Maedica最新文献

筛选
英文 中文
Multidisciplinary Insights into Perioperative Cardiac Events in Non-Cardiac Surgery: an ECG Holter Monitoring Study. 非心脏手术围手术期心脏事件的多学科洞察:一项心电图动态监测研究。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.182
Alexandru Cosmin Palcau, Livia Florentina Paduraru, Alexandru Dinulescu, Florentina Musat, Daniel Ion, Dan Nicolae Paduraru, Adriana Mihaela Iliesiu
{"title":"Multidisciplinary Insights into Perioperative Cardiac Events in Non-Cardiac Surgery: an ECG Holter Monitoring Study.","authors":"Alexandru Cosmin Palcau, Livia Florentina Paduraru, Alexandru Dinulescu, Florentina Musat, Daniel Ion, Dan Nicolae Paduraru, Adriana Mihaela Iliesiu","doi":"10.26574/maedica.2025.20.2.182","DOIUrl":"10.26574/maedica.2025.20.2.182","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular complications after non-cardiac surgery have a major impact on perioperative morbidity and mortality. Despite several scales and scores for assessing the preoperative cardiovascular status, an individualized assessment focused on each patient is mandatory.</p><p><strong>Aim: </strong>To identify the new cardiac events that occur after non-cardiac surgery.</p><p><strong>Methods: </strong>In 100 patients hospitalized in the general surgery department with acute and chronic surgical pathologies, the perioperative cardiac events were assessed using Holter monitoring along with clinical and biochemical markers, including C reactive protein (CRP) and high-sensitive troponin (hscTnI).</p><p><strong>Results: </strong>Out of the 100 participants with a mean age of 54.5 (43-77.9) years, 54% were men. Ten patients developed paroxysmal postoperative atrial fibrillation (AF), which was related with longer surgery time 165 (150-180) vs 120 (90-150) minutes (p=0.002) and postoperative anaemia [haemoglobin (Hg) 10.4 (9.37-12.6) vs 12.1 (11-13.2) g/dL, (p=0.041)]. Higher CRP levels were also correlated with paroxysmal AF. The AF group correlated with higher values of presurgical CRP: 81 (46.5-186.75) vs 27 (6-102.5) mg/dL, (p=0.041). Higher postsurgical CRP values were also found in the AF group: 76 (47.75-110.75) vs 40.5 (12-82.5) mg/dL (p=0.045). Sinus pauses were present in nine patients and there was a strong association between sinus pauses and age (p = 0.011), history of high blood pressure (HBP) (p = 0.031), intraoperative HBP (p = 0.026) and the preexisting AF (p = 0.028). Postsurgical ST changes were present in 30 patients and ST depression was correlated with age (p < 0.001), prolonged surgery time [150 (120-180) vs 120 (90-150) minutes (p < 0.001)], history of HBP [(33.3% vs 12.2%) (p=0.017)] and intraoperative maximum values of BP (p = 0.007).</p><p><strong>Conclusions: </strong>There is an increased risk of cardiovascular events during the postoperative period of non-cardiac surgery in patients with advanced age, pre-existing diseases (hypertension, preexisting atrial fibrillation, diabetes mellitus), the level of inflammation and longer intraoperative stress. Holter monitoring revealed rhythm and conduction disorders as well as ST segment changes that were associated with the inflammatory status and slightly elevated cardiac enzyme levels. Future studies are needed to see the impact of cardiac complications in the long term.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"182-191"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Importance of Diet in Patients with Obstructive Sleep Apnea Syndrome and Continuous Positive Airway Pressure Therapy - a Case Report. 饮食在阻塞性睡眠呼吸暂停综合征和持续气道正压治疗患者中的重要性- 1例报告。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.432
Romica Burcea, Florin Dumitru Mihaltan
{"title":"The Importance of Diet in Patients with Obstructive Sleep Apnea Syndrome and Continuous Positive Airway Pressure Therapy - a Case Report.","authors":"Romica Burcea, Florin Dumitru Mihaltan","doi":"10.26574/maedica.2025.20.2.432","DOIUrl":"10.26574/maedica.2025.20.2.432","url":null,"abstract":"<p><strong>Introduction: </strong>The increase in the proportion of obese patients in both paediatric and elderly populations worldwide made obstructive sleep apnea syndrome (OSAS) an important contributor to the range of comorbidities encountered in the current population. Continuous positive airway pressure (CPAP) therapy is the main treatment for OSAS and it has an effect in decreasing the severity of OSAS, with decreasing the apnea hypopnea index (AHI) and improving hypoxemia.</p><p><strong>Results: </strong>and discussion: We present the case of a 48-year-old woman with newly diagnosed severe OSAS for which she was on CPAP therapy. After the patient followed a diet and had a significant weight loss, her symptomatology improved and overnight cardiorespiratory polygraphy showed a decrease in nocturnal respiratory events. This demonstrates the important role that weight loss plays in certain diseases - in this case, in a patient with OSAS.</p><p><strong>Conclusions: </strong>Losing weight can have important benefits in many diseases. In OSAS, weight reduction is associated with significant improvement in symptoms and nocturnal respiratory events, including apnea and hypopnea.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"432-436"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary Tract Injuries in Abdominal, Laparoscopic and Robotic Surgery: a Comprehensive Review. 腹部、腹腔镜和机器人手术中的尿路损伤:综合综述。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.358
