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Application of comprehensive evaluation methods in the clinical efficacy evaluation of traditional Chinese medicine: a narrative review 综合评价方法在中药临床疗效评价中的应用述评
Longhua Chinese medicine Pub Date : 2022-01-01 DOI: 10.21037/lcm-21-63
Jing Hu, Huina Zhang, Shuo Feng, Bo Li
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引用次数: 0
Fu xie theory: a theoretical basis for the future of medicine 傅协理论:医学未来的理论基础
Longhua Chinese medicine Pub Date : 2022-01-01 DOI: 10.21037/lcm-2022-01
Darong Wu
{"title":"Fu xie theory: a theoretical basis for the future of medicine","authors":"Darong Wu","doi":"10.21037/lcm-2022-01","DOIUrl":"https://doi.org/10.21037/lcm-2022-01","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45781357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A narrative review of phytochemical profile of Saffron and principal crocetin glycosides 藏红花和主要番红花苷的植物化学成分综述
Longhua Chinese medicine Pub Date : 2022-01-01 DOI: 10.21037/lcm-21-70
N. Tung, Nguyen Ngoc Hieu, Vu Van Tuan, Y. Shoyama
{"title":"A narrative review of phytochemical profile of Saffron and principal crocetin glycosides","authors":"N. Tung, Nguyen Ngoc Hieu, Vu Van Tuan, Y. Shoyama","doi":"10.21037/lcm-21-70","DOIUrl":"https://doi.org/10.21037/lcm-21-70","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47377193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ear acupuncture and neuromodulation 耳针与神经调控
Longhua Chinese medicine Pub Date : 2021-09-01 DOI: 10.21037/lcm-21-34
Marcos Lisboa Neves, M. D. D. Silva
{"title":"Ear acupuncture and neuromodulation","authors":"Marcos Lisboa Neves, M. D. D. Silva","doi":"10.21037/lcm-21-34","DOIUrl":"https://doi.org/10.21037/lcm-21-34","url":null,"abstract":"© Longhua Chinese Medicine. All rights reserved. Longhua Chin Med 2021;4:20 | https://dx.doi.org/10.21037/lcm-21-34 Dear reader: The present work was developed to contribute to the knowledge and improvement of ear acupuncture treatment. It was prepared for clinicians, researchers and other individuals interested in Chinese Medicine as part of the constant search for therapeutic practices that can help patients. In addition, the present work can help increase knowledge on a technique that many therapists use routinely on their patients without an in-depth understanding of its mechanisms of action. Interest in therapeutic approaches targeting the auricular pavilion has existed since ancient times and across several civilizations, such as the Egyptian, Greek, and Chinese civilizations, with records in books dated centuries before Christ. However, the first systematization of the auricular map with the representation of the somatic and visceral points was performed by a French doctor, Paul Nogier, who presented his work at an acupuncture congress in 1956 and later published his findings in a German scientific magazine (1). Parallel to the advances in science, ear acupuncture has been consolidated within traditional Chinese medicine. Concomitantly, Nogier’s auriculotherapy was gaining adherents in Europe. Regardless of the form of application, the therapy gained recognition from health professionals worldwide, leading to the publication of a standardized international nomenclature of auricular points by the World Health Organization in 1990 (2). The existence of a consensus between clinicians and researchers on a possible relationship between the pinna and the rest of the body, which justifies the ear acupuncture clinical action, has always been a great challenge for science. The investigation of its biological plausibility started in 1984 when Nomura and Mizuno revealed a relationship between the auricular branch of the vagus nerve and the nucleus of the solitary tract and spinal trigeminal nucleus (3). This finding supported the development of a series of other studies mainly using experimental models in rodents. The auriculotherapy studies reproduced the relationship between the auricle and autonomic nuclei of the brainstem, showing the effectiveness of atrial stimulation in models of nociception, sepsis, and autonomic regulation. Although there have already been a series of scientific publications on ear acupuncture potential mechanisms and a variety of attempts to validate auricular cartographies, a study published in 2015, for the first time, showed the relationship of stimulation of the auricular pavilion with brain structures in humans. Frangos et al. used transcutaneous electrostimulation of the auricular branch of the vagus nerve and recorded a brain image using functional magnetic nuclear resonance (4). It is believed that atrial vagus nerve stimulation is one of the main explanations for the therapeutic efficacy of auricular acupuncture in","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43941190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of auriculotherapy based on syndrome differentiation for constipation vs. western medicine: a systematic review of randomized controlled trials 辨证论治耳法治疗便秘与西药的疗效和安全性:随机对照试验的系统评价
