Medicine international最新文献

{"title":"Diagnostic challenges in biliary cytology of biliary inflammatory pseudotumor of the liver: A case report and a review of the literature.","authors":"Yumiko Higuchi, Toshihiko Kato, Eishin Kurihara, Tomonari Toyama, Takuya Fusegawa, Mami Ubukata, Tomiko Yoshizawa, Tomohiro Imaizumi, Akiko Suzuki, Mei Oshima, Fuki Endo, Shun Matsumoto, Katsuhiro Hagiwara, Yosuke Otake, Shiro Sugihara, Noriyuki Tani, Yasuo Imai","doi":"10.3892/mi.2026.303","DOIUrl":"10.3892/mi.2026.303","url":null,"abstract":"<p><p>Biliary inflammatory pseudotumor (IPT) of the liver is a rare benign tumor of which radiographic images, such as biliary stricture and dilatation, resemble those of cholangiocarcinoma (CC). Although repeated biliary cytology via endoscopic nasobiliary drainage (ENBD) is performed for differential diagnosis, a correct diagnosis remains difficult. The present study describes the case of a 76-year-old female patient with chronic liver disease. During surveillance, intrahepatic CC was suspected by imaging analyses; however, the carcinoembryonic antigen and CA19-9 levels were within normal ranges. Percutaneous core needle biopsy was not performed due to technical reasons; however, a left lobectomy was performed based on the diagnosis of malignancy by ENBD bile cytology. A pathological examination of the resected liver demonstrated biliary IPT. Reflecting on the cytological diagnosis of this case, a multi-reviewer re-evaluation of the biliary cytology of this IPT case and 2 cases of well-differentiated CC was then performed, which demonstrated difficulty in distinguishing between them. On the whole, ENBD cytology can play a limited role in differentiation between benign and malignant bile strictures. Surgical indication should be carefully determined and percutaneous core needle biopsy may be warranted in patients with normal tumor marker levels.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 2","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected complication following total thyroidectomy: A case report and brief review of the literature.","authors":"Aso N Qadir, Shaho F Ahmed, Farman J Ahmed, Bootan Jasim Raheem, Twana Omer Saeed, Ashna Othman Hussein, Zana Hama Amin, Diya Tahir Qadir, Berun A Abdalla, Fahmi H Kakamad","doi":"10.3892/mi.2026.302","DOIUrl":"10.3892/mi.2026.302","url":null,"abstract":"<p><p>Supraventricular tachycardia (SVT) involves a group of supraventricular tachyarrhythmiasfast heart rhythms originating above the ventricles. While SVT is commonly associated with hyperthyroidism, its occurrence in hypothyroidism is rare. The present case report describes a case of SVT occurring in the setting of post-thyroidectomy hypothyroidism. A 50-year-old female patient with a history of total thyroidectomy presented with palpitations and chest tightness. A 12-lead electrocardiogram (ECG) demonstrated atrioventricular nodal reentrant tachycardia (AVNRT) with a heart rate of 200 bpm. A laboratory evaluation revealed elevated thyroid-stimulating hormone levels, indicating biochemical hypothyroidism. Adenosine was administered, successfully restoring sinus rhythm. She was discharged with a revised levothyroxine regimen. At the 2-month follow-up, she remained asymptomatic, hemodynamically stable and free of recurrent arrhythmia. Ventricular and supraventricular arrhythmias, including SVT and Torsades de Pointes, are uncommon in hypothyroidism. The most common underlying mechanism is re-entry, with AVNRT being most common. In addition, the present study reviewed 4 cases of SVT following thyroidectomy reported in the literature. Palpitations were universal, and dyspnea occurred in 3 cases. In total, 2 patients were on hypothyroid treatment at the time, and similarly, 2 patients received adenosine intravenously. Myocardial structural changes, and slow cardiac repolarization lead to early after-depolarizations. A review of case reports revealed SVT occurring during hypothyroid states, particularly in women, often presenting with palpitations and diagnosed via ECG. Management relies on ECG-guided diagnosis and acute treatment with vagal maneuvers or adenosine. The identification of SVT in hypothyroidism is rare, but should be considered. ECG is key for diagnosis and management.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 2","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac arrest complicating routine throat pack insertion in oral and maxillofacial surgery under general anesthesia: A case report.","authors":"Kana Yamada, Makoto Adachi","doi":"10.3892/mi.2026.301","DOIUrl":"10.3892/mi.2026.301","url":null,"abstract":"<p><p>Throat packs are routinely inserted during oral and maxillofacial surgery and are generally considered safe. However, severe vagally mediated cardiovascular reflexes can rarely occur during airway or oropharyngeal manipulation. The present study describes a rare case of cardiac arrest directly attributed to throat pack insertion. A healthy 54-year-old male patient underwent third molar extraction under general anesthesia. Immediately following throat pack placement, he developed sudden cardiac arrest with complete electrical asystole lasting ~20 sec. Spontaneous circulation returned rapidly following the intravenous administration of ephedrine (8 mg) without the need for chest compressions. This event was most consistent with a vagal reflex-mediated response. The present case report indicates that vigilant hemodynamic monitoring, adequate ventilation and appropriate anesthetic depth are essential even during routine adjunctive steps, such as throat pack insertion.