Spyridon Polykalas, Athanasia Chronopoulou, Maria-Sotiria Bompoula, Nikolaos Garmpis, Christos Damaskos, Gerasimos Tsourouflis, Stylianos Kykalos, Dimitrios Dimitroulis
{"title":"Urinary Tract Injuries in Abdominal, Laparoscopic and Robotic Surgery: a Comprehensive Review.","authors":"Spyridon Polykalas, Athanasia Chronopoulou, Maria-Sotiria Bompoula, Nikolaos Garmpis, Christos Damaskos, Gerasimos Tsourouflis, Stylianos Kykalos, Dimitrios Dimitroulis","doi":"10.26574/maedica.2025.20.2.358","DOIUrl":"10.26574/maedica.2025.20.2.358","url":null,"abstract":"<p><strong>Background/aim: </strong>Urinary tract injuries (UTIs) are a significant complication in abdominal, laparoscopic and robotic surgeries. Due to the proximity of the urinary tract to critical structures, procedures like colorectal surgery, hysterectomy and prostatectomy pose risks. Minimally invasive techniques like laparoscopy and robotic surgery offer benefits but introduce unique challenges. This review explores the incidence, risk factors and management strategies for UTIs across surgical approaches.</p><p><strong>Materials and methods: </strong>A systematic review of PubMed, Embase and Web of Science was conducted. Studies on abdominal, gynecological, and urological surgeries reporting UTIs were included. After screening, 17 studies published between 1990 and 2024 were analyzed. The PRISMA method was used for selection and data extraction.</p><p><strong>Results: </strong>The incidence of UTI varies by surgery type: for open surgery, higher rates (0.5%-3.0%) were recorded due to invasive techniques and longer operative times, particularly in colorectal surgeries and hysterectomies. In laparoscopic surgery, a lower incidence (0.1%-1.0%) was noted, though thermal injury and visualization challenges remain. Finally, in robotic surgery, incidence ranges from 0.2% to 1.5%, with enhanced precision reducing the risk of UTIs in complex surgeries like prostatectomy and hysterectomy.</p><p><strong>Conclusion: </strong>The primary causes of UTIs include direct trauma, thermal injury and postoperative ischemia. Advanced technologies like robotic systems and intraoperative imaging reduce risks but require surgeon expertise. Preventing UTIs in surgery involves meticulous planning, advanced intraoperative technologies and comprehensive postoperative care. Continued research into minimally invasive techniques will further reduce complication rates and improve patient outcomes.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"358-365"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Esophageal Surgery in Greece during the 19th Century. 19世纪希腊的食道手术。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.445
Konstantinos Laios, Alexandros Samolis, Pavlos Lytsikas-Sarlis, Dimitrios Tsapralis, Panagiotis Sakarellos, Constantinos G Zografos, Irina Noskova, Dimitrios Zisiadis, Gregory Tsoucalas, Dimitrios Schizas
{"title":"Esophageal Surgery in Greece during the 19th Century.","authors":"Konstantinos Laios, Alexandros Samolis, Pavlos Lytsikas-Sarlis, Dimitrios Tsapralis, Panagiotis Sakarellos, Constantinos G Zografos, Irina Noskova, Dimitrios Zisiadis, Gregory Tsoucalas, Dimitrios Schizas","doi":"10.26574/maedica.2025.20.2.445","DOIUrl":"10.26574/maedica.2025.20.2.445","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this manuscript is to highlight the endeavors of the Greek surgeons during the 19 th century to perform various types of operation on esophagus.</p><p><strong>Methods: </strong>Research has been conducted in the archives of National Greek Library and the medical archives of the major Greek hospitals during the 19 th century.</p><p><strong>Results: </strong>The research found that the surgery of esophagus during the 19 th century in Greece was limited to esophagostomy, removal of foreign objects, dilation and suturing.</p><p><strong>Conclusion: </strong>Greek surgeons of the 19 th century faced similar problems as their colleagues in Europe in the surgical approach of the esophagus.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"445-449"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12346995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the COVID-19 Pandemic on Brain Metastases in Breast Cancer Patients. COVID-19大流行对乳腺癌患者脑转移的影响
