Medicine international最新文献_第7页

Carotid artery stenting and endarterectomy surgery techniques: A 30‑year time‑lapse 颈动脉支架和内膜切除手术技术：30年的时间回顾

Medicine international Pub Date : 2023-11-16 DOI: 10.3892/mi.2023.121

P. Nana, Konstantinos Spanos, G. Kouvelos, V. Georgakopoulou, Ioannis G. Lempesis, N. Trakas, P. Sklapani, Konstantinos Paterakis, George Fotakopoulos, Alexandros Brotis

引用次数: 0

Pleomorphic giant cell carcinoma of the prostate: A case report and mini‑review of the literature 前列腺多形性巨细胞癌1例报告及文献复习

Medicine international Pub Date : 2023-11-10 DOI: 10.3892/mi.2023.120

Saman Fakhralddin, Rawa Ali, Ari Abdullah, Farman Faraj, Dlsoz Hussein, Shvan Mohammed, Berun Abdalla, Fahmi Kakamad, Hawbash Rahim

{"title":"Pleomorphic giant cell carcinoma of the prostate: A case report and mini‑review of the literature","authors":"Saman Fakhralddin, Rawa Ali, Ari Abdullah, Farman Faraj, Dlsoz Hussein, Shvan Mohammed, Berun Abdalla, Fahmi Kakamad, Hawbash Rahim","doi":"10.3892/mi.2023.120","DOIUrl":"https://doi.org/10.3892/mi.2023.120","url":null,"abstract":"Pleomorphic giant cell carcinoma (PGCC) is an exceptionally uncommon form of prostate adenocarcinoma. It consists of unusually large and irregular cells with varied nuclei. The present study describes a rare case of prostatic PGCC. A 65‑year‑old male patient presented to the urology clinic with severe dysuria, nocturia, and frequent, urgent, and difficult urination for a period of 3 months. Pelvic magnetic resonance imaging revealed a large pelvic mass. A prostate biopsy was performed, and immunohistochemical analysis revealed positivity for the pan‑epithelial markers, AE1/AE3, alpha‑methyl acyl‑CoA racemase, and focally for sphingolipid activator protein‑2. While waiting for his pathology report, the patient's condition deteriorated, and he was diagnosed with intestinal obstruction. The patient underwent laparotomy and end colostomy. Later, he developed severe sepsis and wound dehiscence. After 2 weeks, the patient succumbed due to multiorgan failure. Prostatic PGCC cases are frequently associated with previous chemo‑, hormone, or radiation therapy. Prior to the diagnosis of PGCC, it is critical to rule out urothelial carcinoma. Early recognition of this rare condition can lead to more effective therapy. Prostatic PGCC is extremely rare. Immunohistochemistry for prostatic markers, such as prostate‑specific membrane antigen, prostate‑specific antigen, NK3 homeobox 1 and androgen receptor, can be used to confirm its origin.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135091746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological significance and prognostic implications of Ube2v1 expression in colorectal cancer. 结直肠癌中Ube2v1表达的临床病理意义及预后意义

Medicine international Pub Date : 2023-10-31 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.119

Qiang Ma, Jin Bao, Naiying Sun, Xingjie Yang, Li Liu, Ying Chen, Wenjun Guo, Lixiang Gao

