Korean journal of clinical oncology最新文献

{"title":"Extraabdominal parasitic lipoleiomyoma.","authors":"Tae Hoon Lee,&nbsp;Se-Jin Baek","doi":"10.14216/kjco.21008","DOIUrl":"https://doi.org/10.14216/kjco.21008","url":null,"abstract":"<p><p>Extrauterine parasitic lipoleiomyoma is a very rare fatty tumor, with uncertain histopathogenesis. Although imaging studies play an important role in preoperative localization and diagnosis of lipoleiomyoma, a pathological evaluation is paramount for confirmation of diagnosis. We describe a case of a 49-year-old woman with a palpable mass in the right inguinal area. Computed tomography of the abdomen and pelvis revealed a fluid- and fat-containing mass. Histopathological examination of the mass, which was successfully resected, confirmed the diagnosis of lipoleiomyoma. The patient was discharged on a postoperative day 2 without any complications.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/50/kjco-17-1-48.PMC9942745.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of the outcomes of totally implantable access port implantation performed by surgical residents.","authors":"Se-Beom Jeon,&nbsp;Youngbae Jeon,&nbsp;Kyoung-Won Han,&nbsp;Yong-Soon Chun,&nbsp;Jeong-Heum Baek","doi":"10.14216/kjco.21003","DOIUrl":"https://doi.org/10.14216/kjco.21003","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the clinical outcomes after totally implantable access port (TIAP) implantation performed by general surgery residents in patients with colorectal cancer.</p><p><strong>Methods: </strong>A total of 291 consecutive patients who underwent TIAP implantations were evaluated. The patients were divided into three groups: second-, third-, and fourth-grade residents.</p><p><strong>Results: </strong>The mean follow-up was 22.1 months (range, 1-87 months). The total times of operation, puncture, and cannulation decreased as the resident grade increased (P<0.001). Early complications significantly decreased with higher resident grades (P=0.039). The non-use of ultrasonography and non-use of C-arm were identified as independent risk factors for complications. Resident grades between second and third (P=0.005) and between second and fourth (P=0.041) were identified as independent risk factors for optimal tip position.</p><p><strong>Conclusion: </strong>TIAP implantation can be safely and effectively performed by residents. Low-grade residents were associated with early complications.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/ba/kjco-17-1-15.PMC9942736.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of sentinel lymph node biopsy with radioisotope alone and the prediction of sentinel node status using PET-CT in breast cancer.","authors":"Ran Song,&nbsp;Seong Uk Kwon,&nbsp;Dae Sung Yoon,&nbsp;In Eui Bae,&nbsp;In Seok Choi,&nbsp;Won Jun Choi,&nbsp;Sang Eok Lee,&nbsp;Ju Ik Moon,&nbsp;Nak Song Sung,&nbsp;Seung Jae Lee,&nbsp;Seung Jae Roh,&nbsp;Sung Gon Kim","doi":"10.14216/kjco.21004","DOIUrl":"https://doi.org/10.14216/kjco.21004","url":null,"abstract":"<p><strong>Purpose: </strong>Sentinel lymph node biopsy (SLNB) using both a radioactive isotope (RI) and blue dye is considered highly effective; however, there were limitations with the use of both agents in some hospitals, and blue dye has been shown to have some adverse effects. Additionally, preoperative prediction of sentinel lymph node (SLN) status using the maximum standardized uptake value (SUVmax) on positron emission tomography-computed tomography (PET-CT) can help avoid unnecessary axillary dissection or SLNB. Thus, we evaluated the efficacy and oncologic safety of SLNB using an RI alone in terms of long-term outcomes and determined the association between SLN metastasis and SUVmax of the primary tumor.</p><p><strong>Methods: </strong>This retrospective study was conducted at Konyang University Hospital between March 2011 and May 2018. Overall, 142 patients with breast cancer who underwent SLNB using an RI alone were enrolled. Data on identification and false-negative rates were collected. The SUVmax of primary tumors on PET-CT were analyzed for their association with SLN metastasis.</p><p><strong>Results: </strong>The identification and false-negative rates were 98.6% and 0%, respectively. There was no axillary local recurrence in patients with negative SLN findings. The correlation between the SUVmax of the primary tumor and SLN status was significant (r=0.249, P=0.005); the cutoff value for negative SLN metastasis was <2.15.