Medicine international最新文献

{"title":"Comparative analysis of treatments for vertebrogenic chronic low back pain: Intradiscal steroid injections vs. basivertebral nerve radiofrequency ablation.","authors":"Evangelos Sakellariou, Panagiotis Karampinas, Athanasios Galanis, Evangelia Argyropoulou, Dimitris Tzortzis, Andreas Morakis, Nikolaos Parchas, Meletis Rozis, Vasileios Marougklianis, Angelos Kaspiris, Elias Vasiliadis, Spyros Pneumaticos","doi":"10.3892/mi.2025.275","DOIUrl":"10.3892/mi.2025.275","url":null,"abstract":"<p><p>Vertebrogenic chronic low back pain (CLBP) significantly impairs the quality of life of patients, necessitating effective treatment strategies. The present study compared two intervention strategies for this condition: Intradiscal steroid injection (IDSI) in one group with 12 patients, vs. intraosseous basivertebral nerve radiofrequency ablation (BVA) in another group of 10 patients. The present study included patients aged 18-70 years, irrespective of sex, whilst specific inclusion and exclusion criteria were applied. IDSI involves corticosteroid injections into the intervertebral disc, reducing inflammation and pain, whereas BVA targets the basivertebral nerve to disrupt pain signals. A retrospective analysis of the Oswestry Disability Index (ODI) scores of the patients before and after treatment revealed that both treatments effectively reduce disability. The IDSI revealed a higher percentage of complete symptom resolution (at 75%), whereas BVA appeared to provide more consistent and notable improvements across patients, with complete symptom resolution at 70%. Despite potential side-effects, such as transient pain, increased blood sugar levels, nerve damage or infection, both treatments provide substantial pain relief and benefits that outweigh typical side-effects, presumably underscoring the importance of personalized treatment plans. Nonetheless, taking into consideration the notable limitations of the present study, it is essential to emphasize the requirement for further larger-scale research.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 6","pages":"76"},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12557464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cost of care in patients with flares vs. remission in ulcerative colitis: A perspective from a developing country.","authors":"Ashutosh I Yadav, Vishavdeep Singh Rana, Amol N Patil, Parna Pathak, Usha Dutta, Vishal Sharma","doi":"10.3892/mi.2025.274","DOIUrl":"10.3892/mi.2025.274","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic relapsing-remitting disease that results in not only physical, mental and social, but also a significant financial burden to patients and their caregivers. The present study aimed to analyse the monthly cost of care for patients with UC in remission during their regular follow-up and compare this to the expenses born during an episode of acute exacerbation in order to estimate the costs of such episodes of acute severe UC (ASUC). Patients in remission defined using the simple clinical colitis activity index (SCCAI) of <3 were recruited from the outpatient department. Patients with flares were those requiring admission for ASUC. Demographic and clinical data were recorded for each patient. A prevalence-based, micro-costing, human capital approach was used to estimate the direct and indirect monthly per capita mean cost-of-illness. The present study enrolled 25 patients with UC who were in remission (SCCAI of <3) and 51 patients with UC who presented with flares and required hospitalisation for ASUC between January, 2022 to June, 2024. The average monthly cost of care for patients with UC in remission in a tertiary government setup was calculated to be 4,112/- INR. The direct medical cost was 3,676/- INR and the direct non-medical cost was 435/- INR. The cost of management of an episode of ASUC was 44,634/- INR per individual per episode. The direct medical cost was 20,038/- INR, the direct non-medical cost was 4,087/- INR and the indirect cost was 20,509/- INR. The cost of the flares managed surgically was 155,967±100,554/- INR, which was significantly higher than that of flares managed medically (26,922±22,751/- INR; P<0.001). The cost of illness during episodes of acute flares contribute disproportionately to a high financial burden in care of patients with UC. Direct medical costs due to the cost of medications is a major contributor to the cost of care for patients with UC in remission whereas during a period of flares, the indirect cost due to productivity loss is responsible for the majority of the financial burden.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 6","pages":"75"},"PeriodicalIF":0.