{"title":"Clinicopathological significance and prognostic implications of Ube2v1 expression in colorectal cancer.","authors":"Qiang Ma, Jin Bao, Naiying Sun, Xingjie Yang, Li Liu, Ying Chen, Wenjun Guo, Lixiang Gao","doi":"10.3892/mi.2023.119","DOIUrl":"10.3892/mi.2023.119","url":null,"abstract":"The present study aimed to investigate the expression of ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1) in colorectal cancer (CRC) and its clinical significance. The differential expression of Ube2v1 in CRC tissues and normal intestinal tissues, as well as the association between Ube2v1 expression and the prognosis of patients with CRC were analyzed using bioinformatics analyses. TIMER database analysis revealed higher Ube2v1 expression in CRC tissues than in normal intestinal tissues. Cancerous and normal tissues collected retrospectively from 37 cases of CRC between July, 2022 and June, 2023 were analyzed for Ube2v1 expression using immunohistochemistry, and the associations between Ube2v1 expression and the clinical pathological features of patients with CRC were analyzed. Ube2v1 expression was associated with lymph node metastasis in patients with CRC (P<0.05). However, bioinformatics analysis using the GEPIA2 and HPA database revealed that Ube2v1 was not associated with the overall survival of patients with CRC. On the whole, the present study demonstrates that due to its high expression and association with lymph node metastasis, Ube2v1 may serve as a potential target for the treatment of CRC.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weekly phototherapy is an effective therapy for patients with vitiligo. 每周光疗是白癜风患者的有效治疗方法。

Medicine international Pub Date : 2023-10-30 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.118

Jing-Yu Wang, Shu-Lan Yao, Xin-Yi Hou, Hai-Lu Xiao, Bin Lu

引用次数: 0

Issues with the targeted therapy of non‑small cell lung cancer with thyroid metastases: A case report. 甲状腺转移的非小细胞肺癌癌症靶向治疗的问题：一例病例报告。

Medicine international Pub Date : 2023-10-17 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.117

Ertugrul Bayram, Tugba Toyran, Burak Güney, Aysun Hatice Uguz, Derya Gümürdülü, Semra Paydas

引用次数: 0

Castleman disease: Experience from a single institution. Castleman病：单一机构的经验。

Medicine international Pub Date : 2023-10-06 eCollection Date: 2023-11-01 DOI: 10.3892/mi.2023.116

Sherry S Abraham, Geetha Narayanan, Sugeeth Mangalapilly Thambi, Jayasudha Arundhathi Vasudevan, Deepa Susan Joy Philip, Prakash N Purushothaman, Sreejith G Nair, Rekha Nair

{"title":"Castleman disease: Experience from a single institution.","authors":"Sherry S Abraham, Geetha Narayanan, Sugeeth Mangalapilly Thambi, Jayasudha Arundhathi Vasudevan, Deepa Susan Joy Philip, Prakash N Purushothaman, Sreejith G Nair, Rekha Nair","doi":"10.3892/mi.2023.116","DOIUrl":"https://doi.org/10.3892/mi.2023.116","url":null,"abstract":"Castleman disease (CD) describes a group of rare heterogeneous lymphoproliferative disorders characterized by enlarged hyperplastic lymph nodes. It is classified into unicentric CD (UCD) and multicentric CD (MCD). The present retrospective study examined the data of 11 patients with CD diagnosed and treated at a tertiary cancer center from 2017 to 2022. The median age of the study group was 41 years (range, 24 to 68 years). There were 8 males and 3 females. In total, 7 patients were diagnosed with UCD and 4 patients with MCD. The hyaline-vascular variant was the most common histology in both UCD and MCD. Among the 7 patients with UCD, 5 patients underwent excision, 1 patient underwent debulking followed by radiotherapy and 1 patient received single agent rituximab. Of the patients with UCD, 6 had a complete response (CR) and 1 patient had a partial response (PR). All 4 patients with MCD received systemic treatment, which included single agent rituximab (2 patients), rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (RCHOP) (1 patient) and CHOP (1 patient). Among the patients with MCD, 1 patient attained a CR, 2 patients had a PR and 1 patient succumbed. The 3-year survival rate for the study population was 91%. In summary, CD is a rare disease occurring in immunodeficient patients. UCD is more common and is associated with better outcomes. Surgery is the mainstay of management in UCD whereas MCD requires combination chemotherapy.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of increasing levels of exposure therapy in the treatment of maladaptive behaviors and anxiety. 提高暴露治疗水平对适应不良行为和焦虑的疗效。

Medicine international Pub Date : 2023-10-03 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.115

