Medicine international最新文献_第4页

Elderly patient with unresectable advanced‑stage hepatocellular carcinoma who received atezolizumab plus bevacizumab and achieved a complete response: A case report 无法切除的晚期肝细胞癌老年患者接受阿特珠单抗加贝伐单抗治疗后获得完全缓解：病例报告

Medicine international Pub Date : 2024-03-20 DOI: 10.3892/mi.2024.147

Shuhei Arima, Tatsuo Kanda, Mai Totsuka, Masayuki Honda, Shini Kanezawa, Reina Sasaki-Tanaka, Naoki Matsumoto, Ryota Masuzaki, Hiroaki Yamagami, Masahiro Ogawa, Hirofumi Kogure

引用次数: 0

Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report 一名酒精相关性肝病患者的重症戊型肝炎病毒基因 3b 型：病例报告

Medicine international Pub Date : 2024-03-07 DOI: 10.3892/mi.2024.146

Tatsuo Kanda, Shuhei Arima, Reina Sasaki-Tanaka, Mai Totsuka, Masayuki Honda, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Masaharu Takahashi, Hiroaki Okamoto, Hirofumi Kogure

{"title":"Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report","authors":"Tatsuo Kanda, Shuhei Arima, Reina Sasaki-Tanaka, Mai Totsuka, Masayuki Honda, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Masaharu Takahashi, Hiroaki Okamoto, Hirofumi Kogure","doi":"10.3892/mi.2024.146","DOIUrl":"https://doi.org/10.3892/mi.2024.146","url":null,"abstract":". Hepatitis E virus (HEV) infection occasion‑ ally causes acute‑on‑chronic liver failure in patients with alcohol‑associated cirrhosis. These reports have been published mainly from highly HEV genotype 1‑endemic countries. The present study describes the case of a patient with severe HEV genotype 3b infection and alcohol‑associated liver disease. A male patient in his 70s who consumed alcohol, and who had begun consuming alcohol at the age of 12, had high levels of alanine aminotransferase (ALT) and total bilirubin. The peak levels of ALT and total bilirubin were 1,067 IU/l and 26.3 mg/dl, respectively. A computed tomography scan revealed an atrophic liver. Upon admission, both anti‑HEV immunoglobulin A and HEV RNA were positive, and his HEV was genotype 3b. He also had chronic kidney disease, as his estimated glomerular filtration rate was <45 ml/min/1.73 m 2 , and ribavirin could not be used. The abnormal levels of the liver function parameters of the patient gradually improved due to conservative treatment, and he was discharged on day 43. On the whole, the present study demonstrates that careful attention should be paid to patients with viral hepatitis, including hepatitis E, when alcohol‑associated liver disease is present. Novel anti‑HEV drugs need to be developed for severe HEV infections with chronic kidney disease.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging and cancer: Clinical role of tumor markers in the geriatric population (Review) 衰老与癌症：肿瘤标志物在老年人群中的临床作用（综述）

Medicine international Pub Date : 2024-03-06 DOI: 10.3892/mi.2024.145

S. Sundaresan, Palanirasu Rajapriya, SelvarajKaveri Lavanya

{"title":"Aging and cancer: Clinical role of tumor markers in the geriatric population (Review)","authors":"S. Sundaresan, Palanirasu Rajapriya, SelvarajKaveri Lavanya","doi":"10.3892/mi.2024.145","DOIUrl":"https://doi.org/10.3892/mi.2024.145","url":null,"abstract":". Aging, with the progressive deterioration and functional decline of several organ systems, is highly hetero‑ geneous for both between and within individuals. Tumor markers are widely used in clinical practice as a screening test for individuals >50 years of age. More specifically, caring for elderly patients is a public health concern, given the incidence of cancer and its related mortality and morbidity. A multidisci‑ plinary diagnostic procedure known as a geriatric assessment is capable of identifying functional, psychological and physi‑ ological issues that are missed by standard evaluation. The present review focuses on cancers affecting the geriatric population, highlights current opportunities and challenges, and highlights the unmet need for clinically relevant tumor markers in elderly patients with cancer. A comprehensive geriatric examination, including a biological assessment, still requires conveniently available tumor markers and their levels in older populations in order to forecast deterioration or loss of functional balance. These tumor indicators ought to make it possible to track patients using other outcomes, such overall survival and functional impairment. Despite the notable progress made in the understanding of human biology, the mechanisms and networks underlying aging remain largely unknown. In addition, as elderly patients are a highly heterogeneous population, age‑related changes cannot be distinguished solely by chronological age. Strong clinical studies, well‑established protocols and meta‑analyses may contribute to the better utilization of tumor biomarkers in the elderly population. Hence, the present review addresses the effects of aging on tumor markers and the usefulness of tumor marker values for the geriatric population.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenergic receptor system as a pharmacological target in the treatment of epilepsy (Review). 肾上腺素能受体系统作为治疗癫痫的药理靶点（综述）。