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 2","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic cancer detection and management with artificial intelligence and augmented reality (Review).","authors":"Hanisha Reddy Kukunoor, Adithya Andanappa, Kaushalendra Mani Tripathi, Iram Fatima, Ozoemena Z Akah, Ansari Maha Faisal, Fawad Talat, Harsh Bhatia, Arlette Villalobos, Prachi Dawer, Yusra Qamar","doi":"10.3892/mi.2026.297","DOIUrl":"10.3892/mi.2026.297","url":null,"abstract":"<p><p>Metastatic cancer remains a significant global health challenge, contributing to the majority of cancer-related mortality due to late detection, therapeutic resistance and the complexity of disseminated disease. Recent advances in artificial intelligence (AI) and augmented reality (AR) are transforming the landscape of metastatic cancer detection and management. AI-driven tools, including radiomics, deep learning models, and predictive analytics, enhance early identification of metastatic lesions, improve diagnostic accuracy, and support personalized treatment strategies by integrating multimodal clinical, imaging and molecular data. At the same time, AR technologies are increasingly applied in image-guided surgery, real-time tumor visualization and patient education, enabling more precise interventions and improved clinical decision-making. The combined use of AI and AR fosters multidisciplinary collaboration, facilitates comprehensive treatment planning, and may ultimately improve patient outcomes. However, despite these advancements, several challenges limit widespread implementation, including algorithmic bias, variability in data quality, concerns regarding patient privacy, and regulatory and ethical constraints. Furthermore, integration into clinical workflows requires robust validation, clinician training, and standardized guidelines. Future efforts are required to focus on developing transparent, generalizable AI models, strengthening data-security frameworks, and enhancing AR usability to ensure equitable, safe, and effective incorporation of these emerging technologies into metastatic cancer care.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12856537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic management in a pregnant patient with acute ischemic stroke in the revascularization window: A case report.","authors":"Antonia Ioana Vasile, Amelia Damiana Trifu, Cristina Nica, Simona Trifu","doi":"10.3892/mi.2026.296","DOIUrl":"https://doi.org/10.3892/mi.2026.296","url":null,"abstract":"<p><p>Pregnancy is considered a relative contraindication for thrombolysis. Moreover, mechanical thrombectomy should be considered for pregnant patients, as it would be indicated in non-pregnant patients. The present study describes the clinical case of a 29-year-old female full-term pregnant patient who presented to the emergency room with a sudden onset symptomatology characterized by pronunciation disorder and motor impairment in the right arm with numbness at the same level, and with a National Institutes of Health Stroke Scale score of 7 points. The patient presented in the revascularization window, and the series of acute medical interventions were as follows: Clinical examination, native head computed tomography (CT) scan, emergency cesarean section, CT angiography of the cerebral arteries, and, eventually, mechanical thrombectomy. A brain MRI revealed a hyperintense lesion in diffusion sequence with low apparent diffusion coefficient correspondence at the frontal level of the left side, affecting the middle and precentral gyrus. A transesophageal ultrasound revealed a small patent foramen ovale with a risk of paradoxical embolism score of 8 points. Usual thrombophilia laboratory test results were negative; however, a homozygous methylenetetrahydrofolate reductase gene mutation and a heterozygous positive plasminogen activator inhibitor-1 gene mutation were detected. On the whole, the present case report emphasizes the importance of evaluating inherited genetic thrombophilia and PFO in young patients suffering a stroke. Moreover, the need for the psychological and psychiatric evaluation for possible reactive depression, anxiety and burnout in young patients suffering a stroke, and particularly in the peripartum period, is highlighted.