</p><p><strong>Conclusion: </strong>The single agent method using an RI is not inferior to other methods and serves as a feasible option for SLNB. And the number of excised SLNs could be minimized when the SUVmax of primary tumor is extremely low.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/30/kjco-17-1-23.PMC9942744.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells.","authors":"Eui Tae Kim,&nbsp;Dong-Guk Park","doi":"10.14216/kjco.20020","DOIUrl":"https://doi.org/10.14216/kjco.20020","url":null,"abstract":"<p><strong>Purpose: </strong>A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.</p><p><strong>Methods: </strong>We treated HCT116 colon cancer cells with artesunate, holo-transferrin, deferoxamine mesylate, ferrostatin, necrostatin-1, and YM155. We observed the growth inhibition of artesunate on HCT116 colon cancer cells by morphologic findings. Inhibition of cell growth was assessed by MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) assay and long-term growth inhibition by colony-forming assay. Apoptosis was investigated by flow cytometry and Western blot analysis.</p><p><strong>Results: </strong>Artesunate inhibited the proliferation of HCT116 colon cancer cells effectively. Co-treatment with YM155, a specific survivin inhibitor, enhanced the artesunate-induced cell death. Co-treatment with the iron-chelating agent deferoxamine rescued artesunate induced cell death and increased long-term cell survival and proliferation.</p><p><strong>Conclusion: </strong>In this study, we demonstrated that artesunate-induced cytotoxicity in HCT116 colon cancer cells by suppressing the expression of survivin and partially by ferroptosis. Our findings suggest that the co-treatment artesunate with YM155 can induce more potent cell death on HCT116 colon cancer cells and shows new insight for the treatment of colorectal cancer patients.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"131-137"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/e5/kjco-16-2-131.PMC9942729.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal sarcomas: Outcomes of repeated resections.","authors":"Hyeonuk Hwang,&nbsp;Yoon-Hye Kwon,&nbsp;Han-Ki Lim,&nbsp;Jeesun Kim,&nbsp;Kyu Joo Park","doi":"10.14216/kjco.20015","DOIUrl":"https://doi.org/10.14216/kjco.20015","url":null,"abstract":"<p><strong>Purpose: </strong>Retroperitoneal sarcomas (RPS) are rare malignant tumors arising from mesenchymal cells. The objective of this study was to review the treatment experiences and to identify prognostic factors for overall survival (OS) after primary resection and subsequent reoperations for recurrences.</p><p><strong>Methods: </strong>The medical records of patients who underwent resection for RPS at our institution between June 2002 and December 2016 were retrospectively reviewed. Univariate and multivariable Cox proportional hazards modeling was used to assess the prognostic factors for OS.</p><p><strong>Results: </strong>A total of 48 patients were enrolled. On multivariable analysis in primary resection group, the FNCLCC (Fédération Nationale des Centres de Lutte Contre le Cancer) grade was a significant prognostic factor for OS (P=0.006). The patients who received chemotherapy after primary resection were significantly associated with poor prognosis (P=0.009). The 5-year OS rate after primary resection (n=48) were 58.1% and the 5-year cumulative reoperation rate after primary resection was 62.5%. After second resection for recurrence after primary resection (n=23), the 5-year OS rate was 64.3%. There was a tendency towards decreased surgery-free survival rate as the number of repeated resections for recurrent RPS increased. In the subset of patients (n=16) who underwent more than 3 repeated resections at our institute, the 5-year OS rate was 75.0%, indicating that repeated resections are not associated with worse outcome.</p><p><strong>Conclusion: </strong>Only low tumor grade was an independent favorable prognostic factor for OS. Although the prognosis for RPS remains poor, repeated resections for recurrence are not associated with poor prognosis. Aggressive surgical strategies for recurred RPS patients are warranted.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/c9/kjco-16-2-96.PMC9942735.