Medicine international Pub Date : 2024-02-27 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.144

Ercan Ozdemir

{"title":"Adrenergic receptor system as a pharmacological target in the treatment of epilepsy (Review).","authors":"Ercan Ozdemir","doi":"10.3892/mi.2024.144","DOIUrl":"10.3892/mi.2024.144","url":null,"abstract":"Epilepsy is a complex and common neurological disorder characterized by spontaneous and recurrent seizures, affecting ~75 million individuals worldwide. Numerous studies have been conducted to develop new pharmacological drugs for the effective treatment of epilepsy. In recent years, numerous experimental and clinical studies have focused on the role of the adrenergic receptor (AR) system in the regulation of epileptogenesis, seizure susceptibility and convulsions. α1-ARs (α1A, α1B and α1D), α2-ARs (α2A, α2B and α2C) and β-ARs (β1, β2 and β3), known to have convulsant or anticonvulsant effects, have been isolated. Norepinephrine (NE), the key endogenous agonist of ARs, is considered to play a crucial role in the pathophysiology of epileptic seizures. However, the effects of NE on different ARs have not been fully elucidated. Although the activation of some AR subtypes produces conflicting results, the activation of α1, α2 and β receptor subtypes, in particular, produces anticonvulsant effects. The present review focuses on NE and ARs involved in epileptic seizure formation and discusses therapeutic approaches.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial. 比较评估口腔黏膜下纤维化治疗中腔内注射胎盘素、透明质酸酶和地塞米松的疗效：随机对照试验。

Medicine international Pub Date : 2024-02-26 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.143

Jay Goyal, Shruthi Iyer, Chinmayee Palande, Ujwala Brahmankar, Janice John, Kshitija Patil

{"title":"Comparative assessment of the efficacy of an intralesional injection of placentrex, hyaluronidase and dexamethasone in the management of oral submucous fibrosis: A randomized controlled trial.","authors":"Jay Goyal, Shruthi Iyer, Chinmayee Palande, Ujwala Brahmankar, Janice John, Kshitija Patil","doi":"10.3892/mi.2024.143","DOIUrl":"10.3892/mi.2024.143","url":null,"abstract":"The prevalent symptoms of oral submucous fibrosis (OSMF) are a burning sensation and trismus. The aim of the present study was to compare the efficacy of placentrex, hyaluronidase and dexamethasone, and their combination in the treatment of OSMF. For this purpose, 160 patients with OSMF were divided into four groups (each with 40 patients at a 1:1:1:1 allocation ratio). The patients in group 1 (control) received only oral supplements, along with regular mouth-opening exercises; patients in group 2 received an injection of placental extract; patients in group 3 were injected with hyaluronidase and dexamethasone; and patients in group 4 received a combination of injections from groups 2 and 3. The injections were administered once weekly for 12 weeks and patients were followed-up for 12 months. The data of the patients (mouth opening ability and a burning sensation) were analyzed using ANOVA and the Kruskal-Wallis test. The maximum increase in mouth opening (7.30±0.80 mm) was noted in group 4, and the lease increase was observed in the control group (0.37±0.16 mm), from baseline levels to the end of the 12th week. The maximum relapse in mouth opening of 1.62±0.45 mm was noted in group 2, and a minimum relapse of 0.20±0.08 mm was noted in group 4. On the whole, the present study demonstrates that the intralesional injection of a combination of the three drugs (placentrex, hyaluronidase and dexamethasone) in addition to the use of oral supplements and mouth opening exercises has a high level of efficacy in improving trismus and burning sensation in patients with OSMF.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical genomic profiling of malignant giant cell tumor of bone: A retrospective analysis using a real‑world database. 恶性骨巨细胞瘤的临床基因组剖析：利用真实世界数据库进行回顾性分析。

Medicine international Pub Date : 2024-02-22 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.141

Yusuke Tsuda, Koichi Okajima, Yuki Ishibashi, Liuzhe Zhang, Toshihide Hirai, Hidenori Kage, Aya Shinozaki-Ushiku, Katsutoshi Oda, Sakae Tanaka, Hiroshi Kobayashi