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal treatment and tumour biology-driven long-term survival in PSC-associated hilar cholangiocarcinoma: A case report.","authors":"Evangelia Florou, Michael Heneghan, Debashis Sarker, Parthi Srinivasan, Andreas Prachalias","doi":"10.3892/mi.2026.295","DOIUrl":"10.3892/mi.2026.295","url":null,"abstract":"<p><p>Primary sclerosing cholangitis (PSC) is a recognised risk factor for hilar cholangiocarcinoma (hCCA). In selected patients, neoadjuvant chemoradiotherapy followed by liver transplantation provides the optimal chance of long-term survival. However, for the patient described in the present case report, at the time of the patient s treatment, the UK did not have an approved transplant programme for cholangiocarcinoma, and access to liver transplantation was limited, often necessitating upfront surgical resection despite its complexity and limited curative potential. The present study describes the case of a 52-year-old male patient with PSC who was diagnosed with hCCA and underwent an extended right hepatectomy. After 26 months, progressive liver dysfunction due to PSC-related cirrhosis prompted liver transplantation, which was approved following a lengthy appeals process. Over the following years, the patient developed metastases in the bowel, lungs and abdominal wall, all of which were successfully managed with surgical resections. He remained disease-free for 8 years following his initial diagnosis before developing intrahepatic recurrence. The tumour was HER2-positive, and the compassionate use of zanidatamab was initiated following progression on standard therapies. At the time of the writing of the present case report, the patient remained alive 101 months following this initial diagnosis. On the whole, the present case report highlights the potential impact of tumour biology and multimodal treatment in PSC-associated hCCA. The prolonged survival of the patient despite delayed transplant and metastatic recurrence suggests that PSC-related hCCA may follow a more indolent course compared to <i>de novo</i> cases. Future efforts are required to focus on tumour profiling and stratified therapeutic approaches to better guide treatment in this complex disease.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melkersson-Rosenthal syndrome with facial swelling and palsy and associated diagnostic challenges: A case report.","authors":"Alina Teresa Sánchez Vázquez, Anahí Parcero Tamay, María J Calvo Domínguez, Martha Patricia Pacheco Arenas, Valeria Iuxely Medrano Pichardo","doi":"10.3892/mi.2025.294","DOIUrl":"10.3892/mi.2025.294","url":null,"abstract":"<p><p>Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder characterized by recurrent orofacial edema, peripheral facial palsy and a fissured tongue, although the complete triad is rarely observed. The present study reports the case of a 22-year-old male patient who initially presented with facial paralysis, later developing cheek edema, dermatosis and systemic symptoms; the histopathological findings consistent with granulomatous cheilitis. Laboratory analyses revealed a low C1q level and positive antinuclear antibody. Based on clinical and biopsy findings, MRS was diagnosed. The patient responded well to a 6-month regimen of deflazacort, epinastine and methotrexate. On the whole, the present case report illustrates an incomplete, yet clinically significant form of MRS. Diagnosis is primarily clinical, supported by histology and exclusion of similar conditions. Treatment focuses on symptom control with corticosteroids; immunomodulators or biologics may be used in refractory cases. Early recognition is essential, even in the absence of the full triad.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the humanized mouse model in research into SARS-CoV-2 infection (Review).","authors":"Xiaoyue Feng, Yadong Wang, Yuan Li, Jinzhao Long, Fang Liu, Haiyan Yang","doi":"10.3892/mi.2025.293","DOIUrl":"10.3892/mi.2025.293","url":null,"abstract":"<p><p>The coronavirus disease 2019 (COVID-19) pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a profound impact on global public health. The complexity of its pathogenic mechanisms and host interactions urgently requires high-fidelity animal models to support research. Humanized mouse models break the species barrier through gene editing and immune reconstitution technologies, providing a key tool to simulate human infection characteristics and pathological processes. A number of studies have reported the application of humanized mouse models in the fields of COVID-19 research, such as SARS-CoV-2 pathogenesis, anti-SARS-CoV-2 drug discovery and vaccine development, etc. The present review aimed to systematically document the latest advances in the application of humanized mouse models based on different construction strategies, such as receptor humanization, immune system humanization and composite humanization. These models have not only elucidated the pathogenicity differences and immune escape mechanisms of SARS-CoV-2 variants, but have also validated the efficacy of broad-spectrum anti-SARS-CoV-2 strategies, including angiotensin-converting enzyme 2-targeted therapies, antibody cocktail regimens and mucosal vaccines. Additionally, humanized mouse models have played a pivotal role in investigating the mechanisms underlying long COVID. By revealing the multi-system pathogenic mechanisms of pulmonary fibrosis, neurodegeneration and intestinal microbiota dysregulation, these models provide a theoretical foundation for the development of targeted intervention strategies.