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12555847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric patient with maturity-onset diabetes of the young type 5 and 17q12 deletion syndrome: A case report.","authors":"Marta Rico-Rodríguez, Sandra Fuentes-Cantero, Marta Carolina García-Rivera, Gema María Varo-Sánchez","doi":"10.3892/mi.2025.260","DOIUrl":"10.3892/mi.2025.260","url":null,"abstract":"<p><p>Maturity-onset diabetes of the young type 5 (MODY5), a rare disease, is often misdiagnosed as type 2 diabetes, leading to delays in diagnosis. 17q12 deletion syndrome is a rare chromosomal abnormality, the signs and symptoms of which can vary widely among different patients, including those with MODY5. The present study reports the case of a 9-year-old patient with chromosomal 17q12 deletion syndrome identified by the <i>de novo</i> deletion of the 1.49 Mb segment in the 17q12 band of the HNF1B gene by genetic analysis. The patient presented with MODY5, a short stature and hypertransaminasemia as clinical features. The risk of inheritance of 17q12 deletion syndrome is ~50%, and genetic counseling is recommended for all patients who are suspected to have or are diagnosed with 17q12 deletion syndrome.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 5","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key lessons from the COVID-19 pandemic: Role of intensive care, politics and science communication (Review).","authors":"Ioannis N Mammas, Michalis Agrafiotis, Aikaterini Kazani, Chryssie Koutsaftiki, Alexia Papatheodoropoulou, Simon B Drysdale, Maria Theodoridou, Demetrios A Spandidos","doi":"10.3892/mi.2025.259","DOIUrl":"10.3892/mi.2025.259","url":null,"abstract":"<p><p>The post-coronavirus disease 2019 (COVID-19) era calls for a comprehensive analysis of the recent COVID-19 pandemic to extract important lessons for the international scientific community for the improvement of its readiness towards future pandemic threats and challenges. The present review article presents key aspects of the COVID-19 pandemic, with the main topics covered being the following: i) The recent advances in intensive care, focusing particularly on high flow nasal oxygen therapy; ii) COVID-19 and politics; and iii) COVID-19 and science communication. Both medical aspects of the COVID-19 pandemic as well as non-medical issues, including politics and science communication, should be further evaluated and be definitely included in future medical educational programs, worldwide.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 5","pages":"60"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of kinetochore-associated 1 gene increases lagging chromosomes and contributes to chromosomal instability in gastric cancer cells.","authors":"Daiki Ohsaki, Kazuki Kanayama","doi":"10.3892/mi.2025.258","DOIUrl":"10.3892/mi.2025.258","url":null,"abstract":"<p><p>Gastric cancer (GC) is classified into four molecular subtypes according to the Epstein-Barr virus-positive status, microsatellite instability, genomic stability and chromosomal instability (CIN). The CIN subtype is characterized by a high frequency of gene amplifications in receptor tyrosine kinases (RTKs) and a poor prognosis. In addition, the CIN subtype often exhibits intratumoral heterogeneity and indicates insensitivity to targeted drugs. Elucidating the molecular mechanisms of CIN in GC is therapeutically crucial; however, the molecular mechanisms involved are not yet fully understood. The kinetochore-associated 1 (<i>KNTC1</i>) gene encodes kinetochore-associated protein 1 (KNTC1), a major component of the outer kinetochore. The downregulation of <i>KNTC1</i> causes a high frequency of lagging chromosomes and consequent aneuploidy and CIN in <i>Drosophila</i> and <i>Caenorhabditis elegans</i>. However, the association between <i>KNTC1</i> and CIN in GC has not yet been clarified. Therefore, the present study investigated the role of <i>KNTC1</i> in GC CIN. It was found that GC cell lines with a high frequency of lagging chromosomes had a low <i>KNTC1</i> mRNA expression. Notably, <i>KNTC1</i> knockdown increased the frequency of lagging chromosomes in GC cell lines. In particular, GC cell lines with the amplification of RTK genes exhibited a significant increase in the frequency of lagging chromosomes. On the whole, the findings of the present study suggest that the suppression of <i>KNTC1</i> expression may contribute to CIN in GC and may be involved in the generation of intratumoral genetic heterogeneity in GC.