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Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial. 比较评估口腔黏膜下纤维化治疗中腔内注射胎盘素、透明质酸酶和地塞米松的疗效：随机对照试验。
Medicine international Pub Date : 2024-02-26 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.143
Jay Goyal, Shruthi Iyer, Chinmayee Palande, Ujwala Brahmankar, Janice John, Kshitija Patil
{"title":"Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial.","authors":"Jay Goyal, Shruthi Iyer, Chinmayee Palande, Ujwala Brahmankar, Janice John, Kshitija Patil","doi":"10.3892/mi.2024.143","DOIUrl":"10.3892/mi.2024.143","url":null,"abstract":"<p><p>The prevalent symptoms of oral submucous fibrosis (OSMF) are a burning sensation and trismus. The aim of the present study was to compare the efficacy of placentrex, hyaluronidase and dexamethasone, and their combination in the treatment of OSMF. For this purpose, 160 patients with OSMF were divided into four groups (each with 40 patients at a 1:1:1:1 allocation ratio). The patients in group 1 (control) received only oral supplements, along with regular mouth-opening exercises; patients in group 2 received an injection of placental extract; patients in group 3 were injected with hyaluronidase and dexamethasone; and patients in group 4 received a combination of injections from groups 2 and 3. The injections were administered once weekly for 12 weeks and patients were followed-up for 12 months. The data of the patients (mouth opening ability and a burning sensation) were analyzed using ANOVA and the Kruskal-Wallis test. The maximum increase in mouth opening (7.30±0.80 mm) was noted in group 4, and the lease increase was observed in the control group (0.37±0.16 mm), from baseline levels to the end of the 12th week. The maximum relapse in mouth opening of 1.62±0.45 mm was noted in group 2, and a minimum relapse of 0.20±0.08 mm was noted in group 4. On the whole, the present study demonstrates that the intralesional injection of a combination of the three drugs (placentrex, hyaluronidase and dexamethasone) in addition to the use of oral supplements and mouth opening exercises has a high level of efficacy in improving trismus and burning sensation in patients with OSMF.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"4 2","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical genomic profiling of malignant giant cell tumor of bone: A retrospective analysis using a real‑world database. 恶性骨巨细胞瘤的临床基因组剖析：利用真实世界数据库进行回顾性分析。
Medicine international Pub Date : 2024-02-22 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.141
Yusuke Tsuda, Koichi Okajima, Yuki Ishibashi, Liuzhe Zhang, Toshihide Hirai, Hidenori Kage, Aya Shinozaki-Ushiku, Katsutoshi Oda, Sakae Tanaka, Hiroshi Kobayashi
{"title":"Clinical genomic profiling of malignant giant cell tumor of bone: A retrospective analysis using a real‑world database.","authors":"Yusuke Tsuda, Koichi Okajima, Yuki Ishibashi, Liuzhe Zhang, Toshihide Hirai, Hidenori Kage, Aya Shinozaki-Ushiku, Katsutoshi Oda, Sakae Tanaka, Hiroshi Kobayashi","doi":"10.3892/mi.2024.141","DOIUrl":"10.3892/mi.2024.141","url":null,"abstract":"<p><p>Malignant giant cell tumor of bone (GCTB) is identified by the presence of multinucleated giant cells, with an aggressive behavior and a high risk of metastasis, which has not been genetically characterized in detail. H3 histone family member 3A (<i>H3F3A</i>) gene mutations are highly recurrent and specific in GCTB. The present study analyzed the clinical information and genomic sequencing data of eight cases of malignant GCTB (out of 384 bone sarcoma samples) using an anonymized genomic database. There were 5 males and 3 females among the cases, with a median age of 33 years at the time of the initial diagnosis. H3F3A G34W and G34L mutations were detected in 3 patients and 1 patient, respectively. In 75% of cases without <i>H3F3A</i> mutation, mitogen-activated protein kinase (MAPK) signaling pathway gene alterations were found (KRAS single nucleotide variant, KRAS amplification, nuclear respiratory factor 1<i>-BRAF</i> fusion). Moreover, the collagen type I alpha 2 chain<i>-ALK</i> fusion was detected in remaining one case. The most frequent gene alterations were related to cell cycle regulators, including <i>TP53</i>, <i>RB1</i>, cyclin-dependent kinase inhibitor 2A/B and cyclin E1 (75%, 6 of 8 cases). On the whole, the present study discovered recurrent MAPK signaling gene alterations or other gene alterations in cases of malignant GCTB. Of note, two fusion genes should be carefully validated following the pathology re-review by sarcoma pathologists. These two fusion genes may be detected in resembling tumors, which contain giant cells, apart from malignant GCTB. The real-world data used herein provide a unique perspective on genomic alterations in clinicopathologically diagnosed malignant GCTB.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"4 2","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated pseudo‑abducens palsy and contralateral occipital headache with thalamic stroke: A case report and mini‑review of the literature. 丘脑中风引起的孤立性假性外展神经麻痹和对侧枕部头痛：病例报告和文献综述。
Medicine international Pub Date : 2024-02-22 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.142
Jamir Pitton Rissardo, Hossam Tharwat Ali, Asad Riaz, Ana Leticia Fornari Caprara
{"title":"Isolated pseudo‑abducens palsy and contralateral occipital headache with thalamic stroke: A case report and mini‑review of the literature.","authors":"Jamir Pitton Rissardo, Hossam Tharwat Ali, Asad Riaz, Ana Leticia Fornari Caprara","doi":"10.3892/mi.2024.142","DOIUrl":"10.3892/mi.2024.142","url":null,"abstract":"<p><p>The abducens nerve (sixth cranial nerve) is essential for lateral eye movement, and its malfunction can cause a variety of issues with vision. Pseudo-abducens palsy is a rare neurological condition that causes a limitation in eye abduction, while the abducens nerve is still functioning. Thalamic pain syndrome, a severe complication of cerebrovascular events, presents as intense neuropathic pain provoked by temperature fluctuations. Although thalamic strokes are infrequently associated with ocular abnormalities, some studies suggest an association between isolated pseudo-abducens palsy and thalamic infarctions. The present study describes the case of a 38-year-old male patient with 1-day progressive diplopia and occipital headache who had abducens palsy on the left side as a result of a right thalamic infarction. The patient had a 10-year history of smoking and a 1-year history of hypertension, which was poorly controlled. The diagnosis was supported by a neurological examination, imaging and stroke etiology investigations. The patient recovered well within 5 days, highlighting the good prognosis of an acute thalamic presentation. In addition, a mini-review of the literature was performed and two similar reports were identified upon searching the literature using the Embase, Google Scholar, Lilacs, Medline, SciELO and ScienceDirect databases. On the whole, the present study demonstrates that understanding the complex neuronal connections inside the thalamus is critical for a proper diagnosis and appropriate intervention strategies in patients with thalamic stroke with oculomotor impairments. Further research is required to elucidate the underlying causes and develop treatment techniques for thalamic infarction consequences.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"4 2","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alveolar adenoma with a single cyst: A case report 伴有单个囊肿的肺泡腺瘤：病例报告
Medicine international Pub Date : 2024-02-16 DOI: 10.3892/mi.2024.140
Hiroshi Matsui, T. Utsumi, Natsumi Maru, Y. Taniguchi, Tomohito Saito, H. Hino, Kaori Ishida, Koji Tsuta, Tomohiro Murakawa