Longhua Chinese medicine Pub Date : 2021-09-01 DOI: 10.21037/lcm-20-41
Tianyuan Wang, Xuejiao Wang, Shuangshuang He, Ruochong Wang, Qingyun He, Lei Xu, Min Fang, Botan Li
{"title":"Efficacy and safety of auriculotherapy based on syndrome differentiation for constipation vs. western medicine: a systematic review of randomized controlled trials","authors":"Tianyuan Wang, Xuejiao Wang, Shuangshuang He, Ruochong Wang, Qingyun He, Lei Xu, Min Fang, Botan Li","doi":"10.21037/lcm-20-41","DOIUrl":"https://doi.org/10.21037/lcm-20-41","url":null,"abstract":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China; Beijing Institute of Traditional Chinese Medicine, Beijing, China; Beijing Evidence-Based Chinese Medicine Center, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, Beijing, China; Graduate School, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China Contributions: (I) Conception and design: T Wang, B Li; (II) Administrative support: None; (III) Provision of study materials or patients: T Wang; (IV) Collection and assembly of data: T Wang, X Wang, B Li, L Xu, R Wang; (V) Data analysis and interpretation: S He, Q He, M Fang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Bo Li. Beijing Hospital of Traditonal Chinese Medicine, Capital Medical University, No. 23 Art Gallery Back Street, Dongcheng District, Beijing 100010, China. Email: libo@bjzhongyi.com.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42255681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese medicine: a gift from the Chinese people to the rest of humanity 中医药:中国人民送给全人类的礼物
Longhua Chinese medicine Pub Date : 2021-06-30 DOI: 10.21037/lcm-21-24
Ramon Ma Calduch Farnòs
{"title":"Chinese medicine: a gift from the Chinese people to the rest of humanity","authors":"Ramon Ma Calduch Farnòs","doi":"10.21037/lcm-21-24","DOIUrl":"https://doi.org/10.21037/lcm-21-24","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41733044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artemisia annua and artemisinins are ineffective against human Babesia microti and six Candida sp. 黄花蒿和青蒿素对人类小巴贝斯虫和六种念珠菌无效。
Longhua Chinese medicine Pub Date : 2021-06-01 DOI: 10.21037/lcm-21-2
Mostafa A Elfawal, Olivia Gray, Claire Dickson-Burke, Pamela J Weathers, Stephen M Rich
{"title":"<i>Artemisia</i> annua and artemisinins are ineffective against human <i>Babesia microti</i> and six <i>Candida</i> sp.","authors":"Mostafa A Elfawal, Olivia Gray, Claire Dickson-Burke, Pamela J Weathers, Stephen M Rich","doi":"10.21037/lcm-21-2","DOIUrl":"10.21037/lcm-21-2","url":null,"abstract":"<p><strong>Background: </strong><i>Artemisia annua</i> L.is a well-established medicinal herb used for millennia to treat parasites and fever-related ailments caused by various microbes. Although effective against many infectious agents, the plant is not a miracle cure and there are infections where it has proved ineffective or limited. It is important to report those failures.</p><p><strong>Methods: </strong>Here artemisinin, artesunate and dried leaf slurries of <i>A. annua</i> were used daily for 6 days <i>in vivo</i> against <i>Babesia microti</i> in mice 2 days post infection at 100 µg artemisinin/kg body weight. Parasitemia was measure before and 15 days days post treatment. Artemisinin and extracts of <i>A. annua</i> also were tested <i>in vitro</i> against six <i>Candida</i> sp. at artemisinin concentrations up to 180 µM and growth measured after cultures were fed drugs once at different stages of growth and also after repeated dosing.</p><p><strong>Results: </strong><i>A. annua</i>, artesunate, and artemisinin were ineffective in reducing or eliminating parasitemia in <i>B. microti</i>-infected mice treated at 100 µg artemisinin/kg body weight. Although the growth of exponential cultures of many of the tested <i>Candida</i> sp. was inhibited, the response was not sustained and both artemisinin and <i>Artemisia</i> were essentially ineffective at concentrations of artemisinin at up to 180 µM of artemisinin.</p><p><strong>Conclusions: </strong>Together these results show that artemisinin, its derivatives, and <i>A. annua</i> are ineffective against <i>B. microti</i> and at least six species of <i>Candida</i>.</p>","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/ff/nihms-1720579.PMC8312716.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39227616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Chinese medicine in Poland 波兰的中医药管理