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.250
Ruxandra Vatavu, Alexandru Misailoaie, Roxana Florentina Gavril, Codrin Gabriel Lucasievici, Anca Sava
{"title":"Impact of the COVID-19 Pandemic on Brain Metastases in Breast Cancer Patients.","authors":"Ruxandra Vatavu, Alexandru Misailoaie, Roxana Florentina Gavril, Codrin Gabriel Lucasievici, Anca Sava","doi":"10.26574/maedica.2025.20.2.250","DOIUrl":"10.26574/maedica.2025.20.2.250","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of the COVID-19 pandemic on the diagnosis and treatment delays of brain metastases secondary to breast cancer, and to compare patient demographics, disease characteristics and outcomes before and during the pandemic.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted on 100 patients who were surgically treated for brain metastases in the Neurosurgery Clinic of \"Prof. Dr. Nicolae Oblu\" Clinical Emergency Hospital, Iasi, Romania. Patients were divided into two groups: pre-pandemic (2018-2020, n=57) and pandemic (2020-2022, n=43). Clinicopathological data, including demographics, metastasis localization, number and duration, were collected and analyzed.</p><p><strong>Results: </strong>The pandemic period saw a shift towards younger patients, with 51% younger than 55 years compared to an average age of 57.9 years before the pandemic. Metastases were mostly located in the parietal lobe (61%). Despite a balanced rural-urban patient distribution, diagnostic delays were observed, with an average metastasis duration of 17 months. Patients from rural areas and older subjects showed tendencies towards later diagnosis. The number of metastases varied, with nearly half presenting a single lesion.</p><p><strong>Conclusions: </strong>COVID-19 pandemic-related disruptions in healthcare services led to delayed diagnosis and treatment of brain metastases, particularly impacting older and rural patients. These findings underscore the need for improved healthcare resilience and equitable access to oncological care to minimize delays and optimize outcomes during public health emergencies.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"250-256"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corneal Topography - a Review of Available Investigation Methods and Impact in the Diagnosis and Follow-Up of Keratoconus. 角膜地形学-圆锥角膜的现有调查方法及其对诊断和随访的影响。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.374
Maria-Silvia Dina, Maria-Cristina Marinescu, Catalina-Gabriela Corbu, Mihaela-Monica Constantin, Catalina-Ioana Tataru, Calin-Petru Tataru
{"title":"Corneal Topography - a Review of Available Investigation Methods and Impact in the Diagnosis and Follow-Up of Keratoconus.","authors":"Maria-Silvia Dina, Maria-Cristina Marinescu, Catalina-Gabriela Corbu, Mihaela-Monica Constantin, Catalina-Ioana Tataru, Calin-Petru Tataru","doi":"10.26574/maedica.2025.20.2.374","DOIUrl":"10.26574/maedica.2025.20.2.374","url":null,"abstract":"<p><p>Keratoconus is a bilateral non-inflammatory ectatic disease of the cornea, with an asymmetrical evolution, that occurs in young people during puberty, progressing during the second and third decades and stabilizing around the age of 40. It is characterised by an insidious and progressive thinning of the cornea, myopia and astigmatism, which lead to a decrease in visual acuity. Slit-lamp examination findings in the early stages of keratoconus may appear normal. However, in advanced stages of untreated keratoconus, visual acuity is diminished, which leads to a lower quality of life. Corneal topography is essential in the early diagnosis of the disease, analyzing the corneal geometry and thus helping to establish the method of treatment and to follow patients' evolution. This investigation combines the projection of a light source and a video capture system of corneal images with computer processing, providing maps of the distribution of dioptric power over the entire surface of the cornea. Topography can be classified into measuring the anterior surface of the cornea (keratometry and reflection-based topography) as well as both the anterior and posterior surfaces of the cornea (Scheimpflug slit-lamp scanning and pinhole optics). Understanding and reading corneal topographies is essential in correctly diagnosing and staging a keratoconus case. The present review constitutes a comprehensive evaluation of available methods and expected typical results and interpretation, in order to support clinicians in better managing this underdiagnosed ectasia affecting young patients.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"374-382"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Plasmacytoma - Rare Occurrence in Multiple Myeloma: Case Presentation and Short Review of the Literature. 肺浆细胞瘤-罕见的多发性骨髓瘤:病例报告和简短的文献回顾。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.422