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight change in patients with differentiated thyroid carcinoma after total thyroidectomy versus lobectomy.","authors":"Hae-Ryong Cho,&nbsp;Ra-Yeong Song,&nbsp;Kyung Ho Kang","doi":"10.14216/kjco.20019","DOIUrl":"https://doi.org/10.14216/kjco.20019","url":null,"abstract":"<p><strong>Purpose: </strong>Thyroid hormone is an important hormone in maintaining metabolism and homeostasis in the body. There exists a common perception among patients that thyroid surgery will cause weight gain. Prevention of any undesired weight gain could be important for the maintenance of well-being in most patients. Our study compares changes in body mass index (BMI) and weight after total thyroidectomy or lobectomy in thyroid cancer patients.</p><p><strong>Methods: </strong>A total of 967 patients with differentiated thyroid carcinoma were enrolled in the study, from March 2011 to July 2016 at Chung-Ang University Hospital. Exclusion criteria were less than lobectomy, modified radical neck dissection, recurred operation, and combined operation for other causes. Primary endpoints were change in body weight and BMI at 2 years after surgery. A subgroup analysis was performed for patients with significant weight change.</p><p><strong>Results: </strong>There were no differences between both groups in BMI after 2 years of thyroid operation. Thyroid stimulating hormone (TSH) levels were not significantly different. Fifteen percent of patients showed significant change in body weight after 2 years of operation. The subgroup analysis of these patients showed no significant differences in gender, age, or extent of operation between those who had gained weight compared to those who had lost weight. There were also no differences in postoperative TSH levels, levothyroxine supplementation, or radioactive iodine treatment.</p><p><strong>Conclusion: </strong>There was a minimal postoperative increase in mean BMI over the years in patients undergoing thyroidectomy for differentiated thyroid cancer. However, weight change did not differ in those undergoing thyroid lobectomy or total thyroidectomy.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"127-130"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/11/kjco-16-2-127.PMC9942726.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications and outcomes following inguinal lymphadenectomy for malignant melanoma in an Asian population.","authors":"A Lee,&nbsp;Hyun Jeong Kim,&nbsp;Eunjin Kim,&nbsp;Jee Youn Lee,&nbsp;Juhan Lee,&nbsp;Jae Geun Lee,&nbsp;Choong-Kun Lee,&nbsp;Sang Joon Shin,&nbsp;Kee Yang Chung,&nbsp;Myoung Soo Kim","doi":"10.14216/kjco.20012","DOIUrl":"https://doi.org/10.14216/kjco.20012","url":null,"abstract":"<p><strong>Purpose: </strong>Melanoma is a potentially fatal cutaneous malignancy and regional lymph node (LN) metastases are the most important predictors of mortality. This study aimed to analyze clinical features and risk factors of complications associated with inguinal LN dissection (LND) to establish treatment protocols.</p><p><strong>Methods: </strong>This single-center retrospective study (2000 to 2018) consisted of patients who underwent inguinal area sentinel LN biopsy (SLNB) or LND due to malignant melanoma. Risk factors and outcomes were analyzed.</p><p><strong>Results: </strong>One hundred patients underwent SLNB alone (n=67; patients with negative SLNB), complete LND (CLND) after positive SLNB (n=19), or radical LND without SLNB (n=14). Five-year overall survival and disease-free survival rates among these groups were 87.3%, 57.4%, and 61.9%, and 59.0%, 22.7%, and 28.1%, respectively. The complication rate in the SLNB alone group was lower than the other groups (22.4% vs. 47.4% and 35.7%, respectively; P=0.048). Seroma was the most common complication in the SLNB alone group (15.0%); lymphedema was most common in the CLND after SLNB group (21.1%). Multivariate analysis of risk factors for postoperative complications found the hazard ratio for body mass index >28 kg/m² was 4.376 (95% confidence interval [CI], 1.243-15.401; P=0.022). The hazard ratio for LND (including CLND after SLNB and radical LND without SLNB) was 3.263 (95% CI, 1.248-8.529; P=0.016).</p><p><strong>Conclusion: </strong>Inguinal LND is a higher risk procedure compared to SLNB and other sites for postoperative complications, irrespective of meticulous surgical techniques. More studies are needed to establish treatment protocols (e.g., observation vs. CLND after a positive SLNB result) and the risks and benefits in Asian populations.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/60/kjco-16-2-71.PMC9942730.