{"title":"Clinical genomic profiling of malignant giant cell tumor of bone: A retrospective analysis using a real‑world database.","authors":"Yusuke Tsuda, Koichi Okajima, Yuki Ishibashi, Liuzhe Zhang, Toshihide Hirai, Hidenori Kage, Aya Shinozaki-Ushiku, Katsutoshi Oda, Sakae Tanaka, Hiroshi Kobayashi","doi":"10.3892/mi.2024.141","DOIUrl":"10.3892/mi.2024.141","url":null,"abstract":"Malignant giant cell tumor of bone (GCTB) is identified by the presence of multinucleated giant cells, with an aggressive behavior and a high risk of metastasis, which has not been genetically characterized in detail. H3 histone family member 3A (H3F3A) gene mutations are highly recurrent and specific in GCTB. The present study analyzed the clinical information and genomic sequencing data of eight cases of malignant GCTB (out of 384 bone sarcoma samples) using an anonymized genomic database. There were 5 males and 3 females among the cases, with a median age of 33 years at the time of the initial diagnosis. H3F3A G34W and G34L mutations were detected in 3 patients and 1 patient, respectively. In 75% of cases without H3F3A mutation, mitogen-activated protein kinase (MAPK) signaling pathway gene alterations were found (KRAS single nucleotide variant, KRAS amplification, nuclear respiratory factor 1-BRAF fusion). Moreover, the collagen type I alpha 2 chain-ALK fusion was detected in remaining one case. The most frequent gene alterations were related to cell cycle regulators, including TP53, RB1, cyclin-dependent kinase inhibitor 2A/B and cyclin E1 (75%, 6 of 8 cases). On the whole, the present study discovered recurrent MAPK signaling gene alterations or other gene alterations in cases of malignant GCTB. Of note, two fusion genes should be carefully validated following the pathology re-review by sarcoma pathologists. These two fusion genes may be detected in resembling tumors, which contain giant cells, apart from malignant GCTB. The real-world data used herein provide a unique perspective on genomic alterations in clinicopathologically diagnosed malignant GCTB.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated pseudo‑abducens palsy and contralateral occipital headache with thalamic stroke: A case report and mini‑review of the literature. 丘脑中风引起的孤立性假性外展神经麻痹和对侧枕部头痛：病例报告和文献综述。

Medicine international Pub Date : 2024-02-22 eCollection Date: 2024-03-01 DOI: 10.3892/mi.2024.142

Jamir Pitton Rissardo, Hossam Tharwat Ali, Asad Riaz, Ana Leticia Fornari Caprara

{"title":"Isolated pseudo‑abducens palsy and contralateral occipital headache with thalamic stroke: A case report and mini‑review of the literature.","authors":"Jamir Pitton Rissardo, Hossam Tharwat Ali, Asad Riaz, Ana Leticia Fornari Caprara","doi":"10.3892/mi.2024.142","DOIUrl":"10.3892/mi.2024.142","url":null,"abstract":"The abducens nerve (sixth cranial nerve) is essential for lateral eye movement, and its malfunction can cause a variety of issues with vision. Pseudo-abducens palsy is a rare neurological condition that causes a limitation in eye abduction, while the abducens nerve is still functioning. Thalamic pain syndrome, a severe complication of cerebrovascular events, presents as intense neuropathic pain provoked by temperature fluctuations. Although thalamic strokes are infrequently associated with ocular abnormalities, some studies suggest an association between isolated pseudo-abducens palsy and thalamic infarctions. The present study describes the case of a 38-year-old male patient with 1-day progressive diplopia and occipital headache who had abducens palsy on the left side as a result of a right thalamic infarction. The patient had a 10-year history of smoking and a 1-year history of hypertension, which was poorly controlled. The diagnosis was supported by a neurological examination, imaging and stroke etiology investigations. The patient recovered well within 5 days, highlighting the good prognosis of an acute thalamic presentation. In addition, a mini-review of the literature was performed and two similar reports were identified upon searching the literature using the Embase, Google Scholar, Lilacs, Medline, SciELO and ScienceDirect databases. On the whole, the present study demonstrates that understanding the complex neuronal connections inside the thalamus is critical for a proper diagnosis and appropriate intervention strategies in patients with thalamic stroke with oculomotor impairments. Further research is required to elucidate the underlying causes and develop treatment techniques for thalamic infarction consequences.","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar adenoma with a single cyst: A case report 伴有单个囊肿的肺泡腺瘤：病例报告

Medicine international Pub Date : 2024-02-16 DOI: 10.3892/mi.2024.140

Hiroshi Matsui, T. Utsumi, Natsumi Maru, Y. Taniguchi, Tomohito Saito, H. Hino, Kaori Ishida, Koji Tsuta, Tomohiro Murakawa

引用次数: 0

Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions 使用无烟烟草的口腔癌前病变和癌症患者体内 GSH、总蛋白和白蛋白水平的比较评估

Medicine international Pub Date : 2024-02-15 DOI: 10.3892/mi.2024.139

Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil

引用次数: 0

Comparative evaluation of GSH, total protein and albumin levels in patients using smokeless tobacco with oral precancerous and cancerous lesions 使用无烟烟草的口腔癌前病变和癌症患者体内 GSH、总蛋白和白蛋白水平的比较评估

Medicine international Pub Date : 2024-02-15 DOI: 10.3892/mi.2024.139

Anand V Nimbal, Bhagyashri M. Ahirrao, Aruna Vishwakarma, P. Vishwakarma, Alisha Wani, Asmita Patil

引用次数: 0