Daniela Diaconescu, Iuliana Iordan, Ion Dumitru, Ana-Maria Ilinescu, Delia Soare, Georgiana Ene, Horia Bumbea
{"title":"Pulmonary Plasmacytoma - Rare Occurrence in Multiple Myeloma: Case Presentation and Short Review of the Literature.","authors":"Daniela Diaconescu, Iuliana Iordan, Ion Dumitru, Ana-Maria Ilinescu, Delia Soare, Georgiana Ene, Horia Bumbea","doi":"10.26574/maedica.2025.20.2.422","DOIUrl":"10.26574/maedica.2025.20.2.422","url":null,"abstract":"<p><p>Multiple myeloma is a hematological malignancy mostly diagnosed in the elderly. It is characterized by a chronic evolution with alternating periods of remission and relapses. Plasmacytoma, a tumor comprised of monoclonal plasma cells, is a typical finding in multiple myeloma patients, being more frequently observed during relapses. The most involved sites are bones, kidneys, liver, skin, ear, nose and throat. Extramedullary lung plasmacytomas are a rare presentation, with an incidence of well under 5% of all plasmacytomas. The clinical manifestations are heterogeneous and depend on the affected site. Differentiating plasmacytoma from other pathologies can be challenging, with the diagnosis being established via tumor biopsy. The presence of plasmacytoma is associated with poor prognosis and is a marker of rapid disease progression. We report the case of a 63-year-old patient diagnosed with IgA lambda multiple myeloma, stage IIIB Salmon-Durie complicated by lung plasmacytoma identified in the setting of relapse. Despite undergoing treatment, the disease exhibited an aggressive course, rapidly progressive towards death. The case underlines the rarity of pulmonary plasmacytoma and the diagnostic challenges.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"422-427"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Therapeutic Approaches in Systemic Mastocytosis: an Updated Review. 系统性肥大细胞增多症的创新治疗方法:最新综述。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.342
Delia Soare, Poliana Leru, Horia Bumbea
{"title":"Innovative Therapeutic Approaches in Systemic Mastocytosis: an Updated Review.","authors":"Delia Soare, Poliana Leru, Horia Bumbea","doi":"10.26574/maedica.2025.20.2.342","DOIUrl":"10.26574/maedica.2025.20.2.342","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic mastocytosis (SM) is a heterogeneous clonal disorder characterized by the accumulation of abnormal mast cells in various tissues, predominantly the bone marrow. Given the rarity of the disease, the available data in Romania are extremely limited. It is estimated that the total number of diagnosed patients is approximately 170. In recent years, significant advances have been made in understanding the molecular pathogenesis of SM, leading to the development of targeted therapies that have transformed the management of this condition. The approval of tyrosine kinase inhibitors (TKIs), particularly midostaurin and avapritinib, has provided new therapeutic options for patients with advanced SM, demonstrating significant improvements in overall survival (OS) and symptom control.</p><p><strong>Objective: </strong>To conduct a systematic review of clinical trials, observational studies and international or national guidelines published since 2000 to evaluate the efficacy, safety and mechanistic rationale of innovative therapeutic approaches for SM - including KIT inhibitors, monoclonal antibody-based therapies, stem cell transplant - and to compare the impact of these interventions with conventional cytoreductive and symptomatic treatments on overall response rate, survival, mediator-related symptom burden, quality of life and treatment-related adverse events.</p><p><strong>Materials and methods: </strong>A comprehensive search was performed in MEDLINE ( via PubMed), Embase, the Cochrane Central Register of Controlled Trials and Web of Science from 1 January 2000 to 1 May 2025. ClinicalTrials.gov, WHO ICTRP. Search strings combined controlled vocabulary ( e.g. , \"Mastocytosis\") and free-text terms for the disease (systemic mastocytosis, advanced SM, indolent SM) with key innovative interventions (KIT inhibitors, avapritinib, midostaurin, monoclonal antibodies, stem cell transplant). No language limits were set at the search stage; non-English full texts were excluded only if an accurate translation could not be obtained. As the review relied exclusively on published or publicly available data, ethical approval and informed consent were not required.</p><p><strong>Conclusion: </strong>The present review provides an updated overview of the evolving therapeutic landscape of SM, emphasizing recent clinical trial data, novel targeted therapies and emerging treatment paradigms. We discuss the implications of this progress on patient outcomes and future directions for personalized medicine in SM.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"342-352"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Significance of Micrometastases and Isolated Tumor Cells in Breast Cancer. 乳腺癌微转移及分离肿瘤细胞的临床意义。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.353