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 5","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic fallopian tube necrosis with hydatid of Morgagni secondary to post‑caesarean intra‑abdominal adhesions entrapment in the 36th week of pregnancy: A case report and mini‑review of the literature.","authors":"Anna Thanasa, Efthymia Thanasa, Ioannis-Rafail Antoniou, Emmanouil Xydias, Apostolos Ziogas, Alexandros Leroutsos, Athanasios Chasiotis, Ioannis Paraoulakis, Ioannis Thanasas","doi":"10.3892/mi.2025.231","DOIUrl":"https://doi.org/10.3892/mi.2025.231","url":null,"abstract":"<p><p>Surgical adhesions in the pelvis are a well-known complication following cesarean sections. The present study describes a unique case involving acute intra-abdominal inflammation due to ischemic necrosis of the fallopian tube with a hydatid of Morgagni, resulting from entrapment in post-operative adhesions and leading to preterm labor. The patient described herein, a woman in her 36th week of pregnancy with a history of two prior lower-segment cesarean sections, presented with diffuse abdominal pain escalating in intensity and intermittent vomiting. A diagnosis of preterm labor was established, prompting a decision to proceed with cesarean section. The procedure was uneventful, revealing numerous post-operative pelvic adhesions intraoperatively. Further examination revealed ischemic necrosis of the left fallopian tube with a small hydatid of Morgagni, attributed to entrapment due to an adhesion, with no involvement of the left ovary. Upon dissecting the adhesion, tubal perfusion was promptly restored. A decision was made to preserve the affected fallopian tube and perform surgical drainage of the hydatid of Morgagni. Both the mother and newborn were discharged in excellent condition from the clinic on the 4th post-operative day. The case descrbied herein underscores the rarity of preterm labor resulting from ischemic tubal necrosis with a hydatid of Morgagni, secondary to post-cesarean section adhesions. It emphasizes the importance of an intraoperative examination for tubal and ovarian conditions to detect surgical adhesions and underscores the value of preoperative diagnosis and the prevention of post-operative adhesions in pregnant women undergoing cesarean section.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 3","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative fibroepithetial stromal polyp of the vulva with strong clinical suspicion for vulvar malignancy: A case report and mini‑review of the literature.","authors":"Efthymia Thanasa, Anna Thanasa, Ioannis-Rafail Antoniou, Emmanouil Xydias, Apostolos Ziogas, Evangelos Kamaretsos, Athanasios Chasiotis, Alexandros Leroutsos, Evangelia Simopoulou, Maria Mousia, Ioannis Thanasas","doi":"10.3892/mi.2025.230","DOIUrl":"https://doi.org/10.3892/mi.2025.230","url":null,"abstract":"<p><p>Fibroepithelial stromal polyps of the vulva are rare clinical entities, typically appearing as isolated polypoid stromal lesions, covered by squamous epithelium. The presence of non-traumatic ulcerative lesions on the tumor surface, particularly when the tumor is relatively small, necessitates the differentiation from malignant lesions of the vulva. The present study describes the case of a 44-year-old patient who presented to an outpatient gynecological clinic, reporting as her sole symptom the presence of a mass in the vulval region, which had been increasing in size over the past 12 months. Upon examination and palpation of the external genitalia, a painless pedunculated tumor measuring ~5 cm, originating from the upper third of the right labium majus, covered with normal skin, but bearing ulcerative lesions, was found. An ulcerative fibroepithelial polyp of the vulva was suspected, and surgical treatment with wide excision of the lesion was decided upon. A histological examination of the surgical specimen confirmed the diagnosis. The immunohistochemical analysis of the tumor ruled out malignancy. Following an uneventful post-operative course, the patient was discharged from the clinic the following day. At 6 months post-operatively, no recurrence of the fibroepithelial polyp was found at the site of pedicle resection. The present study, also provides a brief literature review of this rare disease entity following the case presentation, highlighting the necessity of wide surgical excision of vulvar fibroepithelial polyps and their differentiation from vulvar malignancies.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 3","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fuzzy‑set qualitative comparative analysis and fuzzy cognitive maps: Exploring pregnancy outcomes and maternal depression.","authors":"Antigoni Sarantaki, Anastasia Nomikou, Katerina Tzimourta, Eirini Orovou, Kleanthi Gourounti, Stavroula Barbounaki","doi":"10.3892/mi.2025.229","DOIUrl":"https://doi.org/10.3892/mi.2025.229","url":null,"abstract":"<p><p>The maternal antenatal attachment scale (MAAS), the pregnancy outcome questionnaire (POQ) and the Centre for Epidemiologic Studies Depression Scale (CESD), among other approaches, have been developed to address pregnancy-related psychological issues. However, the need to develop and validate effective scales to screen the complex experiences of pregnant women continues to be extensively discussed in the literature. The aim of the present study was to build