused by tuberculous granulomatous inflammation. A 58-year-old female patient presented with generalized body pain persisting for 1 year. She had a history of recurrent renal stones (>20 times) and an incidental finding of multinodular goiter involving the parathyroid on neck ultrasound. A blood analysis revealed elevated levels of serum calcium (11.26 mg/dl) and parathyroid hormone (154.7 pg/ml). The patient underwent the resection of the affected left thyroid lobe under general anesthesia. A histopathological examination revealed parathyroid adenoma with caseating granulomatous inflammation involving the adenoma with focal lymphocytic thyroiditis of the left thyroid gland. Although granulomatous parathyroid disease with parathyroid adenoma causing hypercalcemia is an extremely rare event, it can occur. The treatment of choice is surgical resection.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"3 5","pages":"49"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0