Fatih Bal

{"title":"Efficacy of increasing levels of exposure therapy in the treatment of maladaptive behaviors and anxiety.","authors":"Fatih Bal","doi":"10.3892/mi.2023.115","DOIUrl":"https://doi.org/10.3892/mi.2023.115","url":null,"abstract":"The present study examined the effectiveness of increasing levels of exposure therapy, which is applied for the treatment of maladaptive behaviors and anxiety. A total of 16 sessions were applied to the study group in the experimental group three times a week for 10 weeks. Patients aged ≥18 years whom the referring clinician evaluated as meeting the criteria for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-V-TR) Generalized Anxiety Disorder were included in the study. For the control group, demographic characteristics and Spielberger's State-Trait Anxiety Inventory were applied in the first session, followed by Spielberger's State-Trait Anxiety Inventory as a post-test and follow-up. Electroencephalography (EEG) recordings of the study group were obtained at the cortical level. Electrodes for EEG measurements were recorded using the International 10/20 Electrode Placement System. EEG data were obtained using the EEG Analysis Program software. Following the data collection phase, all data were entered into cells based on items using SPSS 25 software. When the findings obtained in the study were examined, it was determined that the increasing levels of exposure and behavioral therapy applied for maladaptive anxiety decreased the anxiety levels compared to those before therapy. This finding can be interpreted as that the cortical function-oriented application method for anxiety effectively reduced the anxiety levels of the study group. However, EEG asymmetry revealed a change in the data before and after the application. These findings demonstrate that the application affects the EEG asymmetry changes at the cortical level.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet and metabolism are back: The oldest known Islamic medical manuscript bridges the gap from ancient to modern gout management. 饮食和新陈代谢又回来了：已知最古老的伊斯兰医学手稿弥合了从古代到现代痛风管理的差距。

Medicine international Pub Date : 2023-10-02 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.114

Styliani Geronikolou, George P Chrousos, Demetrios A Spandidos, Athanasios Diamantopoulos

{"title":"Diet and metabolism are back: The oldest known Islamic medical manuscript bridges the gap from ancient to modern gout management.","authors":"Styliani Geronikolou, George P Chrousos, Demetrios A Spandidos, Athanasios Diamantopoulos","doi":"10.3892/mi.2023.114","DOIUrl":"https://doi.org/10.3892/mi.2023.114","url":null,"abstract":"Gout is a chronic disease frequently associated with lifestyle; its prevalence is increasing in Western societies, as well as in the Middle East. Apart from its partial genetic features, diet accounts for 12% of the causality of the disease, while purine-rich foods contribute decisively to its development and evaluation. The influential Persian physician of the medieval ages, Abu Bakr Muhammad Ibn Zakariya al-Razi (or by his Latin name Rhazes; 860-925 AD), wrote a short book (20 chapters) entitled 'Treatise on gout'. Rhazes adopted the Hippocratic humoralism, and suggested that the disease results from metabolic excess in the peripheral blood, presenting sex dimorphism and age-dependence. His therapeutic guidelines include a diet prescribed by a physician, the use of laxatives and emetics, counter-balancing excess or deficiency of bile or phlegm and analgesics, bloodletting, foot and steam baths, as well as salves and poultices as preventive measures. He appends differential dietary restrictions/suggestions for phlegmatic or choleric patients: Small rations and intake of good quality foods low in purine by 20% for phlegmatic and 28% for choleric patients, as well as the restriction of foods high in purine by 27% for phlegmatic and 22% for the choleric patients. Finally, the acidic to alkaloid food intake ratio suggested is 2/5 for choleric and 3/7 for phlegmatic patients. His suggested foods and drugs are vitamin C and B-rich complexes, thereby inhibiting the accumulation of tophi.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and successful management of subglottic tracheal stenosis in a 2‑year‑old child: A case report and a mini‑review of the literature. 2岁儿童声门下气管狭窄的挑战和成功治疗：一例病例报告和文献综述。

Medicine international Pub Date : 2023-09-20 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.113

Fahmi H Kakamad, Mariwan L Fatah, Rezheen J Rashid, Karzan M Hasan, Bilal A Mohammed, Honar Othman Kareem, Sarwat T San Ahmed, Khdir Hussein Hamad Khoshnaw, Sanaa O Karim, Berun A Abdalla, Sarhang Sedeeq Abdullah