Christos Ampatzis, Stefanos Zervoudis, Panagiotis Eskitzis, Panagiotis Tsikouras, Anthi Papakonstantinou, Georgios Iatrakis
{"title":"Clinical Significance of Micrometastases and Isolated Tumor Cells in Breast Cancer.","authors":"Christos Ampatzis, Stefanos Zervoudis, Panagiotis Eskitzis, Panagiotis Tsikouras, Anthi Papakonstantinou, Georgios Iatrakis","doi":"10.26574/maedica.2025.20.2.353","DOIUrl":"10.26574/maedica.2025.20.2.353","url":null,"abstract":"<p><p>We decided to do a literature search for information about the clinical significance of micrometastases (pN1mi) and isolated tumor cells (ITCs). A detailed search was conducted in the existing bibliography. We found that pN1mi and ITCs had differences in prognosis and were handled in a different way. However, some researchers do not accept this difference. Many studies have shown no differences in their prognosis and the distinction of these terms is questioned. This fact is attributed to different definitions, diagnostic approaches that have been used and not well organised research. For their diagnosis, single hematoxylin and eosin (H) stain slide section, and not routine immunohistochemical (IHC) stain, is recommended, despite a lot of institutions perform multiple level sections and IHC stains for each block of sentinel lymph nodes (SLNs). Once the limits within pN1mi and ITCs were defined, they have been based in small data, and here is an area where we should focus and build evidence based definitions that have proven differences and importance in clinical management. As for their therapy, in ITCs cases, axillary lymph node dissection (ALND) is omitted, but a large amount of data questions the safety of this omission. In pN1mi cases, ALND is performed.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"353-357"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and Radiological Outcomes of Open Versus Arthroscopic Latarjet for Anterior Shoulder Instability. 开放与关节镜下Latarjet治疗前肩不稳的功能和放射学结果。
Maedica Pub Date : 2025-06-01 DOI: 10.26574/maedica.2025.20.2.289
Christos Koukos, Georgia Kanellopoulou, Dimitrios Giotis, Christos Yiannakopoulos, Stylianos Kapetanakis, Christos Konstantinidis, Saseendar Shanmugasundaram, Emilios E Pakos, Koray Sahin, Fredy Montoya
{"title":"Functional and Radiological Outcomes of Open Versus Arthroscopic Latarjet for Anterior Shoulder Instability.","authors":"Christos Koukos, Georgia Kanellopoulou, Dimitrios Giotis, Christos Yiannakopoulos, Stylianos Kapetanakis, Christos Konstantinidis, Saseendar Shanmugasundaram, Emilios E Pakos, Koray Sahin, Fredy Montoya","doi":"10.26574/maedica.2025.20.2.289","DOIUrl":"10.26574/maedica.2025.20.2.289","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study is to compare the clinical, functional and radiographic outcomes among 42 patients with anterior shoulder instability treated with either the open or arthroscopic Latarjet procedure.</p><p><strong>Materials and methods: </strong>Between 2011 and 2018, we treated 42 patients with anterior shoulder instability, 19 underwent the open Latarjet procedure (OLP) and 23 underwent the arthroscopic Latarjet procedure (ALP). In the OLP group, 17 patients were males, with a mean age of 21.3 years (range: 16-37 years ) and a mean follow-up of 6.2 years (range: 5.5-7.2 years). In the ALP group, 20 patients were males, with a mean age of 20.6 years (range: 17-31 years) and a mean follow-up of 2.5 years (range: 2-3.1 years). All procedures were performed by a single surgeon. Functional outcomes were assessed using the University of California-Los Angeles (UCLA) shoulder score and the constant score (CS). Radiographic evaluations included standard radiographs and computed tomography (CT) scans. The two groups were compared to analyze differences in outcomes.</p><p><strong>Results: </strong>All patients returned to their pre-injury level of activity. The arthroscopic Latarjet procedure resulted in better graft integration and inferior screw positioning. No major complications were reported in either group.</p><p><strong>Conclusions: </strong>Anterior shoulder instability remains a complex issue in orthopedics regarding the optimal management approach. However, this study suggests that the arthroscopic Latarjet procedure offers advantages, including superior visualization and effective restoration of damage.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 2","pages":"289-295"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信