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decrease of peripheral blood lymphocyte count predicts response to neoadjuvant chemotherapy in breast cancer patients.","authors":"Ok Hee Lee,&nbsp;Sun-Young Min","doi":"10.14216/kjco.20013","DOIUrl":"https://doi.org/10.14216/kjco.20013","url":null,"abstract":"<p><strong>Purpose: </strong>Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) holds promise as a significant prognostic factor to predict NAC response in breast cancer patients. The absolute peripheral blood lymphocyte (PBL) count has been suggested as an independent predictor of response to NAC. The current study evaluated the relationship between pCR and the change of PBL count in patients treated with NAC.</p><p><strong>Methods: </strong>A total of 61 patients with histologically confirmed breast cancer treated with NAC followed by mastectomy between January 2010 and December 2019 were analyzed retrospectively. Correlational analyses confirmed a statistically significant relationship between PBL count and pCR. Following conformational correlational analyses, patients were divided into two groups according to cutoff values using the receiver operating characteristics curve and a logistic regression was conducted to determine the optimal conditions for achieving pCR.</p><p><strong>Results: </strong>A total of 14 patients (22.9%) achieved pCR. Most PBL counts decreased after NAC relevant to pCR. Logistic regression analysis revealed that a small decrease of PBL was associated with pCR (P=0.028). The cutoff value of PBL decrease was 755×10⁶/L, which was used to divide patients into high and low reduction groups. The pCR rate was 11.43% and 38.46% for the high and low reduction group, respectively (area under the curve, 0.707; 95% confidence interval, 0.556-0.858; P=0.020). The high reduction group was found to have more difficulty achieving pCR.</p><p><strong>Conclusion: </strong>The decrease of PBL is significantly associated with pCR. Our data support that the decrease of PBL after NAC may be useful factors in predicting the response to NAC in breast cancer patients.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/32/kjco-16-2-79.PMC9942727.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyrotropin suppression therapy for papillary thyroid carcinoma with a huge recurred neck lymph node.","authors":"Jung Bum Choi,&nbsp;Dong-Il Kim,&nbsp;Hyun-June Paik,&nbsp;Seung Joo Lee,&nbsp;Chang Shin Jung,&nbsp;Seok Kyung Kang,&nbsp;Youn Joo Jung,&nbsp;Hyun Yul Kim","doi":"10.14216/kjco.20023","DOIUrl":"https://doi.org/10.14216/kjco.20023","url":null,"abstract":"<p><p>Differentiated thyroid cancer (DTC) originating from thyroid tissue is affected by thyrotropin (TSH). TSH suppression therapy is usually recommended after thyroidectomy in cases of DTC. A 57-year-old woman who harbored a very huge recurred lymph node underwent TSH suppression therapy because of the risk of surgical complications. After TSH suppression, the huge neck lymph node exhibited a response and decreased in size. She had been followed up for 144 months. TSH suppression therapy could be considered as an alternative treatment option in a recurred DTC patient with a high perioperative risk.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"145-147"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/35/kjco-16-2-145.PMC9942732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary fibrous tumor of the lesser omentum mimicking stomach gastrointestinal stromal tumor.","authors":"Seonghoon Kim,&nbsp;Jaehyuk Heo,&nbsp;Pyungsu Kim,&nbsp;Hyeseung Han,&nbsp;Hoyoon Bang","doi":"10.14216/kjco.20022","DOIUrl":"https://doi.org/10.14216/kjco.20022","url":null,"abstract":"<p><p>Solitary fibrous tumor (SFT) is a mesenchymal tumor that rarely occurs in the abdomen. We report a very rare case of an abdominal SFT in the lesser omentum. A 39-year-old Korean man was referred to our center for management of a 9 cm incidental mass in the abdominal space found on a chest computed tomography (CT) during a routine medical examination. He had no symptoms, and there were no specific findings on physical examination. A contrast enhancement CT was performed, and an extraluminal gastrointestinal stromal tumor in the stomach or a pancreatic origin mass was suspected. Surgery was performed and an enclosed mass in the lesser omentum was observed, which was resected completely. The postoperative course was uneventful. Based on microscopy, the omental tumor was diagnosed as SFT.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"16 2","pages":"142-144"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/a7/kjco-16-2-142.PMC9942725.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}