Longhua Chinese medicine Pub Date : 2021-06-01 DOI: 10.21037/lcm-20-38
Marek Kalmus
{"title":"Regulation of Chinese medicine in Poland","authors":"Marek Kalmus","doi":"10.21037/lcm-20-38","DOIUrl":"https://doi.org/10.21037/lcm-20-38","url":null,"abstract":": The Polish Jesuit missionary Michl Piotr Boym was the first European in the middle of 17th century, who studied Chinese medicine and brought that knowledge from China to Europe. Two first doctoral theses on Chinese medicine were defended in Poland in the 1930s. Medical acupuncture was introduced in 1978 and taught by Prof. Zbigniew Garnuszewski in Warsaw and officially recognized. The real traditional Chinese medicine (TCM) education started in 1986 in Krakow and after some years of private education the first TCM school was established. In Poland, education in TCM is not regulated until now and different TCM schools have their own curriculum, level and duration of education. There are six associations for acupunture and TCM in Poland. Two of them are really active. TCM and acupuncture are not regulated by Polish law, but they are not prohibited. Acupuncturists as well as herbalist-phytotherapists are officially recognized by the Ministry of Labour and Social Policy. TCM can be practiced clinically by anyone and is not controlled by any professional TCM authorities. The number of TCM clinics is growing all over Poland due to the weakness of the public health system. Many patients are seeking holistic and safe treatment free of negative side effects.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45953957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The traditional Chinese medicine WuJiaPi (Acanthopanacis cortex) and its main anti-inflammatory terpenoids 中药五加皮及其主要抗炎萜类化合物
Longhua Chinese medicine Pub Date : 2021-06-01 DOI: 10.21037/LCM-21-1
C. Bailly
{"title":"The traditional Chinese medicine WuJiaPi (Acanthopanacis cortex) and its main anti-inflammatory terpenoids","authors":"C. Bailly","doi":"10.21037/LCM-21-1","DOIUrl":"https://doi.org/10.21037/LCM-21-1","url":null,"abstract":": The root bark of the plant Acanthopanax gracilistylus is commonly used in traditional Chinese medicine for the treatment of rheumatism, arthritis and other inflammatory pathologies and conditions. The medication, referred to as Acanthopanacis cortex or WuJiaPi, is also used for a long time to strengthen bones (to reduce osteoporosis) and to protect the liver and kidneys. The antioxidant, anti-inflammatory and anti-proliferative properties of WuJiaPi extracts have been well-characterized and associated with the presence of various bioactive terpenoids (such as gracilistones, wujiapiosides) and phenylpropanoid glycosides (such as eleutherosides). Among them, the lupane triterpene acankoreagenin (also known as HLEDA) stands as a potent inhibitor of the NF- κ B signaling pathway, capable of blocking the secretion of the alarmin HMGB1 and reducing the expression of pro-inflammatory cytokines by activated or infected macrophages. Acankoreagenin displays marked anti-inflammatory and anti-oedema actions in vitro and in vivo , comparable to the activity of the analogue impressic acid. This brief review shed light on the biological properties of this pentacyclic sapogenin and its various glycoside derivatives. Among the 16 acankoreosides isolated from various Acanthopanax species, acankoreoside A emerges as one of the most potent regulators of NF- κ B and an efficient blocker of inflammatory cytokines production. Acankoreosides B and D also exhibit significant anti-inflammatory effects. Acankoreagenin, acankoreosides and a few other terpenoids contribute importantly to the efficacy of the WuJiaPi TCM.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46861724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to define level of evidence for tinnitus treatment by acupuncture? 如何定义针灸治疗耳鸣的证据水平?