and validate fuzzy models that represent the necessary and sufficient causal combinations that lead to higher levels of anxiety regarding pregnancy outcomes, maternal prenatal attachment to the unborn child and depressive symptoms, respectively. For this purpose, measurements from the MAAS, POQ and CESD scales, along with demographic data, were collected from 135 pregnant women, including cases of natural conception (NC) and assisted reproduction (ART) births. Fuzzy-set qualitative comparative analysis (FSQCA) was employed to produce sets of causal combinations, which were validated against their consistency and coverage. These combinations were then used to develop and validate fuzzy cognitive maps (FCMs) to model the fluctuations in the status of pregnant women. To the best of our knowledge, the present study is the first to utilize FSQCA or FCM to address this issue. The results indicated that the POQ was the distinguishing factor between NC and ART that led to higher MAAS levels. Marital status (MS) and state anxiety were found to lead to higher POQ levels for pregnancies derived from NC. For pregnancies following ART, the factors to consider include income, week of pregnancy, MS, MAAS intensity and trait anxiety. POQ was found to lead to higher levels of CESD for ART pregnancies, while NC, MS and state anxiety are also prerequisites. On the whole, the present study demonstrates that the proposed FSQCA- and FCM-based approach enables obstetricians and midwives to incorporate their expertise in evaluating cases on an individual basis, while also providing a framework for creating intelligent systems to support healthcare policy decisions.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 3","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4‑related disease with endobronchial nodules: A case report and literature review.","authors":"Cheuk Cheung Derek Leung, Yu Hong Chan, Man Ying Ho, Yiu Cheong Yeung","doi":"10.3892/mi.2025.227","DOIUrl":"10.3892/mi.2025.227","url":null,"abstract":"<p><p>The present case report describes the case of a rare presentation of IgG4-related lung disease (IgG4-RLD) with endobronchial nodules and systemic involvement. An 84-year-old male presented with unexplained weight loss and enlarged submandibular lymph nodes. Diagnostic examinations revealed elevated serum IgG4 levels, along with findings of endobronchial nodules during bronchoscopy. Biopsies of endobronchial nodules revealed benign bronchial mucosa with fibrosis and inflammatory infiltration; however, he was not diagnosed with IgG4-RLD. A histological examination of the left salivary gland and submandibular lymph nodes confirmed the diagnosis of IgG4-related disease, revealing storiform fibrosis and abundant IgG4-positive plasma cells. The patient was treated with prednisolone, resulting in a reduction in submandibular swelling and decreased serum IgG4 levels. This case emphasizes the importance of considering IgG4-RLD as a potential diagnosis in patients presenting with endobronchial nodules and systemic disease. Accurate sampling methods, such as surgical lung biopsy or transbronchial cryobiopsies, are crucial for definitive diagnosis. Increased awareness among physicians can lead to timely recognition and appropriate management of this rare condition.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 3","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of vasovagal reactions in whole blood donation and contributing factors.","authors":"Sinan Demircioğlu, Ali Türk, Atilla Tomruk, Havva Demircioğlu, Atakan Tekinalp","doi":"10.3892/mi.2025.221","DOIUrl":"10.3892/mi.2025.221","url":null,"abstract":"<p><p>The aim of the present study was to identify the frequency of vasovagal reactions (VVRs) and the factors influencing their occurrence. For this purpose, a total of 742 donors who applied for whole blood donation at a blood center were included in the study. The frequency of VVR and its association with donor-related factors were assessed. The results revealed that the median age of the donors was 36 years, with 9.8% female and 90.2% male donors. VVRs were observed in 4.9% of the donors. The median age of the donors who experienced VVRs was found to be lower than that of those who did not experience VVRs. The incidence of VVRs was higher in first-time donors. The median blood donation rate for donors who experienced VVRs was 2, compared to 4 for those who did not, and the difference was statistically significant. On the whole, the present study demonstrates that the frequency of VVRs is higher in first-time blood donors, and that the blood donation rate is lower for those who experience VVRs. Preventive measures for VVRs, particularly for first-time donors, could increase the rate of blood donation.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 3","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}