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood gas analysis: Clinical applications, interpretation and future directions (Review).","authors":"Mercedes Núñez Sanagustín, Joško Osredkar","doi":"10.3892/mi.2025.291","DOIUrl":"10.3892/mi.2025.291","url":null,"abstract":"<p><p>Blood gas analysis represents a cornerstone diagnostic method in clinical practice, providing rapid assessment of respiratory and metabolic status through evaluation of pH, partial pressure of oxygen, partial pressure of carbon dioxide and bicarbonate. The present comprehensive review discusses recent advances in blood gas analysis, including emerging artificial intelligence (AI) applications, controversial practices in venous vs. arterial sampling and closed-loop management systems in critical care. The present review critically synthesizes evidence from recent systematic reviews and meta-analyses, addressing key controversies, such as the clinical utility of venous blood gas analysis with venous-to-arterial conversion technology (sensitivity, 97.6%; specificity, 36.9% for respiratory failure diagnosis) and automated interpretation systems. The present review encompasses physiological foundations, evidence-based clinical applications, structured interpretation methodologies and quality improvement strategies. Emphasis is placed on technological innovations including AI-assisted interpretation, non-invasive monitoring technologies and integration with closed-loop therapeutic systems. Through the analysis of >50 recent publications and current guidelines, the present review aimed to provide evidence-based recommendations for modern clinical practice, highlighting when venous sampling provides adequate diagnostic information, while reducing patient discomfort. Future perspectives include predictive algorithms for early clinical deterioration recognition and personalized diagnostic approaches. The present review aimed to provide unique clinical value by bridging traditional blood gas analysis with cutting-edge technological applications, providing practitioners with contemporary, evidence-based guidance for optimal patient care.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid biopsies for <i>in vitro</i> fertilization: Non-invasive innovations (Review).","authors":"Senem Aslan Öztürk, Nergis Özlem Kiliç, Duygu Kütük, Çağri Öner","doi":"10.3892/mi.2025.290","DOIUrl":"10.3892/mi.2025.290","url":null,"abstract":"<p><p>Non-invasive fluid biopsies are emerging as a promising, low-risk complementary method to traditional diagnostic approaches in reproductive biology, allowing for repeated sampling throughout different stages of assisted reproductive technology. These approaches hold significant potential, not only for clinical diagnosis, but also for personalized medicine. The present review summarizes recent findings on key biomolecular components found in accessible body fluids, such as follicular fluid, embryo culture medium, uterine secretions and saliva, namely cell-free nucleic acids, extracellular vesicles and microRNAs. These biomarkers indicate critical cellular events, such as apoptosis, oxidative stress, mitochondrial dysfunction and intercellular signaling pathways. Special emphasis is placed on the molecular profile of granulosa and cumulus cells, which are essential for oocyte maturation and have strong predictive value for fertilization potential and subsequent pregnancy outcomes. Their molecular signatures provide critical information about the developmental competence of the oocyte and early embryo. However, limitations such as maternal contamination, mosaicism and variable compliance, along with a lack of guideline-level approval, currently restrict their routine clinical use. These non-invasive samples are valuable complements to current invasive methods, providing information about chromosomal competence and embryo viability without compromising embryo integrity. Overall, the current evidence highlights the potential of fluid-based biomarker discovery to improve the outcomes of <i>in vitro</i> fertilization (IVF) and support the development of personalized, sustainable fertility treatments. The present review aimed to summarize and critically evaluate developments in non-invasive liquid biopsy techniques in IVF, highlight their clinical applications for improving IVF outcomes, and examine the molecular profile of granulosa and cumulus cells as determinants of oocyte and embryo quality. The fundamental hypothesis is that non-invasive liquid biopsies can serve as effective, low-risk alternatives to traditional invasive diagnostic approaches, minimizing harm to patients and embryos, while improving embryo selection, preimplantation genetic testing and overall IVF success.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}