Journal of psychopathology and clinical science最新文献

{"title":"Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.","authors":"Juyoen Hur, Rachael M Tillman, Hyung Cho Kim, Paige Didier, Allegra S Anderson, Samiha Islam, Melissa D Stockbridge, Andres De Los Reyes, Kathryn A DeYoung, Jason F Smith, Alexander J Shackman","doi":"10.1037/abn0000940","DOIUrl":"10.1037/abn0000940","url":null,"abstract":"<p><p>Social anxiety-which typically emerges in adolescence-lies on a continuum and, when extreme, can be devastating. Socially anxious individuals are prone to heightened fear, anxiety, and the avoidance of contexts associated with potential social scrutiny. Yet most neuroimaging research has focused on acute social threat. Much less attention has been devoted to understanding the neural systems recruited during the uncertain anticipation of potential encounters with social threat. Here we used a novel functional magnetic resonance imaging paradigm to probe the neural circuitry engaged during the anticipation and acute presentation of threatening faces and voices in a racially diverse sample of 66 adolescents selectively recruited to encompass a range of social anxiety and enriched for clinically significant levels of distress and impairment. Results demonstrated that adolescents with more severe social anxiety symptoms experience heightened distress when anticipating encounters with social threat, and reduced discrimination of uncertain social threat and safety in the bed nucleus of the stria terminalis, a key division of the central extended amygdala (EAc). Although the EAc-including the bed nucleus of the stria terminalis and central nucleus of the amygdala-was robustly engaged by the acute presentation of threatening faces and voices, the degree of EAc engagement was unrelated to the severity of social anxiety. Together, these observations provide a neurobiologically grounded framework for conceptualizing adolescent social anxiety and set the stage for the kinds of prospective-longitudinal and mechanistic research that will be necessary to determine causation and, ultimately, to develop improved interventions for this often-debilitating illness. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"41-56"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A viewpoint on stress generation methodology.","authors":"Thomas J Harrison, Daniel N Klein, Josephine H Shih","doi":"10.1037/abn0000964","DOIUrl":"10.1037/abn0000964","url":null,"abstract":"<p><p>This article provides an overview of Stress Generation Methodology. Stress generation is a phenomenon in which individuals with depression or vulnerability to depression experience greater dependent stressful life events (SLEs), defined as stressors in which individuals at least partially contributed to occurrence. The stress generation process demonstrates how depressed individuals shape their environments, contributing to depression maintenance and exacerbation. Subsequent extensions have shown that other forms of psychopathology and a variety of cognitive and personality risk factors also predict stress generation. The focus on stress generation in women is accompanied by an emphasis on interpersonal stress. In addition to emphasizing communal SLEs, stress generation studies have also focused on communal vulnerability factors. However, men do not typically exhibit communal vulnerabilities to the degree that women do. Thus, it is also important to broaden the scope of vulnerability factors examined to include vulnerabilities associated with stress generation in men. These could include impulsivity, anger and aggression, and the need for autonomy and self-definition, all of which tend to be more common in males. Lastly, studies often employ self-report measures of SLEs which could artificially accentuate gender differences in stress generation findings. As existing studies may be more sensitive to detecting stress generation in women, future research should examine this phenomenon with the following methodological refinements: (a) use male-only or adequately sized samples with equal gender representation to test gender moderation effects, (b) expand the range of SLEs to include agentic and achievement-oriented stressors and use wider assessment windows, and (c) examine vulnerability factors that may be relevant to men such as impulsivity, anger, aggression, and the need for autonomy and self-definition. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"1-2"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antecedents, reasons for, and consequences of suicide attempts: Results from a qualitative study of 89 suicide attempts among army soldiers.","authors":"Matthew K Nock, Adam C Jaroszewski, Charlene A Deming, Catherine R Glenn, Alexander J Millner, Mark Knepley, James A Naifeh, Murray B Stein, Ronald C Kessler, Robert J Ursano","doi":"10.1037/abn0000935","DOIUrl":"10.1037/abn0000935","url":null,"abstract":"<p><p>Most studies aimed at understanding suicidal behavior have focused on quantifying the associations between putative risk factors and suicidal behavior in comparative studies of cases and controls. The current study, in comparison, exclusively focused on cases-89 Army soldiers presenting for hospital care following a suicide attempt-and attempted to reveal the antecedents of, reasons for, and consequences of suicide attempts. This mixed-methods study using qualitative interviews and self-report surveys/interviews revealed that in most cases, the most recent onset of suicidal thoughts began shortly before the suicide attempt and were not disclosed to others, limiting opportunities for intervention via traditional approaches. The primary reason given for attempting suicide was to escape from psychologically aversive conditions after concluding that no other effective strategies or options were available. Participants reported both negative (e.g., self-view, guilt) and positive (e.g., learning new skills, receiving support) consequences of their suicide attempt-and described things they believe would have prevented them from making the attempt. These findings provide new insights into the motivational and contextual factors for suicidal behavior and highlight several novel directions for prevention and intervention efforts. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"6-17"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the dynamics of addiction relapse via the double-well potential system.","authors":"Haya Fatimah, Michael D Hunter, Marina A Bornovalova","doi":"10.1037/abn0000960","DOIUrl":"10.1037/abn0000960","url":null,"abstract":"<p><p>Substance use relapse is difficult to define, and previous work has used one-size-fits-all ad hoc definitions. Researchers have called for a dynamic and personalized understanding of relapse as a concept and model, necessitating novel statistical tools. We aimed to develop and validate a novel statistical model of latent relapse processes: the double-well potential model (DWPM). This model describes posttreatment substance use in terms of a dynamical system with stable equilibria of abstinence and relapse, person-specific dominant equilibria (tilt), the ease of changing between equilibria (steepness), and an overall relapse risk (RR). Using timeline follow-back data from <i>N</i> = 139 adults with a substance use disorder transitioning back to the community after residential treatment, we examined individual differences and the criterion-related validity of DWPM parameters to determine the clinical utility of the double-well model. While nonuse was the predominant stable state across participants, we found significant between-subjects variability steepness and RR. These individual differences were predictable via demographics, baseline psychopathology, treatment history, and treatment condition. Steepness and RR also predicted long-term outcomes, including life satisfaction and criminal behavior, above and beyond traditional metrics of relapse (proportion of days used and time to first use). Thus, the DWPM is a strong theoretical and statistical representation of the underlying relapse processes. Moreover, the parameters show criterion-related validity and may be useful in precision medicine. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"69-80"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where does attention-deficit/hyperactivity disorder fit in the psychopathology hierarchy? A symptom-focused analysis.","authors":"Zheyue Peng, Kasey Stanton, Beatriz Dominguez-Alvarez, Ashley L Watts","doi":"10.1037/abn0000966","DOIUrl":"https://doi.org/10.1037/abn0000966","url":null,"abstract":"<p><p>Modern psychopathology classification systems position attention-deficit/hyperactivity disorder (ADHD) with different groups of conditions, either with externalizing or neurodevelopmental. As such, the optimal placement of ADHD in modern classification systems remains unclear. We advanced the literature by mapping ADHD symptoms onto three transdiagnostic psychopathology spectra-externalizing, neurodevelopmental, and internalizing-and their symptoms. ADHD symptoms had varied associations with different spectra, with subsets of symptoms relating most strongly to externalizing, others to neurodevelopmental, and still others to internalizing. Impulsivity, poor schoolwork, and low perseverance were most closely tied to externalizing, cognitive disengagement symptoms (e.g., confused, stared blankly, daydreamed) and immaturity were most closely tied to neurodevelopment, and cognitive disengagement symptoms were also tied to internalizing. Our findings advise against conceptualizing and treating ADHD as a unitary construct and against placing ADHD exclusively under either externalizing or neurodevelopmental spectra. Symptom-focused approaches will better inform modern psychopathology classification systems. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability as a biomarker for transdiagnostic depressive and anxiety symptom trajectory in adolescents and young adults.","authors":"Alainna Wen, Tomislav D Zbozinek, Julian Ruiz, Richard E Zinbarg, Robin Nusslock, Michelle G Craske","doi":"10.1037/abn0000946","DOIUrl":"https://doi.org/10.1037/abn0000946","url":null,"abstract":"<p><p>Internalizing psychopathology is associated with abnormalities in heart rate variability (HRV). Lower HRV that reflects reduced parasympathetic nervous system activity has been observed in depressive and anxiety disorders. Existing studies predominantly used categorical rather than dimensional approaches, the latter of which better addresses clinical comorbidity and heterogeneity. Moreover, there is little evidence on the role of HRV in longitudinal symptom trajectory in adolescents and young adults. The current study examined the association between HRV and internalizing symptom trajectory using a dimensional approach-the tri-level model of depression and anxiety. Adolescents and young adults (N = 362) were recruited in a 3-year longitudinal study, where they completed electrocardiogram recordings and self-report symptom questionnaires. Multilevel modeling was conducted with high-frequency power bands (HF power) of interbeat intervals at baseline as the predictor, and tri-level symptom factors over 3 years as the outcome. HF power significantly predicted the trajectory of the broad General Distress symptom factor, but not the intermediate Fears or Anhedonia-Apprehension symptom factors. Higher HF power was associated with a decline in General Distress over time. This association was held when neuroticism, other tri-level symptom factors, and demographic variables were covaried. That is, greater parasympathetic nervous system activity at baseline was significantly associated with a greater decline in the broad internalizing symptom factor, but not symptom factors that are more specific to depressive or anxiety disorders. Parasympathetic activity, therefore, may be a transdiagnostic biomarker for internalizing symptoms in adolescents and young adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"638-646"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From deconstruction to reconstruction: A search for natural kinds in developmental psychopathology.","authors":"Melissa A Brotman, Simone P Haller, Daniel S Pine, Nathan A Fox","doi":"10.1037/abn0000897","DOIUrl":"10.1037/abn0000897","url":null,"abstract":"<p><p>A \"natural kind\" is a specific classification that identifies some structure of truth and reality, a delimited entity. Psychiatric disorders are not natural kinds. As one moves from physics and chemistry to biology and medicine, natural kinds degrade, and the boundaries of differentiating phenomena become less clear. Within psychiatry, the categorization of psychopathology has further ontological challenges, especially across development. We suggest that to identify and isolate clinical subgroups, it is critical to integrate external validators in an iterative process, with the goal of linking classification to treatments with maximal clinical benefit. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"609-612"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward understanding autism heterogeneity: Identifying clinical subgroups and neuroanatomical deviations.","authors":"Jente Meijer, Bruno Hebling Vieira, Camille Elleaume, Zofia Baranczuk-Turska, Nicolas Langer, Dorothea L Floris","doi":"10.1037/abn0000914","DOIUrl":"https://doi.org/10.1037/abn0000914","url":null,"abstract":"<p><p>Autism spectrum disorder (\"autism\") is a neurodevelopmental condition characterized by substantial behavioral and neuroanatomical heterogeneity. This poses significant challenges to understanding its neurobiological mechanisms and developing effective interventions. Identifying phenotypically more homogeneous subgroups and shifting the focus from average group differences to individuals is a promising approach to addressing heterogeneity. In the present study, we aimed to parse clinical and neuroanatomical heterogeneity in autism by combining clustering of clinical features with normative modeling based on neuroanatomical measures (cortical thickness [CT] and subcortical volume) within the Autism Brain Imaging Data Exchange data sets (N autism = 861, N nonautistic individuals [N NAI] = 886, age range = 5-64). First, model-based clustering was applied to autistic symptoms as measured by the Autism Diagnostic Observation Schedule to identify clinical subgroups of autism (N autism = 499). Next, we ran normative modeling on CT and subcortical parcellations (N autism = 690, N NAI = 744) and examined whether clinical subgrouping resulted in increased neurobiological homogeneity within the subgroups compared to the entire autism group by comparing their spatial overlap of neuroanatomical deviations. We further investigated whether the identified subgroups improved the accuracy of autism classification based on the neuroanatomical deviations using supervised machine learning with cross-validation. Results yielded two clinical subgroups primarily differing in restrictive and repetitive behaviors (RRBs). Both subgroups showed increased homogeneity in localized deviations with the high-RRB subgroup showing increased volume deviations in the cerebellum and the low-RRB subgroup showing decreased CT deviations predominantly in the postcentral gyrus and fusiform cortex. Nevertheless, substantial within-group heterogeneity remained highlighted by the lack of improvement of the classifier's performance when distinguishing between the subgroups and NAI. Future research should aim to further reduce heterogeneity incorporating additional neuroanatomical clustering in even larger samples. This will eventually pave the way for more tailored behavioral interventions and improving clinical outcomes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"667-677"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared principles for disentangling heterogeneity in neuroscience and psychopathology.","authors":"Brian Kraus, Caterina Gratton","doi":"10.1037/abn0000907","DOIUrl":"https://doi.org/10.1037/abn0000907","url":null,"abstract":"<p><p>A primary goal of clinical neuroscience is to identify associations between individual differences in psychopathology and the brain. However, despite a significant amount of resources invested in this endeavor, few reliable neural correlates of psychopathology have been identified. A common suspect for this lack of success is the significant heterogeneity in symptoms observed in psychiatric disorders. However, this is not the only potential source of heterogeneity, as substantial heterogeneity is also observed in brain structure and function. Thus, for clinical neuroscience to identify reliable neural correlates of psychopathology, it will be necessary to better understand heterogeneity in both psychopathology and the brain. In this commentary, we suggest four shared principles that can help disentangle heterogeneity in both of these domains: (a) the brain and behavior should both be treated as complex measures, (b) a priori assumptions should be viewed with caution unless they can be replicated robustly in individuals, (c) complex models of individual differences require appropriate data to estimate them, and (d) the field would benefit from an increased focus on extensively measuring individuals, such as through the use of personalized models of psychopathology and neuroimaging data. Together, these shared principles can aid in better characterizing-and separating relevant and irrelevant-heterogeneity in measures of psychopathology and neuroimaging. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"613-617"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective associations between early adolescent reward functioning and later dimensions of psychopathology.","authors":"Matthew Mattoni, Samantha Pegg, Autumn Kujawa, Daniel N Klein, Thomas M Olino","doi":"10.1037/abn0000942","DOIUrl":"10.1037/abn0000942","url":null,"abstract":"<p><p>Individual differences in reward functioning have been associated with numerous disorders in adolescence. Given relations with multiple forms of psychopathology, it is unclear whether these associations are disorder specific or reflective of shared variance across multiple disorders. In a sample of adolescents (N = 418), we examined associations between neural and self-reported indices of early reward functioning (age 12) with different levels of a hierarchical psychopathology model assessed later in adolescence (age 18). We examined whether prospective relationships between reward functioning are specific to individual disorders or better explained by transdiagnostic dimensions. We found modest results for prospective associations between reward indices and different dimensions of psychopathology, with most significant associations not surviving correction for multiple comparisons. We discuss the benefits and limitations of the modeling approach used to examine dimension-specific associations that future work can build on. Overall, more work is needed to better understand how reward functioning is specifically associated with different forms of and hierarchical levels of psychopathology. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"630-637"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}