Longhua Chinese medicine Pub Date : 2021-05-31 DOI: 10.21037/LCM-21-17
E. Onishi
{"title":"How to define level of evidence for tinnitus treatment by acupuncture?","authors":"E. Onishi","doi":"10.21037/LCM-21-17","DOIUrl":"https://doi.org/10.21037/LCM-21-17","url":null,"abstract":"© Longhua Chinese Medicine. All rights reserved. Longhua Chin Med 2021 | http://dx.doi.org/10.21037/lcm-21-17 In order to answer this question, the authors of the article “Efficacy of acupuncture for tinnitus: an umbrella review” analyzed systematic reviews published until mid2020, but unfortunately it has not yet been possible to confirm the effect of this therapy (1). Not because of the lack of effectiveness of acupuncture as a therapeutic tool, but because of difficulties in analyzing the data, also described on published papers, such as low quality of studies, type of intervention (manual or electrical stimuli), among others (2,3). In order to understand these findings, some points must be identified and analyzed. Most of medical knowledge was obtained from observing the phenomena related to the pathologic process, the natural history of disease. Thousands of years ago, only the enviable ability to identify and interpret these phenomena combined in the so-called patterns of disharmony was able to constitute one of the fundamental pillars of Traditional Chinese Medicine (TCM). For the description of patterns of disharmony used for diagnosis, TCM considers sometimes vague and nonspecific symptoms not valued by the Cartesian point of view of Western Medicine. Perhaps one of the biggest challenges for ENT doctors is dealing with tinnitus, a sensation of sound in the absence of external sound stimulus with many possible causes. Even the classic concept of tinnitus—“auditory phantom sensation”—emphasizes the difficulty to explain the symptom and to identify causes besides hearing loss. Due to these characteristics and similarities of its pathophysiological mechanism, tinnitus has often been compared to chronic pain or phantom limbs (4). Previous studies have demonstrated that central nervous system structures related to emotions (limbic system) and reaction to sound (autonomic nervous system) play a fundamental role in determining the degree of discomfort (5) and can be modulated by acupuncture with evidence by functional image exams (6). Many drugs and therapies are used in common (7). The good results obtained with the use of acupuncture for pain treatment justify its application in patients with tinnitus (4,6,7). The study of TCM organs physiology (Zang Fu) makes it possible to identify two main causes of tinnitus with very different characteristics: the Kidney (Shen) Deficiency syndrome and the Liver (Gan) Excess. The clinical characteristics of Kidney (Shen) deficiency tinnitus are lowfrequency tinnitus with a history of insidious, gradual onset, memory difficulties, low back pain, dizziness and hearing loss in older patients. Tinnitus due to the Liver (Gan) excess has a sudden high frequency onset, in younger individuals and related to emotional tension, irritability and headache (8). These psychoacoustic characteristics of tinnitus have been ignored for a long time by otorhinolaryngologists, but recent studies indicate that in some patients ","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44765621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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