{"title":"Challenges and successful management of subglottic tracheal stenosis in a 2‑year‑old child: A case report and a mini‑review of the literature.","authors":"Fahmi H Kakamad, Mariwan L Fatah, Rezheen J Rashid, Karzan M Hasan, Bilal A Mohammed, Honar Othman Kareem, Sarwat T San Ahmed, Khdir Hussein Hamad Khoshnaw, Sanaa O Karim, Berun A Abdalla, Sarhang Sedeeq Abdullah","doi":"10.3892/mi.2023.113","DOIUrl":"10.3892/mi.2023.113","url":null,"abstract":"Tracheal stenosis is a narrowing of the windpipe that can lead to shortness of breath, stridor and even suffocation. The present study reports the clinical course of a patient with this condition in an aim to help clinicians obtain more information about this rare condition and identify potential treatment options. A 2-year-old female child presented with progressive shortness of breath and stridor. She was initially managed with tracheostomy; however, this was unsuccessful in relieving the stenosis. Subsequent interventions, including rigid bronchoscopy and dilatation were successful in relieving the condition. A benign hypertrophy of the bronchial wall was identified through biopsy. The patient was treated with steroids and antibiotics, and she experienced a marked improvement in symptoms and remained asymptomatic after a 1-year follow-up. Tracheal stenosis is a rare, yet serious condition that may be life-threatening. Thus, the early diagnosis and treatment of this condition are essential in order to improve outcomes.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review). 入住重症监护室的COVID-19危重患者实验室特征的时间演变（综述）。

Medicine international Pub Date : 2023-09-14 eCollection Date: 2023-09-01 DOI: 10.3892/mi.2023.112

Stelios Kokkoris, Angeliki Kanavou, Panagiotis Kremmydas, Dimitrios Katsaros, Stavros Karageorgiou, Aikaterini Gkoufa, Vasiliki Epameinondas Georgakopoulou, Demetrios A Spandidos, Charalampos Giannopoulos, Marina Kardamitsi, Christina Routsi

{"title":"Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review).","authors":"Stelios Kokkoris, Angeliki Kanavou, Panagiotis Kremmydas, Dimitrios Katsaros, Stavros Karageorgiou, Aikaterini Gkoufa, Vasiliki Epameinondas Georgakopoulou, Demetrios A Spandidos, Charalampos Giannopoulos, Marina Kardamitsi, Christina Routsi","doi":"10.3892/mi.2023.112","DOIUrl":"10.3892/mi.2023.112","url":null,"abstract":"In the context of coronavirus disease 2019 (COVID-19), laboratory medicine has played a crucial role in both diagnosis and severity assessment. Although the importance of baseline laboratory findings has been extensively reported, data regarding their evolution over the clinical course are limited. The aim of the present narrative review was to provide the dynamic changes of the routine laboratory variables reported in patients with severe COVID-19 over the course of their critical illness. A search was made of the literature for articles providing data on the time-course of routine laboratory tests in patients with severe COVID-19 during their stay in the intensive care unit (ICU). White blood cell, neutrophil and lymphocyte counts, neutrophil to lymphocyte ratio, platelet counts, as well as D-dimer, fibrinogen, C-reactive protein, lactate dehydrogenase and serum albumin levels were selected as disease characteristics and routine laboratory parameters. A total of 25 research articles reporting dynamic trends in the aforementioned laboratory parameters over the clinical course of severe COVID-19 were identified. During the follow-up period provided by each study, the majority of the laboratory values remained persistently abnormal in both survivors and non-survivors. Furthermore, in the majority of studies, the temporal trends of laboratory values distinctly differentiated patients between survivors and non-survivors. In conclusion, there are distinct temporal trends in selected routine laboratory parameters between survivors and non-survivors with severe COVID-19 admitted to the ICU, indicating their importance in the prognosis of clinical outcome.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0