{"title":"Alveolar adenoma with a single cyst: A case report","authors":"Hiroshi Matsui, T. Utsumi, Natsumi Maru, Y. Taniguchi, Tomohito Saito, H. Hino, Kaori Ishida, Koji Tsuta, Tomohiro Murakawa","doi":"10.3892/mi.2024.140","DOIUrl":"https://doi.org/10.3892/mi.2024.140","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"44 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions 使用无烟烟草的口腔癌前病变和癌症患者体内 GSH、总蛋白和白蛋白水平的比较评估
Medicine international Pub Date : 2024-02-15 DOI: 10.3892/mi.2024.139
Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil
{"title":"Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions","authors":"Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil","doi":"10.3892/mi.2024.139","DOIUrl":"https://doi.org/10.3892/mi.2024.139","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"426 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions 使用无烟烟草的口腔癌前病变和癌症患者体内 GSH、总蛋白和白蛋白水平的比较评估
Medicine international Pub Date : 2024-02-15 DOI: 10.3892/mi.2024.139
Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil
{"title":"Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions","authors":"Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil","doi":"10.3892/mi.2024.139","DOIUrl":"https://doi.org/10.3892/mi.2024.139","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance and main parameters promoting the breast‑feeding strategy (Review) 促进母乳喂养策略的临床意义和主要参数（综述）
Medicine international Pub Date : 2024-02-09 DOI: 10.3892/mi.2024.138
Eleni Nixarlidou, C. Margioula-Siarkou, Aristarchos Almperis, E. Vavoulidis, Antonio Simone Laganà, Konstantinos Dinas, S. Petousis
{"title":"Clinical significance and main parameters promoting the breast‑feeding strategy (Review)","authors":"Eleni Nixarlidou, C. Margioula-Siarkou, Aristarchos Almperis, E. Vavoulidis, Antonio Simone Laganà, Konstantinos Dinas, S. Petousis","doi":"10.3892/mi.2024.138","DOIUrl":"https://doi.org/10.3892/mi.2024.138","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"233 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance and main parameters promoting the breast‑feeding strategy (Review) 促进母乳喂养策略的临床意义和主要参数（综述）
Medicine international Pub Date : 2024-02-09 DOI: 10.3892/mi.2024.138
Eleni Nixarlidou, C. Margioula-Siarkou, Aristarchos Almperis, E. Vavoulidis, Antonio Simone Laganà, Konstantinos Dinas, S. Petousis
{"title":"Clinical significance and main parameters promoting the breast‑feeding strategy (Review)","authors":"Eleni Nixarlidou, C. Margioula-Siarkou, Aristarchos Almperis, E. Vavoulidis, Antonio Simone Laganà, Konstantinos Dinas, S. Petousis","doi":"10.3892/mi.2024.138","DOIUrl":"https://doi.org/10.3892/mi.2024.138","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune checkpoint inhibitors in metastatic melanoma therapy (Review) 免疫检查点抑制剂在转移性黑色素瘤治疗中的应用（综述）
Medicine international Pub Date : 2024-02-09 DOI: 10.3892/mi.2024.137
Vedant Shah, Viraj Panchal, Abhi Shah, Bhavya Vyas, Siddharth Agrawal, Sanket Bharadwaj
{"title":"Immune checkpoint inhibitors in metastatic melanoma therapy (Review)","authors":"Vedant Shah, Viraj Panchal, Abhi Shah, Bhavya Vyas, Siddharth Agrawal, Sanket Bharadwaj","doi":"10.3892/mi.2024.137","DOIUrl":"https://doi.org/10.3892/mi.2024.137","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"25 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune checkpoint inhibitors in metastatic melanoma therapy (Review) 免疫检查点抑制剂在转移性黑色素瘤治疗中的应用（综述）
Medicine international Pub Date : 2024-02-09 DOI: 10.3892/mi.2024.137
Vedant Shah, Viraj Panchal, Abhi Shah, Bhavya Vyas, Siddharth Agrawal, Sanket Bharadwaj
{"title":"Immune checkpoint inhibitors in metastatic melanoma therapy (Review)","authors":"Vedant Shah, Viraj Panchal, Abhi Shah, Bhavya Vyas, Siddharth Agrawal, Sanket Bharadwaj","doi":"10.3892/mi.2024.137","DOIUrl":"https://doi.org/10.3892/mi.2024.137","url":null,"abstract":"","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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